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List of works by Ramesh Akkina

2016 International meeting of the Global Virus Network

scientific article (publication date: June 2017)

A humanized mouse model for HIV-2 infection and efficacy testing of a single-pill triple-drug combination anti-retroviral therapy

scientific article published on 29 November 2016

A humanized mouse-based HIV-1 viral outgrowth assay with higher sensitivity than in vitro qVOA in detecting latently infected cells from individuals on ART with undetectable viral loads

scientific article published on 19 April 2017

A mouse model for human norovirus

scientific article published on 16 July 2013

A topical microbicide gel formulation of CCR5 antagonist maraviroc prevents HIV-1 vaginal transmission in humanized RAG-hu mice

scientific article

An aptamer-siRNA chimera suppresses HIV-1 viral loads and protects from helper CD4(+) T cell decline in humanized mice

scientific article

Bispecific short hairpin siRNA constructs targeted to CD4, CXCR4, and CCR5 confer HIV-1 resistance

scientific article published on January 2003

CXCR4 and CCR5 shRNA transgenic CD34+ cell derived macrophages are functionally normal and resist HIV-1 infection

scientific article

Current status of gene therapy strategies to treat HIV/AIDS.

scientific article

Decreased 4-1BB expression on HIV-specific CD4+ T cells is associated with sustained viral replication and reduced IL-2 production

scientific article published on 29 April 2009

Dengue virus infection and immune response in humanized RAG2(-/-)gamma(c)(-/-) (RAG-hu) mice

scientific article

Derivation of normal macrophages from human embryonic stem (hES) cells for applications in HIV gene therapy

scientific article published on 19 April 2006

Ex vivo selection and expansion of cells based on expression of a mutated inosine monophosphate dehydrogenase 2 after HIV vector transduction: effects on lymphocytes, monocytes, and CD34+ stem cells

scientific article published on 2 May 2006

Functional in vivo delivery of multiplexed anti-HIV-1 siRNAs via a chemically synthesized aptamer with a sticky bridge

scientific article published on 20 November 2012

Gene therapy strategies for HIV/AIDS: preclinical modeling in humanized mice

scientific article

HIV pre-exposure prophylaxis: mucosal tissue drug distribution of RT inhibitor Tenofovir and entry inhibitor Maraviroc in a humanized mouse model

scientific article published on 7 August 2014

HIV-1 infection and CD4 T cell depletion in humanized Rag2-/-yc-/- mice

HIV-1 infection and CD4 T cell depletion in the humanized Rag2-/-gamma c-/- (RAG-hu) mouse model

scientific article

HIV-1 resistance conferred by siRNA cosuppression of CXCR4 and CCR5 coreceptors by a bispecific lentiviral vector

scientific article

Human immune responses and potential for vaccine assessment in humanized mice

scientific article published on 27 April 2013

Humanized Mice for Studying Human Immune Responses and Generating Human Monoclonal Antibodies

scientific article published on April 2014

Humanized Rag1-/- γc-/- mice support multilineage hematopoiesis and are susceptible to HIV-1 infection via systemic and vaginal routes

scientific article

Humanized Rag2(-/-)gammac(-/-) (RAG-hu) mice can sustain long-term chronic HIV-1 infection lasting more than a year

scientific article published on 18 November 2009

Identification of novel influenza A virus proteins translated from PA mRNA

scientific article published on 12 December 2012

Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID "Meet the Experts" 2015 Workshop Summary

scientific article published on 16 December 2015

Inhibition of HIV-1 by lentiviral vector-transduced siRNAs in T lymphocytes differentiated in SCID-hu mice and CD34+ progenitor cell-derived macrophages

scientific article

Lentiviral transduction of Tar Decoy and CCR5 ribozyme into CD34+ progenitor cells and derivation of HIV-1 resistant T cells and macrophages

scientific article

Modeling HIV infection and therapies in humanized mice

scientific article published on 09 July 2012

Modeling HIV-1 Mucosal Transmission and Prevention in Humanized Mice

scientific article published on January 2016

Modeling the evolution of SIV sooty mangabey progenitor virus towards HIV-2 using humanized mice

scientific article

Mucosal tissue pharmacokinetics of the integrase inhibitor raltegravir in a humanized mouse model: Implications for HIV pre-exposure prophylaxis

scientific article

Mucosal transmission of R5 and X4 tropic HIV-1 via vaginal and rectal routes in humanized Rag2-/- gammac -/- (RAG-hu) mice

scientific article

Multimodal analysis of drug transporter expression in gastrointestinal tissue

scientific article published on 05 June 2017

New generation humanized mice for virus research: comparative aspects and future prospects

scientific article

New insights into HIV impact on hematopoiesis

scientific article published on September 2013

Oral pre-exposure prophylaxis by anti-retrovirals raltegravir and maraviroc protects against HIV-1 vaginal transmission in a humanized mouse model

scientific article

Potent suppression of HIV type 1 infection by a short hairpin anti-CXCR4 siRNA.

scientific article published on August 2003

Pseudotyping of lentiviral vector with novel vesiculovirus envelope glycoproteins derived from Chandipura and Piry viruses

scientific article

RNA-based anti-HIV-1 gene therapeutic constructs in SCID-hu mouse model

scientific article published on December 2002

Regulation of virus-specific CD4+ T cell function by multiple costimulatory receptors during chronic HIV infection

scientific article published on 23 July 2010

Safety and Efficacy of a Lentiviral Vector Containing Three Anti-HIV Genes-CCR5 Ribozyme, Tat-rev siRNA, and TAR Decoy-in SCID-hu Mouse-Derived T Cells

Safety and efficacy of a lentiviral vector containing three anti-HIV genes--CCR5 ribozyme, tat-rev siRNA, and TAR decoy--in SCID-hu mouse-derived T cells

scientific article published on 3 April 2007

Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells

scientific article

Stable gene transfer of CCR5 and CXCR4 siRNAs by sleeping beauty transposon system to confer HIV-1 resistance

scientific article published on 30 July 2008

Systemic administration of combinatorial dsiRNAs via nanoparticles efficiently suppresses HIV-1 infection in humanized mice

scientific article published on 27 September 2011

Thymic plasmacytoid dendritic cells are susceptible to productive HIV-1 infection and efficiently transfer R5 HIV-1 to thymocytes in vitro

scientific article

Topical gel formulation of broadly neutralizing anti-HIV-1 monoclonal antibody VRC01 confers protection against HIV-1 vaginal challenge in a humanized mouse model

scientific article published on 24 July 2012

siRNAs, ribozymes and RNA decoys in modeling stem cell-based gene therapy for HIV/AIDS.

scientific article

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