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List of works by P. Reed Larsen

A 21-year-old woman with consumptive hypothyroidism due to a vascular tumor expressing type 3 iodothyronine deiodinase

scientific article

A Cohort Analysis of Clinical and Ultrasound Variables Predicting Cancer Risk in 20,001 Consecutive Thyroid Nodules

scientific article published on 01 November 2019

A Global Loss of Dio2 Leads to Unexpected Changes in Function and Fiber Types of Slow Skeletal Muscle in Male Mice

scientific article published on 01 May 2019

A Novel Retinoid X Receptor-Independent Thyroid Hormone Response Element Is Present in the Human Type 1 Deiodinase Gene ⬇️

scientific article published on September 1, 1995

A Type 2 Deiodinase-Dependent Increase in Vegfa Mediates Myoblast-Endothelial Cell Crosstalk During Skeletal Muscle Regeneration

scientific article published on 12 August 2020

A novel cell type-specific mechanism for thyroid hormone-dependent negative regulation of the human type 1 deiodinase gene

scientific article published on 26 August 2004

A standardized assessment of thyroid nodules in children confirms higher cancer prevalence than in adults.

scientific article

Activation and inactivation of thyroid hormone by type I iodothyronine deiodinase

scientific article

Activation of thyroid hormone is transcriptionally regulated by epidermal growth factor in human placenta-derived JEG3 cells

scientific article

Acute posttranscriptional regulation of cerebrocortical and pituitary iodothyronine 5'-deiodinases by thyroid hormone

scientific article published on 01 March 1984

Anatomical distribution of phenolic and tyrosyl ring iodothyronine deiodinases in the nervous system of normal and hypothyroid rats

scientific article published on 01 August 1981

Atypical expression of type 2 iodothyronine deiodinase in thyrotrophs explains the thyroxine-mediated pituitary thyrotropin feedback mechanism.

scientific article published on 5 January 2006

Bethesda Categorization of Thyroid Nodule Cytology and Prediction of Thyroid Cancer Type and Prognosis

scientific article published on 12 November 2015

Bioavailability of thyroid hormones from oral replacement preparations

scientific article published on 01 September 1982

Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases.

scientific article

CARs and drugs: a risky combination

scientific article published in March 2005

Capacity for cooperative binding of thyroid hormone (T3) receptor dimers defines wild type T3 response elements

scientific article

Cardiac expression of human type 2 iodothyronine deiodinase increases glucose metabolism and protects against doxorubicin-induced cardiac dysfunction in male mice

scientific article published on 16 July 2013

Catalysis leads to posttranslational inactivation of the type 1 deiodinase and alters its conformation ⬇️

scientific article published on April 27, 2012

Catecholamine stimulation of iodothyronine 5'-deiodinase activity in rat dispersed brown adipocytes

scientific article

Cellular and structural biology of the deiodinases

scientific article

Cerebral cortex responds rapidly to thyroid hormones

scientific article published on 01 October 1981

Characterization of the 5'-flanking and 5'-untranslated regions of the cyclic adenosine 3',5'-monophosphate-responsive human type 2 iodothyronine deiodinase gene

scientific article

Characterization of the promoter of the rat sarcoplasmic endoplasmic reticulum Ca2+-ATPase 1 gene and analysis of thyroid hormone responsiveness

scientific article published on December 1996

Chronic cardiac-specific thyrotoxicosis increases myocardial beta-adrenergic responsiveness.

scientific article

Clinical, Sonographic, and Pathological Characteristics of RAS-Positive Versus BRAF-Positive Thyroid Carcinoma

scientific article published on 30 September 2016

Cloning and expression of the chicken type 2 iodothyronine 5'-deiodinase

scientific article

Cloning and in vitro expression of the human selenoprotein, type I iodothyronine deiodinase

scientific article published on October 1, 1992

Comparison of iodothyronine 5'-deiodinase and other thyroid-hormone-dependent enzyme activities in the cerebral cortex of hypothyroid neonatal rat. Evidence for adaptation to hypothyroidism

