List of works - Richard S Jope

(+)-Naloxone blocks Toll-like receptor 4 to ameliorate deleterious effects of stress on male mouse behaviors

scientific article published on 26 August 2020

A pre-conditioning stress accelerates increases in mouse plasma inflammatory cytokines induced by stress

scientific article published on 7 May 2015

AMP-activated protein kinase (AMPK) activating agents cause dephosphorylation of Akt and glycogen synthase kinase-3.

scientific article

Activation of the ATM-Snail pathway promotes breast cancer metastasis ⬇️

scientific article published on August 24, 2012

Anesthesia and post-mortem interval profoundly influence the regulatory serine phosphorylation of glycogen synthase kinase-3 in mouse brain

scientific article published on February 2005

Astrocytes modulate the polarization of CD4+ T cells to Th1 cells.

scientific article published on 28 January 2014

Brain region differences in regulation of Akt and GSK3 by chronic stimulant administration in mice ⬇️

scientific article published on March 10, 2012

Cellular stress increases RGS2 mRNA and decreases RGS4 mRNA levels in SH-SY5Y cells

scientific article published on 02 June 2006

Comparison of inflammatory and behavioral responses to chronic stress in female and male mice

scientific article published in 2022

Convergence of the Mammalian Target of Rapamycin Complex 1- and Glycogen Synthase Kinase 3-β–Signaling Pathways Regulates the Innate Inflammatory Response ⬇️

scientific article published on March 21, 2011

Cotinine administration improves impaired cognition in the mouse model of Fragile X syndrome

scientific article published on 24 October 2016

DDX3 regulates DNA damage-induced apoptosis and p53 stabilization

scientific article published on 5 March 2013

Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances

scientific article

Differential regulation of STAT family members by glycogen synthase kinase-3

scientific article published on 11 June 2008

Direct, activating interaction between glycogen synthase kinase-3beta and p53 after DNA damage

scientific article

Distinct characteristics of hippocampal pathogenic TH17 cells in a mouse model of depression.

scientific article published on 23 April 2018

Elevated glycogen synthase kinase-3 activity in Fragile X mice: key metabolic regulator with evidence for treatment potential.

scientific article

Evidence of reactive astrocytes but not peripheral immune system activation in a mouse model of Fragile X syndrome

scientific article

Examination of methylphenidate-mediated behavior regulation by glycogen synthase kinase-3 in mice ⬇️

scientific article published on October 23, 2012

GSK3 influences social preference and anxiety-related behaviors during social interaction in a mouse model of fragile X syndrome and autism.

scientific article

Glycogen Synthase Kinase-3 Is an Early Determinant in the Differentiation of Pathogenic Th17 Cells ⬇️

scientific article published on December 29, 2010

Glycogen Synthase Kinase-3: A Promising Therapeutic Target for Fragile X Syndrome ⬇️

scientific article published on January 1, 2011

Glycogen Synthase Kinase-3β (GSK3β) Binds to and Promotes the Actions of p53 ⬇️

scientific article published on September 30, 2003

Glycogen synthase kinase-3 (GSK3) in psychiatric diseases and therapeutic interventions

scientific article published on November 2006

Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics

scientific article

Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases

scientific article

Glycogen synthase kinase-3 beta is highly activated in nuclei and mitochondria

scientific article

Glycogen synthase kinase-3 in the etiology and treatment of mood disorders

scientific article

Glycogen synthase kinase-3 inhibitors: Rescuers of cognitive impairments

scientific article published on 31 July 2013

Glycogen synthase kinase-3 promotes the synergistic action of interferon-gamma on lipopolysaccharide-induced IL-6 production in RAW264.7 cells

scientific article published on March 2009

Glycogen synthase kinase-3 regulates endoplasmic reticulum (ER) stress-induced CHOP expression in neuronal cells.

scientific article published on 26 February 2011

Glycogen synthase kinase-3beta, mood stabilizers, and neuroprotection

scientific article

Glycogen synthase kinase‐3 levels and phosphorylation undergo large fluctuations in mouse brain during development ⬇️

scientific article published on December 1, 2012

HSP105 interacts with GRP78 and GSK3 and promotes ER stress-induced caspase-3 activation

scientific article

Heat shock protein-90 dampens and directs signaling stimulated by insulin-like growth factor-1 and insulin

scientific article published in September 2004

Impairments in cognition and neural precursor cell proliferation in mice expressing constitutively active glycogen synthase kinase-3.

scientific article

In vivo regulation of GSK3 phosphorylation by cholinergic and NMDA receptors

scientific article

In vivo regulation of glycogen synthase kinase-3beta (GSK3beta) by serotonergic activity in mouse brain

scientific article

Inactivation of the enzyme GSK3α by the kinase IKKi promotes AKT-mTOR signaling pathway that mediates interleukin-1-induced Th17 cell maintenance

scientific article published on 8 November 2012

Inflammation and lithium: clues to mechanisms contributing to suicide-linked traits

scientific article

Inflammatory T Helper 17 Cells Promote Depression-like Behavior in Mice ⬇️

scientific article published on November 20, 2012

Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3).

