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List of works by Galila Agam

3'(2')-phosphoadenosine 5'-phosphate phosphatase is reduced in postmortem frontal cortex of bipolar patients

scientific article published in October 2002

A CSF and postmortem brain study of D-serine metabolic parameters in schizophrenia

scientific article

A molecular cell biology of lithium.

scientific article published in November 2004

Activity-dependent neuroprotective protein (ADNP) expression level is correlated with the expression of the sister protein ADNP2: deregulation in schizophrenia

scientific article

Acute intracerebroventricular inositol does not reverse the effect of chronic lithium treatment in the forced swim test

scientific article

Antidepressive-like effects of rapamycin in animal models: Implications for mTOR inhibition as a new target for treatment of affective disorders

scientific article

Autophagy has a key role in the pathophysiology of schizophrenia

scientific article

Behavioral evidence for the existence of two pools of cellular inositol

scientific article published on 01 December 1994

Behavioral reversal of lithium effects by four inositol isomers correlates perfectly with biochemical effects on the PI cycle: depletion by chronic lithium of brain inositol is specific to hypothalamus, and inositol levels may be abnormal in postmor

scientific article published on September 1, 1998

Behavioural phenotyping of sodium-myo-inositol cotransporter heterozygous knockout mice with reduced brain inositol

scientific article published on 17 July 2006

Beware of your mouse strain; differential effects of lithium on behavioral and neurochemical phenotypes in Harlan ICR mice bred in Israel or the USA.

scientific article published on 15 May 2014

Bipolar disorder: Neurochemistry and drug mechanisms.

scientific article published on April 2005

CSF homocysteine is not elevated in schizophrenia

scientific article published in February 2005

CSF inositol does not predict antidepressant response to inositol. Short communication

scientific article published on 01 January 1996

CSF inositol in schizophrenia and high-dose inositol treatment of schizophrenia

scientific article published on 01 December 1994

Chronic Lithium Treatment Enhances the Number of Quiescent Neural Progenitors but Not the Number of DCX-Positive Immature Neurons.

scientific article published on 29 January 2015

Chronic dietary inositol enhances locomotor activity and brain inositol levels in rats

scientific article published in October 1998

Chronic lithium treatment affects rat brain and serum dehydroepiandrosterone (DHEA) and DHEA-sulphate (DHEA-S) levels

scientific article published on 16 January 2004

Chronic oral carbamazepine treatment elicits mood-stabilising effects in mice.

scientific article published in February 2014

Copy number variation of the SELENBP1 gene in schizophrenia

scientific article

Dissecting disease entities out of the broad spectrum of bipolar-disorders.

scientific article published in November 2017

Diurnality, Type 2 Diabetes, and Depressive-Like Behavior

scientific article published on 25 December 2018

Dual Role of Autophagy in Diseases of the Central Nervous System

scientific article published on 28 May 2019

Effect of age, sex steroids, brain region, and genetic strain on brain inositol monophosphatase activity

scientific article published in October 1996

Effect of bipolar disorder on lymphocyte inositol monophosphatase mRNA levels

scientific article

Effect of valproate derivatives on human brain myo-inositol-1-phosphate (MIP) synthase activity and amphetamine-induced rearing.

scientific article published in July 2007

Effects of the putative lithium mimetic ebselen on pilocarpine-induced neural activity

scientific article published on 17 July 2020

Elevated urinary ADAM12 protein levels in lithium-treated bipolar patients

scientific article published on 27 October 2006

GSK-3 and the neurodevelopmental hypothesis of schizophrenia

scientific article

GSK-3 parameters in lymphocytes of schizophrenic patients

scientific article published on September 2002

GSK-3 parameters in postmortem frontal cortex and hippocampus of schizophrenic patients

scientific article published in December 2004

GSK-3beta in cerebrospinal fluid of schizophrenia patients

scientific article published on 27 April 2004

Gene-expression studies in understanding the mechanism of action of lithium

scientific article published on January 2012

Genetic correlational analysis of glycogen synthase kinase-3 beta and prepulse inhibition in inbred mice

scientific article

Global leukocyte DNA methylation is not altered in euthymic bipolar patients

scientific article published on 6 March 2009

Glycogen synthase kinase (GSK)-3beta levels and activity in a neurodevelopmental rat model of schizophrenia

scientific article published in March 2003

Glycogen synthase kinase-3beta heterozygote knockout mice as a model of findings in postmortem schizophrenia brain or as a model of behaviors mimicking lithium action: negative results

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

article by Daniel J Klionsky et al published January 2021 in Autophagy

High-dose peripheral inositol raises brain inositol levels and reverses behavioral effects of inositol depletion by lithium

scientific article published on 01 October 1994

Homozygote inositol transporter knockout mice show a lithium-like phenotype

scientific article published in June 2008

How does lithium work on manic depression? Clinical and psychological correlates of the inositol theory

scientific article published on January 1996

Human 1-D-myo-inositol-3-phosphate synthase is functional in yeast

scientific article published on 15 March 2004

Human MIP synthase splice variants in bipolar disorder

scientific article published in November 2007

Hyperhomocysteinemia does not affect global DNA methylation and nicotinamide N-methyltransferase expression in mice ⬇️

scientific article published on December 17, 2010

IMPA1 is essential for embryonic development and lithium-like pilocarpine sensitivity

scientific article published on 25 April 2007

IP3 accumulation and/or inositol depletion: two downstream lithium's effects that may mediate its behavioral and cellular changes.

