Search filters

List of works by Jesse Alt

6-Hydroxy-1,2,4-triazine-3,5(2H,4H)-dione Derivatives as Novel D-Amino Acid Oxidase Inhibitors

scientific article published on 26 August 2015

A new model for prenatal brain damage. I. GABAA receptor activation induces cell death in developing rat hippocampus

scientific article

A novel model for prenatal brain damage. II. Long-term deficits in hippocampal cell number and hippocampal-dependent behavior following neonatal GABAA receptor activation

scientific article

Bioanalysis of 6-diazo-5-oxo-l-norleucine in plasma and brain by ultra-performance liquid chromatography mass spectrometry

scientific article published on 10 January 2015

Brain estradiol content in newborn rats: sex differences, regional heterogeneity, and possible de novo synthesis by the female telencephalon

scientific article published on 26 February 2004

Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer

scientific article published on 24 August 2016

Correction: JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress.

scientific article published on 13 March 2019

D-Amino acid oxidase inhibitors based on the 5-hydroxy-1,2,4-triazin-6(1H)-one scaffold.

scientific article published on 23 February 2016

D-Amino-Acid Oxidase Inhibition Increases D-Serine Plasma Levels in Mouse But not in Monkey or Dog.

scientific article published on 16 October 2015

Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors.

scientific article published on 30 November 2012

Design, synthesis, and pharmacological evaluation of fluorinated tetrahydrouridine derivatives as inhibitors of cytidine deaminase

scientific article published on 24 February 2014

Development of a high-throughput method for the determination of pharmacological levels of plasma D-serine.

scientific article published on 16 August 2011

Discovery of 6-Diazo-5-oxo-l-norleucine (DON) Prodrugs with Enhanced CSF Delivery in Monkeys: A Potential Treatment for Glioblastoma

scientific article published on 25 August 2016

Discovery of a para-Acetoxy-benzyl Ester Prodrug of a Hydroxamate-Based Glutamate Carboxypeptidase II Inhibitor as Oral Therapy for Neuropathic Pain

scientific article published on 31 July 2017

Dose-dependent inhibition of GCPII to prevent and treat cognitive impairment in the EAE model of multiple sclerosis

scientific article published on 26 January 2016

Enhanced Brain Delivery of 2-(Phosphonomethyl)pentanedioic Acid Following Intranasal Administration of Its γ-Substituted Ester Prodrugs

scientific article

Enhanced Oral Bioavailability of 2-(Phosphonomethyl)-pentanedioic Acid (2-PMPA) from its (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl (ODOL)-Based Prodrugs

scientific article published on 24 September 2019

Glutamate carboxypeptidase II is not an amyloid peptide‐degrading enzyme ⬇️

scientific article published on March 23, 2013

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

scientific article published on 07 November 2019

Inhibition of glutamate carboxypeptidase II (GCPII) activity as a treatment for cognitive impairment in multiple sclerosis

scientific article

Inhibition of mTORC1 in pediatric low-grade glioma depletes glutathione and therapeutically synergizes with carboplatin

scientific article published on 01 February 2019

Inhibition of xc- transporter-mediated cystine uptake by sulfasalazine analogs ⬇️

scientific article published on August 12, 2011

JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress

scientific article published on 13 August 2018

MBRS-61. IN VIVO METABOLOMICS REVEALS A POTENT COMBINATION THERAPY FOR MYC-DRIVEN MEDULLOBLASTOMA.

scientific article published on 22 June 2018

N-(Pivaloyloxy)alkoxy-carbonyl Prodrugs of the Glutamine Antagonist 6-Diazo-5-oxo-l-norleucine (DON) as a Potential Treatment for HIV Associated Neurocognitive Disorders.

scientific article

Neurological sequelae induced by alphavirus infection of the CNS are attenuated by treatment with the glutamine antagonist 6-diazo-5-oxo-l-norleucine

scientific article

Oral administration of D-alanine in monkeys robustly increases plasma and cerebrospinal fluid levels but experimental D-amino acid oxidase inhibitors had minimal effect

scientific article published on 10 June 2016

Orally bioavailable glutamine antagonist prodrug JHU-083 penetrates mouse brain and suppresses the growth of MYC-driven medulloblastoma

scientific article published on 21 July 2019

Palonosetron exhibits unique molecular interactions with the 5-HT3 receptor

scientific article

Palonosetron triggers 5-HT(3) receptor internalization and causes prolonged inhibition of receptor function

scientific article published on 15 October 2009

Peptidomimetics of Arg-Phe-NH2 as small molecule agonists of Mas-related gene C (MrgC) receptors.

scientific article

Prostate-specific membrane antigen (PSMA)-mediated laminin proteolysis generates a pro-angiogenic peptide

scientific article published on 8 July 2016

Reversible Disulfide Formation of the Glutamate Carboxypeptidase II Inhibitor E2072 Results in Prolonged Systemic Exposures In Vivo ⬇️

scientific article published on September 4, 2012

Selective CNS Uptake of the GCP-II Inhibitor 2-PMPA following Intranasal Administration

scientific article published on 7 July 2015

Structure-Metabolism Relationships in the Glucuronidation of d-Amino Acid Oxidase Inhibitors.

scientific article

Synthesis and SAR of 1-hydroxy-1H-benzo[d]imidazol-2(3H)-ones as Inhibitors of D-Amino Acid Oxidase.

scientific article

Synthesis of kojic acid derivatives as secondary binding site probes of D-amino acid oxidase

scientific article published on May 2013

The Antiemetic 5-HT3 Receptor Antagonist Palonosetron Inhibits Substance P-Mediated Responses In Vitro and In Vivo ⬇️

scientific article published on August 19, 2010

The Diversity of Chemoprotective Glucosinolates in Moringaceae (Moringa spp.).

scientific article

The NAAG'ing Concerns of Modeling Human Alzheimer's Disease in Mice

scientific article published on 01 January 2019

The Novel Glutamine Antagonist Prodrug JHU395 Has Antitumor Activity in Malignant Peripheral Nerve Sheath Tumor

scientific article published on 08 October 2019

Unbiased Metabolic Profiling Predicts Sensitivity of High MYC-Expressing Atypical Teratoid/Rhabdoid Tumors to Glutamine Inhibition with 6-Diazo-5-Oxo-L-Norleucine

scientific article published on 12 July 2019

δ-Thiolactones as prodrugs of thiol-based glutamate carboxypeptidase II (GCPII) inhibitors

scientific article published on 27 December 2013

Paulina is supported by:

About Paulina

Help