List of works - Michael A Crackower

A Specific Role of Phosphatidylinositol 3–Kinase γ

A human tissue-based functional assay platform to evaluate the immune function impact of small molecule inhibitors that target the immune system

scientific article published on 18 July 2017

A story of two ACEs

scientific article

Angiotensin-converting enzyme 2 is an essential regulator of heart function

scientific article (publication date: 20 June 2002)

Angiotensin-converting enzyme 2 protects from severe acute lung failure

scientific article published in July 2005

Assessment of multiple pharmacological mechanisms in the ascaris sensitive sheep model of allergic asthma.

scientific article published on 14 August 2013

DREAM is a critical transcriptional repressor for pain modulation

scientific article (publication date: 11 January 2002)

Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases

scientific article published on 05 November 2010

Essential role of Fkbp6 in male fertility and homologous chromosome pairing in meiosis

scientific article

Exploring the role of SYK in respiratory in vivo models

scientific article published on 14 August 2013

Gene expression profiling following NRF2 and KEAP1 siRNA knockdown in human lung fibroblasts identifies CCL11/Eotaxin-1 as a novel NRF2 regulated gene

scientific article

Gene expression profiling in patients with chronic obstructive pulmonary disease and lung cancer

scientific article

Genes related to emphysema are enriched for ubiquitination pathways

scientific article

Identification of distinct plasma biomarker signatures in patients with rapid and slow declining forms of COPD

scientific article published on 01 February 2010

Immunoglobulin E signal inhibition during allergen ingestion leads to reversal of established food allergy and induction of regulatory T cells

scientific article

Inhibition of spleen tyrosine kinase attenuates IgE-mediated airway contraction and mediator release in human precision cut lung slices

scientific article published on 15 July 2016

Inhibition of spleen tyrosine kinase attenuates allergen-mediated airway constriction.

scientific article published in December 2013

Inhibition of αvβ5 Integrin Attenuates Vascular Permeability and Protects against Renal Ischemia-Reperfusion Injury

scientific article published on 6 January 2017

Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress

article

Loss of angiotensin-converting enzyme-2 leads to the late development of angiotensin II-dependent glomerulosclerosis

scientific article

Mice with a targeted mutation of patched2 are viable but develop alopecia and epidermal hyperplasia

scientific journal article

Mutant meiotic chromosome core components in mice can cause apparent sexual dimorphic endpoints at prophase or X-Y defective male-specific sterility

scientific article published on 28 June 2005

Pharmacological Characterization of MK-7246, a Potent and Selective CRTH2 (Chemoattractant Receptor-Homologous Molecule Expressed on T-Helper Type 2 Cells) Antagonist ⬇️

scientific article published on October 13, 2010

Phenotypic responses of differentiated asthmatic human airway epithelial cultures to rhinovirus

scientific article

Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure.

scientific article published on 8 September 2003

Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways

scientific article

Structure-function relationships in the neuropeptide S receptor: molecular consequences of the asthma-associated mutation N107I

scientific article

Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers

scientific article

The role of ACE2 in cardiovascular physiology

scientific article

The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease

scientific article published in August 2004

The use of strictly standardized mean difference for hit selection in primary RNA interference high-throughput screening experiments

scientific article published on 13 April 2007

List of works by Michael A Crackower

A Specific Role of Phosphatidylinositol 3–Kinase γ

A human tissue-based functional assay platform to evaluate the immune function impact of small molecule inhibitors that target the immune system

A story of two ACEs

Angiotensin-converting enzyme 2 is an essential regulator of heart function

Angiotensin-converting enzyme 2 protects from severe acute lung failure

Assessment of multiple pharmacological mechanisms in the ascaris sensitive sheep model of allergic asthma.

DREAM is a critical transcriptional repressor for pain modulation

Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases

Essential role of Fkbp6 in male fertility and homologous chromosome pairing in meiosis

Exploring the role of SYK in respiratory in vivo models

Gene expression profiling following NRF2 and KEAP1 siRNA knockdown in human lung fibroblasts identifies CCL11/Eotaxin-1 as a novel NRF2 regulated gene

Gene expression profiling in patients with chronic obstructive pulmonary disease and lung cancer

Genes related to emphysema are enriched for ubiquitination pathways

Identification of distinct plasma biomarker signatures in patients with rapid and slow declining forms of COPD

Immunoglobulin E signal inhibition during allergen ingestion leads to reversal of established food allergy and induction of regulatory T cells

Inhibition of spleen tyrosine kinase attenuates IgE-mediated airway contraction and mediator release in human precision cut lung slices

Inhibition of spleen tyrosine kinase attenuates allergen-mediated airway constriction.

Inhibition of αvβ5 Integrin Attenuates Vascular Permeability and Protects against Renal Ischemia-Reperfusion Injury

Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress

Loss of angiotensin-converting enzyme-2 leads to the late development of angiotensin II-dependent glomerulosclerosis

Mice with a targeted mutation of patched2 are viable but develop alopecia and epidermal hyperplasia

Mutant meiotic chromosome core components in mice can cause apparent sexual dimorphic endpoints at prophase or X-Y defective male-specific sterility

Pharmacological Characterization of MK-7246, a Potent and Selective CRTH2 (Chemoattractant Receptor-Homologous Molecule Expressed on T-Helper Type 2 Cells) Antagonist ⬇️

Phenotypic responses of differentiated asthmatic human airway epithelial cultures to rhinovirus

Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure.

Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways

Structure-function relationships in the neuropeptide S receptor: molecular consequences of the asthma-associated mutation N107I

Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers

The role of ACE2 in cardiovascular physiology

The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease

The use of strictly standardized mean difference for hit selection in primary RNA interference high-throughput screening experiments