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List of works by Uri Seligsohn

A 13-bp deletion in alpha(IIb) gene is a founder mutation that predominates in Palestinian-Arab patients with Glanzmann thrombasthenia

scientific article published on December 2005

A 14-bp deletion (codon 554 del AAGgtaacagagtg) at exon 14/intron N junction of the coagulation factor XI gene disrupts splicing and causes severe factor XI deficiency

scientific article published in January 1996

A Glanzmann's thrombasthenia cluster among Iraqi Jews in Israel

scientific article published on 01 December 1984

A common ancestral mutation (C128X) occurring in 11 non-Jewish families from the UK with factor XI deficiency

scientific article

A mutation in LMAN1 (ERGIC-53) causing combined factor V and factor VIII deficiency is prevalent in Jews originating from the island of Djerba in Tunisia

scientific article

A mutation in the β3 cytoplasmic tail causes variant Glanzmann thrombasthenia by abrogating transition of αIIbβ3 to an active state ⬇️

scientific article published on February 1, 2012

A novel Phe171Cys mutation in integrin alpha causes Glanzmann thrombasthenia by abrogating alphabeta complex formation

scientific article

A novel ancestral splicing mutation in the multidrug resistance protein 2 gene causes Dubin-Johnson syndrome in Ashkenazi Jewish patients.

scientific article

A relatively high frequency of severe (type III) von Willebrand's disease in Israel

scientific article

A single genetic origin for a common Caucasian risk factor for venous thrombosis

scientific article published on 01 January 1997

A single genetic origin for the common prothrombotic G20210A polymorphism in the prothrombin gene ⬇️

scientific article published on August 15, 1998

A unique interaction between alphaIIb and beta3 in the head region is essential for outside-in signaling-related functions of alphaIIbbeta3 integrin

scientific article published on 22 March 2010

ADAMTS-13 regulates platelet adhesion under flow. A new method for differentiation between inherited and acquired thrombotic thrombocytopenic purpura.

scientific article

Abnormal Excretion of the Isomers of Urinary Coproporphyrin by Patients with Dubin—Johnson Syndrome in Israel ⬇️

scientific article published on 01 January 1971

Abnormal cytoplasmic extensions associated with active αIIbβ3 are probably the cause for macrothrombocytopenia in Glanzmann thrombasthenia-like syndrome

scientific article

Abnormal plasma clot structure and stability distinguish bleeding risk in patients with severe factor XI deficiency

scientific article

Acquired von Willebrand disease in a patient with angiodysplasia resulting from immune-mediated clearance of von Willebrand factor

scientific article published on 01 January 1997

Activated factor VII: presence in factor IX concentrates and persistence in the circulation after infusion ⬇️

scientific article published on May 1, 1979

Activation of human factor VII in plasma and in purified systems: roles of activated factor IX, kallikrein, and activated factor XII ⬇️

scientific article published on October 1, 1979

Age estimates of ancestral mutations causing factor VII deficiency and Dubin-Johnson syndrome in Iranian and Moroccan Jews are consistent with ancient Jewish migrations

scientific article

Age estimates of two common mutations causing factor XI deficiency: recent genetic drift is not necessary for elevated disease incidence among Ashkenazi Jews

scientific article published on April 1999

An allosteric disulfide bond is involved in enhanced activation of factor XI by protein disulfide isomerase

scientific article published on 30 August 2016

An αIIb mutation in patients with Glanzmann thrombasthenia located in the N‐terminus of blade 1 of the β‐propeller (Asn2Asp) disrupts a calcium binding site in blade 6 ⬇️

scientific article published on January 1, 2011

Analysis of genetic polymorphisms related to thrombosis and other risk factors in patients with retinal vein occlusion

scientific article published on 01 October 1998

Analysis of prothrombotic and vascular risk factors in patients with nonarteritic anterior ischemic optic neuropathy

scientific article published on 01 April 1999

Association between hyperflexibility of the thumb and an unexplained bleeding tendency: is it a rule of thumb? ⬇️

scientific article published on 01 May 1998

Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex

scientific article (publication date: June 2003)

