List of works - Margus Pooga

314 PepFect6-miRNA-146a nanocomplexes inhibit inflammatory responses in keratinocytes and in a mouse model of irritant contact dermatitis

article

Ablation of RIC8A function in mouse neurons leads to a severe neuromuscular phenotype and postnatal death

scientific article

Adenosine-oligoarginine conjugate, a novel bisubstrate inhibitor, effectively dissociates the actin cytoskeleton

scientific article published on July 2008

Amphipathic CPPs upregulate Ca in cells’ cytosol and induce lysosomal exocytosis

Anticonvulsant activity of a nonpeptide galanin receptor agonist

scientific article

Arginine-Rich Cell-Penetrating Peptides Require Nucleolin and Cholesterol-Poor Subdomains for Translocation across Membranes.

scientific article published on 6 March 2018

CPP–protein constructs induce a population of non-acidic vesicles during trafficking through endo-lysosomal pathway

scientific article published on 03 July 2009

Cell transduction pathways of transportans

scientific article published in November 2005

Cell-penetrating peptide secures an efficient endosomal escape of an intact cargo upon a brief photo-induction.

scientific article published on 13 July 2013

Cell-penetrating peptides as versatile vehicles for oligonucleotide delivery

scientific article published on 10 January 2012

Cell-penetrating peptides recruit type A scavenger receptors to the plasma membrane for cellular delivery of nucleic acids

scientific article published on 23 November 2016

Cell-penetrating peptides split into two groups based on modulation of intracellular calcium concentration

scientific article

Cellular delivery of oligonucleotides by PepFect

Cellular translocation of proteins by transportan

Characteristics of Cell-Penetrating Peptide/Nucleic Acid Nanoparticles

scientific article published on 12 November 2015

Characterization of Peptide-Oligonucleotide Complexes Using Electron Microscopy, Dynamic Light Scattering, and Protease Resistance Assay

scientific article published on 01 January 2019

Classes of Cell-Penetrating Peptides

scientific article published on 01 January 2015

Comparison of Peptide- and Lipid-Based Delivery of miR-34a-5p Mimic into PPC-1 Cells

scientific article published on 28 June 2017

Deletion of RIC8A in neural precursor cells leads to altered neurogenesis and neonatal lethality of mouse

scientific article published on 2 January 2015

Differential endosomal pathways for radically modified peptide vectors

scientific article published on 16 September 2013

Direct translocation as major cellular uptake for CADY self-assembling peptide-based nanoparticles

scientific article

Distribution of CPP-Protein Complexes in Freshly Resected Human Tissue Material

scientific article

Enhancement of siRNA transfection by the optimization of fatty acid length and histidine content in the CPP

scientific article published on 01 September 2019

Expression Pattern and Localization Dynamics of Guanine Nucleotide Exchange Factor RIC8 during Mouse Oogenesis

scientific article published on 10 June 2015

Formulation of Stable and Homogeneous Cell-Penetrating Peptide NF55 Nanoparticles for Efficient Gene Delivery In Vivo

scientific article published on 20 October 2017

Glycosaminoglycans are required for translocation of amphipathic cell-penetrating peptides across membranes.

scientific article published on 23 April 2016

Identification of the ability of highly charged nanomolar inhibitors of protein kinases to cross plasma membranes and carry a protein into cells

scientific article

Insight into Cell-Entry Mechanisms of CPPs by Electron Microscopy

Insights into cell entry and intracellular trafficking of peptide and protein drugs provided by electron microscopy

scientific article published on 24 April 2013

Lack of Gata3 results in conotruncal heart anomalies in mouse

scientific journal article

Lipid-based Transfection Reagents Exhibit Cryo-induced Increase in Transfection Efficiency.

scientific article

Liquid-phase synthesis of a pegylated adenosine-oligoarginine conjugate, cell-permeable inhibitor of cAMP-dependent protein kinase

scientific article published in September 2003

Mapping of protein transduction pathways with fluorescent microscopy

scientific article published on January 2011

Naturally occurring CD4+ CD25+ cells in modulating immune response to administered coagulation factor VIII in factor VIII-deficient mice

scientific article published on 22 August 2010

New generation of efficient peptide-based vectors, NickFects, for the delivery of nucleic acids

scientific article published on 26 January 2013

NickFects, Phosphorylated Derivatives of Transportan 10 for Cellular Delivery of Oligonucleotides

Nucleotide exchange factor RIC-8 is indispensable in mammalian early development

scientific journal article

Optimization of in vivo DNA delivery with NickFect peptide vectors

scientific article published on 21 September 2016

Penetration without cells: membrane translocation of cell-penetrating peptides in the model giant plasma membrane vesicles.

scientific article

PepFect14 peptide vector for efficient gene delivery in cell cultures

scientific article published on 14 December 2012

Peptide and Protein Delivery with Cell-penetrating Peptides

Peptide-mediated delivery: an overview of pathways for efficient internalization

scientific article

Peptide-mediated protein delivery-which pathways are penetrable?

