List of works - Stephan Pleschka

Acetylsalicylic acid (ASA) blocks influenza virus propagation via its NF-kappaB-inhibiting activity

scientific article (publication date: July 2007)

Activation of c-jun N-terminal kinase upon influenza A virus (IAV) infection is independent of pathogen-related receptors but dependent on amino acid sequence variations of IAV NS1.

scientific article

Anti-viral properties and mode of action of standardized Echinacea purpurea extract against highly pathogenic avian influenza virus (H5N1, H7N7) and swine-origin H1N1 (S-OIV)

scientific article

Antiviral activity of the MEK-inhibitor U0126 against pandemic H1N1v and highly pathogenic avian influenza virus in vitro and in vivo

scientific article

Apoptosis signaling in influenza virus propagation, innate host defense, and lung injury

scientific article published on 17 February 2012

Bivalent role of the phosphatidylinositol-3-kinase (PI3K) during influenza virus infection and host cell defence

scientific article published on August 2006

Borna disease virus nucleoprotein interacts with the CDC2-cyclin B1 complex

scientific article

Borna disease virus: a unique pathogen and its interaction with intracellular signalling pathways

scientific article published on 12 March 2009

Caspase 3 activation is essential for efficient influenza virus propagation

scientific article

Constitutive activation of the transcription factor NF-kappaB results in impaired borna disease virus replication

scientific article

Effect of an Echinacea-Based Hot Drink Versus Oseltamivir in Influenza Treatment: A Randomized, Double-Blind, Double-Dummy, Multicenter, Noninferiority Clinical Trial

scientific article

Efficient generation of recombinant influenza A viruses employing a new approach to overcome the genetic instability of HA segments

scientific article

Higher polymerase activity of a human influenza virus enhances activation of the hemagglutinin-induced Raf/MEK/ERK signal cascade.

scientific article

Identification of specific residues in avian influenza A virus NS1 that enhance viral replication and pathogenicity in mammalian systems

scientific article published on 12 July 2016

Improved dual promotor-driven reverse genetics system for influenza viruses.

scientific article

In Silico Prediction and Experimental Confirmation of HA Residues Conferring Enhanced Human Receptor Specificity of H5N1 Influenza A Viruses

scientific article

Influenza A Virus Virulence Depends on Two Amino Acids in the N-Terminal Domain of Its NS1 Protein To Facilitate Inhibition of the RNA-Dependent Protein Kinase PKR.

scientific article published on March 2017

Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses

scientific article published on 17 January 2007

Influenza virus-induced caspase-dependent enlargement of nuclear pores promotes nuclear export of viral ribonucleoprotein complexes

scientific article published on 25 March 2015

Influenza-virus-induced signaling cascades: targets for antiviral therapy?

scientific article

Inhibition of influenza virus-induced NF-kappaB and Raf/MEK/ERK activation can reduce both virus titers and cytokine expression simultaneously in vitro and in vivo

scientific article published on 27 May 2011

Inhibitory activity of a standardized elderberry liquid extract against clinically-relevant human respiratory bacterial pathogens and influenza A and B viruses

scientific article

Lung epithelial apoptosis in influenza virus pneumonia: the role of macrophage-expressed TNF-related apoptosis-inducing ligand

scientific article published on 08 December 2008

Lung-specific expression of active Raf kinase results in increased mortality of influenza A virus-infected mice

scientific article published on August 2004

MEK inhibition impairs influenza B virus propagation without emergence of resistant variants

scientific article published on March 2004

Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection

scientific article published on 21 March 2016

Macrophage-expressed IFN-β contributes to apoptotic alveolar epithelial cell injury in severe influenza virus pneumonia

scientific article

Membrane accumulation of influenza A virus hemagglutinin triggers nuclear export of the viral genome via protein kinase Calpha-mediated activation of ERK signaling

scientific article

NF-kappaB-dependent induction of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas/FasL is crucial for efficient influenza virus propagation

scientific article published on 12 May 2004

NS reassortment of an H7-type highly pathogenic avian influenza virus affects its propagation by altering the regulation of viral RNA production and antiviral host response

scientific article published on 25 August 2010

Origin of the European avian-like swine influenza viruses

scientific article published on 29 July 2014

Overview of Influenza Viruses ⬇️

scientific article published on January 1, 2013

Phylogenetic analysis of human influenza A/H3N2 viruses isolated in 2015 in Germany indicates significant genetic divergence from vaccine strains.

scientific article

RNA viruses and the mitogenic Raf/MEK/ERK signal transduction cascade

scientific article published on October 2008

Rac1 and PAK1 are upstream of IKK-epsilon and TBK-1 in the viral activation of interferon regulatory factor-3.

scientific article published on June 2004

Reassortment of NS segments modifies highly pathogenic avian influenza virus interaction with avian hosts and host cells.

scientific article

Replication and adaptive mutations of low pathogenic avian influenza viruses in tracheal organ cultures of different avian species.

scientific article

Ribonuclease from Bacillus Acts as an Antiviral Agent against Negative- and Positive-Sense Single Stranded Human Respiratory RNA Viruses

scientific article (publication date: 2017)

Ringing the alarm bells: signalling and apoptosis in influenza virus infected cells

scientific article

The Influenza A Virus Genotype Determines the Antiviral Function of NF-κB

scientific article

The MEK-inhibitor CI-1040 displays a broad anti-influenza virus activity in vitro and provides a prolonged treatment window compared to standard of care in vivo

scientific article published on April 2017

The NS segment of H5N1 avian influenza viruses (AIV) enhances the virulence of an H7N1 AIV in chickens.

