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List of works by David Piwnica-Worms

18F-AFETP, 18F-FET, and 18F-FDG imaging of mouse DBT gliomas

scientific article published on 06 May 2013

18F-fluorodeoxyglucose positron emission tomography correlates with tumor immunometabolic phenotypes in resected lung cancer

scientific article published on 16 April 2020

A Coclinical Radiogenomic Validation Study: Conserved Magnetic Resonance Radiomic Appearance of Periostin-Expressing Glioblastoma in Patients and Xenograft Models

scientific article published on 27 July 2018

A Novel Mitochondrial Inhibitor Blocks MAPK Pathway and Overcomes MAPK Inhibitor Resistance in Melanoma

scientific article published on 22 August 2019

A bioluminescent transposon reporter-trap identifies tumor-specific microenvironment-induced promoters in Salmonella for conditional bacterial-based tumor therapy

scientific article

A fluorescence-coupled assay for gamma aminobutyric acid (GABA) reveals metabolic stress-induced modulation of GABA content in neuroendocrine cancer

scientific article

A generator-produced gallium-68 radiopharmaceutical for PET imaging of myocardial perfusion

scientific article

A high-throughput fluorimetric assay for 2-hydroxyglutarate identifies Zaprinast as a glutaminase inhibitor

scientific article

A rapid bioluminescence assay for measuring myeloperoxidase activity in human plasma.

scientific article

APT102, a novel adpase, cooperates with aspirin to disrupt bone metastasis in mice.

scientific article published on July 2008

Ac-rkkrrorrrGK(QSY21)DEVDAPC(Alexa Fluor 647)-NH2

scientific article published on 22 July 2010

Advances in bioluminescence imaging of live animal models

scientific article

An aggregation sensing reporter identifies leflunomide and teriflunomide as polyglutamine aggregate inhibitors

scientific article

An anti-apoptotic peptide improves survival in lethal total body irradiation

scientific article

An improved cell-penetrating, caspase-activatable, near-infrared fluorescent peptide for apoptosis imaging

scientific article

Analysis of RAS protein interactions in living cells reveals a mechanism for pan-RAS depletion by membrane-targeted RAS binders

scientific article published on 18 May 2020

Androgen Receptor Signaling in Castration-Resistant Prostate Cancer Alters Hyperpolarized Pyruvate to Lactate Conversion and Lactate Levels In Vivo.

scientific article published on 10 May 2018

Antagonism of inhibitor of apoptosis proteins increases bone metastasis via unexpected osteoclast activation

scientific article published on 26 December 2012

Asp-960/Glu-961 controls the movement of the C-terminal tail of the epidermal growth factor receptor to regulate asymmetric dimer formation

scientific article

Assessing Metabolic Intervention with a Glutaminase Inhibitor in Real-Time by Hyperpolarized Magnetic Resonance in Acute Myeloid Leukemia

scientific article published on 06 August 2019

Automated, Resin-Based Method to Enhance the Specific Activity of Fluorine-18 Clicked PET Radiotracers.

scientific article published on 2 February 2017

Biochemical and in vivo characterization of a small, membrane-permeant, caspase-activatable far-red fluorescent peptide for imaging apoptosis

scientific article published on 10 March 2007

Bioluminescence Imaging Captures the Expression and Dynamics of Endogenous p21 Promoter Activity in Living Mice and Intact Cells ⬇️

scientific article published on July 26, 2011

Bioluminescence imaging of myeloperoxidase activity in vivo

scientific article

Bioluminescence imaging of period1 gene expression in utero.

scientific article published in January 2007

Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo

scientific article published on January 2007

Breast Cancer Cell Targeting by Prenylation Inhibitors Elucidated in Living Animals with a Bioluminescence Reporter ⬇️

scientific article published on June 12, 2012

CD47 regulates bone mass and tumor metastasis to bone

scientific article

CD8+ T cells regulate bone tumor burden independent of osteoclast resorption

scientific article

CXCL12 Mediates Trophic Interactions between Endothelial and Tumor Cells in Glioblastoma ⬇️

scientific article published on March 12, 2012

CXCL12 alone is insufficient for gliomagenesis in Nf1 mutant mice.

scientific article published on July 2010

CXCR4 regulates growth of both primary and metastatic breast cancer

scientific article

Caspase-3 Substrates for Noninvasive Pharmacodynamic Imaging of Apoptosis by PET/CT

scientific article published on 31 August 2018

Caspase-Activated Cell-Penetrating Peptides Reveal Temporal Coupling Between Endosomal Release and Apoptosis in an RGC-5 Cell Model ⬇️

scientific article published on August 30, 2012

Cerenkov radiation energy transfer (CRET) imaging: a novel method for optical imaging of PET isotopes in biological systems

scientific article

Characterization of a 67Ga/68Ga radiopharmaceutical for SPECT and PET of MDR1 P-glycoprotein transport activity in vivo: validation in multidrug-resistant tumors and at the blood-brain barrier.

