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List of works by Jackie D Kendall

A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types ⬇️

scientific article published on August 15, 2011

Biological characterization of SN32976, a selective inhibitor of PI3K and mTOR with preferential activity to PI3Kα, in comparison to established pan PI3K inhibitors

scientific article published on 9 May 2017

Combining properties of different classes of PI3Kα inhibitors to understand the molecular features that confer selectivity.

scientific article

Development and evaluation of PIK75 nanosuspension, a phosphatidylinositol-3-kinase inhibitor.

scientific article

Development of PIK-75 nanosuspension formulation with enhanced delivery efficiency and cytotoxicity for targeted anti-cancer therapy.

scientific article published on 28 April 2013

Discovery of pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors.

scientific article

Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolism in vivo ⬇️

scientific article published on February 15, 2012

Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling.

scientific article published on June 2007

Formation of fluorophores from the kynurenine pathway metabolite N-formylkynurenine and cyclic amines involves transamidation and carbon-carbon bond formation at the 2-position of the amine

scientific article published on 20 April 2015

Identification of a unique co-operative phosphoinositide 3-kinase signaling mechanism regulating integrin alpha IIb beta 3 adhesive function in platelets

scientific article published on 02 August 2007

Novel pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors: Exploring the benzenesulfonohydrazide SAR ⬇️

scientific article published on November 25, 2011

Novel pyrazolo[1,5-a]pyridines with improved aqueous solubility as p110α-selective PI3 kinase inhibitors

scientific article published on 25 November 2016

Oncogenic Mutations of p110α Isoform of PI 3-Kinase Upregulate Its Protein Kinase Activity ⬇️

scientific article published on January 1, 2013

Phosphatidylinositol 3-kinase inhibitor (PIK75) containing surface functionalized nanoemulsion for enhanced drug delivery, cytotoxicity and pro-apoptotic activity in ovarian cancer cells

scientific article

Phosphoinositide-3-kinase (PI3K) inhibitors: identification of new scaffolds using virtual screening.

scientific article

Potent and selective nonpeptidic inhibitors of procollagen C-proteinase

scientific article published on 26 June 2007

Synthesis and biological evaluation of novel analogues of the pan class I phosphatidylinositol 3-kinase (PI3K) inhibitor 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474).

scientific article

Synthesis and biological evaluation of novel phosphatidylinositol 3-kinase inhibitors: Solubilized 4-substituted benzimidazole analogs of 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474) ⬇️

scientific article published on April 6, 2013

Synthesis and biological evaluation of solubilized sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474

scientific article published on 25 February 2019

Synthesis and biological evaluation of sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474.

scientific article published on 20 September 2017

Synthesis, biological evaluation and molecular modelling of sulfonohydrazides as selective PI3K p110alpha inhibitors.

scientific article published on 4 September 2007

Targeting of nanoparticles in cancer: drug delivery and diagnostics

scientific article

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