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List of works by Robert T. Dorr

1,4-Disubstituted Anthracene Antitumor Agents ⬇️

scientific article published on 01 November 1997

2-[2'-(Dimethylamino)ethyl]-1,2-dihydro- 3H-dibenz[de,h]isoquinoline-1,3-diones with substituents at positions 4, 8, 9, 10, and 11. Synthesis, antitumor activity, and quantitative structure-activity relationships

scientific article published on 01 December 1996

2-substituted 1,2-dihydro-3H-dibenz[de,h]isoquinoline-1,3-diones. A new class of antitumor agent

scientific article published on 01 March 1993

6- and 7-substituted 2-[2'-(dimethylamino)ethyl]-1,2-dihydro-3H-dibenz[de,h] isoquinoline-1,3-diones: synthesis, nucleophilic displacements, antitumor activity, and quantitative structure-activity relationships

scientific article published on 01 April 1996

A phase I and pharmacodynamic evaluation of polyethylene glycol-conjugated L-asparaginase in patients with advanced solid tumors

scientific article

A phase I trial of AUC-directed carboplatin with infusional doxorubicin and ifosfamide plus G-CSF in patients with advanced gynecologic malignancies

scientific article

A phase I trial of beta-all-trans-retinoic acid delivered via a collagen sponge and a cervical cap for mild or moderate intraepithelial cervical neoplasia

scientific article published on 01 November 1983

A phase I trial of imexon, a pro-oxidant, in combination with docetaxel for the treatment of patients with advanced breast, non-small cell lung and prostate cancer.

scientific article published on 6 June 2009

Abstract 797: Gemcitabine resistant pancreatic cancer cell lines acquire an invasive phenotype with characteristics of EMT

scientific article published on 09 August 2012

Alkylation of DNA by C-10 of 2,7-diaminomitosene

scientific article published on 01 January 1990

Alpha-globulins suppress human leukocyte tumor necrosis factor secretion.

scientific article published in May 1989

Amino-substituted 2-[2'-(dimethylamino)ethyl]-1,2-dihydro-3H- dibenz[de,h]isoquinoline-1,3-diones. Synthesis, antitumor activity, and quantitative structure--activity relationship

scientific article published on March 1995

Analogues of amonafide and azonafide with novel ring systems

scientific article published on 01 August 2000

Analytical and biological inequivalence of two commercial formulations of the antitumor agent bleomycin ⬇️

scientific article published on January 1, 1998

Anti-tumor activity and mechanism of action for a cyanoaziridine-derivative, AMP423 ⬇️

scientific article published on December 21, 2011

Antitumor activity of combretastatin-A4 phosphate, a natural product tubulin inhibitor

scientific article published on 01 January 1996

Bisantrene solubility and skin toxicity studies: Efficacy of sodium bicarbonate as a local ulceration antidote ⬇️

scientific article published on 01 January 1984

Bleomycin compatibility with selected intravenous medications

scientific article published on January 1, 1982

Case report: topical DMSO for mitomycin-C-induced skin ulceration

scientific article

Characterization of a membrane-active anti-tumor agent, UA8967 ⬇️

scientific article published on November 23, 2012

Characterization of experimental mitoxantrone cardiotoxicity and its partial inhibition by ICRF-187 in cultured neonatal rat heart cells

scientific article published on February 1993

Characterization of novel diaryl oxazole-based compounds as potential agents to treat pancreatic cancer

scientific article published on 05 August 2009

Chemoprevention of human actinic keratoses by topical 2-(difluoromethyl)-dl-ornithine

scientific article published on 01 December 2000

Cimetidine enhancement of cyclophosphamide antitumour activity

scientific article

Cold protection and heat enhancement of doxorubicin skin toxicity in the mouse

scientific article published on 01 April 1985

Combination chemotherapy with cyclophosphamide, vincristine, adriamycin, and dexamethasone (CVAD) plus oral quinine and verapamil in patients with advanced breast cancer

scientific article published on January 1997

Comparison of young clinical investigators' accuracy and reproducibility when measuring pulmonary and skin surface nodules using a circumferential measurement versus a standard caliper measurement: American Association for Cancer Research/American S

scientific article published in January 2000

Correlates of imexon sensitivity in human multiple myeloma cell lines

scientific article published on January 2006

Cytotoxic activity of Apomine is due to a novel membrane-mediated cytolytic mechanism independent of apoptosis in the A375 human melanoma cell line

scientific article published on 6 October 2006

Daily variation in non-protein sulfhydryl levels of human bone marrow

scientific article

Dermal toxicity of topical (-)epigallocatechin-3-gallate in BALB/c and SKH1 mice

scientific article

Direct relation of DNA lesions in multidrug-resistant human myeloma cells to intracellular doxorubicin concentration.