scientific article published on February 2005

Characterization of a novel 99mTc-carbonyl complex as a functional probe of MDR1 P-glycoprotein transport activity

scientific article published in January 2002

Characterization of coelenterazine analogs for measurements of Renilla luciferase activity in live cells and living animals

scientific article published on January 2004

Characterization of novel histidine-tagged Tat-peptide complexes dual-labeled with (99m)Tc-tricarbonyl and fluorescein for scintigraphy and fluorescence microscopy

scientific article published in November 2002

Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100.

scientific article published on 02 December 2008

Chromatin Remodeling Underlies the Senescence-Associated Secretory Phenotype of Tumor Stromal Fibroblasts That Supports Cancer Progression ⬇️

scientific article published on March 15, 2012

Combined VEGF and CXCR4 antagonism targets the GBM stem cell population and synergistically improves survival in an intracranial mouse model of glioblastoma

scientific article

Combining Hyperpolarized Real-Time Metabolic Imaging and NMR Spectroscopy To Identify Metabolic Biomarkers in Pancreatic Cancer

scientific article published on 04 June 2019

Conjugation to a SMAC mimetic potentiates sigma-2 ligand induced tumor cell death in ovarian cancer

scientific article

Continuous delivery of D-luciferin by implanted micro-osmotic pumps enables true real-time bioluminescence imaging of luciferase activity in vivo

scientific article published in March 2007

Contribution of p53 to metastasis

scientific article

Current state of imaging protein-protein interactions in vivo with genetically encoded reporters

scientific article published on January 2007

Cyclic AMP suppression is sufficient to induce gliomagenesis in a mouse model of neurofibromatosis-1

scientific article published on 15 June 2010

DAPK3 suppresses acini morphogenesis and is required for mouse development

scientific article

Detection of protein-protein interactions in live cells and animals with split firefly luciferase protein fragment complementation

scientific article

Development of a Potential Gallium-68-Labelled Radiotracer Based on DOTA-Curcumin for Colon-Rectal Carcinoma: From Synthesis to In Vivo Studies

article

Disruption of CXCR4 enhances osteoclastogenesis and tumor growth in bone

scholarly article

Dissection of platelet and myeloid cell defects by conditional targeting of the beta3-integrin subunit.

scientific article

Dual-color click beetle luciferase heteroprotein fragment complementation assays.

scientific article

Dynamic analysis of the epidermal growth factor (EGF) receptor-ErbB2-ErbB3 protein network by luciferase fragment complementation imaging

scientific article published on 06 September 2013

Early Detection of Pancreatic Intraepithelial Neoplasias (PanINs) in Transgenic Mouse Model by Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy ⬇️

scientific article published on 25 May 2020

Evaluating new therapies in gastrointestinal stromal tumor using in vivo molecular optical imaging

scientific article published on 22 April 2014

Evidence for a plasma membrane-mediated permeability barrier to Tat basic domain in well-differentiated epithelial cells: lack of correlation with heparan sulfate

scientific article published on October 2002

Excess exogenous pyruvate inhibits lactate dehydrogenase activity in live cells in an MCT1-dependent manner

scientific article published on 20 May 2021

F11R is a novel monocyte prognostic biomarker for malignant glioma

scientific article

Factors affecting human T cell engraftment, trafficking, and associated xenogeneic graft-vs-host disease in NOD/SCID beta2mnull mice.

scientific article

Fasting protects mice from lethal DNA damage by promoting small intestinal epithelial stem cell survival.

scientific article

Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity

scientific article

Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kappaB and MAPK signaling pathways.

scientific article

Fluorophore-conjugated iron oxide nanoparticle labeling and analysis of engrafting human hematopoietic stem cells

scientific article

Forkhead box O1 (FOXO1) protein, but not p53, contributes to robust induction of p21 expression in fasted mice.

scientific article published on 05 August 2013

From the Guest Editor: Illuminating Cancer In Vivo With Molecular Imaging

scientific article published on 01 May 2015

Generation of a highly inducible Gal4-->Fluc universal reporter mouse for in vivo bioluminescence imaging

scholarly article

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

scientific article published on 24 June 2015

Granulocyte colony-stimulating factor enhances bone tumor growth in mice in an osteoclast-dependent manner

scientific article

Hedgehog signaling inhibition blocks growth of resistant tumors through effects on tumor microenvironment.

