List of works - Sarah Lincoln

alpha-Synuclein locus triplication causes Parkinson's disease

scientific article

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

scientific article (publication date: 18 November 2004)

Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

scientific article published in The Lancet

Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications

scientific article (publication date: February 2004)

Lewy bodies and parkinsonism in families with parkin mutations

scientific article (publication date: September 2001)

Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: evidence of a common founder across European populations

scientific article

Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants

scientific article

Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter

scientific article published in June 2001

A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1.

scientific article published in April 1998

Lrrk2 pathogenic substitutions in Parkinson's disease

scientific article published on 17 September 2005

Complex relationship between Parkin mutations and Parkinson disease

scientific article

alpha-Synuclein promoter confers susceptibility to Parkinson's disease

scientific article published in October 2004

Linkage disequilibrium and association of MAPT H1 in Parkinson disease

scientific article

Novel late-onset Alzheimer disease loci variants associate with brain gene expression

scientific article

LRRK2 mutations in Parkinson disease

scientific article published on 01 September 2005

-Synuclein and Parkinson disease susceptibility

scientific article published on 13 September 2007

Anatomical localization of leucine-rich repeat kinase 2 in mouse brain

scientific article published on 28 February 2006

TREM2 is associated with increased risk for Alzheimer's disease in African Americans

scientific article published on 10 April 2015

In vivo silencing of alpha-synuclein using naked siRNA

scientific article

Human whole genome genotype and transcriptome data for Alzheimer's and other neurodegenerative diseases

scientific article

Low frequency of pathogenic mutations in the ubiquitin carboxy-terminal hydrolase gene in familial Parkinson's disease

scientific article

Association of MAPT haplotypes with Alzheimer's disease risk and MAPT brain gene expression levels

scientific article

Identification of a novel risk locus for progressive supranuclear palsy by a pooled genomewide scan of 500,288 single-nucleotide polymorphisms

scientific article published on 8 March 2007

Localization of frontotemporal dementia with parkinsonism in an Australian kindred to chromosome 17q21-22.

scientific article published in November 1997

DJ-1 mutations are a rare cause of recessively inherited early onset parkinsonism mediated by loss of protein function

scientific article published in March 2004

Parkin mutations and early-onset parkinsonism in a Taiwanese cohort

scientific article published in January 2005

DNMT1 mutation hot spot causes varied phenotypes of HSAN1 with dementia and hearing loss.

scientific article published on 30 January 2013

FGF20 and Parkinson's disease: no evidence of association or pathogenicity via alpha-synuclein expression

scientific article

The Ile93Met mutation in the ubiquitin carboxy-terminal-hydrolase-L1 gene is not observed in European cases with familial Parkinson's disease

scientific article

Refinement of the PARK3 locus on chromosome 2p13 and the analysis of 14 candidate genes

scientific article published in September 2001

Late-onset Alzheimer disease risk variants mark brain regulatory loci

scientific article published on 23 July 2015

A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression

scientific article published on 8 December 2016

Compound heterozygous PANK2 mutations confirm HARP and Hallervorden-Spatz syndromes are allelic

scientific article published in November 2003

Conserved brain myelination networks are altered in Alzheimer's and other neurodegenerative diseases

scientific article published on 26 October 2017

Linkage exclusion in French families with probable Parkinson's disease

article

Gene expression, methylation and neuropathology correlations at progressive supranuclear palsy risk loci.

scientific article published on 26 April 2016

Pathology of PD in monozygotic twins with a 20-year discordance interval

scientific article published in April 2001

Biochemical characterization of torsinB.

scientific article published on August 2004

Clinical, 18F-dopa PET, and genetic analysis of an ethnic Chinese kindred with early-onset parkinsonism and parkin gene mutations

scientific article

Alpha-synuclein missense and multiplication mutations in autosomal dominant Parkinson's disease

scientific article

UCHL1 is associated with Parkinson's disease: A case-unaffected sibling and case-unrelated control study

scholarly article by Maurizio Facheris et al published June 2005 in Neuroscience Letters

Two large British kindreds with familial Parkinson's disease: a clinico-pathological and genetic study

scientific article published in January 2002

Identification of the human ubiquitin specific protease 31 (USP31) gene: structure, sequence and expression analysis

scientific article

Parkin-proven disease: common founders but divergent phenotypes

scientific article

Lack of mutations in DJ-1 in a cohort of Taiwanese ethnic Chinese with early-onset parkinsonism

article

The human sideroflexin 5 (SFXN5) gene: sequence, expression analysis and exclusion as a candidate for PARK3.