scientific article published in November 1988

Disposition and metabolism of topically administered alpha-tocopherol acetate: a common ingredient of commercially available sunscreens and cosmetics

scientific article published on 01 January 1996

Effects of a superpotent melanotropic peptide in combination with solar UV radiation on tanning of the skin in human volunteers

scientific article

Efficacy of sodium thiosulfate as a local antidote to mechlorethamine skin toxicity in the mouse

scientific article published on 01 January 1988

Enhancement of regression of cervical intraepithelial neoplasia II (moderate dysplasia) with topically applied all-trans-retinoic acid: a randomized trial

scientific article published on April 1994

Ethonafide-induced cytotoxicity is mediated by topoisomerase II inhibition in prostate cancer cells

scientific article

Evaluation of topically applied trans-retinoic acid in the treatment of cervical intraepithelial lesions

scientific article published on 01 August 1982

Experimental dacarbazine antitumor activity and skin toxicity in relation to light exposure and pharmacologic antidotes.

scientific article

Experimental model of doxorubicin extravasation in the mouse

scientific article published on 01 November 1980

Failure of DMSO and vitamin E to prevent doxorubicin skin ulceration in the mouse

scientific article published on 01 May 1983

Human tumor models in the severe combined immune deficient ( scid ) mouse ⬇️

scientific article published on January 1, 1997

Identification and characterization of in vitro metabolites of 2-[2'-(dimethylamino)ethyl]-1,2-dihydro-3H-dibenz [de,h]isoquinoline-1,3-dione (Azonafide) ⬇️

scientific article published on February 1, 1998

Imexon Induces an Oxidative Endoplasmic Reticulum Stress Response in Pancreatic Cancer Cells ⬇️

scientific article published on January 24, 2012

Imexon activates an intrinsic apoptosis pathway in RPMI8226 myeloma cells

scientific article published in November 2002

Imexon enhances gemcitabine cytotoxicity by inhibition of ribonucleotide reductase

scientific article

Imexon-based combination chemotherapy in A375 human melanoma and RPMI 8226 human myeloma cell lines

scientific article published on 28 February 2007

In vitro cytotoxicity against fresh human tumors and P388 leukemia predicts the differential in vivo activity of a series of anthracene anticancer drugs

scientific article published on February 1991

In vitro cytotoxicity and DNA damage production in Chinese hamster ovary cells and topoisomerase II inhibition by 2-[2'-(dimethylamino)ethyl]-1, 2-dihydro-3H-dibenz[de,h]isoquinoline-1,3-diones with substitutions at the 6 and 7 positions (azonafides

scientific article published on March 1997

In vitro rat myocyte cardiotoxicity model for antitumor antibiotics using adenosine triphosphate/protein ratios ⬇️

scientific article published on September 15, 1988

In vitro retinoid binding and release from a collagen sponge material in a simulated intravaginal environment

scientific article published on 01 November 1982

Increased eumelanin expression and tanning is induced by a superpotent melanotropin [Nle4-D-Phe7]-alpha-MSH in humans

scientific article

Induction of apoptosis and cell cycle arrest by imexon in human pancreatic cancer cell lines

scientific article

Induction of mitochondrial changes in myeloma cells by imexon

scientific article

Induction of oxidative stress and apoptosis in myeloma cells by the aziridine-containing agent imexon

scientific article

Inhibition of protein synthesis by imexon reduces HIF-1alpha expression in normoxic and hypoxic pancreatic cancer cells

scientific article published on 08 July 2008

Interaction of cimetidine but not ranitidine with cyclophosphamide in mice

scientific article published on 01 April 1986

Interaction of dacarbazine and imexon, in vitro and in vivo, in human A375 melanoma cells

scientific article published on September 1, 2011

Interactions of mitomycin C with mammalian DNA detected by alkaline elution

scientific article published in August 1985

Intracellular localization of 6- and 7-substituted 2-[2'-(dimethylamino)ethyl]-1,2-dihydro-3H-dibenz[de,h]isoquino line-1,3-diones (azonafides) is not the limiting factor for their cytotoxicity: an in vitro confocal microscopy study

scientific article

Lack of Ranitidine Effects on Cyclophosphamide Bon Marrow Toxicity or Metabolism: A Placebo-Controlled Clinical Trial ⬇️

scientific article published on 01 December 1991

Lack of experimental vesicant activity for the anticancer agents cisplatin, melphalan, and mitoxantrone

scientific article published in January 1986

Magnetic Resonance Imaging Identifies Differential Response to Pro-Oxidant Chemotherapy in a Xenograft Model

scientific article published on 17 May 2016

Methotrexate: bioavailability and pharmacokinetics

scientific article published on 01 July 1985

Mitochondrial-mediated disregulation of Ca2+ is a critical determinant of Velcade (PS-341/bortezomib) cytotoxicity in myeloma cell lines

scientific article

Mitomycin C resistant L1210 leukemia cells: association with pleiotropic drug resistance.

scientific article

Mitomycin C toxicity and pharmacokinetics in mice given sulfur nucleophiles

scientific article published on 01 July 1988

Modulation of experimental doxorubicin skin toxicity by beta-adrenergic compounds ⬇️

scientific article published on 01 June 1981

Molecular and cellular characterization of imexon-resistant RPMI8226/I myeloma cells.

scientific article published on January 2002

New Perspectives on an Old Friend: Optimizing Carboplatin for the Treatment of Solid Tumors

scientific article

New antitumor agents containing the anthracene nucleus

scientific article published on 01 August 1987

Novel antitumor 2-cyanoaziridine-1-carboxamides.

scientific article

Pharmacokinetic analysis by high-performance liquid chromatography of intravenous nordihydroguaiaretic acid in the mouse

scientific article published in April 2001

Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals

scientific article (publication date: 15 August 2003)

Pharmacokinetics of the green tea derivative, EGCG, by the topical route of administration in mouse and human skin

scientific article

Pharmacologic antidotes to experimental doxorubicin skin toxicity: a suggested role for beta-adrenergic compounds

scientific article published on 01 November 1981

Phase 1 study of topical perillyl alcohol cream for chemoprevention of skin cancer

scientific article published in May 2008

Phase I pharmacokinetic study of tea polyphenols following single-dose administration of epigallocatechin gallate and polyphenon E.

scientific article

Phase I trial of imexon in patients with advanced malignancy

scientific article published on 01 May 2007

Preclinical antitumor activity of the azonafide series of anthracene-based DNA intercalators

scientific article published on March 2001

Preclinical antitumor activity, pharmacokinetics and pharmacodynamics of imexon in mice

scientific article published on 01 November 2006

Preventing the autophagic survival response by inhibition of calpain enhances the cytotoxic activity of bortezomib in vitro and in vivo ⬇️

scientific article published on April 10, 2013

Prevention of photocarcinogenesis by topical administration of pure epigallocatechin gallate isolated from green tea

scientific article published on 01 January 1996

Quantitation of ellipsoid tumor areas using a circumferential measuring device

scientific article published on 01 January 1988

Role of glutathione and its associated enzymes in multidrug-resistant human myeloma cells.

scientific article

Safety of autotransplants with high-dose melphalan in renal failure: a pharmacokinetic and toxicity study.

scientific article published on June 1996

Sequence-dependent cytotoxicity of combination chemotherapy using paclitaxel, carboplatin and bleomycin in human lung and ovarian cancer

scientific article published in August 2001

Skin ulceration potential of paclitaxel in a mouse skin model in vivo

scientific article published on 01 July 1996

Skin ulceration potential without therapeutic anticancer activity for epipodophyllotoxin commercial diluents

scientific article published on 01 January 1983

Structure-activity relationships for mitomycin C and mitomycin A analogues

scientific article published in July 1991

Structure-activity studies of antitumor agents based on pyrrolo[1,2-a]benzimidazoles: new reductive alkylating DNA cleaving agents

scientific article

The antitumor agent imexon activates antioxidant gene expression: evidence for an oxidative stress response

scientific article published on June 2007

The clinical relevance of multidrug resistance

scientific article published on January 1990

The diaryl oxazole PC-046 is a tubulin-binding agent with experimental anti-tumor efficacy in hematologic cancers

scientific article published on 14 September 2013

The limited role of corticosteroids in ameliorating experimental doxorubicin skin toxicity in the mouse

scientific article published on January 1980

The state-of-the-art in chemoprevention of skin cancer

scientific article

Topical DMSO treatment for pegylated liposomal doxorubicin-induced palmar-plantar erythrodysesthesia

scientific article

Topical absorption and inactivation of cytotoxic anticancer agents in vitro

scientific article published on August 15, 1992

Tumor Xenograft Response to Redox-Active Therapies Assessed by Magnetic Resonance Imaging Using a Thiol-Bearing DOTA Complex of Gadolinium ⬇️

scientific article published on June 1, 2012

UA62784, a novel inhibitor of centromere protein E kinesin-like protein

scientific article published on January 2009

Verapamil reversal of doxorubicin resistance in multidrug-resistant human myeloma cells and association with drug accumulation and DNA damage.

scientific article published in November 1988

Vinca alkaloid skin toxicity: antidote and drug disposition studies in the mouse

scientific article published on 01 January 1985

tetra-O-methylnordihydroguaiaretic acid inhibits melanoma in vivo

scientific article published in September 2001

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