scientific article published on 20 December 2011

Human cord blood progenitors with high aldehyde dehydrogenase activity improve vascular density in a model of acute myocardial infarction.

scientific article

Hyperpolarized [1-13C]pyruvate-to-[1-13C]lactate conversion is rate-limited by monocarboxylate transporter-1 in the plasma membrane

scientific article published on 24 August 2020

IFNγR signaling mediates alloreactive T-cell trafficking and GVHD ⬇️

scientific article published on September 12, 2012

Identification of a ligand-induced transient refractory period in nuclear factor-kappaB signaling.

scientific article

Illuminating Cancer Systems with Genetically Engineered Mouse Models and Coupled Luciferase ReportersIn Vivo ⬇️

scientific article published on April 12, 2013

Imaging 26S proteasome activity and inhibition in living mice

scientific article

Imaging pulmonary gene expression with positron emission tomography

scientific article

Imaging reversal of multidrug resistance in living mice with bioluminescence: MDR1 P-glycoprotein transports coelenterazine

scholarly article

Imaging spontaneous tumorigenesis: inflammation precedes development of peripheral NK tumors

scientific article published on 29 October 2008

Imaging: Strategies, Controversies, and Opportunities ⬇️

scientific article published on February 1, 2012

Immunodeficient mouse strains display marked variability in growth of human melanoma lung metastases

scientific article

In Vivo Optical Imaging of Acute Cell Death Using a Near-Infrared Fluorescent Zinc−Dipicolylamine Probe ⬇️

scientific article published on April 4, 2011

In vitro and in vivo characterization of a dual-function green fluorescent protein--HSV1-thymidine kinase reporter gene driven by the human elongation factor 1 alpha promoter

scientific article published in April 2002

In vivo RNA interference-mediated ablation of MDR1 P-glycoprotein

scientific article published on June 2005

In vivo cell death mediated by synthetic ion channels

scientific article

Induction of antitumor immunity in mice by the combination of nanoparticle-based photothermolysis and anti-PD-1 checkpoint inhibition

scientific article published on 12 February 2020

Interleukin 12 stimulates IFN-gamma-mediated inhibition of tumor-induced regulatory T-cell proliferation and enhances tumor clearance

scientific article published on 20 October 2009

Interrogating Cellular Communication in Cancer with Genetically Encoded Imaging Reporters

scientific article published on 31 July 2020

Interrogation of inhibitor of nuclear factor κB α/nuclear factor κB (IκBα/NF-κB) negative feedback loop dynamics: from single cells to live animals in vivo

scientific article

Intracellular calcium regulates nonsense-mediated mRNA decay

scientific article

Kinetics of in vivo elimination of suicide gene-expressing T cells affects engraftment, graft-versus-host disease, and graft-versus-leukemia after allogeneic bone marrow transplantation

scientific article published on September 2004

Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals

scientific article

Knocking down nucleolin expression in gliomas inhibits tumor growth and induces cell cycle arrest.

scientific article

LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy

scientific article

Linkage between cellular communications, energy utilization, and proliferation in metastatic neuroendocrine cancers

scholarly article

Loss of Par-1a/MARK3/C-TAK1 Kinase Leads to Reduced Adiposity, Resistance to Hepatic Steatosis, and Defective Gluconeogenesis ⬇️

scientific article published on August 23, 2010

Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo

scholarly article

Luciferase fragment complementation imaging of conformational changes in the epidermal growth factor receptor

scientific article published on 26 January 2009

Measuring brain tumor growth: combined bioluminescence imaging-magnetic resonance imaging strategy

scientific article published on September 2009

Mechanics of EGF Receptor/ErbB2 kinase activation revealed by luciferase fragment complementation imaging ⬇️

scientific article published on December 21, 2011

Mechanism-Specific Pharmacodynamics of a Novel Complex-I Inhibitor Quantified by Imaging Reversal of Consumptive Hypoxia with [18F]FAZA PET In Vivo

scientific article published on 21 November 2019

Mistiming Death: Modeling the Time-Domain Variability of Tumor Apoptosis and Implications for Molecular Imaging of Cell Death

scientific article published on 09 June 2020

Molecular imaging of gene expression and protein function in vivo with PET and SPECT.

