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List of works by Stephanie R. McKeown

A cytochrome P450 2B6 meditated gene therapy strategy to enhance the effects of radiation or cyclophosphamide when combined with the bioreductive drug AQ4N.

scientific article published in July 2005

AQ4N: a new approach to hypoxia-activated cancer chemotherapy

scientific article

AQ4N: an alkylaminoanthraquinone N-oxide showing bioreductive potential and positive interaction with radiation in vivo

scientific article published on July 1995

Androgen deprivation results in time-dependent hypoxia in LNCaP prostate tumours: informed scheduling of the bioreductive drug AQ4N improves treatment response.

scientific article published on 23 November 2012

Antitumour prodrug development using cytochrome P450 (CYP) mediated activation

scientific article

Bioreductive GDEPT using cytochrome P450 3A4 in combination with AQ4N.

scientific article published in January 2003

Cancer-BIT Life Sciences' second world congress. 22-25 June 2009, Beijing, China

scientific article published on 01 September 2009

Cell cycle checkpoint function in bladder cancer

scientific article published on December 2003

Comet assay measures of DNA damage are predictive of bladder cancer cell treatment sensitivity in vitro and outcome in vivo.

scientific article published on 8 October 2013

Cytochrome P450 1B1 expression in rat esophageal tumorigenesis promoted by gastric and duodenal reflux

scientific article published on 01 February 2009

Cytochrome P450 1B1 mRNA untranslated regions interact to inhibit protein translation

scientific article

DNA damage following combination of radiation with the bioreductive drug AQ4N: possible selective toxicity to oxic and hypoxic tumour cells

scientific article

Enhancement of chemotherapy and radiotherapy of murine tumours by AQ4N, a bioreductively activated anti-tumour agent

scientific article published on June 2000

Enhancement of the anti-tumour effect of cyclophosphamide by the bioreductive drugs AQ4N and tirapazamine

scientific article published on April 2000

Evaluation of the antiangiogenic potential of AQ4N.

scientific article published in March 2008

Evidence for a therapeutic gain when AQ4N or tirapazamine is combined with radiation

scientific article published on July 1996

Gene expression in normal urothelium depends on location within the bladder: a possible link to bladder carcinogenesis

scientific article published on 24 January 2006

Gene-directed enzyme prodrug therapy: a current assessment.

scientific article published in August 2004

Hypoxia selects for androgen independent LNCaP cells with a more malignant geno- and phenotype

scientific article

Investigation of pericytes, hypoxia, and vascularity in bladder tumors: association with clinical outcomes.

scientific article published in January 2008

Involvement of human cytochromes P450 (CYP) in the reductive metabolism of AQ4N, a hypoxia activated anthraquinone di-N-oxide prodrug

scientific article published on 01 November 1998

Modification of the alkaline Comet assay to allow simultaneous evaluation of mitomycin C-induced DNA cross-link damage and repair of specific DNA sequences in RT4 cells

scientific article published on 01 August 2003

Mutant SOD1 mediated pathogenesis of Amyotrophic Lateral Sclerosis

scientific article

Nitric Oxide Up-Regulates RUNX2 in LNCaP Prostate Tumours: Implications for Tumour Growth In Vitro and In Vivo

scientific article published on 19 July 2015

Pericytes influence endothelial cell growth characteristics: role of plasminogen activator inhibitor type 1 (PAI-1).

scientific article published on 13 September 2005

Potential of a Funalia trogii laccase enzyme as an anticancer agent

article published in 2014

Potential use of the comet assay in the clinical management of cancer

scientific article published on 05 February 2008

Radiotherapy for benign disease; assessing the risk of radiation-induced cancer following exposure to intermediate dose radiation.

scientific article

Royal academy of medicine in Ireland section of biomedical sciences

Targeting Hypoxic Prostate Tumors Using the Novel Hypoxia-Activated Prodrug OCT1002 Inhibits Expression of Genes Associated with Malignant Progression

scientific article published on 3 October 2016

The chemopotentiation of cisplatin by the novel bioreductive drug AQ4N

scientific article

The chemopotentiation of cisplatin by the novel bioreductive drug AQ4N.

scientific article published on 12 November 2002

The unidirectional hypoxia-activated prodrug OCT1002 inhibits growth and vascular development in castrate-resistant prostate tumors.

scientific article

Tumor-selective drug activation: a GDEPT approach utilizing cytochrome P450 1A1 and AQ4N.

scientific article published on June 2006

Use of the Comet-FISH Assay to Compare DNA Damage and Repair in p53 and hTERT Genes following Ionizing Radiation ⬇️

scientific article published on November 7, 2012

Use of the comet-FISH assay to demonstrate repair of the TP53 gene region in two human bladder carcinoma cell lines

scientific article published on 01 January 2003

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