Bleeding predictors in factor-XI-deficient patients ⬇️

scientific article published on November 1, 1997

Cataract extraction without prophylactic treatment in patients with severe factor XI deficiency

scientific article published on 5 September 2009

Cerebrovascular Events in Patients With Significant Stenosis of the Carotid Artery Are Associated With Hyperhomocysteinemia and Platelet Antigen-1 (Leu33Pro) Polymorphism ⬇️

scientific article published on December 1, 2001

Characterization of mutations causing factor VII deficiency in 61 unrelated Israeli patients

scientific article published on October 2004

Characterization of seven novel mutations causing factor XI deficiency

scientific article

Characterization of three mutations causing von Willebrand disease type IIA in five unrelated families

scientific article published on 01 June 1992

Chronic monocytic leukemia: a case with an eight-year survival

scientific article published on 01 November 1967

Clinical and economical advantages of anticoagulant treatment in specialized clinics

scientific article published in September 2002

Clinical and genetic aspects of Glanzmann's thrombasthenia in Israel: report of 22 cases

scientific article published on December 15, 1975

Clinical and laboratory aspects of disseminated intravascular coagulation (DIC): a study of 118 cases

scientific article published on February 28, 1978

Clinical utility gene card for: Glanzmann thrombasthenia

scientific article

Clinical utility gene card for: Glanzmann thrombasthenia

Coexistence of hereditary homocystinuria and factor V Leiden--effect on thrombosis

scientific article published on 01 March 1996

Combined Factor-V and Factor- VIII Deficiency: Report of Four Cases ⬇️

scientific article published in May 1969

Combined factor V and factor VIII deficiency among non-Ashkenazi Jews

scientific article published in November 1982

Combined factors V and VIII deficiency--the solution

scientific article published in July 1998

Correlation of baseline plasminogen activator inhibitor activity with patency of the infarct artery after thrombolytic therapy in acute myocardial infarction

scientific article published on 01 December 1989

Could the 185delAG BRCA1 mutation be an ancient Jewish mutation?

scientific article published on November 1, 1997

Coupled amidolytic assay for factor VII: its use with a clotting assay to determine the activity state of factor VII.

scientific article published in November 1978

Current strategy for genetic analysis of haemophilia A families

scientific article

Cyclosporine therapy for acquired factor VIII inhibitor in a patient with systemic lupus erythematosus

scientific article published on 01 September 1996

Deciphering the mystery of combined factor V and factor VIII deficiency

scientific article published on 01 May 2006

Decreased factor VIII clotting antigen levels in the combined factor V and VIII deficiency

scientific article published in January 1984

Dental surgery in patients with severe factor XI deficiency without plasma replacement

scientific article published on 01 August 1992

Detection of Haemophilia A Carriers by Replicate Factor VIII Activity and Factor VIII Antigenicity Determinations ⬇️

scientific article published on July 1, 1979

Detection of the Glanzmann's thrombasthenia mutations in Arab and Iraqi-Jewish patients by polymerase chain reaction and restriction analysis of blood or urine samples

scientific article published on 01 October 1991

Discerning the ancestry of European Americans in genetic association studies

scientific article

Disseminated intravascular coagulation in experimental heatstroke

scientific article published on December 31, 1971

Disulfide bond disruption by a beta 3-Cys549Arg mutation in six Jordanian families with Glanzmann thrombasthenia causes diminished production of constitutively active alpha IIb beta 3.

scientific article published in December 2007

Disulfide bond disruption by a β3-Cys549Arg mutation in six Jordanian families with Glanzmann thrombasthenia causes diminished production of constitutively active αIIbβ3

Disulfide bond exchanges in integrins αIIbβ3 and αvβ3 are required for activation and post-ligation signaling during clot retraction

scientific article published on 7 February 2014

Diversity of Glanzmann thrombasthenia in southern India: 10 novel mutations identified among 15 unrelated patients.

