List of works - Shenping Liu

(3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: a potent, selective, orally active dipeptidyl peptidase IV inhibitor

scientific article

(3R,4S)-4-(2,4,5-Trifluorophenyl)-pyrrolidin-3-ylamine inhibitors of dipeptidyl peptidase IV: synthesis, in vitro, in vivo, and X-ray crystallographic characterization

scientific article

Allosteric inhibition of Staphylococcus aureus D-alanine:D-alanine ligase revealed by crystallographic studies

scholarly article

Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists

scientific article published on 16 August 2016

Biophysical and Mechanistic Insights into Novel Allosteric Inhibitor of Spleen Tyrosine Kinase ⬇️

scientific article published on January 4, 2012

Crystal Structure of a Human IκB Kinase β Asymmetric Dimer ⬇️

scientific article published on June 21, 2013

Crystal Structures of Cholesteryl Ester Transfer Protein in Complex with Inhibitors ⬇️

scientific article published on September 7, 2012

Crystal structures of interleukin 17A and its complex with IL-17 receptor A ⬇️

scientific article published on January 1, 2013

Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro

scientific article

Discovery and structural characterization of an allosteric inhibitor of bacterial cis-prenyltransferase

scientific article published on 6 November 2014

Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment

scientific article published on 6 October 2015

Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors

scientific article

Identification of a brain penetrant PDE9A inhibitor utilizing prospective design and chemical enablement as a rapid lead optimization strategy

scientific article

Insights into Mechanism of Glucokinase Activation ⬇️

scientific article published on April 20, 2012

Ligand-protein interactions of selective casein kinase 1δ inhibitors

scientific article

Potent inhibitors of LpxC for the treatment of Gram-negative infections

scientific article

Pyridone methylsulfone hydroxamate LpxC inhibitors for the treatment of serious gram-negative infections

scientific article

Pyrimidone-based series of glucokinase activators with alternative donor-acceptor motif

scientific article

Structural basis for the catalytic mechanism of human phosphodiesterase 9

scientific article

Structural basis for the guanine nucleotide-binding activity of tissue transglutaminase and its regulation of transamidation activity

scientific article

Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities

scientific article

List of works by Shenping Liu

(3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: a potent, selective, orally active dipeptidyl peptidase IV inhibitor

(3R,4S)-4-(2,4,5-Trifluorophenyl)-pyrrolidin-3-ylamine inhibitors of dipeptidyl peptidase IV: synthesis, in vitro, in vivo, and X-ray crystallographic characterization

Allosteric inhibition of Staphylococcus aureus D-alanine:D-alanine ligase revealed by crystallographic studies

Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists

Biophysical and Mechanistic Insights into Novel Allosteric Inhibitor of Spleen Tyrosine Kinase ⬇️

Crystal Structure of a Human IκB Kinase β Asymmetric Dimer ⬇️

Crystal Structures of Cholesteryl Ester Transfer Protein in Complex with Inhibitors ⬇️

Crystal structures of interleukin 17A and its complex with IL-17 receptor A ⬇️

Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro

Discovery and structural characterization of an allosteric inhibitor of bacterial cis-prenyltransferase

Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment

Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors

Identification of a brain penetrant PDE9A inhibitor utilizing prospective design and chemical enablement as a rapid lead optimization strategy

Insights into Mechanism of Glucokinase Activation ⬇️

Ligand-protein interactions of selective casein kinase 1δ inhibitors

Potent inhibitors of LpxC for the treatment of Gram-negative infections

Pyridone methylsulfone hydroxamate LpxC inhibitors for the treatment of serious gram-negative infections

Pyrimidone-based series of glucokinase activators with alternative donor-acceptor motif

Structural basis for the catalytic mechanism of human phosphodiesterase 9

Structural basis for the guanine nucleotide-binding activity of tissue transglutaminase and its regulation of transamidation activity

Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities