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List of works by David A. Dichek

A Rabbit Model for Testing Helper-Dependent Adenovirus-Mediated Gene Therapy for Vein Graft Atherosclerosis

scientific article published on 28 September 2017

A Rabbit Model of Durable Transgene Expression in Jugular Vein to Common Carotid Artery Interposition Grafts

A critical developmental role for tgfbr2 in myogenic cell lineages is revealed in mice expressing SM22-Cre, not SMMHC-Cre.

scientific article published on 2 August 2006

ABCA1 Overexpression in Endothelial Cells In Vitro Enhances ApoAI-Mediated Cholesterol Efflux and Decreases Inflammation

scientific article published on 02 October 2018

Adenoviral Gene Transfer in Arteries of Hypercholesterolemic Nonhuman Primates ⬇️

scientific article published on April 10, 1998

Aortopathy in a Mouse Model of Marfan Syndrome Is Not Mediated by Altered Transforming Growth Factor β Signaling

scientific article published on 24 January 2017

Apo A-I (Apolipoprotein A-I) Vascular Gene Therapy Provides Durable Protection Against Atherosclerosis in Hyperlipidemic Rabbits

scientific article published on 9 November 2017

Apolipoprotein A-I vascular gene therapy reduces vein-graft atherosclerosis

scientific article published in September 2023

Assessment of Subclinical Atherosclerosis in Asymptomatic People In Vivo: Measurements Suitable for Biomarker and Mendelian Randomization Studies

scientific article published in January 2024

Cationic Liposomes Enhance Adenovirus Entry via a Pathway Independent of the Fiber Receptor andαv-Integrins ⬇️

scientific article published on March 1, 1998

Constriction of carotid arteries by urokinase-type plasminogen activator requires catalytic activity and is independent of NH(2)-terminal domains

scholarly article by Philip G Massey et al published November 2009 in Thrombosis and Haemostasis

Efficient gene transfer and durable transgene expression in grafted rabbit veins

scientific article

Endothelium-Specific In Vivo Gene Transfer ⬇️

scientific article published on September 1, 1995

Exosome-Mediated Transfer of Anti-miR-33a-5p from Transduced Endothelial Cells Enhances Macrophage and Vascular Smooth Muscle Cell Cholesterol Efflux

scientific article published on 16 January 2020

Expression of apolipoprotein A-I in rabbit carotid endothelium protects against atherosclerosis

scientific article

Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction ⬇️

scientific article published on July 1, 1997

Gene therapy for arterial thrombosis ⬇️

scientific article published on September 1, 1997

Helper-dependent adenoviral vector achieves prolonged, stable expression of interleukin-10 in rabbit carotid arteries but does not limit early atherogenesis

scientific article

Helper-dependent adenoviral vectors are superior in vitro to first-generation vectors for endothelial cell-targeted gene therapy

scientific article

Helper-dependent adenovirus is superior to first-generation adenovirus for expressing transgenes in atherosclerosis-prone arteries

scientific article

Identification of intracellular pathways through which TGF-beta1 upregulates PAI-1 expression in endothelial cells

scientific article published on September 2005

Improved animal models for testing gene therapy for atherosclerosis.

scientific article published on 14 February 2014

Improved vascular gene transfer with a helper-dependent adenoviral vector

scientific article published on 23 August 2004

In Vivo Gene Transfer to the Rabbit Common Carotid Artery Endothelium.

scientific article

In vivo expression of a conditional TGF-beta1 transgene: no evidence for TGF-beta1 transgene expression in SM22alpha-tTA transgenic mice

scientific article

Increased expression of urokinase during atherosclerotic lesion development causes arterial constriction and lumen loss, and accelerates lesion growth

scientific article

Jugular Vein Injection of High-Titer Lentiviral Vectors Does Not Transduce the Aorta

scientific article published on 10 December 2020

Level of macrophage uPA expression is an important determinant of atherosclerotic lesion growth in Apoe-/- mice.