scientific article

Dubin-Johnson Syndrome. Abnormal excretion of the isomers of urinary coproporphyrin by clinically unaffected family members

scientific article published on September 1, 1973

Dubin-Johnson syndrome in Israel. I. Clinical, laboratory, and genetic aspects of 101 cases

scientific article published on October 1, 1970

Dubin-Johnson syndrome in Israel. II. Association with factor-VII deficiency

scientific article published on October 1, 1970

ERGIC-53 gene structure and mutation analysis in 19 combined factors V and VIII deficiency families

scientific article (publication date: April 1999)

Effect of corticosteroids upon fibrinogen metabolism in rabbits.

scientific article

Effect of four missense mutations in the factor XIII A-subunit gene on protein stability: studies with recombinant proteins

scientific article published on 01 March 2006

Effect of phenobarbital on liver functions in patients with Dubin-Johnson syndrome

scientific article published on August 1, 1974

Effects of factor VIII inhibitor bypassing activity (FEIBA), recombinant factor VIIa or both on thrombin generation in normal and haemophilia A plasma

scientific article published on 21 March 2008

Extensive venous and arterial thrombosis associated with an inhibitor to activated protein C

scientific article published on 01 August 1999

Extra-adrenal effect of ACTH on fibrinogen synthesis

scientific article published in May 1973

Factor VIII gene rearrangement in hemophilia A carrier detection: a word of caution

scientific article published in August 1994

Factor XI deficiency in French Basques is caused predominantly by an ancestral Cys38Arg mutation in the factor XI gene

scientific article published on April 2002

Factor XI deficiency in humans

scientific article published on July 2009

Factor XI in haemostasis and thrombosis: Past, present and future

scholarly article by Uri Seligsohn published 2007 in Thrombosis and Haemostasis

Factor XI in haemostasis and thrombosis: past, present and future

scientific article published in July 2007

Factor XIII deficiency due to a Leu660Pro mutation in the factor XIII subunit-a gene in three unrelated Palestinian Arab families

scientific article published on 01 June 1997

False-positive tests for heparin-induced thrombocytopenia in patients with antiphospholipid syndrome and systemic lupus erythematosus

scientific article

Fibrin-dependent platelet procoagulant activity requires GPIb receptors and von Willebrand factor.

scientific article

Genotype-phenotype correlation in combined deficiency of factor V and factor VIII.

scientific article published on 7 April 2008

Glanzmann thrombasthenia caused by an 11.2-kb deletion in the glycoprotein IIIa (beta3) is a second mutation in Iraqi Jews that stemmed from a distinct founder

scientific article published on May 1997

Glanzmann thrombasthenia in two Iraqi-Jewish siblings is caused by a novel splice junction mutation in the glycoprotein IIb ⬇️

scientific article published on April 1, 1998

Glanzmann thrombasthenia: a model disease which paved the way to powerful therapeutic agents

scientific article (publication date: 14 August 2003)

Glanzmann thrombasthenia: new insights from an historical perspective.

scientific article published on October 1994

Glanzmann's thrombasthenia associated with deletion-insertion and alternative splicing in the glycoprotein IIb gene

scientific article published on January 1995

Hereditary deficiency of blood clotting factor VII and Dubin-Johnson syndrome in an Israeli family

scientific article published on 01 September 1969

Hereditary factor XIII deficiency: report of four families and definition of the carrier state

scientific article published on 01 March 1984

High prevalences of vitamin B12 and folic acid deficiency in elderly subjects in Israel ⬇️

scientific article published on November 1, 2003

Homozygous protein C deficiency manifested by massive venous thrombosis in the newborn

scientific article published on 01 March 1984

Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin-Johnson syndrome

scientific article (publication date: 5 October 2001)

Identification of a region in glycoprotein IIIa involved in subunit association with glycoprotein IIb: further lessons from Iraqi-Jewish Glanzmann thrombasthenia

scientific article published on 01 August 2001

Immunoblot analysis of platelet glycoprotein IIb in patients with Glanzmann thrombasthenia in Israel

scientific article published on 01 July 1989

Immunologic and biochemical characterization of homozygous and heterozygous Glanzmann thrombasthenia in the Iraqi-Jewish and Arab populations of Israel: comparison of techniques for carrier detection

scientific article published on 01 April 1986

Improved method for genotyping apolipoprotein E polymorphisms by a PCR-based assay simultaneously utilizing two distinct restriction enzymes ⬇️

scientific article published on 01 September 1997

Induction of an inhibitor antibody to factor XI in a patient with severe inherited factor XI deficiency by Rh immune globulin.

