List of works - Lynn A. Hyde

A computer-aided procedure for measuring Hebb-Williams maze performance

scientific article published in October 1996

Absence of postnatal testosterone fails to demasculinize the male rat's corpus callosum

scientific article published in September 1996

Age-progressing cognitive impairments and neuropathology in transgenic CRND8 mice

scientific article published in February 2005

Age-related deficits in context discrimination learning in Ts65Dn mice that model Down syndrome and Alzheimer's disease ⬇️

scientific article published on December 1, 2001

Altered activity, social behavior, and spatial memory in mice lacking the NTAN1p amidase and the asparagine branch of the N-end rule pathway

scientific journal article

Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology

scientific article

Automated evaluation of sensitivity to foot shock in mice: inbred strain differences and pharmacological validation

scientific article published in March 2007

Avoidance learning in autoimmune mice

scientific article published in December 2000

BXSB mice can learn complex visual pattern discriminations

scientific article

Characterization of the nociceptin receptor (ORL-1) agonist, Ro64-6198, in tests of anxiety across multiple species

scientific article

Characterization of the selective mGluR1 antagonist, JNJ16259685, in rodent models of movement and coordination

scientific article

Chronic Verubecestat Treatment Suppresses Amyloid Accumulation in Advanced Aged Tg2576-AβPPswe Mice Without Inducing Microhemorrhage

scientific article published on 08 August 2017

Cyclic hydroxyamidines as amide isosteres: discovery of oxadiazolines and oxadiazines as potent and highly efficacious γ-secretase modulators in vivo

scientific article published on 08 December 2011

Design and Validation of Bicyclic Iminopyrimidinones As Beta Amyloid Cleaving Enzyme-1 (BACE1) Inhibitors: Conformational Constraint to Favor a Bioactive Conformation ⬇️

scientific article published on November 8, 2012

Design and synthesis of tricyclic sulfones as gamma-secretase inhibitors with greatly reduced Notch toxicity

scientific article published on 23 February 2010

Design and synthesis of water soluble β-aminosulfone analogues of SCH 900229 as γ-secretase inhibitors

scientific article published on 7 May 2016

Differential learning strategies in spatial and nonspatial versions of the Morris water maze in the C57BL/6J inbred mouse strain

scientific article published in July 2002

Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer's Disease.

scientific article

Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity.

scientific article published on 28 February 2017

Discovery of a Novel, Potent Spirocyclic Series of γ-Secretase Inhibitors

scientific article

Discovery of a Potent Pyrazolopyridine Series of γ-Secretase Modulators

scientific article published on 29 March 2011

Discovery of a Tetrahydrobenzisoxazole Series of γ-Secretase Modulators

scientific article published on 19 September 2017

Discovery of amide and heteroaryl isosteres as carbamate replacements in a series of orally active gamma-secretase inhibitors

scientific article published on 30 October 2007

Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor That Affords Robust CNS Aβ Reduction

scientific article

Discovery of fused 5,6-bicyclic heterocycles as γ-secretase modulators ⬇️

scientific article published on December 13, 2010

Discovery of gamma-secretase inhibitors efficacious in a transgenic animal model of Alzheimer's disease

scientific article published on 10 October 2006

Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)-A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer's Disease

scientific article published on 18 November 2016

Effects of ectopias and their cortical location on several measures of learning in BXSB mice ⬇️

scientific article published on December 1, 2001

Effects of neocortical ectopias and environmental enrichment on Hebb-Williams maze learning in BXSB mice

scientific article published on 01 July 2001

Effects of neocortical ectopias upon the acquisition and retention of a non-spatial reference memory task in BXSB mice

scientific article published in December 1998

Effects of the non-pseudoautosomal region of the Y-chromosome on behavior in female offspring of two congenic strains of mice

scientific article published in January 2000

Estrogen restores cognition and cholinergic phenotype in an animal model of Down syndrome

scientific article

Generation of Leads for γ-Secretase Modulation

scientific article published on 04 August 2020

Iminoheterocycles as gamma-secretase modulators.