scientific article published on 03 September 2009

Lipoprotein clearance mechanisms in LDL receptor-deficient "Apo-B48-only" and "Apo-B100-only" mice ⬇️

scientific article published on October 15, 1998

Local Vascular Gene Therapy With Apolipoprotein A-I to Promote Regression of Atherosclerosis

scientific article published on 8 December 2016

Macrophage-targeted overexpression of urokinase causes accelerated atherosclerosis, coronary artery occlusions, and premature death

scientific article published on 19 April 2004

Mechanisms of TGF-beta1-induced intimal growth: plasminogen-independent activities of plasminogen activator inhibitor-1 and heterogeneous origin of intimal cells

scientific article published on 12 April 2007

Mechanisms of cardiac fibrosis induced by urokinase plasminogen activator.

scientific article

Mechanisms of urokinase plasminogen activator (uPA)-mediated atherosclerosis: role of the uPA receptor and S100A8/A9 proteins

scientific article

New Mouse Model of Abdominal Aortic Aneurysm: Put Out to Expand

scientific article published in November 2017

Novel expression cassettes for increasing apolipoprotein AI transgene expression in vascular endothelial cells

Overexpression of endothelial nitric oxide synthase improves endothelium-dependent vasodilation in arteries infused with helper-dependent adenovirus

scientific article

Overexpression of transforming growth factor β1 in arterial endothelium causes hyperplasia, apoptosis, and cartilaginous metaplasia ⬇️

scientific article published on June 9, 1998

Overexpression of urokinase by macrophages or deficiency of plasminogen activator inhibitor type 1 causes cardiac fibrosis in mice

scientific article published on 05 August 2004

Overexpression of urokinase by plaque macrophages causes histological features of plaque rupture and increases vascular matrix metalloproteinase activity in aged apolipoprotein e-null mice

scientific article

Parallel Murine and Human Plaque Proteomics Reveals Pathways of Plaque Rupture

scientific article published on 30 July 2020

Plasminogen mediates the atherogenic effects of macrophage-expressed urokinase and accelerates atherosclerosis in apoE-knockout mice

scholarly article

Plasminogen promotes cholesterol efflux by the ABCA1 pathway.

scientific article

Postnatal Deletion of the Type II Transforming Growth Factor-β Receptor in Smooth Muscle Cells Causes Severe Aortopathy in Mice

scientific article published on 22 October 2015

Receptor-mediated regulation of plasminogen activator function: plasminogen activation by two directly membrane-anchored forms of urokinase

scientific article published on 01 September 2000

Reduction of mouse atherosclerosis by urokinase inhibition or with a limited-spectrum matrix metalloproteinase inhibitor

scientific article

Regional Variability in the Time Course of TGF-β1 Expression, Cellular Proliferation and Extracellular Matrix Expansion following Arterial Injury ⬇️

scientific article published on 01 January 1997

Regulated transgene expression in vascular smooth muscle

scientific article published on 01 October 2005

Smooth muscle cells give rise to osteochondrogenic precursors and chondrocytes in calcifying arteries

scientific article published on 05 February 2009

Stable In Vivo Transgene Expression in Endothelial Cells with Helper-Dependent Adenovirus: Roles of Promoter and Interleukin-10.

scientific article published on 14 November 2016

TGF-[beta]1 limits plaque growth, stabilizes plaque structure, and prevents aortic dilation in apolipoprotein E-null mice.

scientific article published on 26 March 2009

TGF-β (Transforming Growth Factor-β) Signaling Protects the Thoracic and Abdominal Aorta From Angiotensin II-Induced Pathology by Distinct Mechanisms

scientific article published on 20 July 2017

Targeted rearrangement of floxed alleles in smooth muscle cells in vivo

scientific article published on 01 December 2007

Targeting and delivery of microRNA-targeting antisense oligonucleotides in cardiovascular diseases

scientific article published in June 2023

Transforming growth factor beta 1 induces neointima formation through plasminogen activator inhibitor-1-dependent pathways

scientific article

Transforming growth factor-β signaling in myogenic cells regulates vascular morphogenesis, differentiation, and matrix synthesis

scientific article published on 06 October 2011

What's the Skinny on Elastin Deficiency and Supravalvular Aortic Stenosis?

scientific article

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