scientific article published on 17 February 2010

Perforin oligomers form arcs in cellular membranes: a locus for intracellular delivery of granzymes.

scientific article

Pre-administration of PepFect6-microRNA-146a nanocomplexes inhibits inflammatory responses in keratinocytes and in a mouse model of irritant contact dermatitis

scientific article

Prediction of Cell-Penetrating Peptides

article published in 2005

Protein cargo delivery properties of cell-penetrating peptides. A comparative study

scientific article published in November 2004

Protein delivery with transportans is mediated by caveolae rather than flotillin-dependent pathways

scientific article

RIC8A is essential for the organisation of actin cytoskeleton and cell-matrix interaction

scientific article published on 16 May 2017

Retro-inversion of certain cell-penetrating peptides causes severe cellular toxicity

scientific article published on 9 November 2010

Role of autophagy in cell-penetrating peptide transfection model.

scientific article published on 3 October 2017

S4(13)-PV cell-penetrating peptide forms nanoparticle-like structures to gain entry into cells

scientific article published in April 2010

S4(13)-PV cell-penetrating peptide induces physical and morphological changes in membrane-mimetic lipid systems and cell membranes: implications for cell internalization

scientific article published on 31 December 2011

Saturated Fatty Acid Analogues of Cell-Penetrating Peptide PepFect14: Role of Fatty Acid Modification in Complexation and Delivery of Splice-Correcting Oligonucleotides.

scientific article published on 17 February 2017

Scavenger receptor-mediated uptake of cell-penetrating peptide nanocomplexes with oligonucleotides

scientific article

Studying the uptake of cell-penetrating peptides

scientific article published on 01 January 2006

Systemic Delivery of Folate-PEG siRNA Lipopolyplexes with Enhanced Intracellular Stability for In Vivo Gene Silencing in Leukemia

scientific article

Targeted deletion of RIC8A in mouse neural precursor cells interferes with the development of the brain, eyes, and muscles.

scientific article published on 30 January 2018

Targeted gene silencing in human embryonic stem cells using cell-penetrating peptide PepFect 14

article

Targeting of antisense PNA oligomers to human galanin receptor type 1 mRNA.

scientific article

The membrane repair response masks membrane disturbances caused by cell-penetrating peptide uptake

scientific article published on 11 September 2008

The role of endocytosis in the uptake and intracellular trafficking of PepFect14–nucleic acid nanocomplexes via class A scavenger receptors

scientific article published on 25 September 2015

The role of integrin β1 in the heterogeneity of human embryonic stem cells culture

article

Translocation of cell-penetrating peptides across the plasma membrane is controlled by cholesterol and microenvironment created by membranous proteins

scientific article

Tumoral gene silencing by receptor-targeted combinatorial siRNA polyplexes

scientific article published on 7 June 2016

Unraveling the Mechanisms of Peptide-Mediated Delivery of Nucleic Acids Using Electron Microscopy

scientific article published on January 2015

Von Willebrand factor-specific antibodies developing upon treatment of FVIII-deficient mice with different FVIII preparations

scientific article

von Willebrand factor and transforming growth factor-beta modulate immune response against coagulation factor VIII in FVIII-deficient mice

scientific article published on 21 March 2007

List of works by Margus Pooga

314 PepFect6-miRNA-146a nanocomplexes inhibit inflammatory responses in keratinocytes and in a mouse model of irritant contact dermatitis

Ablation of RIC8A function in mouse neurons leads to a severe neuromuscular phenotype and postnatal death

Adenosine-oligoarginine conjugate, a novel bisubstrate inhibitor, effectively dissociates the actin cytoskeleton

Amphipathic CPPs upregulate Ca in cells’ cytosol and induce lysosomal exocytosis

Anticonvulsant activity of a nonpeptide galanin receptor agonist

Arginine-Rich Cell-Penetrating Peptides Require Nucleolin and Cholesterol-Poor Subdomains for Translocation across Membranes.

CPP–protein constructs induce a population of non-acidic vesicles during trafficking through endo-lysosomal pathway

Cell transduction pathways of transportans

Cell-penetrating peptide secures an efficient endosomal escape of an intact cargo upon a brief photo-induction.