scientific article published in August 2010

In Vivo Characterization of a Novel γ-Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects

scientific article published on 14 March 2013

In two species, females exhibit superior working memory and inferior reference memory on the water radial-arm maze

scientific article published in August 2000

Increased auditory startle response and reduced prepulse inhibition of startle in transgenic mice expressing a double mutant form of amyloid precursor protein

scientific article published in December 2003

Increased seizure threshold and severity in young transgenic CRND8 mice

scientific article

Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice

scientific article

Lack of activational influence of ovarian hormones on the size of the female rat's corpus callosum

scientific article published in August 1996

Lack of shuttlebox avoidance learning in autoimmune bxsb mice: A test of learned helplessness ⬇️

scientific article published on August 1, 1997

Learning and memory in the autoimmune BXSB mouse: effects of neocortical ectopias and environmental enrichment

scientific article published in July 1996

Learning in Year-Old Female Autoimmune BXSB Mice ⬇️

scientific article published on April 1, 1998

MK-8719, a novel and selective O-GlcNAcase inhibitor that reduces the formation of pathological tau and ameliorates neurodegeneration in a mouse model of tauopathy

scientific article published on 03 June 2020

MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibition.

scientific article published on 25 September 2015

MitoPark mice, an animal model of Parkinson's disease, show enhanced prepulse inhibition of acoustic startle and no loss of gating in response to the adenosine A(2A) antagonist SCH 412348

scientific article published on 23 October 2013

Motor learning in Ts65Dn mice, a model for Down syndrome

scientific article

Non-spatial water radial-arm maze learning in mice

scientific article published in April 2000

Novel orally active morpholine N-arylsulfonamides gamma-secretase inhibitors with low CYP 3A4 liability

scientific article published on 19 September 2009

Overcoming Time Dependent Inhibition (TDI) of Cytochrome P450 3A4 (CYP3A4) Resulting from Bioactivation of a Fluoropyrimidine Moiety

scientific article published on 15 November 2018

Pharmacological BACE Inhibition Improves Axonal Regeneration in Nerve Injury and Disease Models

scientific article published on 31 March 2020

Reactivity to object and spatial novelty is normal in older Ts65Dn mice that model Down syndrome and Alzheimer's disease

scientific article published in July 2002

Small conformationally restricted piperidine N-arylsulfonamides as orally active gamma-secretase inhibitors

scientific article published on 15 August 2007

Spatial ability of XY sex-reversed female mice

scientific article published in July 2000

Spatial and nonspatial Morris maze learning: impaired behavioral flexibility in mice with ectopias located in the prefrontal cortex

scientific article published in July 2002

Structure activity relationship studies of tricyclic bispyran sulfone γ-secretase inhibitors ⬇️

scientific article published on November 24, 2012

Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitor ⬇️

scientific article published on February 16, 2012

Structure-Based Design of an Iminoheterocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in Nonhuman Primates

scientific article

Studies to investigate the in vivo therapeutic window of the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY411,575) in the CRND8 mouse

scientific article published on 31 August 2006

Substituted 4-morpholine N-arylsulfonamides as γ-secretase inhibitors

scientific article published on 13 August 2016

Synthesis and SAR Studies of Fused Oxadiazines as γ-Secretase Modulators for Treatment of Alzheimer's Disease

scientific article

Synthesis and SAR study of tricyclic sulfones as γ-secretase inhibitors: C-6 and C-8 positions ⬇️

scientific article published on 05 April 2011

Tetracyclic sulfones as potent gamma-secretase inhibitors: synthesis and structure-activity relationship studies

scientific article published on 28 April 2010

The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer's disease patients

scientific article published on November 2016

The Discovery of Pyridone and Pyridazone Heterocycles as γ-Secretase Modulators

scientific article published on 24 May 2010

The anxiolytic-like profile of the nociceptin receptor agonist, endo-8-[bis(2-chlorophenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octane-3-carboxamide (SCH 655842): comparison of efficacy and side effects across rodent species

scientific article published on 28 April 2011

The discovery of fused oxadiazepines as gamma secretase modulators for treatment of Alzheimer's disease

scientific article published on 29 November 2012

The effects of neocortical ectopias on Lashley III water maze learning in New Zealand Black mice

scientific article published in December 2000

Transgenic overexpression of neuromedin U promotes leanness and hypophagia in mice

scientific article published in April 2005

Tricyclic sulfones as orally active gamma-secretase inhibitors: synthesis and structure-activity relationship studies.