scientific article

Intranasal siRNA administration reveals IGF2 deficiency contributes to impaired cognition in Fragile X syndrome mice.

scientific article published on 23 March 2017

Is Glycogen Synthase Kinase-3 a Central Modulator in Mood Regulation? ⬇️

scientific article published on July 28, 2010

Ketamine up-regulates a cluster of intronic miRNAs within the serotonin receptor 2C gene by inhibiting glycogen synthase kinase-3.

scientific article published on 10 October 2016

Ketamine-induced inhibition of glycogen synthase kinase-3 contributes to the augmentation of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor signaling

scientific article published on 30 September 2016

Lipopolysaccharide-induced interleukin-6 production is controlled by glycogen synthase kinase-3 and STAT3 in the brain

scientific article published on 11 March 2009

Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of fragile X syndrome.

scientific article

Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes

scientific article

Lithium facilitates apoptotic signaling induced by activation of the Fas death domain-containing receptor

scientific article

Lithium regulates glycogen synthase kinase-3beta in human peripheral blood mononuclear cells: implication in the treatment of bipolar disorder.

scientific article published on 27 June 2006

Muscarinic receptor activation protects cells from apoptotic effects of DNA damage, oxidative stress, and mitochondrial inhibition

scientific article

Neural precursor cells are protected from apoptosis induced by trophic factor withdrawal or genotoxic stress by inhibitors of glycogen synthase kinase 3.

scientific article

Nuclear accumulation of glycogen synthase kinase-3 during replicative senescence of human fibroblasts

scientific article published in October 2004

Physiological and pathological changes in glucose regulate brain Akt and glycogen synthase kinase-3.

scientific article

Rapid accumulation of Akt in mitochondria following phosphatidylinositol 3-kinase activation

scientific article

Regulation of Cell Survival Mechanisms in Alzheimer′s Disease by Glycogen Synthase Kinase‐3 ⬇️

scientific article published on May 11, 2011

Regulation of Th1 cells and experimental autoimmune encephalomyelitis by glycogen synthase kinase-3.

scientific article published on 19 April 2013

Resolution of the nuclear localization mechanism of glycogen synthase kinase-3: functional effects in apoptosis

scientific article

Stress-induced neuroinflammation is mediated by GSK3-dependent TLR4 signaling that promotes susceptibility to depression-like behavior

scientific article published on 6 January 2016

Stressed and Inflamed, Can GSK3 Be Blamed?

scientific article published on 19 November 2016

TNFα disrupts blood brain barrier integrity to maintain prolonged depressive-like behavior in mice

scientific article published on 13 February 2018

Tau is hyperphosphorylated at multiple sites in mouse brain in vivo after streptozotocin-induced insulin deficiency

scientific article published on December 2006

The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways

scientific article

The role of DDX3 in regulating Snail

scientific article

Toll-like receptor 2 (TLR2)-deficiency impairs male mouse recovery from a depression-like state

scientific article published on 29 May 2020

Up-regulation of insulin-like growth factor 2 by ketamine requires glycogen synthase kinase-3 inhibition

scientific article published on 16 August 2016

XIAP associates with GSK3 and inhibits the promotion of intrinsic apoptotic signaling by GSK3.

scientific article

List of works by Richard S Jope

(+)-Naloxone blocks Toll-like receptor 4 to ameliorate deleterious effects of stress on male mouse behaviors

A pre-conditioning stress accelerates increases in mouse plasma inflammatory cytokines induced by stress

AMP-activated protein kinase (AMPK) activating agents cause dephosphorylation of Akt and glycogen synthase kinase-3.

Activation of the ATM-Snail pathway promotes breast cancer metastasis ⬇️

Anesthesia and post-mortem interval profoundly influence the regulatory serine phosphorylation of glycogen synthase kinase-3 in mouse brain

Astrocytes modulate the polarization of CD4+ T cells to Th1 cells.

Brain region differences in regulation of Akt and GSK3 by chronic stimulant administration in mice ⬇️

Cellular stress increases RGS2 mRNA and decreases RGS4 mRNA levels in SH-SY5Y cells

Comparison of inflammatory and behavioral responses to chronic stress in female and male mice

Convergence of the Mammalian Target of Rapamycin Complex 1- and Glycogen Synthase Kinase 3-β–Signaling Pathways Regulates the Innate Inflammatory Response ⬇️

Cotinine administration improves impaired cognition in the mouse model of Fragile X syndrome

DDX3 regulates DNA damage-induced apoptosis and p53 stabilization

Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances

Differential regulation of STAT family members by glycogen synthase kinase-3

Direct, activating interaction between glycogen synthase kinase-3beta and p53 after DNA damage

Distinct characteristics of hippocampal pathogenic TH17 cells in a mouse model of depression.

Elevated glycogen synthase kinase-3 activity in Fragile X mice: key metabolic regulator with evidence for treatment potential.

