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List of works by John W. Harney

A Novel Retinoid X Receptor-Independent Thyroid Hormone Response Element Is Present in the Human Type 1 Deiodinase Gene ⬇️

scientific article published on September 1, 1995

A novel cell type-specific mechanism for thyroid hormone-dependent negative regulation of the human type 1 deiodinase gene

scientific article published on 26 August 2004

A novel mechanism of thyroid hormone-dependent negative regulation by thyroid hormone receptor, nuclear receptor corepressor (NCoR), and GAGA-binding factor on the rat cD44 promoter.

scientific article published on 27 January 2005

Activation and inactivation of thyroid hormone by type I iodothyronine deiodinase

scientific article

Activation of thyroid hormone is transcriptionally regulated by epidermal growth factor in human placenta-derived JEG3 cells

scientific article

Agouti-related protein (AGRP) has a central inhibitory action on the hypothalamic-pituitary-thyroid (HPT) axis; comparisons between the effect of AGRP and neuropeptide Y on energy homeostasis and the HPT axis

scientific article published in October 2002

Antioxidant function of a novel selenoprotein in Drosophila melanogaster

scientific article published on December 2003

Atypical expression of type 2 iodothyronine deiodinase in thyrotrophs explains the thyroxine-mediated pituitary thyrotropin feedback mechanism.

scientific article published on 5 January 2006

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

scientific article

Capacity for cooperative binding of thyroid hormone (T3) receptor dimers defines wild type T3 response elements

scientific article

Catalysis leads to posttranslational inactivation of the type 1 deiodinase and alters its conformation ⬇️

scientific article published on April 27, 2012

Characterization of the 5'-flanking and 5'-untranslated regions of the cyclic adenosine 3',5'-monophosphate-responsive human type 2 iodothyronine deiodinase gene

scientific article

Chronic cardiac-specific thyrotoxicosis increases myocardial beta-adrenergic responsiveness.

scientific article

Cloning and Functional Characterization of Human Selenophosphate Synthetase, an Essential Component of Selenoprotein Synthesis ⬇️

scientific article published on September 15, 1995

Cloning and expression of the chicken type 2 iodothyronine 5'-deiodinase

scientific article

Cloning and in vitro expression of the human selenoprotein, type I iodothyronine deiodinase

scientific article published on October 1, 1992

Coupled tRNA(Sec)-dependent assembly of the selenocysteine decoding apparatus

scientific article published in March 2003

Decoding apparatus for eukaryotic selenocysteine insertion

scientific article

Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation

scientific article

Differential capacity of wild type promoter elements for binding and trans-activation by retinoic acid and thyroid hormone receptors

scientific article published on October 1, 1992

Distinct subcellular localization of transiently expressed types 1 and 2 iodothyronine deiodinases as determined by immunofluorescence confocal microscopy

scientific article

Dominant negative inhibition by mutant thyroid hormone receptors is thyroid hormone response element and receptor isoform specific

scientific article published on October 1993

Effect of 3,5,3'-Triiodothyronine (T3) administration on dio1 gene expression and T3 metabolism in normal and type 1 deiodinase-deficient mice ⬇️

scientific article published on November 1, 1995

Effects of varying the position of thyroid hormone response elements within the rat growth hormone promoter: implications for positive and negative regulation by 3,5,3'-triiodothyronine

scientific article

Efficient incorporation of multiple selenocysteines involves an inefficient decoding step serving as a potential translational checkpoint and ribosome bottleneck

scientific article

Endoplasmic reticulum-associated degradation of the human type 2 iodothyronine deiodinase (D2) is mediated via an association between mammalian UBC7 and the carboxyl region of D2.

scientific article

Enhancement of thyroid hormone receptor isoform specificity by insertion of a distant half-site into a thyroid hormone response element

scientific article published on 01 April 1996

Expression and characterization of nonmammalian selenoprotein P in the zebrafish, Danio rerio

scientific article

Functional characterization of the eukaryotic SECIS elements which direct selenocysteine insertion at UGA codons

scientific article

Functional characterization of the rat growth hormone promoter elements required for induction by thyroid hormone with and without a co-transfected beta type thyroid hormone receptor

scientific article published on January 1989

Functionality of mutations at conserved nucleotides in eukaryotic SECIS elements is determined by the identity of a single nonconserved nucleotide ⬇️

scientific article published on January 1, 1998

Further Characterization of Thyroid Hormone Response Elements in the Human Type 1 Iodothyronine Deiodinase Gene1 ⬇️

scientific article published on 01 March 1998

Glutathione depletion in hippocampal cells increases levels of H and L ferritin and glutathione S-transferase mRNAs

scientific article published on May 2007

Human type 3 iodothyronine selenodeiodinase is located in the plasma membrane and undergoes rapid internalization to endosomes

scientific article published on 4 November 2002

Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats

scientific article

Identification of critical amino acids for 3,5,3'-triiodothyronine deiodination by human type 1 deiodinase based on comparative functional-structural analyses of the human, dog, and rat enzymes.

scientific article published in August 1994

In vivo dimerization of types 1, 2, and 3 iodothyronine selenodeiodinases

scientific article

Inflammation-inducible type 2 deiodinase expression in the leptomeninges, choroid plexus, and at brain blood vessels in male rodents

scientific article published on 06 March 2014

Interplay between termination and translation machinery in eukaryotic selenoprotein synthesis

scientific article

Is there a negative TRE in the luciferase reporter cDNA?

scientific article published on August 1996

Knockdown of the type 3 iodothyronine deiodinase (D3) interacting protein peroxiredoxin 3 decreases D3-mediated deiodination in intact cells.

scientific article published on 09 October 2009

Lipopolysaccharide induces type 2 iodothyronine deiodinase in the mediobasal hypothalamus: implications for the nonthyroidal illness syndrome

scientific article

Metabolic instability of type 2 deiodinase is transferable to stable proteins independently of subcellular localization

scientific article published on 23 August 2006

Mice with a Targeted Deletion of the Type 2 Deiodinase Are Insulin Resistant and Susceptible to Diet Induced Obesity ⬇️

scientific article published on June 16, 2011

Molecular biological and biochemical characterization of the human type 2 selenodeiodinase

scientific article published on August 1996

Multihormonal regulation of the human, rat, and bovine growth hormone promoters: differential effects of 3',5'-cyclic adenosine monophosphate, thyroid hormone, and glucocorticoids

scientific article published on 01 September 1988

Mutation of the Secys residue 266 in human type 2 selenodeiodinase alters 75Se incorporation without affecting its biochemical properties

scientific article published on 01 May 1999

Mutations of the rat growth hormone promoter which increase and decrease response to thyroid hormone define a consensus thyroid hormone response element

scientific article

Neuropeptide Y1 and Y5 receptors mediate the effects of neuropeptide Y on the hypothalamic-pituitary-thyroid axis

scientific journal article

Nuclear assembly of UGA decoding complexes on selenoprotein mRNAs: a mechanism for eluding nonsense-mediated decay?

scientific article published on March 2006

Oligomeric binding of T3 receptor is required for maximal T3 response.

scientific article published on October 1991

Overexpression of type 2 iodothyronine deiodinase in follicular carcinoma as a cause of low circulating free thyroxine levels

scientific article

Physiological role and regulation of iodothyronine deiodinases: A 2011 update ⬇️

scientific article published on March 21, 2011

Pituitary cells respond to thyroid hormone by discrete, gene-specific pathways

scientific article published on 01 April 1995

Polarized targeting of epithelial cell proteins in thyrocytes and MDCK cells

scientific article published on 01 April 1999

Recognition of UGA as a selenocysteine codon in Type I deiodinase requires sequences in the 3′ untranslated region ⬇️

scientific article published on September 19, 1991

Regional physiological adaptation of the central nervous system deiodinases to iodine deficiency

scientific article published in July 2001

Regulation of human thioredoxin reductase expression and activity by 3'-untranslated region selenocysteine insertion sequence and mRNA instability elements

scientific article published on September 1999

Repression mediates cell-type-specific expression of the rat growth hormone gene

scientific article

Retinoid-X receptor (RXR) differentially augments thyroid hormone response in cell lines as a function of the response element and endogenous RXR content

scientific article published on February 1995

SECIS-SBP2 interactions dictate selenocysteine incorporation efficiency and selenoprotein hierarchy

scientific article

Selective inhibition of selenocysteine tRNA maturation and selenoprotein synthesis in transgenic mice expressing isopentenyladenosine-deficient selenocysteine tRNA.

scientific article

Selective proteolysis of human type 2 deiodinase: a novel ubiquitin-proteasomal mediated mechanism for regulation of hormone activation

scientific article

Selenocysteine confers the biochemical properties characteristic of the type I iodothyronine deiodinase ⬇️

scientific article published on 01 August 1991

Selenocysteine incorporation directed from the 3'UTR: characterization of eukaryotic EFsec and mechanistic implications

scientific article

Selenocysteine incorporation in eukaryotes: insights into mechanism and efficiency from sequence, structure, and spacing proximity studies of the type 1 deiodinase SECIS element

scientific article

Selenocysteine insertion or termination: factors affecting UGA codon fate and complementary anticodon:codon mutations

scientific article

Selenocysteine insertion sequence element characterization and selenoprotein expression

scientific article published on January 2002

Selenoprotein P expression, purification, and immunochemical characterization

scientific article

Sequences required for cell-type specific thyroid hormone regulation of rat growth hormone promoter activity

scientific article published on 01 November 1986

Severe hypothyroidism caused by type 3 iodothyronine deiodinase in infantile hemangiomas

scientific article published on 01 July 2000

Structural and functional differences in the dio1 gene in mice with inherited type 1 deiodinase deficiency