scientific article published on 20 November 2007

Inherited bleeding disorders common in Jews

scientific article published on 01 May 2010

Inherited factor XI deficiency confers no protection against acute myocardial infarction

scientific article published in April 2003

Inherited platelet disorders

scientific article published on 01 July 2012

Inherited thrombophilia: Part 1

scientific article published on 01 November 1996

Inherited thrombophilia: Part 2

scientific article published on 01 December 1996

Inhibitors to Factor XI in patients with severe Factor XI deficiency

scientific article

Linkage of combined factors V and VIII deficiency to chromosome 18q by homozygosity mapping

scientific article published on February 1997

Low Concentrations of Recombinant Factor VIIa May Improve the Impaired Thrombin Generation of Glanzmann Thrombasthenia Patients

scientific article published on 31 December 2018

Major mutations in calf-1 and calf-2 domains of glycoprotein IIb in patients with Glanzmann thrombasthenia enable GPIIb/IIIa complex formation, but impair its transport from the endoplasmic reticulum to the Golgi apparatus

scientific article published on 27 February 2003

Methionine synthase A2756G and methylenetetrahydrofolate reductase A1298C polymorphisms are not risk factors for idiopathic venous thromboembolism

scientific article (publication date: 2001)

Molecular characterization of four novel mutations causing factor VII deficiency

scientific article published on 01 January 2000

Molecular diversity of Glanzmann thrombasthenia in southern India: new insights into mRNA splicing and structure-function correlations of alphaIIbbeta3 integrin (ITGA2B, ITGB3).

scientific article published in April 2006

Monitoring oral anticoagulant therapy by telephone communication

scientific article published in April 2005

Multiple myeloma with terminal erythroleukemia

scientific article published in January 1976

Mutations in the alphaIIb and beta3 genes that cause Glanzmann thrombasthenia can be distinguished by a simple procedure using transformed B-lymphocytes

scientific article published on February 1, 1998

Natural and artificial mutations in αIIb integrin lead to a structural deformation of a calcium-binding site

scientific article published on October 2014

New observations on factor XI deficiency

scientific article

Nonarteritic anterior ischemic optic neuropathy is associated with a specific platelet polymorphism located on the glycoprotein Ibalpha gene

scientific article published on 01 January 2004

Of four mutations in the factor VII gene in Tunisian patients, one novel mutation (Ser339Phe) in three unrelated families abrogates factor X activation

scientific article published on July 2005

One of the two common mutations causing factor XI deficiency in Ashkenazi Jews (type II) is also prevalent in Iraqi Jews, who represent the ancient gene pool of Jews.

scientific article published in January 1995

Patients with severe factor XI deficiency have a reduced incidence of deep-vein thrombosis

scientific article published on 05 November 2010

Patterns of incorporation of 75 Se-methionine into fibrinogen and other plasma proteins in rabbits stimulated by different test conditions

scientific article published on 01 February 1973

Persistent neonatal thrombocytopenia can be caused by IgA antiplatelet antibodies in breast milk of immune thrombocytopenic mothers

scientific article

Plasma levels of microparticles at 24 weeks of gestation do not predict subsequent pregnancy complications

scientific article published on 09 August 2008

Plasma replacement therapy during labor is not mandatory for women with severe factor XI deficiency

scientific article published on 01 January 2005

Platelet factor XI: intracellular localization and mRNA splicing following platelet activation

scientific article published on 21 April 2017

Platelet fibrinogen and vitronectin in Glanzmann thrombasthenia: evidence consistent with specific roles for glycoprotein IIb/IIIA and alpha v beta 3 integrins in platelet protein trafficking ⬇️