scientific article published on November 1982

Comparison of kidney and brown adipose tissue iodothyronine 5'-deiodinases

scientific article published on 01 August 1987

Contributions of plasma triiodothyronine and local thyroxine monodeiodination to triiodothyronine to nuclear triiodothyronine receptor saturation in pituitary, liver, and kidney of hypothyroid rats. Further evidence relating saturation of pituitary

scientific article published on 01 May 1978

DARPP-32 and CREB are present in type 2 iodothyronine deiodinase-producing tanycytes: implications for the regulation of type 2 deiodinase activity

scientific article

Different pathways of iodothyronine 5′-deiodination in rat cerebral cortex ⬇️

scientific article published on August 31, 1981

Differential Growth Rates of Benign vs. Malignant Thyroid Nodules

scientific article published on 12 October 2017

Differential capacity of wild type promoter elements for binding and trans-activation by retinoic acid and thyroid hormone receptors

scientific article published on October 1, 1992

Direct repeats

scientific article published in Nature

Distinct subcellular localization of transiently expressed types 1 and 2 iodothyronine deiodinases as determined by immunofluorescence confocal microscopy

scientific article

Distribution of hypophysiotropic thyrotropin-releasing hormone (TRH)-synthesizing neurons in the hypothalamic paraventricular nucleus of the mouse

scientific article published on October 2010

Divergent changes of thyroxine-5'-monodeiodination in rat pituitary and liver during maturation

scientific article published on 01 May 1980

Dominant negative inhibition by mutant thyroid hormone receptors is thyroid hormone response element and receptor isoform specific

scientific article published on October 1993

Effect of 3,5,3'-Triiodothyronine (T3) administration on dio1 gene expression and T3 metabolism in normal and type 1 deiodinase-deficient mice ⬇️

scientific article published on November 1, 1995

Effects of varying the position of thyroid hormone response elements within the rat growth hormone promoter: implications for positive and negative regulation by 3,5,3'-triiodothyronine

scientific article

Endoplasmic reticulum-associated degradation of the human type 2 iodothyronine deiodinase (D2) is mediated via an association between mammalian UBC7 and the carboxyl region of D2.

scientific article

Enhancement of thyroid hormone receptor isoform specificity by insertion of a distant half-site into a thyroid hormone response element

scientific article published on 01 April 1996

Evidence for two pathways of iodothyronine 5'-deiodination in rat pituitary that differ in kinetics, propylthiouracil sensitivity, and response to hypothyroidism

scientific article

Evidence for two tissue-specific pathways for in vivo thyroxine 5'-deiodination in the rat.

scientific article published on May 1982

Evidence that Cysteine, not Selenocysteine, is in the Catalytic Site of Type II Iodothyronine Deiodinase ⬇️

scientific article published on July 1, 1991

Functional Analysis of Genetic Variation in the SECIS Element of Thyroid Hormone Activating Type 2 Deiodinase

scientific article published on 01 May 2019

Functional analysis of novel genetic variation in the thyroid hormone activating type 2 deiodinase

scientific article published on 20 August 2014

Functional characterization of the eukaryotic SECIS elements which direct selenocysteine insertion at UGA codons

scientific article

Functional characterization of the rat growth hormone promoter elements required for induction by thyroid hormone with and without a co-transfected beta type thyroid hormone receptor

scientific article published on January 1989

Further Characterization of Thyroid Hormone Response Elements in the Human Type 1 Iodothyronine Deiodinase Gene1 ⬇️

scientific article published on 01 March 1998

Genetic and biological subgroups of low-stage follicular thyroid cancer

scientific article published on April 2003

High dose of (131)I therapy for the treatment of hyperthyroidism caused by Graves' disease

scientific article published in March 2002

How are childhood thyroid nodules discovered: opportunities for improving early detection

scientific article

Human type 3 iodothyronine selenodeiodinase is located in the plasma membrane and undergoes rapid internalization to endosomes

scientific article published on 4 November 2002

Hypothyroidism During Tyrosine Kinase Inhibitor Therapy Is Associated with Longer Survival in Patients with Advanced Nonthyroidal Cancers

scientific article published in April 2018

Hypothyroidism after sunitinib treatment for patients with gastrointestinal stromal tumors.

