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List of works by Donald Metcalf

156 A Novel Mutation in the Nfkb2 Gene Generates an NFκB2 ‘Super Repressor’

article

A convenient method for preparation of an engineered mouse interleukin-3 analog with high solubility and wild-type bioactivity

scientific article

A key role for G-CSF-induced neutrophil production and trafficking during inflammatory arthritis

scientific article published on 29 September 2008

A kinase-dead allele of Lyn attenuates autoimmune disease normally associated with Lyn deficiency

scientific article published in February 2009

A mutation in the translation initiation codon of Gata-1 disrupts megakaryocyte maturation and causes thrombocytopenia

scientific article

A novel mutation in the Nfkb2 gene generates an NF-kappa B2 "super repressor".

scientific article published in December 2007

A promising new treatment for refractory aplastic anemia

scientific article published on 01 July 2012

A reporter mouse reveals lineage-specific and heterogeneous expression of IRF8 during lymphoid and myeloid cell differentiation

scientific article

Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β.

scientific article published on 25 May 2015

Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2a

scientific article

Affinity maturation of leukemia inhibitory factor and conversion to potent antagonists of signaling.

scientific article

Agm1/Pgm3-mediated sugar nucleotide synthesis is essential for hematopoiesis and development

scientific journal article

Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene

scientific article published on 21 January 2005

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

scientific article

Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production

scientific article published in December 2014

Architectural defects in the spleens of Nkx2-3-deficient mice are intrinsic and associated with defects in both B cell maturation and T cell-dependent immune responses

scientific journal article

Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling

scientific article

Blimp1 is limiting for transformation in a mouse plasmacytoma model

scientific article published on 27 March 2009

Blocking LIF action in the uterus by using a PEGylated antagonist prevents implantation: a nonhormonal contraceptive strategy.

scholarly article

Cellular Processing of Murine Colony-Stimulating Factor (Multi-CSF, GM-CSF, G-CSF) Receptors by Normal Hemopoietic Cells and Cell Lines

scientific article published on 01 January 1988

Characterization of thrombopoietin (TPO)-responsive progenitor cells in adult mouse bone marrow with in vivo megakaryocyte and erythroid potential ⬇️

scientific article published on January 30, 2012

Clearance and fate of leukemia-inhibitory factor (LIF) after injection into mice

scientific article published on 01 September 1991

Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor

scientific article

Clonogenic mast cell progenitors and their excess numbers in chimeric BALB/c mice with inactivated GATA-1

scholarly article

Concise review: hematopoietic stem cells and tissue stem cells: current concepts and unanswered questions

scientific article published on 9 August 2007

Concordant mast cell and basophil production by individual hematopoietic blast colony-forming cells ⬇️

scientific article published on May 13, 2013

Correction for Zhang et al., The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

scientific article published on 8 May 2015

Correction: A Reporter Mouse Reveals Lineage-Specific and Heterogeneous Expression of IRF8 during Lymphoid and Myeloid Cell Differentiation

Critical role for granulocyte colony-stimulating factor in inflammatory arthritis

scholarly article

Crowding-dependent production of colony-stimulating factors by cultured syngeneic or allogeneic hematopoietic cells

scientific article

Deficiency of 5-hydroxyisourate hydrolase causes hepatomegaly and hepatocellular carcinoma in mice

scientific article

Development of hydrocephalus in mice lacking SOCS7.

scholarly article

Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo

scientific article published on 7 October 2007

Distinct roles for leukemia inhibitory factor receptor alpha-chain and gp130 in cell type-specific signal transduction

scientific article (publication date: 8 August 1997)

Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage

scientific article

Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors

scientific article

Early lineage priming by trisomy of Erg leads to myeloproliferation in a Down syndrome model

scientific article published on 14 May 2015

Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance

scientific article

Enforced expression of the homeobox gene Mixl1 impairs hematopoietic differentiation and results in acute myeloid leukemia

scholarly article

Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis.

scientific article published on 20 December 2013

Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice

scientific article published on 14 June 2011

FADD and caspase-8 are required for cytokine-induced proliferation of hemopoietic progenitor cells.

scientific article published on 19 May 2005

Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1

scientific article

Functional analysis of Asb-1 using genetic modification in mice

scientific article

Genetic reduction of embryonic leukemia-inhibitory factor production rescues placentation in SOCS3-null embryos but does not prevent inflammatory disease

scientific article

Granulocyte colony-stimulating factor and neutrophils--forgotten mediators of inflammatory disease

scientific article published on September 2006

Growth and Differentiation Factors

scientific article

Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)

scientific article (publication date: June 2002)

Hematopoietic cytokines

scientific article

Hematopoietic defects in the Ts1Cje mouse model of Down syndrome

scientific article published on 24 December 2008

Hematopoietic overexpression of the transcription factor Erg induces lymphoid and erythro-megakaryocytic leukemia.

scientific article

Hhex Regulates Hematopoietic Stem Cell Self-Renewal and Stress Hematopoiesis via Repression of Cdkn2a

scientific article published on 2 June 2017

IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome.

scientific article published on 20 October 2015

IL-6 promotes acute and chronic inflammatory disease in the absence of SOCS3.

scientific article

Inactivation of PU.1 in adult mice leads to the development of myeloid leukemia

scholarly article

Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes

scientific article

Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells.

scientific article published on December 1996

Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1.