scientific article published on 06 December 2016

Identification of eukaryotic elongation factor-2 as a novel cellular target of lithium and glycogen synthase kinase-3.

scientific article published on 12 August 2010

Individual differences and evidence-based psychopharmacology ⬇️

scientific article published on September 27, 2012

Individual differences in allocation of funds in the dictator game associated with length of the arginine vasopressin 1a receptor RS3 promoter region and correlation between RS3 length and hippocampal mRNA

scientific article (publication date: April 2008)

Inhibition of inositol monophosphatase (IMPase) at the calbindin-D28k binding site: molecular and behavioral aspects

scientific article published on 22 April 2013

Inhibition of specific adenylyl cyclase isoforms by lithium and carbamazepine, but not valproate, may be related to their antidepressant effect

scientific article published in December 2009

Inositol levels are decreased in postmortem brain of schizophrenic patients

scientific article published in September 1998

Inositol monophosphatase activity in brain and lymphocyte-derived cell lines of bipolar patients

scientific article published in April 2001

Inositol monophosphatase in immortalized lymphoblastoid cell lines indicates susceptibility to bipolar disorder and response to lithium therapy

scientific article published in November 1998

Inositol treatment in psychiatry

scientific article published on January 1, 1995

Inositol treatment raises CSF inositol levels

scientific article published in November 1993

Inositol-1-phosphatase in red blood cells of manic-depressive patients before and during treatment with lithium

scientific article published in March 1990

Inositol-1-phosphatase of human erythrocytes is inhibited by therapeutic lithium concentrations

scientific article published on February 1989

Inositol-deficient food augments a behavioral effect of long-term lithium treatment mediated by inositol monophosphatase inhibition: an animal model with relevance for bipolar disorder

scientific article published on 01 April 2015

Inositol-related gene knockouts mimic lithium's effect on mitochondrial function

scientific article published on 08 August 2013

Interaction of calbindin D28k and inositol monophosphatase in human postmortem cortex: possible implications for bipolar disorder

scientific article published in February 2005

Intracerebroventricular antisense to inositol monophosphatase-1 reduces enzyme activity but does not affect Li-sensitive behavior

scientific journal article

Is phosphoadenosine phosphate phosphatase a target of lithium's therapeutic effect?

scientific article

Knockout mice in understanding the mechanism of action of lithium

scientific article published in October 2009

Lack of effect of ECS on rat brain inositol monophosphatase activity and inositol levels and of i.c.v. inositol on ictal and post-ictal length

scientific article published in January 1996

Lack of effect of acute, subchronic, or chronic stress on glycogen synthase kinase-3beta protein levels in rat frontal cortex

scientific article

Lack of effect of chronic ketamine administration on depression-like behavior and frontal cortex autophagy in female and male ICR mice.

scientific article published on 26 September 2016

Lack of effect of mood stabilizers or neuroleptics on GSK-3 protein levels and GSK-3 activity

scientific article published in June 2003

Lack of lithium-like behavioral and molecular effects in IMPA2 knockout mice

scientific article published on 12 July 2006

Linking type 2 diabetes mellitus, cardiac hypertrophy and depression in a diurnal animal model

scientific article published on 14 August 2019

Lithium Treatment Is Safe in Children With Intellectual Disability

scholarly article by Junying Yuan published in January 2018

Lithium enhancement of the prolactin response to 5-hydroxytryptophan is not reversible by inositol ⬇️

scientific article published on 01 April 1998

Lithium inhibitable enzymes in postmortem brain of bipolar patients

scientific article published in September 2003

Lithium preferentially inhibits adenylyl cyclase V and VII isoforms

scientific article

Lithium, inositol and mitochondria.

scientific article

Lithium-induced inositol depletion in rat brain after chronic treatment is restricted to the hypothalamus ⬇️

scientific article published on September 1, 1997

Low GSK-3 activity in frontal cortex of schizophrenic patients

scientific article published in October 2001

Low GSK-3beta immunoreactivity in postmortem frontal cortex of schizophrenic patients

scientific article published on 01 May 2000

Low GSK-3beta in schizophrenia as a consequence of neurodevelopmental insult

scientific article

Lymphocyte G-protein receptor kinase (GRK)3 mRNA levels in bipolar disorder

scientific article published on 19 December 2005

Lymphocyte Phospho-Ser-9-GSK-3β/Total GSK-3β Protein Levels Ratio Is Not Affected by Chronic Lithium or Valproate Treatment in Euthymic Patients With Bipolar Disorder

scientific article published on 19 January 2017

Manipulation of inositol-linked second messenger systems as a therapeutic strategy in psychiatry

scientific article published on January 1, 1995

Mitochondrial DNA HV lineage increases the susceptibility to schizophrenia among Israeli Arabs

scientific article published on 12 June 2007

Mitochondrial complex I subunits are altered in rats with neonatal ventral hippocampal damage but not in rats exposed to oxygen restriction at neonatal age.