scientific article

Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats

scientific article

IL-6 promotes nonthyroidal illness syndrome by blocking thyroxine activation while promoting thyroid hormone inactivation in human cells

scientific article

Identification of a thyroid hormone receptor that is pituitary-specific

scientific article published in April 1989

Identification of critical amino acids for 3,5,3'-triiodothyronine deiodination by human type 1 deiodinase based on comparative functional-structural analyses of the human, dog, and rat enzymes.

scientific article published in August 1994

In vitro 3,5,3'-triiodothyronine binding to rat cerebrocortical neuronal and glial nuclei suggests the presence of binding sites unavailable in vivo

scientific article published in May 1985

In vivo dimerization of types 1, 2, and 3 iodothyronine selenodeiodinases

scientific article

In vivo genomic footprinting of thyroid hormone-responsive genes in pituitary tumor cell lines

scientific article

Increased need for thyroxine during pregnancy in women with primary hypothyroidism

scientific article published on 01 July 1990

Inflammation-inducible type 2 deiodinase expression in the leptomeninges, choroid plexus, and at brain blood vessels in male rodents

scientific article published on 06 March 2014

Inhibition of thyroid hormone action by a non-hormone binding c-erbA protein generated by alternative mRNA splicing

scientific journal article

Interrelationships among thyroxine, growth hormone, and the sympathetic nervous system in the regulation of 5'-iodothyronine deiodinase in rat brown adipose tissue

scientific article

Intracellular inactivation of thyroid hormone is a survival mechanism for muscle stem cell proliferation and lineage progression

scientific article published on 13 November 2014

Is there a negative TRE in the luciferase reporter cDNA?

scientific article published on August 1996

Isolation of a cDNA clone encoding a biologically active thyroid hormone receptor

scientific article

Kinetic evidence suggesting two mechanisms for iodothyronine 5'-deiodination in rat cerebral cortex

scientific article

Lack of association between the type 2 deiodinase A/G polymorphism and hypertensive traits: the Framingham Heart Study.

scientific article published on 19 February 2008

Lipopolysaccharide induces type 2 iodothyronine deiodinase in the mediobasal hypothalamus: implications for the nonthyroidal illness syndrome

scientific article

Long-term assessment of a multidisciplinary approach to thyroid nodule diagnostic evaluation.

scientific article

Long-term, treatment-free survival in select patients with distant metastatic papillary thyroid cancer

scientific article

Management of thyroid nodules detected at US: Society of Radiologists in Ultrasound consensus conference statement

scientific article published on 01 December 2006

Management of thyroid nodules detected at US: Society of Radiologists in Ultrasound consensus conference statement

scientific article published on 01 December 2005

Mice with impaired extrathyroidal thyroxine to 3,5,3'-triiodothyronine conversion maintain normal serum 3,5,3'-triiodothyronine concentrations

scientific article published on 30 November 2006

Molecular biological and biochemical characterization of the human type 2 selenodeiodinase

scientific article published on August 1996

Molecular cloning of the selenocysteine-containing enzyme type I iodothyronine deiodinase

scientific article published on February 1993

Multihormonal regulation of the human, rat, and bovine growth hormone promoters: differential effects of 3',5'-cyclic adenosine monophosphate, thyroid hormone, and glucocorticoids

scientific article published on 01 September 1988

Multiple sequences encoding potential thyroid hormone receptors isolated from mouse skeletal muscle cDNA libraries ⬇️

scientific article published on July 11, 1988

Mutation of the Secys residue 266 in human type 2 selenodeiodinase alters 75Se incorporation without affecting its biochemical properties

scientific article published on 01 May 1999

Mutations of the rat growth hormone promoter which increase and decrease response to thyroid hormone define a consensus thyroid hormone response element

scientific article

N-acetylcysteine administration prevents nonthyroidal illness syndrome in patients with acute myocardial infarction: a randomized clinical trial

scientific article

Natural history of benign solid and cystic thyroid nodules

scientific article published on 01 February 2003

Neonatal thyroid function after propylthiouracil therapy for maternal Graves' disease

scientific article published on 01 February 1981

Nutritional and hormonal regulation of thyroid hormone deiodinases

scientific article published on January 1995

Overexpression of type 2 iodothyronine deiodinase in follicular carcinoma as a cause of low circulating free thyroxine levels

scientific article

Photoaffinity Labeling of Rat Type I Iodothyronine Deiodinase* ⬇️

scientific article published on 01 August 1991

Physiological and genetic analyses of inbred mouse strains with a type I iodothyronine 5' deiodinase deficiency

scientific article

Physiological role and regulation of iodothyronine deiodinases: A 2011 update ⬇️

scientific article published on March 21, 2011

Pituitary Nuclear 3,5,3′-Triiodothyronine and Thyrotropin Secretion: An Explanation for the Effect of Thyroxine ⬇️

scientific article published on November 11, 1977

Pituitary cells respond to thyroid hormone by discrete, gene-specific pathways

scientific article published on 01 April 1995

Plasma kinetics, tissue distribution, and cerebrocortical sources of reverse triiodothyronine in the rat.

scientific article published in June 1985

Polarized targeting of epithelial cell proteins in thyrocytes and MDCK cells

scientific article published on 01 April 1999

Potential of brown adipose tissue type II thyroxine 5'-deiodinase as a local and systemic source of triiodothyronine in rats

scientific article

Prevalence and distribution of carcinoma in patients with solitary and multiple thyroid nodules on sonography

scientific article published on 11 July 2006

Prevalence of abnormal thyroid function test results in patients with acute medical illnesses

scientific article published on 01 January 1982

Prospective Studies of Thyroid Function in Patients Receiving Gold Therapy ⬇️

scientific article published on 01 April 1995

Qualitative and quantitative differences in the pathways of extrathyroidal triiodothyronine generation between euthyroid and hypothyroid rats

scientific article

Quantitative Analysis of the Benefits and Risk of Thyroid Nodule Evaluation in Patients ≥70 Years Old.

scientific article published on 2 April 2018

RTHα, a newly recognized phenotype of the resistance to thyroid hormone (RTH) syndrome in patients with THRA gene mutations

scientific article published in July 2013

Radioiodine for Thyroid Cancer — Is Less More? ⬇️

scientific article published on 01 May 2012

Recognition of UGA as a selenocysteine codon in Type I deiodinase requires sequences in the 3′ untranslated region ⬇️

scientific article published on September 19, 1991

Recognition of UGA as a selenocysteine codon in eukaryotes: a review of recent progress

scientific article

Regional Distribution of Type 2 Thyroxine Deiodinase Messenger Ribonucleic Acid in Rat Hypothalamus and Pituitary and Its Regulation by Thyroid Hormone* ⬇️

scientific article published on August 1, 1997

Regional expression of the type 3 iodothyronine deiodinase messenger ribonucleic acid in the rat central nervous system and its regulation by thyroid hormone

scientific article

Regional physiological adaptation of the central nervous system deiodinases to iodine deficiency

scientific article published in July 2001

Regulation of thyroxine 5'-deiodinase activity by 3,5,3'-triiodothyronine in cultured rat anterior pituitary cells

scientific article published in July 1984

Repression mediates cell-type-specific expression of the rat growth hormone gene

scientific article

Review of antithyroid drug use during pregnancy and report of a case of aplasia cutis

scientific article

Risk Factors for New Hypothyroidism During Tyrosine Kinase Inhibitor Therapy in Advanced Nonthyroidal Cancer Patients

scientific article published in April 2018

Selective proteolysis of human type 2 deiodinase: a novel ubiquitin-proteasomal mediated mechanism for regulation of hormone activation

scientific article

Selenocysteine confers the biochemical properties characteristic of the type I iodothyronine deiodinase ⬇️

scientific article published on 01 August 1991

Sequences required for cell-type specific thyroid hormone regulation of rat growth hormone promoter activity

scientific article published on 01 November 1986

Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism

scientific article

Severe hypothyroidism caused by type 3 iodothyronine deiodinase in infantile hemangiomas

scientific article published on 01 July 2000

Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes.