scientific article

Structural features of thyroid hormone response elements that increase susceptibility to inhibition by an RTH mutant thyroid hormone receptor

scientific article published on July 1996

Structure-activity relationships for thyroid hormone deiodination by mammalian type I iodothyronine deiodinases

scientific article published on 01 January 1997

Studies of the hormonal regulation of type 2 5'-iodothyronine deiodinase messenger ribonucleic acid in pituitary tumor cells using semiquantitative reverse transcription-polymerase chain reaction

scientific article

Substitution of cysteine for selenocysteine in type I iodothyronine deiodinase reduces the catalytic efficiency of the protein but enhances its translation

scientific article published on October 1, 1992

Substitution of serine for proline in the active center of type 2 iodothyronine deiodinase substantially alters its in vitro biochemical properties with dithiothreitol but not its function in intact cells

scientific article

Substrate-induced down-regulation of human type 2 deiodinase (hD2) is mediated through proteasomal degradation and requires interaction with the enzyme's active center

scientific article published on 01 March 2000

Supramolecular complexes mediate selenocysteine incorporation in vivo

scientific journal article

The 3'-untranslated region of human type 2 iodothyronine deiodinase mRNA contains a functional selenocysteine insertion sequence element

scientific article

The Caenorhabditis elegans homologue of thioredoxin reductase contains a selenocysteine insertion sequence (SECIS) element that differs from mammalian SECIS elements but directs selenocysteine incorporation

scientific article published in July 1999

The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase

scientific article

The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate

scientific article

The Role of the Active Site Cysteine in Catalysis by Type 1 Iodothyronine Deiodinase* ⬇️

scientific article published on 01 December 1997

The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line

scientific article

The human, but not rat, dio2 gene is stimulated by thyroid transcription factor-1 (TTF-1).

scientific article

The iodothyronine selenodeiodinases are thioredoxin-fold family proteins containing a glycoside hydrolase clan GH-A-like structure

scientific article

The mRNA structure has potent regulatory effects on type 2 iodothyronine deiodinase expression

scientific article

The role of selenocysteine 133 in catalysis by the human type 2 iodothyronine deiodinase

scientific article

The selective loss of the type 2 iodothyronine deiodinase in mouse thyrotrophs increases basal TSH but blunts the thyrotropin response to hypothyroidism

scientific article

The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation

scientific article published on March 2007

The thyroid hormone-inactivating deiodinase functions as a homodimer

scientific article

The type 2 deiodinase A/G (Thr92Ala) polymorphism is associated with decreased enzyme velocity and increased insulin resistance in patients with type 2 diabetes mellitus

scientific article published on 29 March 2005

The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue

scientific article

Thyroid hormone activation in vascular smooth muscle cells is negatively regulated by glucocorticoid

scientific article

Thyroid hormone aporeceptor represses T3-inducible promoters and blocks activity of the retinoic acid receptor

scientific article

Thyroid hormone receptor binds with unique properties to response elements that contain hexamer domains in an inverted palindrome arrangement

scientific article published in April 1994

Thyroxine-induced expression of pyroglutamyl peptidase II and inhibition of TSH release precedes suppression of TRH mRNA and requires type 2 deiodinase ⬇️

scientific article published on July 25, 2011

Topological analysis of the integral membrane protein, type 1 iodothyronine deiodinase (D1).

scientific article published on May 1995

Transforming growth factor-beta promotes inactivation of extracellular thyroid hormones via transcriptional stimulation of type 3 iodothyronine deiodinase

scientific article published on 21 July 2005

Two distinct SECIS structures capable of directing selenocysteine incorporation in eukaryotes

scientific article

Type 1 iodothyronine deiodinase is a sensitive marker of peripheral thyroid status in the mouse.

scientific article published on 9 December 2004

Type 2 iodothyronine deiodinase in rat pituitary tumor cells is inactivated in proteasomes

scientific article

Type 2 iodothyronine deiodinase is highly expressed in human thyroid

scientific article

Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans

scientific article

Type 2 iodothyronine deiodinase levels are higher in slow-twitch than fast-twitch mouse skeletal muscle and are increased in hypothyroidism.

scientific article

Type 2 iodothyronine selenodeiodinase is expressed throughout the mouse skeleton and in the MC3T3-E1 mouse osteoblastic cell line during differentiation.

scientific article

Type 3 lodothyronine deiodinase: cloning, in vitro expression, and functional analysis of the placental selenoenzyme ⬇️

scientific article published on November 1, 1995

Type II iodothyronine deiodinase provides intracellular 3,5,3′-triiodothyronine to normal and regenerating mouse skeletal muscle ⬇️

scientific article published on July 19, 2011

Ubc6p and ubc7p are required for normal and substrate-induced endoplasmic reticulum-associated degradation of the human selenoprotein type 2 iodothyronine monodeiodinase

scientific article

Ubiquitination-induced conformational change within the deiodinase dimer is a switch regulating enzyme activity.

scientific article published on 23 April 2007

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