scientific article published on November 15, 1991

Platelets from Calreticulin mutated essential thrombocythemia patients are less reactive than JAK2 V617F mutated platelets

scientific article published on 23 December 2019

Point mutations regarded as missense mutations cause splicing defects in the factor XI gene ⬇️

scientific article published on October 1, 2011

Possible role of factor XIII subunit A in Fcgamma and complement receptor-mediated phagocytosis

scientific article

Possible role of fibrinogen in the aggregation of white blood cells

scientific article published on 01 August 1987

Prenatal diagnosis of Glanzmann thrombasthenia

scientific article published on July 1, 2003

Prenatal diagnosis of Glanzmann thrombasthenia using the polymorphic markers BRCA1 and THRA1 on chromosome 17 ⬇️

scientific article published on July 1, 1998

Prenatal diagnosis of hereditary protein C deficiency

scientific article published on 01 December 1985

Prerequisites for recombinant factor VIIa-induced thrombin generation in plasmas deficient in factors VIII, IX or XI.

scientific article published in January 2006

Prevalence, causes, and characterization of factor XI inhibitors in patients with inherited factor XI deficiency

scientific article published on 13 February 2003

Prevention Program of Type I Glanzmann Thrombasthenia in Israel: Prenatal Diagnosis ⬇️

scientific article published on 01 January 1988

Prothrombin 20210G>A is an ancestral prothrombotic mutation that occurred in whites approximately 24 000 years ago

scientific article published on 21 February 2006

Purpura fulminans induced by disseminated intravascular coagulation following infection in 2 unrelated children with double heterozygosity for factor V Leiden and protein S deficiency

scientific article published on 01 June 1997

Rare bleeding disorders

scientific article

Recombinant activated factor VII and tranexamic acid are haemostatically effective during major surgery in factor XI-deficient patients with inhibitor antibodies.

scientific article published in September 2009

Reduced incidence of ischemic stroke in patients with severe factor XI deficiency

scientific article published on 11 February 2008

Repeat infusion of recombinant tissue-type plasminogen activator in patients with acute myocardial infarction and early recurrent myocardial ischemia

scientific article published on October 1990

Risk factors associated with postpartum ovarian vein thrombosis

scientific article published on 01 September 1999

Risk factors for failure of heparin thromboprophylaxis in patients with acute traumatic spinal cord injury

scientific article published on 23 October 2009

Role of aspirin in reducing the frequency of second eye involvement in patients with non-arteritic anterior ischaemic optic neuropathy

scientific article published on 01 June 1999

Sequestration studies with chromium-51 labeled red cells as criteria for splenectomy

scientific article published on 01 November 1967

Seven novel mutations in the factor XIII A-subunit gene causing hereditary factor XIII deficiency in 10 unrelated families

article

Severe factor XI deficiency caused by a Gly555 to Glu mutation (factor XI-Glu555): a cross-reactive material positive variant defective in factor IX activation.

scientific article published in October 2004

Severe hereditary deficiency of factor VII during pregnancy. Evidence for the absence of transplacental diffusion of factor VII

scientific article published on 01 October 1970

Simultaneous genotyping of coagulation factor XI type II and type III mutations by multiplex real-time polymerase chain reaction to determine their prevalence in healthy and factor XI-deficient Italians

article

Single and combined prothrombotic factors in patients with idiopathic venous thromboembolism: prevalence and risk assessment

scientific article published in March 1999

Specific cysteines in beta3 are involved in disulfide bond exchange-dependent and -independent activation of alphaIIbbeta3.