scholarly article

Structural and functional differences in the dio1 gene in mice with inherited type 1 deiodinase deficiency

scientific article

Structural features of thyroid hormone response elements that increase susceptibility to inhibition by an RTH mutant thyroid hormone receptor

scientific article published on July 1996

Structure-activity relationships for thyroid hormone deiodination by mammalian type I iodothyronine deiodinases

scientific article published on 01 January 1997

Studies of nuclear 3,5,3'-triiodothyronine binding in primary cultures of rat brain

scientific article

Studies of the hormonal regulation of type 2 5'-iodothyronine deiodinase messenger ribonucleic acid in pituitary tumor cells using semiquantitative reverse transcription-polymerase chain reaction

scientific article

Subcellular distribution of iodothyronine 5'-deiodinase in cerebral cortex from hypothyroid rats

scientific article published in September 1982

Substitution of cysteine for selenocysteine in type I iodothyronine deiodinase reduces the catalytic efficiency of the protein but enhances its translation

scientific article published on October 1, 1992

Substitution of serine for proline in the active center of type 2 iodothyronine deiodinase substantially alters its in vitro biochemical properties with dithiothreitol but not its function in intact cells

scientific article

Substrate-induced down-regulation of human type 2 deiodinase (hD2) is mediated through proteasomal degradation and requires interaction with the enzyme's active center

scientific article published on 01 March 2000

T3 Induces Both Markers of Maturation and Aging in Pancreatic β-Cells.

scientific article published on 6 April 2018

Targeted deletion of thioesterase superfamily member 1 promotes energy expenditure and protects against obesity and insulin resistance ⬇️

scientific article published on March 16, 2012

The 3'-untranslated region of human type 2 iodothyronine deiodinase mRNA contains a functional selenocysteine insertion sequence element

scientific article

The FoxO3/type 2 deiodinase pathway is required for normal mouse myogenesis and muscle regeneration.

scientific article published on 11 October 2010

The Influence of Patient Age on Thyroid Nodule Formation, Multinodularity, and Thyroid Cancer Risk

scientific article

The Predictive Value of the Fine-Needle Aspiration Diagnosis “Suspicious for a Follicular Neoplasm, Hürthle Cell Type” in Patients With Hashimoto Thyroiditis

article

The Role of the Active Site Cysteine in Catalysis by Type 1 Iodothyronine Deiodinase* ⬇️

scientific article published on 01 December 1997

The arrestin domain-containing 3 protein regulates body mass and energy expenditure

scientific article

The deiodinases and the control of intracellular thyroid hormone signaling during cellular differentiation.

scientific article published on 25 May 2012

The guanosine monophosphate reductase gene is conserved in rats and its expression increases rapidly in brown adipose tissue during cold exposure

scientific article

The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line

scientific article

The human, but not rat, dio2 gene is stimulated by thyroid transcription factor-1 (TTF-1).

scientific article

The iodothyronine selenodeiodinases are thioredoxin-fold family proteins containing a glycoside hydrolase clan GH-A-like structure

scientific article

The mRNA structure has potent regulatory effects on type 2 iodothyronine deiodinase expression

scientific article

The role of 3,3',5'-triiodothyronine in the regulation of type II iodothyronine 5'-deiodinase in the rat cerebral cortex

scientific article

The role of selenium in thyroid hormone action

scientific article published on May 1, 1992

The role of selenocysteine 133 in catalysis by the human type 2 iodothyronine deiodinase

scientific article

The selective loss of the type 2 iodothyronine deiodinase in mouse thyrotrophs increases basal TSH but blunts the thyrotropin response to hypothyroidism

scientific article

The structure of the coding and 5'-flanking region of the type 1 iodothyronine deiodinase (dio1) gene is normal in a patient with suspected congenital dio1 deficiency

scientific article published on 01 June 1996

The thyroid hormone-inactivating deiodinase functions as a homodimer

scientific article

The type 2 deiodinase (DIO2) A/G polymorphism is not associated with glycemic traits: the Framingham Heart Study

scientific article published in March 2007

The type 2 deiodinase A/G (Thr92Ala) polymorphism is associated with decreased enzyme velocity and increased insulin resistance in patients with type 2 diabetes mellitus