Evidence of reactive astrocytes but not peripheral immune system activation in a mouse model of Fragile X syndrome

Examination of methylphenidate-mediated behavior regulation by glycogen synthase kinase-3 in mice ⬇️

GSK3 influences social preference and anxiety-related behaviors during social interaction in a mouse model of fragile X syndrome and autism.

Glycogen Synthase Kinase-3 Is an Early Determinant in the Differentiation of Pathogenic Th17 Cells ⬇️

Glycogen Synthase Kinase-3: A Promising Therapeutic Target for Fragile X Syndrome ⬇️

Glycogen Synthase Kinase-3β (GSK3β) Binds to and Promotes the Actions of p53 ⬇️

Glycogen synthase kinase-3 (GSK3) in psychiatric diseases and therapeutic interventions

Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics

Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases

Glycogen synthase kinase-3 beta is highly activated in nuclei and mitochondria

Glycogen synthase kinase-3 in the etiology and treatment of mood disorders

Glycogen synthase kinase-3 inhibitors: Rescuers of cognitive impairments

Glycogen synthase kinase-3 promotes the synergistic action of interferon-gamma on lipopolysaccharide-induced IL-6 production in RAW264.7 cells

Glycogen synthase kinase-3 regulates endoplasmic reticulum (ER) stress-induced CHOP expression in neuronal cells.

Glycogen synthase kinase-3beta, mood stabilizers, and neuroprotection

Glycogen synthase kinase‐3 levels and phosphorylation undergo large fluctuations in mouse brain during development ⬇️

HSP105 interacts with GRP78 and GSK3 and promotes ER stress-induced caspase-3 activation

Heat shock protein-90 dampens and directs signaling stimulated by insulin-like growth factor-1 and insulin

Impairments in cognition and neural precursor cell proliferation in mice expressing constitutively active glycogen synthase kinase-3.

In vivo regulation of GSK3 phosphorylation by cholinergic and NMDA receptors

In vivo regulation of glycogen synthase kinase-3beta (GSK3beta) by serotonergic activity in mouse brain

Inactivation of the enzyme GSK3α by the kinase IKKi promotes AKT-mTOR signaling pathway that mediates interleukin-1-induced Th17 cell maintenance

Inflammation and lithium: clues to mechanisms contributing to suicide-linked traits

Inflammatory T Helper 17 Cells Promote Depression-like Behavior in Mice ⬇️

Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3).

Intranasal siRNA administration reveals IGF2 deficiency contributes to impaired cognition in Fragile X syndrome mice.

Is Glycogen Synthase Kinase-3 a Central Modulator in Mood Regulation? ⬇️

Ketamine up-regulates a cluster of intronic miRNAs within the serotonin receptor 2C gene by inhibiting glycogen synthase kinase-3.

Ketamine-induced inhibition of glycogen synthase kinase-3 contributes to the augmentation of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor signaling

Lipopolysaccharide-induced interleukin-6 production is controlled by glycogen synthase kinase-3 and STAT3 in the brain

Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of fragile X syndrome.

Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes

Lithium facilitates apoptotic signaling induced by activation of the Fas death domain-containing receptor

Lithium regulates glycogen synthase kinase-3beta in human peripheral blood mononuclear cells: implication in the treatment of bipolar disorder.

Muscarinic receptor activation protects cells from apoptotic effects of DNA damage, oxidative stress, and mitochondrial inhibition

Neural precursor cells are protected from apoptosis induced by trophic factor withdrawal or genotoxic stress by inhibitors of glycogen synthase kinase 3.

Nuclear accumulation of glycogen synthase kinase-3 during replicative senescence of human fibroblasts

Physiological and pathological changes in glucose regulate brain Akt and glycogen synthase kinase-3.

Rapid accumulation of Akt in mitochondria following phosphatidylinositol 3-kinase activation

Regulation of Cell Survival Mechanisms in Alzheimer′s Disease by Glycogen Synthase Kinase‐3 ⬇️

Regulation of Th1 cells and experimental autoimmune encephalomyelitis by glycogen synthase kinase-3.

Resolution of the nuclear localization mechanism of glycogen synthase kinase-3: functional effects in apoptosis

Stress-induced neuroinflammation is mediated by GSK3-dependent TLR4 signaling that promotes susceptibility to depression-like behavior

Stressed and Inflamed, Can GSK3 Be Blamed?

TNFα disrupts blood brain barrier integrity to maintain prolonged depressive-like behavior in mice

Tau is hyperphosphorylated at multiple sites in mouse brain in vivo after streptozotocin-induced insulin deficiency

The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways

The role of DDX3 in regulating Snail

Toll-like receptor 2 (TLR2)-deficiency impairs male mouse recovery from a depression-like state

Up-regulation of insulin-like growth factor 2 by ketamine requires glycogen synthase kinase-3 inhibition

XIAP associates with GSK3 and inhibits the promotion of intrinsic apoptotic signaling by GSK3.