scientific article

Molecular imaging of host-pathogen interactions in intact small animals

scientific article published on April 2004

Molecular imaging of protein-protein interactions: controlled expression of p53 and large T-antigen fusion proteins in vivo ⬇️

scientific article published on April 15, 2003

Molecular imaging of pulmonary disease in vivo

scientific article published on August 2009

Molecular imaging strategies for drug discovery and development

scientific article published on 5 July 2006

Monitoring molecular-specific pharmacodynamics of rapamycin in vivo with inducible Gal4->Fluc transgenic reporter mice

scientific article

Monitoring proteasome activity in cellulo and in living animals by bioluminescent imaging: technical considerations for design and use of genetically encoded reporters

scientific article published on 01 January 2005

Multiwalled Carbon Nanotubes for Combination Therapy: a Biodistribution and Efficacy Pilot Study

scientific article published on 12 March 2019

Nano in cancer: linking chemistry, biology, and clinical applications in vivo

scientific article published on 23 August 2011

Noninvasive bioluminescence imaging of herpes simplex virus type 1 infection and therapy in living mice

scientific article

Noninvasive imaging of protein-protein interactions in living animals

scientific article

Noninvasive optical imaging of staphylococcus aureus bacterial infection in living mice using a Bis-dipicolylamine-Zinc(II) affinity group conjugated to a near-infrared fluorophore.

scientific article

Novel chemical library screen identifies naturally occurring plant products that specifically disrupt glioblastoma-endothelial cell interactions

scientific article published on July 2015

Novel derivatives of anaplastic lymphoma kinase inhibitors: Synthesis, radiolabeling, and preliminary biological studies of fluoroethyl analogues of crizotinib, alectinib, and ceritinib

scientific article published on 09 August 2019

Novel treatment option for MUC16-positive malignancies with the targeted TRAIL-based fusion protein Meso-TR3.

scientific article published on 21 January 2014

Nucleoside Diphosphate Kinase-3 (NME3) Enhances TLR5-Induced NFκB Activation

scientific article published on 9 March 2018

Optical imaging of bacterial infection in living mice using a fluorescent near-infrared molecular probe

scientific article

Optimizing luciferase protein fragment complementation for bioluminescent imaging of protein-protein interactions in live cells and animals

scientific article published on January 2004

P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model

scientific article published on 20 October 2005

PDE7B is a novel, prognostically significant mediator of glioblastoma growth whose expression is regulated by endothelial cells

scientific article

Peptide-mediated activation of Akt and extracellular regulated kinase signaling prevents lymphocyte apoptosis

scientific article

Permeation Peptide Conjugates for In Vivo Molecular Imaging Applications

scholarly article by Kristin E. Bullok et al published January 2006 in Molecular imaging : official journal of the Society for Molecular Imaging

Permeation peptide conjugates for in vivo molecular imaging applications

scientific article published on January 2006

Probing multidrug resistance P-glycoprotein transporter activity with SPECT radiopharmaceuticals

scientific article published on January 2010

Proteasome inhibition blocks ligand-induced dynamic processing and internalization of epidermal growth factor receptor via altered receptor ubiquitination and phosphorylation

scientific article

Quantitation of pulmonary transgene expression with PET imaging.

scientific article published in April 2004

Quantitation of selective autophagic protein aggregate degradation in vitro and in vivo using luciferase reporters.

scientific article

Quantitation of the Effect of ErbB2 on Epidermal Growth Factor Receptor Binding and Dimerization ⬇️

scientific article published on July 20, 2012

Quantitative analysis of permeation peptide complexes labeled with Technetium-99m: chiral and sequence-specific effects on net cell uptake

scientific article published in March 2003

Rational design of novel red-shifted BRET pairs: Platforms for real-time single-chain protease biosensors

scientific article published on March 2009

Real-time imaging of beta-catenin dynamics in cells and living mice

scholarly article

Real-time imaging of ligand-induced IKK activation in intact cells and in living mice

scientific article published on 01 August 2005

Real-time imaging of notch activation with a luciferase complementation-based reporter.

scientific article

Recent advances in imaging the lungs of intact small animals

scientific article

Revascularization of ischemic limbs after transplantation of human bone marrow cells with high aldehyde dehydrogenase activity.

scientific article published on 26 March 2009

SNM and AACR announce joint conference

scientific article published on 01 March 2012

Second-generation triple reporter for bioluminescence, micro-positron emission tomography, and fluorescence imaging.

scientific article published on October 2006

Selective cell uptake of modified Tat peptide-fluorophore conjugates in rat retina in ex vivo and in vivo models

scientific article published on 01 June 2006

Senescent stromal-derived osteopontin promotes preneoplastic cell growth

scientific article published on 20 January 2009

Simultaneous inhibition of hedgehog signaling and tumor proliferation remodels stroma and enhances pancreatic cancer therapy.