scientific article published on 9 September 2008

Mitochondrial dysfunction in psychiatric morbidity: current evidence and therapeutic prospects

scientific article

Mitochondrial function parameters as a tool for tailored drug treatment of an individual with psychosis: a proof of concept study

scientific article published on 23 July 2020

Molecular effects of lithium are partially mimicked by inositol-monophosphatase (IMPA)1 knockout mice in a brain region-dependent manner.

scientific article

Mood-stabilizing effects of rapamycin and its analog temsirolimus: relevance to autophagy

scientific article published on 02 August 2017

Myo-inositol-1-phosphate (MIP) synthase: a possible new target for antibipolar drugs

scientific article

Nicotinamide-N-methyltransferase (NNMT) in schizophrenia: genetic association and decreased frontal cortex mRNA levels

scientific article published on 27 July 2011

No association between global leukocyte DNA methylation and homocysteine levels in schizophrenia patients

scientific article published on 13 February 2008

Normobaric Hyperoxia Treatment of Schizophrenia ⬇️

scientific article published on August 1, 2012

Only tryptophan hydroxylase (TPH)-2 is relevant to the CNS.

scientific article published in July 2005

Oxygen restriction of neonate rats elevates neuregulin-1alpha isoform levels: possible relationship to schizophrenia

scientific article

Perinatal oxygen restriction does not result in reduced rat frontal cortex synaptophysin protein levels at adulthood as opposed to postmortem findings in schizophrenia

scientific article published on 15 July 2008

Possible involvement of post-dopamine D2 receptor signalling components in the pathophysiology of schizophrenia.

scientific article published on 6 August 2007

Possible role of 3'(2')-phosphoadenosine-5'-phosphate phosphatase in the etiology and therapy of bipolar disorder

scientific article

Postmortem brain calcineurin protein levels in schizophrenia patients are not different from controls

scientific article published on 7 February 2006

Postmortem parietal cortex TPH2 expression is not altered in schizophrenic, unipolar-depressed, and bipolar patients vs control subjects

scientific article

Psychotropic drugs affect Ser9-phosphorylated GSK-3 beta protein levels in rodent frontal cortex

scientific article

Raised monophosphatase activity in schizophrenic patients

scientific article published on 01 July 1992

Red white and blue - bright light effects in a diurnal rodent model for seasonal affective disorder

scientific article published on 15 April 2019

Reduced GSK-3beta mRNA levels in postmortem dorsolateral prefrontal cortex of schizophrenic patients.

scientific article published on 30 June 2004

Reduced frontal cortex inositol levels in postmortem brain of suicide victims and patients with bipolar disorder ⬇️

scientific article published on August 1, 1997

Reduced inositol content in lymphocyte-derived cell lines from bipolar patients

scientific article published in February 2002

Role of GSK3beta in behavioral abnormalities induced by serotonin deficiency

scholarly article

Role of inositol-1-phosphatase inhibition in the mechanism of action of lithium

scientific article published on January 1990

SMIT1 haploinsufficiency causes brain inositol deficiency without affecting lithium-sensitive behavior

scientific journal article

Schizophrenia, neurodevelopment and glycogen synthase kinase-3

scientific article (publication date: September 2003)

Scyllo-inositol in post-mortem brain of bipolar, unipolar and schizophrenic patients

scientific article published on 01 January 2000

Search for a common mechanism of mood stabilizers.

scientific article

Specific inhibition of adenylyl-cyclase isoform 5 by mood stabilizers may be related to their mechanism of action

scientific article published on 22 April 2010

Specificity of mood stabilizer action on neuronal growth cones.

scientific article published in May 2007

The effect of lithium on expression of genes for inositol biosynthetic enzymes in mouse hippocampus; a comparison with the yeast model

scientific article

The influence of choline treatment on behavioral and neurochemical autistic-like phenotype in Mthfr-deficient mice

scientific article published on 18 September 2020

The inositol monophosphatase inhibitor L-690,330 affects pilocarpine-behavior and the forced swim test

scientific article published on 24 January 2013

The mechanism of lithium action: state of the art, ten years later

scientific article

Trehalose induced antidepressant-like effects and autophagy enhancement in mice

scientific article

Using mitochondrial respiration inhibitors to design a novel model of bipolar disorder-like phenotype with construct, face and predictive validity

scientific article published on 12 February 2021

Valnoctamide as a valproate substitute with low teratogenic potential in mania: a double-blind, controlled, add-on clinical trial

scientific article published on June 2010

Valproate decreases inositol biosynthesis

scientific article published in December 2004

Whether lithium inhibits glycogen synthase kinase (GSK)-3β activity in vivo in humans is still an open question.

scientific article published on 21 July 2016

Yeast bioassay for identification of inositol depleting compounds

scientific article

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