scientific article

Ts65Dn mice, a model for Down syndrome, have deficits in context discrimination learning suggesting impaired hippocampal function

scientific article

Water version of the radial-arm maze: Learning in three inbred strains of mice ⬇️

scientific article published on March 2, 1998

Working memory deficits in BXSB mice with neocortical ectopias

scientific article published on 01 July 2000

fMRI study of olfactory processing in mice under three anesthesia protocols: Insight into the effect of ketamine on olfactory processing

scientific article published on 12 March 2020

List of works by Lynn A. Hyde

A computer-aided procedure for measuring Hebb-Williams maze performance

Absence of postnatal testosterone fails to demasculinize the male rat's corpus callosum

Age-progressing cognitive impairments and neuropathology in transgenic CRND8 mice

Age-related deficits in context discrimination learning in Ts65Dn mice that model Down syndrome and Alzheimer's disease ⬇️

Altered activity, social behavior, and spatial memory in mice lacking the NTAN1p amidase and the asparagine branch of the N-end rule pathway

Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology

Automated evaluation of sensitivity to foot shock in mice: inbred strain differences and pharmacological validation

Avoidance learning in autoimmune mice

BXSB mice can learn complex visual pattern discriminations

Characterization of the nociceptin receptor (ORL-1) agonist, Ro64-6198, in tests of anxiety across multiple species

Characterization of the selective mGluR1 antagonist, JNJ16259685, in rodent models of movement and coordination

Chronic Verubecestat Treatment Suppresses Amyloid Accumulation in Advanced Aged Tg2576-AβPPswe Mice Without Inducing Microhemorrhage

Cyclic hydroxyamidines as amide isosteres: discovery of oxadiazolines and oxadiazines as potent and highly efficacious γ-secretase modulators in vivo

Design and Validation of Bicyclic Iminopyrimidinones As Beta Amyloid Cleaving Enzyme-1 (BACE1) Inhibitors: Conformational Constraint to Favor a Bioactive Conformation ⬇️

Design and synthesis of tricyclic sulfones as gamma-secretase inhibitors with greatly reduced Notch toxicity

Design and synthesis of water soluble β-aminosulfone analogues of SCH 900229 as γ-secretase inhibitors

Differential learning strategies in spatial and nonspatial versions of the Morris water maze in the C57BL/6J inbred mouse strain

Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer's Disease.

Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity.

Discovery of a Novel, Potent Spirocyclic Series of γ-Secretase Inhibitors

Discovery of a Potent Pyrazolopyridine Series of γ-Secretase Modulators

Discovery of a Tetrahydrobenzisoxazole Series of γ-Secretase Modulators

Discovery of amide and heteroaryl isosteres as carbamate replacements in a series of orally active gamma-secretase inhibitors

Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor That Affords Robust CNS Aβ Reduction

Discovery of fused 5,6-bicyclic heterocycles as γ-secretase modulators ⬇️

Discovery of gamma-secretase inhibitors efficacious in a transgenic animal model of Alzheimer's disease

Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)-A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer's Disease

Effects of ectopias and their cortical location on several measures of learning in BXSB mice ⬇️

Effects of neocortical ectopias and environmental enrichment on Hebb-Williams maze learning in BXSB mice

Effects of neocortical ectopias upon the acquisition and retention of a non-spatial reference memory task in BXSB mice

Effects of the non-pseudoautosomal region of the Y-chromosome on behavior in female offspring of two congenic strains of mice

Estrogen restores cognition and cholinergic phenotype in an animal model of Down syndrome

Generation of Leads for γ-Secretase Modulation

Iminoheterocycles as gamma-secretase modulators.