scientific article published in February 2002

Parkinson's disease in Ireland: clinical presentation and genetic heterogeneity in patients with parkin mutations

scientific article published in June 2004

No pathogenic mutations in the beta-synuclein gene in Parkinson's disease

scholarly article by S Lincoln et al published 9 January 1999 in Neuroscience Letters

A kindred with Parkinson's disease not showing genetic linkage to established loci

scholarly article by K. A. Gwinn-Hardy et al published 25 January 2000 in Neurology

LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease (LOAD).

scientific article

List of works by Sarah Lincoln

alpha-Synuclein locus triplication causes Parkinson's disease

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications

Lewy bodies and parkinsonism in families with parkin mutations

Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: evidence of a common founder across European populations

Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants

Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter

A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1.

Lrrk2 pathogenic substitutions in Parkinson's disease

Complex relationship between Parkin mutations and Parkinson disease

alpha-Synuclein promoter confers susceptibility to Parkinson's disease

Linkage disequilibrium and association of MAPT H1 in Parkinson disease

Novel late-onset Alzheimer disease loci variants associate with brain gene expression

LRRK2 mutations in Parkinson disease

-Synuclein and Parkinson disease susceptibility

Anatomical localization of leucine-rich repeat kinase 2 in mouse brain

TREM2 is associated with increased risk for Alzheimer's disease in African Americans

In vivo silencing of alpha-synuclein using naked siRNA

Human whole genome genotype and transcriptome data for Alzheimer's and other neurodegenerative diseases

Low frequency of pathogenic mutations in the ubiquitin carboxy-terminal hydrolase gene in familial Parkinson's disease

Association of MAPT haplotypes with Alzheimer's disease risk and MAPT brain gene expression levels

Identification of a novel risk locus for progressive supranuclear palsy by a pooled genomewide scan of 500,288 single-nucleotide polymorphisms

Localization of frontotemporal dementia with parkinsonism in an Australian kindred to chromosome 17q21-22.

DJ-1 mutations are a rare cause of recessively inherited early onset parkinsonism mediated by loss of protein function

Parkin mutations and early-onset parkinsonism in a Taiwanese cohort

DNMT1 mutation hot spot causes varied phenotypes of HSAN1 with dementia and hearing loss.

FGF20 and Parkinson's disease: no evidence of association or pathogenicity via alpha-synuclein expression

The Ile93Met mutation in the ubiquitin carboxy-terminal-hydrolase-L1 gene is not observed in European cases with familial Parkinson's disease

Refinement of the PARK3 locus on chromosome 2p13 and the analysis of 14 candidate genes

Late-onset Alzheimer disease risk variants mark brain regulatory loci

A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression

Compound heterozygous PANK2 mutations confirm HARP and Hallervorden-Spatz syndromes are allelic

Conserved brain myelination networks are altered in Alzheimer's and other neurodegenerative diseases

Linkage exclusion in French families with probable Parkinson's disease

Gene expression, methylation and neuropathology correlations at progressive supranuclear palsy risk loci.

Pathology of PD in monozygotic twins with a 20-year discordance interval

Biochemical characterization of torsinB.

Clinical, 18F-dopa PET, and genetic analysis of an ethnic Chinese kindred with early-onset parkinsonism and parkin gene mutations

Alpha-synuclein missense and multiplication mutations in autosomal dominant Parkinson's disease

UCHL1 is associated with Parkinson's disease: A case-unaffected sibling and case-unrelated control study

Two large British kindreds with familial Parkinson's disease: a clinico-pathological and genetic study

Identification of the human ubiquitin specific protease 31 (USP31) gene: structure, sequence and expression analysis

Parkin-proven disease: common founders but divergent phenotypes

Lack of mutations in DJ-1 in a cohort of Taiwanese ethnic Chinese with early-onset parkinsonism

The human sideroflexin 5 (SFXN5) gene: sequence, expression analysis and exclusion as a candidate for PARK3.

Parkinson's disease in Ireland: clinical presentation and genetic heterogeneity in patients with parkin mutations

No pathogenic mutations in the beta-synuclein gene in Parkinson's disease

A kindred with Parkinson's disease not showing genetic linkage to established loci

LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease (LOAD).