scientific article published on November 1998

Loss of PU.1: one of the many roads to myeloid leukemia

scientific article

Lymphoid tissue and plasmacytoid dendritic cells and macrophages do not share a common macrophage-dendritic cell-restricted progenitor

scientific article published in July 2014

MOZ and BMI1 act synergistically to maintain hematopoietic stem cells

scientific article published on 20 October 2016

MYC levels govern hematopoietic tumor type and latency in transgenic mice

scientific article published on 14 March 2006

Mcl-1 and Bcl-xL coordinately regulate megakaryocyte survival

article

Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets

scientific article

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression

scientific article published on 01 August 1995

Monocytic leukemia zinc finger protein is essential for the development of long-term reconstituting hematopoietic stem cells

scientific journal article

Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation

scientific article published on 07 April 2014

Multipotential hematopoietic blast colony-forming cells exhibit delays in self-generation and lineage commitment.

scientific article

Murine hematopoietic blast colony-forming cells and their progeny have distinctive membrane marker profiles

scientific article published on 23 October 2009

Murine megakaryocyte progenitor cells and their susceptibility to suppression by G-CSF

scientific article published on 01 January 2005

NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells

scientific article

Negative Regulation of Interleukin-12 Signaling by Suppressor of Cytokine Signaling-1

scientific article published on 08 September 2002

Neutrophils Require SHP1 To Regulate IL-1 Production and Prevent Inflammatory Skin Disease

scientific article published on 15 December 2010

Oct2 enhances antibody-secreting cell differentiation through regulation of IL-5 receptor alpha chain expression on activated B cells.

scientific article published on 4 February 2008

On hematopoietic stem cell fate

scientific article published in June 2007

PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis

scientific article

Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways

scientific article

Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl-/- mice

scientific journal article

Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activity

scientific article

Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1).

scientific article

Programmed anuclear cell death delimits platelet life span.

scientific article

RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis

scientific article published on 8 May 2014

Rapid Inflammation in Mice Lacking Both SOCS1 and SOCS3 in Hematopoietic Cells

scientific article

Reduced Lymphocyte Longevity and Homeostatic Proliferation in Lamin B Receptor-Deficient Mice Results in Profound and Progressive Lymphopenia

scientific article published on 21 November 2011

Regulation of hematopoietic stem cells by their mature progeny

scientific article

Reversible growth factor dependency and autonomy during murine myelomonocytic leukemia induced by oncogenes

scientific article published on 30 September 2013

SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation

scientific article

SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine

scientific article published in September 1999

SOCS2 negatively regulates growth hormone action in vitro and in vivo

scientific journal article

SOCS2 negatively regulates growth hormone action in vitro and in vivo

SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis

scientific article published in February 2004

SOCS3 negatively regulates IL-6 signaling in vivo

scientific article

SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function

scientific article published on July 2004

Socs3 maintains the specificity of biological responses to cytokine signals during granulocyte and macrophage differentiation

scientific article published on 8 April 2008

Stem cell factor can stimulate the formation of eosinophils by two types of murine eosinophil progenitor cells

scientific article published on January 2002

Structural characterization of a murine myeloid leukaemia inhibitory factor

scientific article published on 01 August 1988

Suckling defect in mice lacking the soluble haemopoietin receptor NR6.

scientific article published in June 1999

Suppressor of Cytokine Signaling-1 Has IFN- -Independent Actions in T Cell Homeostasis

scientific article published on 01 January 2003

Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling

scientific journal article

Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity

scientific article published on 27 November 2005

Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection

scientific article

Suppressor of cytokine signaling-1 in T cells and macrophages is critical for preventing lethal inflammation

scientific article published on 17 May 2005

Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130

scientific article published on June 2000

Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling

scientific article

Synergistic and inhibitory interactions in the in vitro control of murine megakaryocyte colony formation

scientific article published on 01 January 2002

The SOCS box of suppressor of cytokine signaling-3 contributes to the control of G-CSF responsiveness in vivo

scientific article

The absence of Tssc6, a member of the tetraspanin superfamily, does not affect lymphoid development but enhances in vitro T-cell proliferative responses

scientific article

The box-1 region of the leukemia inhibitory factor receptor alpha-chain cytoplasmic domain is sufficient for hemopoietic cell proliferation and differentiation.

scientific article published on December 1998

The colony-stimulating factors and cancer

scientific article

The combined absence of NF-kappa B1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells

scientific article

The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12

scientific journal article

The lethal effects of transplantation of Socs1-/- bone marrow cells into irradiated adult syngeneic recipients

scientific article

The preleukemic state of mice reconstituted with Mixl1-transduced marrow cells

scholarly article

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism

scientific article

The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells

scientific article

The unsolved enigmas of leukemia inhibitory factor

scientific article

Thrombocytopenia and erythrocytosis in mice with a mutation in the gene encoding the hemoglobin β minor chain

scientific article

Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene

scientific article

Thrombopoietin and hematopoietic stem cells ⬇️

scientific article published on May 15, 2011

Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance

scientific article published on 26 March 2006

Transgenic expression of GM-CSF in T cells causes disseminated histiocytosis

scientific article published on 30 October 2013

Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia

scholarly article published on 26 March 2013

Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome

scientific article published on 09 December 2009

Twenty proteins containing a C-terminal SOCS box form five structural classes

scientific article published in January 1998

Vaginally administered PEGylated LIF antagonist blocked embryo implantation and eliminated non-target effects on bone in mice

scientific article

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