scientific article published on 29 March 2005

The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue

scientific article

The type I iodothyronine 5'-deiodinase messenger ribonucleic acid is localized to the S3 segment of the rat kidney proximal tubule

scientific article published on 01 May 1993

Thyroid Hormone Promotes Postnatal Rat Pancreatic β-Cell Development and Glucose-Responsive Insulin Secretion Through MAFA ⬇️

scientific article published on January 10, 2013

Thyroid hormone activation in vascular smooth muscle cells is negatively regulated by glucocorticoid

scientific article

Thyroid hormone aporeceptor represses T3-inducible promoters and blocks activity of the retinoic acid receptor

scientific article

Thyroid hormone inactivation in gastrointestinal stromal tumors

scientific article

Thyroid hormone receptor binds to a site in the rat growth hormone promoter required for induction by thyroid hormone

scientific article

Thyroid hormone regulates type I deiodinase messenger RNA in rat liver

scientific article published on 01 May 1990

Thyroid hormone regulation of gene expression

scientific article published on January 1991

Thyroid hormones and skeletal muscle--new insights and potential implications

scientific article

Thyroid nodule size and prediction of cancer

scientific article published on 28 December 2012

Thyroxine 5'-deiodinase activity in brown adipose tissue

scientific article published on 01 March 1983

Thyroxine reverses deficits of nerve growth factor and epidermal growth factor in submandibular glands of mice with muscular dystrophy

scientific article published on 01 April 1982

Thyroxine-induced expression of pyroglutamyl peptidase II and inhibition of TSH release precedes suppression of TRH mRNA and requires type 2 deiodinase ⬇️

scientific article published on July 25, 2011

Timing and magnitude of increases in levothyroxine requirements during pregnancy in women with hypothyroidism

scientific article published in July 2004

Topological analysis of the integral membrane protein, type 1 iodothyronine deiodinase (D1).

scientific article published on May 1995

Transcriptional regulation of iodothyronine deiodinases during embryonic development

scientific article

Transforming growth factor-beta promotes inactivation of extracellular thyroid hormones via transcriptional stimulation of type 3 iodothyronine deiodinase

scientific article published on 21 July 2005

Type 1 iodothyronine deiodinase is a sensitive marker of peripheral thyroid status in the mouse.

scientific article published on 9 December 2004

Type 2 iodothyronin deiodinase transgene expression in the mouse heart causes cardiac-specific thyrotoxicosis

scientific article

Type 2 iodothyronine deiodinase in rat pituitary tumor cells is inactivated in proteasomes

scientific article

Type 2 iodothyronine deiodinase is highly expressed in human thyroid

scientific article

Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans

scientific article

Type 2 iodothyronine deiodinase levels are higher in slow-twitch than fast-twitch mouse skeletal muscle and are increased in hypothyroidism.

scientific article

Type 3 iodothyronine deiodinase is highly expressed in the human uteroplacental unit and in fetal epithelium.

scientific article

Type 3 lodothyronine deiodinase: cloning, in vitro expression, and functional analysis of the placental selenoenzyme ⬇️

scientific article published on November 1, 1995

Type I iodothyronine deiodinase is a selenocysteine-containing enzyme ⬇️

scientific article published on January 31, 1991

Type I iodothyronine deiodinase: unexpected complexities in a simple deiodination reaction

scientific article published on January 1994

Type II iodothyronine deiodinase provides intracellular 3,5,3′-triiodothyronine to normal and regenerating mouse skeletal muscle ⬇️

scientific article published on July 19, 2011

Type-2 Iodothyronine 5′Deiodinase in Skeletal Muscle of C57Bl/6 Mice. I. Identity, Subcellular Localization, and Characterization ⬇️

scientific article published on May 31, 2011

Type-2 iodothyronine 5'deiodinase (D2) in skeletal muscle of C57Bl/6 mice. II. Evidence for a role of D2 in the hypermetabolism of thyroid hormone receptor alpha-deficient mice

scientific article

β-Catenin regulates deiodinase levels and thyroid hormone signaling in colon cancer cells

scientific article published on 03 July 2012

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