scientific article published on 9 January 2018

Single photon emission computed tomography and positron emission tomography imaging of multi-drug resistant P-glycoprotein--monitoring a transport activity important in cancer, blood-brain barrier function and Alzheimer's disease

scientific article published on November 2006

Single-cell imaging of retinal ganglion cell apoptosis with a cell-penetrating, activatable peptide probe in an in vivo glaucoma model

scholarly article

Single-cell resolution imaging of retinal ganglion cell apoptosis in vivo using a cell-penetrating caspase-activatable peptide probe

scientific article

Spatial and Temporal Confined Photothermolysis of Cancer Cells Mediated by Hollow Gold Nanospheres Targeted to Epidermal Growth Factor Receptors.

scientific article published in May 2018

Spectral unmixing of multicolored bioluminescence emitted from heterogeneous biological sources

scientific article published in March 2006

Spying on cancer: molecular imaging in vivo with genetically encoded reporters

scientific article

Squaraine rotaxanes: superior substitutes for Cy-5 in molecular probes for near-infrared fluorescence cell imaging

scientific article

Stably integrated luxCDABE for assessment of Salmonella invasion kinetics.

scientific article published on September 2008

Strain-specific susceptibility for pulmonary metastasis of sarcoma 180 cells in inbred mice

scientific article

Streamlining the Quantitative Metrics Workflow at a Comprehensive Cancer Center

scientific article published on 21 July 2020

Structure-activity relationships, kinetics, selectivity, and mechanistic studies of synthetic hydraphile channels in bacterial and mammalian cells

scientific article published on 26 August 2005

Suicide genes: monitoring cells in patients with a safety switch

scientific article

Suppression of G-protein–Coupled Receptor Kinase 3 Expression Is a Feature of Classical GBM That Is Required for Maximal Growth ⬇️

scientific article published on November 15, 2011

Synthesis and characterization of a Gd-DOTA-D-permeation peptide for magnetic resonance relaxation enhancement of intracellular targets

scientific article published on 01 October 2003

Synthesis and characterization of a small, membrane-permeant, caspase-activatable far-red fluorescent peptide for imaging apoptosis

scientific article published in August 2005

Synthesis of a [(18)F]-labeled ceritinib analogue for positron emission tomography of anaplastic lymphoma kinase, a receptor tyrosine kinase, in lung cancer

scientific article published on 8 February 2016

Synthesis, Molecular Structure, and Properties of a Neutral Schiff Base Phenolic Complex of Magnesium ⬇️

scientific article published on 01 September 1998

Synthesis, characterization, and molecular structure of a gallium(III) complex of an amine-phenol ligand with activity against chloroquine-sensitive Plasmodium falciparum strains.

scientific article published on January 2003

T-cell activation promotes tumorigenesis in inflammation-associated cancer

scientific article

TAT-BH4 and TAT-Bcl-xL peptides protect against sepsis-induced lymphocyte apoptosis in vivo

scientific article published on 01 May 2006

TAT-Bim induces extensive apoptosis in cancer cells

scientific article published on 06 January 2007

Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression

scientific article published on December 2008

Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses

scientific article published on 5 December 2012

The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling

scientific article

The ARF tumor suppressor regulates bone remodeling and osteosarcoma development in mice

scientific article

The bisphosphonate zoledronic acid decreases tumor growth in bone in mice with defective osteoclasts

scientific article

The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis

scientific article published on 05 May 2013

Type I interferons link viral infection to enhanced epithelial turnover and repair.

scientific article

Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease

scientific article

Vascular Endothelial Growth Factor Receptor-1 Is Synthetic Lethal to Aberrant {beta}-Catenin Activation in Colon Cancer

scientific article

Veni, vidi, vici: in vivo molecular imaging of immune response

scientific article published on 01 October 2007

Visualizing protein-protein interactions in living animals

scientific article

Whole-genome analysis informs breast cancer response to aromatase inhibition

scientific article

[(18)F]FHBG PET/CT Imaging of CD34-TK75 Transduced Donor T Cells in Relapsed Allogeneic Stem Cell Transplant Patients: Safety and Feasibility

scientific article published on 25 March 2015

p38 MAPK inhibits nonsense-mediated RNA decay in response to persistent DNA damage in noncycling cells

scientific article published in August 2017

p38MAPK plays a crucial role in stromal-mediated tumorigenesis

scientific article

p53 deficiency linked to B cell translocation gene 2 (BTG2) loss enhances metastatic potential by promoting tumor growth in primary and metastatic sites in patient-derived xenograft (PDX) models of triple-negative breast cancer

scientific article published on 27 January 2016

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