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List of works by Yosef Shiloh

3rd US-EU workshop: systems level understanding of DNA damage responses

scientific article

A Haplotype Common to Intermediate Radiosensitivity Variants of Ataxia-telangiectasia in the UK.

scientific article published in January 1994

A YAC Contig Spanning the Ataxia-Telangiectasia Locus (Groups A and C) at 11q22-q23

scientific article published on 01 November 1994

A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23

scientific article

A missense mutation, S349P, completely inactivates phenylalanine hydroxylase in north African Jews with phenylketonuria

scientific article published on February 1993

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

scientific article

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

scientific article

ATM and ATR: networking cellular responses to DNA damage

scientific article (publication date: February 2001)

ATM and lymphoid malignancies; use of oriented peptide libraries to identify novel substrates of ATM critical in downstream signaling pathways

scientific article

ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage

scientific article

ATM is required for IkappaB kinase (IKKk) activation in response to DNA double strand breaks

scientific article

ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin

scientific article

ATM-dependent phosphorylation of ATF2 is required for the DNA damage response

scientific article

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

scientific article

ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair

scientific article

ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation

scientific article

ATM: expanding roles as a chief guardian of genome stability

scientific article published on 08 September 2014

Abnormal response of ataxia-telangiectasia cells to agents that break the deoxyribose moiety of DNA via a targeted free radical mechanism

scientific article published in October 1983

Absence of mutations in ATM , the gene responsible for ataxia telangiectasia in patients with cerebellar ataxia

article

Accelerated carcinogenesis following liver regeneration is associated with chronic inflammation-induced double-strand DNA breaks

scientific article

Accumulation of DNA Damage and Reduced Levels of Nicotine Adenine Dinucleotide in the Brains of Atm-deficient Mice ⬇️

scientific article published on October 25, 2001

Activation of ATM depends on chromatin interactions occurring before induction of DNA damage

scientific article published on 14 December 2008

Amplification of c-myc and c-erbB-2 proto-oncogenes in human solid tumors: frequency and clinical significance

scientific article published on 01 November 1989

Analysis of the ataxia telangiectasia mutated-mediated DNA damage response in murine cerebellar neurons.

scientific article

Analysis of the relationships between ATM and the Rad54 paralogs involved in homologous recombination repair

scientific journal article

Assignment of the human gamma-crystallin gene cluster (CRYG) to the long arm of chromosome 2, region q33-36

scientific article

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

scientific article

Ataxia-telangiectasia and the ATM gene: linking neurodegeneration, immunodeficiency, and cancer to cell cycle checkpoints

scientific article published on September 1996

Ataxia-telangiectasia: a variant with altered in vitro phenotype of fibroblast cells

scientific article published on 01 February 1989

Ataxia-telangiectasia: mutations in ATM cDNA detected by protein-truncation screening

scientific article published in July 1996

Atm knock-in mice harboring an in-frame deletion corresponding to the human ATM 7636del9 common mutation exhibit a variant phenotype

article

Beyond ATM: The protein kinase landscape of the DNA damage response ⬇️

scientific article published on 08 May 2011

Carrier detection in ataxia-telangiectasia

scientific article published on 01 March 1986

Characterization of ATM gene mutations in 66 ataxia telangiectasia families.

scientific article

Condensin I recruitment and uneven chromatin condensation precede mitotic cell death in response to DNA damage

scientific article

DNA amplification in human gastric carcinomas

scientific article published on 01 February 1993

DNA damage response, bioenergetics, and neurological disease: the challenge of maintaining brain health in an aging human population

scientific article published on 10 May 2013

DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation ⬇️

scientific article

DNA sequences amplified in cancer cells: an interface between tumor biology and human genome analysis

scientific article published on 01 May 1992

DNA-based detection of chromosome deletion and amplification: diagnostic and mechanistic significance

scientific article published on 01 January 1986

Defective potassium currents in ataxia telangiectasia fibroblasts

scientific article

Detection of ataxia telangiectasia heterozygous cell lines by postirradiation cumulative labeling index: measurements with coded samples

scientific article published on 01 January 1987

Differential amplification, assembly, and relocation of multiple DNA sequences in human neuroblastomas and neuroblastoma cell lines

scientific article published on June 1985

Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage.

scientific article

Dissection of a DNA-damage-induced transcriptional network using a combination of microarrays, RNA interference and computational promoter analysis

scientific article

EXPANDER--an integrative program suite for microarray data analysis

scientific article

Elevated Cu/Zn-SOD exacerbates radiation sensitivity and hematopoietic abnormalities of Atm-deficient mice

scientific article

Expander: from expression microarrays to networks and functions

scientific article

Fragments of ATM which have dominant-negative or complementing activity

scientific article published on April 1997

Functional genomic delineation of TLR-induced transcriptional networks

scientific article

Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

scientific article (publication date: 25 May 2000)

Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response

scientific article

G2 chromosomal radiosensitivity in families with ataxia-telangiectasia

scientific article published on 01 December 1989

Genetic Haplotyping of Ataxia-telangiectasia Families Localizes the Major Gene to an ∼ 850 kb Region on Chromosome 11q23.1.

scientific article published in January 1994

Genetic haplotyping of ataxia-telangiectasia families localizes the major gene to an ~850 kb region on chromosome 11 q23.1.

scientific article

Genome instability: Linking ageing and brain degeneration

scientific article published on 31 March 2016

Genome-wide in silico identification of transcriptional regulators controlling the cell cycle in human cells

scientific article

Genotype-phenotype relationships in ataxia-telangiectasia and variants.

scientific article

Identification of ATM mutations using extended RT-PCR and restriction endonuclease fingerprinting, and elucidation of the repertoire of A-T mutations in Israel.

scientific article published in January 1998

In search of drug treatment for genetic defects in the DNA damage response: the example of ataxia-telangiectasia

scientific article published in August 2004

Interaction between ATM protein and c-Abl in response to DNA damage

scientific article (publication date: 29 May 1997)

Investigation of the Functional Link between ATM and NBS1 in the DNA Damage Response in the Mouse Cerebellum ⬇️

scientific article published on February 7, 2011

Involvement of Matrin 3 and SFPQ/NONO in the DNA damage response

scientific article

Involvement of the nuclear proteasome activator PA28γ in the cellular response to DNA double-strand breaks ⬇️

scientific article published on December 15, 2011

Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366

scientific journal article

Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress.

scientific article

MRI evidence of white matter damage in a mouse model of Nijmegen breakage syndrome

scientific article

Matrin 3 Binds and Stabilizes mRNA ⬇️

scientific article published on August 17, 2011

Medical genetics in Israel.

scientific article

Novel DNA sequences at chromosome 10q26 are amplified in human gastric carcinoma cell lines: molecular cloning by competitive DNA reassociation

scientific article published in January 1991

Nuclear ataxia-telangiectasia mutated (ATM) mediates the cellular response to DNA double strand breaks in human neuron-like cells

scientific article (publication date: 23 June 2006)

Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK

scientific article

Origins of hyperphenylalaninemia in Israel.

scientific article published in January 1994

Phosphoproteomics reveals novel modes of function and inter-relationships among PIKKs in response to genotoxic stress

scientific article published on 20 November 2020

Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage

scientific article

Physical and Genetic Mapping at the ATA/ATC Locus on Chromosome 11q22-23.

scientific article published in January 1994

Predominance of null mutations in ataxia-telangiectasia

scientific article published in April 1996

Programs for cell death: apoptosis is only one way to go.

scientific article published on 7 March 2007

RNF20-RNF40: A ubiquitin-driven link between gene expression and the DNA damage response.

scientific article published on 04 August 2011

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

scientific article published on December 1999

Rapid identification of polymorphic CA-repeats in YAC clones

scientific article published on 01 April 1995

Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks

scientific article

Requirement of the MRN complex for ATM activation by DNA damage ⬇️

scientific article published on October 15, 2003

SPIKE--a database, visualization and analysis tool of cellular signaling pathways.

scientific article

SPIKE: a database of highly curated human signaling pathways

scientific article

Systemic DNA damage responses in aging and diseases

scientific article

Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks

scientific article

The ATM protein kinase: regulating the cellular response to genotoxic stress, and more

scientific article published on 13 March 2013

The ATM protein: The importance of being active ⬇️

scientific article published on August 6, 2012

The COP9 signalosome is vital for timely repair of DNA double-strand breaks

scientific article published on 8 April 2015

The ataxia-telangiectasia gene product, a constitutively expressed nuclear protein that is not up-regulated following genome damage

scientific article

The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species

scientific article

The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression

scientific article

The human T cell antigen Leu-2 (T8) is encoded on chromosome 2.

scientific article

The neurological phenotype of ataxia-telangiectasia: solving a persistent puzzle

scientific article

The role of the DNA damage response in neuronal development, organization and maintenance

scientific article published on 23 May 2008

Transcriptional modulation induced by ionizing radiation: p53 remains a central player

scientific article published on 07 July 2011

Two RFLPs identified by a human chromosome #2 clone at 2p15-2p16 (HGM8 assignment no. D2S5).

scientific article

Utilization of oriented peptide libraries to identify substrate motifs selected by ATM.

scientific article

WRN is required for ATM activation and the S-phase checkpoint in response to interstrand cross-link-induced DNA double-strand breaks

scientific article published on 2 July 2008

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