scientific article published on 25 January 2014

The NS segment of an H5N1 highly pathogenic avian influenza virus (HPAIV) is sufficient to alter replication efficiency, cell tropism, and host range of an H7N1 HPAIV

scientific article

The PB1 segment of an influenza A virus H1N1 2009pdm isolate enhances the replication efficiency of specific influenza vaccine strains in cell culture and embryonated eggs.

scientific article

The influenza A virus NS1 protein inhibits activation of Jun N-terminal kinase and AP-1 transcription factors

scientific article published on November 2002

Zoonotic Potential of Influenza A Viruses: A Comprehensive Overview

scholarly article by Ahmed Mostafa published in September 2018

List of works by Stephan Pleschka

Acetylsalicylic acid (ASA) blocks influenza virus propagation via its NF-kappaB-inhibiting activity

Activation of c-jun N-terminal kinase upon influenza A virus (IAV) infection is independent of pathogen-related receptors but dependent on amino acid sequence variations of IAV NS1.

Anti-viral properties and mode of action of standardized Echinacea purpurea extract against highly pathogenic avian influenza virus (H5N1, H7N7) and swine-origin H1N1 (S-OIV)

Antiviral activity of the MEK-inhibitor U0126 against pandemic H1N1v and highly pathogenic avian influenza virus in vitro and in vivo

Apoptosis signaling in influenza virus propagation, innate host defense, and lung injury

Bivalent role of the phosphatidylinositol-3-kinase (PI3K) during influenza virus infection and host cell defence

Borna disease virus nucleoprotein interacts with the CDC2-cyclin B1 complex

Borna disease virus: a unique pathogen and its interaction with intracellular signalling pathways

Caspase 3 activation is essential for efficient influenza virus propagation

Constitutive activation of the transcription factor NF-kappaB results in impaired borna disease virus replication

Effect of an Echinacea-Based Hot Drink Versus Oseltamivir in Influenza Treatment: A Randomized, Double-Blind, Double-Dummy, Multicenter, Noninferiority Clinical Trial

Efficient generation of recombinant influenza A viruses employing a new approach to overcome the genetic instability of HA segments

Higher polymerase activity of a human influenza virus enhances activation of the hemagglutinin-induced Raf/MEK/ERK signal cascade.

Identification of specific residues in avian influenza A virus NS1 that enhance viral replication and pathogenicity in mammalian systems

Improved dual promotor-driven reverse genetics system for influenza viruses.

In Silico Prediction and Experimental Confirmation of HA Residues Conferring Enhanced Human Receptor Specificity of H5N1 Influenza A Viruses

Influenza A Virus Virulence Depends on Two Amino Acids in the N-Terminal Domain of Its NS1 Protein To Facilitate Inhibition of the RNA-Dependent Protein Kinase PKR.

Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses

Influenza virus-induced caspase-dependent enlargement of nuclear pores promotes nuclear export of viral ribonucleoprotein complexes

Influenza-virus-induced signaling cascades: targets for antiviral therapy?

Inhibition of influenza virus-induced NF-kappaB and Raf/MEK/ERK activation can reduce both virus titers and cytokine expression simultaneously in vitro and in vivo

Inhibitory activity of a standardized elderberry liquid extract against clinically-relevant human respiratory bacterial pathogens and influenza A and B viruses

Lung epithelial apoptosis in influenza virus pneumonia: the role of macrophage-expressed TNF-related apoptosis-inducing ligand

Lung-specific expression of active Raf kinase results in increased mortality of influenza A virus-infected mice

MEK inhibition impairs influenza B virus propagation without emergence of resistant variants

Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection

Macrophage-expressed IFN-β contributes to apoptotic alveolar epithelial cell injury in severe influenza virus pneumonia

Membrane accumulation of influenza A virus hemagglutinin triggers nuclear export of the viral genome via protein kinase Calpha-mediated activation of ERK signaling

NF-kappaB-dependent induction of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas/FasL is crucial for efficient influenza virus propagation

NS reassortment of an H7-type highly pathogenic avian influenza virus affects its propagation by altering the regulation of viral RNA production and antiviral host response

Origin of the European avian-like swine influenza viruses

Overview of Influenza Viruses ⬇️

Phylogenetic analysis of human influenza A/H3N2 viruses isolated in 2015 in Germany indicates significant genetic divergence from vaccine strains.

RNA viruses and the mitogenic Raf/MEK/ERK signal transduction cascade

Rac1 and PAK1 are upstream of IKK-epsilon and TBK-1 in the viral activation of interferon regulatory factor-3.

Reassortment of NS segments modifies highly pathogenic avian influenza virus interaction with avian hosts and host cells.

Replication and adaptive mutations of low pathogenic avian influenza viruses in tracheal organ cultures of different avian species.

Ribonuclease from Bacillus Acts as an Antiviral Agent against Negative- and Positive-Sense Single Stranded Human Respiratory RNA Viruses

Ringing the alarm bells: signalling and apoptosis in influenza virus infected cells

The Influenza A Virus Genotype Determines the Antiviral Function of NF-κB

The MEK-inhibitor CI-1040 displays a broad anti-influenza virus activity in vitro and provides a prolonged treatment window compared to standard of care in vivo

The NS segment of H5N1 avian influenza viruses (AIV) enhances the virulence of an H7N1 AIV in chickens.

The NS segment of an H5N1 highly pathogenic avian influenza virus (HPAIV) is sufficient to alter replication efficiency, cell tropism, and host range of an H7N1 HPAIV

The PB1 segment of an influenza A virus H1N1 2009pdm isolate enhances the replication efficiency of specific influenza vaccine strains in cell culture and embryonated eggs.

The influenza A virus NS1 protein inhibits activation of Jun N-terminal kinase and AP-1 transcription factors

Zoonotic Potential of Influenza A Viruses: A Comprehensive Overview