In Vivo Characterization of a Novel γ-Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects

In two species, females exhibit superior working memory and inferior reference memory on the water radial-arm maze

Increased auditory startle response and reduced prepulse inhibition of startle in transgenic mice expressing a double mutant form of amyloid precursor protein

Increased seizure threshold and severity in young transgenic CRND8 mice

Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice

Lack of activational influence of ovarian hormones on the size of the female rat's corpus callosum

Lack of shuttlebox avoidance learning in autoimmune bxsb mice: A test of learned helplessness ⬇️

Learning and memory in the autoimmune BXSB mouse: effects of neocortical ectopias and environmental enrichment

Learning in Year-Old Female Autoimmune BXSB Mice ⬇️

MK-8719, a novel and selective O-GlcNAcase inhibitor that reduces the formation of pathological tau and ameliorates neurodegeneration in a mouse model of tauopathy

MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibition.

MitoPark mice, an animal model of Parkinson's disease, show enhanced prepulse inhibition of acoustic startle and no loss of gating in response to the adenosine A(2A) antagonist SCH 412348

Motor learning in Ts65Dn mice, a model for Down syndrome

Non-spatial water radial-arm maze learning in mice

Novel orally active morpholine N-arylsulfonamides gamma-secretase inhibitors with low CYP 3A4 liability

Overcoming Time Dependent Inhibition (TDI) of Cytochrome P450 3A4 (CYP3A4) Resulting from Bioactivation of a Fluoropyrimidine Moiety

Pharmacological BACE Inhibition Improves Axonal Regeneration in Nerve Injury and Disease Models

Reactivity to object and spatial novelty is normal in older Ts65Dn mice that model Down syndrome and Alzheimer's disease

Small conformationally restricted piperidine N-arylsulfonamides as orally active gamma-secretase inhibitors

Spatial ability of XY sex-reversed female mice

Spatial and nonspatial Morris maze learning: impaired behavioral flexibility in mice with ectopias located in the prefrontal cortex

Structure activity relationship studies of tricyclic bispyran sulfone γ-secretase inhibitors ⬇️

Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitor ⬇️

Structure-Based Design of an Iminoheterocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in Nonhuman Primates

Studies to investigate the in vivo therapeutic window of the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY411,575) in the CRND8 mouse

Substituted 4-morpholine N-arylsulfonamides as γ-secretase inhibitors

Synthesis and SAR Studies of Fused Oxadiazines as γ-Secretase Modulators for Treatment of Alzheimer's Disease

Synthesis and SAR study of tricyclic sulfones as γ-secretase inhibitors: C-6 and C-8 positions ⬇️

Tetracyclic sulfones as potent gamma-secretase inhibitors: synthesis and structure-activity relationship studies

The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer's disease patients

The Discovery of Pyridone and Pyridazone Heterocycles as γ-Secretase Modulators

The anxiolytic-like profile of the nociceptin receptor agonist, endo-8-[bis(2-chlorophenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octane-3-carboxamide (SCH 655842): comparison of efficacy and side effects across rodent species

The discovery of fused oxadiazepines as gamma secretase modulators for treatment of Alzheimer's disease

The effects of neocortical ectopias on Lashley III water maze learning in New Zealand Black mice

Transgenic overexpression of neuromedin U promotes leanness and hypophagia in mice

Tricyclic sulfones as orally active gamma-secretase inhibitors: synthesis and structure-activity relationship studies.

Ts65Dn mice, a model for Down syndrome, have deficits in context discrimination learning suggesting impaired hippocampal function

Water version of the radial-arm maze: Learning in three inbred strains of mice ⬇️

Working memory deficits in BXSB mice with neocortical ectopias

fMRI study of olfactory processing in mice under three anesthesia protocols: Insight into the effect of ketamine on olfactory processing