scientific article

Structural integrity of the glycoprotein IIb and IIIa genes in Glanzmann thrombasthenia patients from Israel

scientific article published in November 1988

Studies on the binding of an alloimmune and two murine monoclonal antibodies to the platelet glycoprotein IIb-IIIa complex receptor

scientific article published on 01 April 1986

Synergistic effects of prothrombotic polymorphisms and atherogenic factors on the risk of myocardial infarction in young males

scientific article published on 01 April 1999

The association of factor V leiden and prothrombin gene mutation and placenta-mediated pregnancy complications: a systematic review and meta-analysis of prospective cohort studies ⬇️

scientific article

The common prothrombotic factors in nulliparous women do not compromise blood flow in the feto-maternal circulation and are not associated with preeclampsia or intrauterine growth restriction

scientific article published on 01 December 2004

The frequent 5,10-methylenetetrahydrofolate reductase C677T polymorphism is associated with a common haplotype in whites, Japanese, and Africans

scientific article

The human platelet alphaIIb gene is not closely linked to its integrin partner beta3

scientific article (publication date: 15 September 1999)

The inheritance of Dubin-Johnson syndrome

scientific article published on September 1, 1973

The inheritance of type I and type III von Willebrand's disease in Israel: linkage analysis, carrier detection and prenatal diagnosis using three intragenic restriction fragment length polymorphisms

scientific article published on 01 April 1992

The interval between prothrombin time tests and the quality of oral anticoagulants treatment in patients with chronic atrial fibrillation

scientific article published on 21 November 2006

The laboratory diagnosis of haemophilia: Recommendations by the Laboratory Activities Committee of the World Federation of Hemophilia

scientific article

The molecular genetic basis of Glanzmann thrombasthenia in the Iraqi-Jewish and Arab populations in Israel

scientific article published on April 1991

The neurology of cobalamin deficiency in an elderly population in Israel

scientific article

The prevalence of factor V G1691A but not of prothrombin G20210A and methylenetetrahydrofolate reductase C677T is remarkably low in French Basques

scientific article published in February 2004

The reduced form of coagulation factor XI is associated with illness severity and coagulopathy in critically-ill septic patients

scientific article published on 01 February 2019

The relative frequency of hereditary thrombotic disorders among 107 patients with thrombophilia in Israel

The role of factor XI in thrombin generation induced by low concentrations of tissue factor

scientific article published on 01 June 2001

The role of protein disulfide isomerase in the post-ligation phase of β3 integrin-dependent cell adhesion

scientific article published on 17 October 2015

The two common mutations causing factor XI deficiency in Jews stem from distinct founders: one of ancient Middle Eastern origin and another of more recent European origin ⬇️

scientific article published on October 1, 1997

Three residues at the interface of factor XI (FXI) monomers augment covalent dimerization of FXI.

scientific article published in June 2009

Thrombasthenia in Iraqi Jews.

scientific article

Thromboembolic events in patients with severe inherited fibrinogen deficiency

scientific article published on 28 December 2015

Thrombophilia as a cause for central and branch retinal artery occlusion in patients without an apparent embolic source

scientific article published in August 2001

Thrombophilia as a multigenic disorder

scientific article published on 01 July 1997

Trp207Gly in platelet glycoprotein Ibalpha is a novel mutation that disrupts the connection between the leucine-rich repeat domain and the disulfide loop structure and causes Bernard-Soulier syndrome

scientific article

Type I Glanzmann thrombasthenia patients from the Iraqi-Jewish and Arab populations in Israel can be differentiated by platelet glycoprotein IIIa immunoblot analysis

scientific article

Type I mutation in the F11 gene is a third ancestral mutation which causes factor XI deficiency in Ashkenazi Jews ⬇️

scientific article published on April 1, 2013

Unique disulfide bonds in epidermal growth factor (EGF) domains of β3 affect structure and function of αIIbβ3 and αvβ3 integrins in different manner

scientific article published on 3 February 2012

Upregulation of osteoclast alpha2beta1 integrin compensates for lack of alphavbeta3 vitronectin receptor in Iraqi-Jewish-type Glanzmann thrombasthenia

scientific article published on 01 September 2003

Variable effects of alpha v suppression on VEGFR-2 expression in endothelial cells of different vascular beds

scientific article

Venous thromboembolism associated with double heterozygosity for R506Q mutation of factor V and for T298M mutation of protein C in a large family of a previously described homozygous protein C-deficient newborn with massive thrombosis

scientific article published in August 1996

von Willebrand factor multimer patterns in pregnancy-induced hypertension

scientific article published on 01 September 1989

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