Cell-penetrating peptides as versatile vehicles for oligonucleotide delivery

Cell-penetrating peptides recruit type A scavenger receptors to the plasma membrane for cellular delivery of nucleic acids

Cell-penetrating peptides split into two groups based on modulation of intracellular calcium concentration

Cellular delivery of oligonucleotides by PepFect

Cellular translocation of proteins by transportan

Characteristics of Cell-Penetrating Peptide/Nucleic Acid Nanoparticles

Characterization of Peptide-Oligonucleotide Complexes Using Electron Microscopy, Dynamic Light Scattering, and Protease Resistance Assay

Classes of Cell-Penetrating Peptides

Comparison of Peptide- and Lipid-Based Delivery of miR-34a-5p Mimic into PPC-1 Cells

Deletion of RIC8A in neural precursor cells leads to altered neurogenesis and neonatal lethality of mouse

Differential endosomal pathways for radically modified peptide vectors

Direct translocation as major cellular uptake for CADY self-assembling peptide-based nanoparticles

Distribution of CPP-Protein Complexes in Freshly Resected Human Tissue Material

Enhancement of siRNA transfection by the optimization of fatty acid length and histidine content in the CPP

Expression Pattern and Localization Dynamics of Guanine Nucleotide Exchange Factor RIC8 during Mouse Oogenesis

Formulation of Stable and Homogeneous Cell-Penetrating Peptide NF55 Nanoparticles for Efficient Gene Delivery In Vivo

Glycosaminoglycans are required for translocation of amphipathic cell-penetrating peptides across membranes.

Identification of the ability of highly charged nanomolar inhibitors of protein kinases to cross plasma membranes and carry a protein into cells

Insight into Cell-Entry Mechanisms of CPPs by Electron Microscopy

Insights into cell entry and intracellular trafficking of peptide and protein drugs provided by electron microscopy

Lack of Gata3 results in conotruncal heart anomalies in mouse

Lipid-based Transfection Reagents Exhibit Cryo-induced Increase in Transfection Efficiency.

Liquid-phase synthesis of a pegylated adenosine-oligoarginine conjugate, cell-permeable inhibitor of cAMP-dependent protein kinase

Mapping of protein transduction pathways with fluorescent microscopy

Naturally occurring CD4+ CD25+ cells in modulating immune response to administered coagulation factor VIII in factor VIII-deficient mice

New generation of efficient peptide-based vectors, NickFects, for the delivery of nucleic acids

NickFects, Phosphorylated Derivatives of Transportan 10 for Cellular Delivery of Oligonucleotides

Nucleotide exchange factor RIC-8 is indispensable in mammalian early development

Optimization of in vivo DNA delivery with NickFect peptide vectors

Penetration without cells: membrane translocation of cell-penetrating peptides in the model giant plasma membrane vesicles.

PepFect14 peptide vector for efficient gene delivery in cell cultures

Peptide and Protein Delivery with Cell-penetrating Peptides

Peptide-mediated delivery: an overview of pathways for efficient internalization

Peptide-mediated protein delivery-which pathways are penetrable?

Perforin oligomers form arcs in cellular membranes: a locus for intracellular delivery of granzymes.

Pre-administration of PepFect6-microRNA-146a nanocomplexes inhibits inflammatory responses in keratinocytes and in a mouse model of irritant contact dermatitis

Prediction of Cell-Penetrating Peptides

Protein cargo delivery properties of cell-penetrating peptides. A comparative study

Protein delivery with transportans is mediated by caveolae rather than flotillin-dependent pathways

RIC8A is essential for the organisation of actin cytoskeleton and cell-matrix interaction

Retro-inversion of certain cell-penetrating peptides causes severe cellular toxicity

Role of autophagy in cell-penetrating peptide transfection model.

S4(13)-PV cell-penetrating peptide forms nanoparticle-like structures to gain entry into cells

S4(13)-PV cell-penetrating peptide induces physical and morphological changes in membrane-mimetic lipid systems and cell membranes: implications for cell internalization

Saturated Fatty Acid Analogues of Cell-Penetrating Peptide PepFect14: Role of Fatty Acid Modification in Complexation and Delivery of Splice-Correcting Oligonucleotides.

Scavenger receptor-mediated uptake of cell-penetrating peptide nanocomplexes with oligonucleotides

Studying the uptake of cell-penetrating peptides

Systemic Delivery of Folate-PEG siRNA Lipopolyplexes with Enhanced Intracellular Stability for In Vivo Gene Silencing in Leukemia

Targeted deletion of RIC8A in mouse neural precursor cells interferes with the development of the brain, eyes, and muscles.

Targeted gene silencing in human embryonic stem cells using cell-penetrating peptide PepFect 14

Targeting of antisense PNA oligomers to human galanin receptor type 1 mRNA.

The membrane repair response masks membrane disturbances caused by cell-penetrating peptide uptake

The role of endocytosis in the uptake and intracellular trafficking of PepFect14–nucleic acid nanocomplexes via class A scavenger receptors

The role of integrin β1 in the heterogeneity of human embryonic stem cells culture

Translocation of cell-penetrating peptides across the plasma membrane is controlled by cholesterol and microenvironment created by membranous proteins

Tumoral gene silencing by receptor-targeted combinatorial siRNA polyplexes

Unraveling the Mechanisms of Peptide-Mediated Delivery of Nucleic Acids Using Electron Microscopy

Von Willebrand factor-specific antibodies developing upon treatment of FVIII-deficient mice with different FVIII preparations

von Willebrand factor and transforming growth factor-beta modulate immune response against coagulation factor VIII in FVIII-deficient mice