List of works - Longhu Zhou

2'-Chloro,2'-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture.

scientific article published on 8 June 2017

Adenosine Dioxolane Nucleoside Phosphoramidates as Antiviral Agents for Human Immunodeficiency and Hepatitis B Viruses

scientific article published on August 2013

Anti-hepatitis C virus activity of novel beta-d-2'-C-methyl-4'-azido pyrimidine nucleoside phosphoramidate prodrugs

scientific article published on 19 October 2009

Asymmetric binding to NS5A by daclatasvir (BMS-790052) and analogs suggests two novel modes of HCV inhibition

scientific article

Biochemical Characterization of the Active Anti-Hepatitis C Virus Metabolites of 2,6-Diaminopurine Ribonucleoside Prodrug Compared to Sofosbuvir and BMS-986094.

scientific article

Chutes and ladders in hepatitis C nucleoside drug development

scientific article

Discovery of a Series of 2'-α-Fluoro,2'-β-bromo-ribonucleosides and Their Phosphoramidate Prodrugs as Potent Pan-Genotypic Inhibitors of Hepatitis C Virus

scientific article published on 07 February 2019

Nucleotide Substrate Specificity of Anti-Hepatitis C Virus Nucleoside Analogs for Human Mitochondrial RNA Polymerase

scientific article published on 30 May 2017

Scaleable processes for the synthesis of (−)-β-d-2,6-diaminopurine dioxolane (Amdoxovir, DAPD) and (−)-β-d-2-aminopurine dioxolane (APD) ⬇️

scientific article published on May 16, 2012

Substrates and Inhibitors of SAMHD1.

scientific article

Synthesis and Evaluation of 2,6-Modified Purine 2'-C-Methyl Ribonucleosides as Inhibitors of HCV Replication

scientific article published on 23 November 2015

Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl-7-deazapurine nucleosides, their phosphoramidate prodrugs and 5'-triphosphates ⬇️

scientific article published on September 29, 2011

Synthesis and biological evaluation of new potent and selective HCV NS5A inhibitors ⬇️

scientific article published on March 29, 2012

Synthesis and evaluation of Janus type nucleosides as potential HCV NS5B polymerase inhibitors

scientific article published on 29 March 2013

Synthesis and evaluation of non-dimeric HCV NS5A inhibitors ⬇️

scientific article published on February 13, 2013

Synthesis and evaluation of novel potent HCV NS5A inhibitors ⬇️

scientific article published on May 24, 2012

Synthesis of purine modified 2′-C-methyl nucleosides as potential anti-HCV agents ⬇️

scientific article published on September 20, 2011

β-D-2'-C-Methyl-2,6-diaminopurine Ribonucleoside Phosphoramidates are Potent and Selective Inhibitors of Hepatitis C Virus (HCV) and Are Bioconverted Intracellularly to Bioactive 2,6-Diaminopurine and Guanosine 5'-Triphosphate Forms

scientific article

List of works by Longhu Zhou

2'-Chloro,2'-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture.

Adenosine Dioxolane Nucleoside Phosphoramidates as Antiviral Agents for Human Immunodeficiency and Hepatitis B Viruses

Anti-hepatitis C virus activity of novel beta-d-2'-C-methyl-4'-azido pyrimidine nucleoside phosphoramidate prodrugs

Asymmetric binding to NS5A by daclatasvir (BMS-790052) and analogs suggests two novel modes of HCV inhibition

Biochemical Characterization of the Active Anti-Hepatitis C Virus Metabolites of 2,6-Diaminopurine Ribonucleoside Prodrug Compared to Sofosbuvir and BMS-986094.

Chutes and ladders in hepatitis C nucleoside drug development

Discovery of a Series of 2'-α-Fluoro,2'-β-bromo-ribonucleosides and Their Phosphoramidate Prodrugs as Potent Pan-Genotypic Inhibitors of Hepatitis C Virus

Nucleotide Substrate Specificity of Anti-Hepatitis C Virus Nucleoside Analogs for Human Mitochondrial RNA Polymerase

Scaleable processes for the synthesis of (−)-β-d-2,6-diaminopurine dioxolane (Amdoxovir, DAPD) and (−)-β-d-2-aminopurine dioxolane (APD) ⬇️

Substrates and Inhibitors of SAMHD1.

Synthesis and Evaluation of 2,6-Modified Purine 2'-C-Methyl Ribonucleosides as Inhibitors of HCV Replication

Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl-7-deazapurine nucleosides, their phosphoramidate prodrugs and 5'-triphosphates ⬇️

Synthesis and biological evaluation of new potent and selective HCV NS5A inhibitors ⬇️

Synthesis and evaluation of Janus type nucleosides as potential HCV NS5B polymerase inhibitors

Synthesis and evaluation of non-dimeric HCV NS5A inhibitors ⬇️

Synthesis and evaluation of novel potent HCV NS5A inhibitors ⬇️

Synthesis of purine modified 2′-C-methyl nucleosides as potential anti-HCV agents ⬇️

β-D-2'-C-Methyl-2,6-diaminopurine Ribonucleoside Phosphoramidates are Potent and Selective Inhibitors of Hepatitis C Virus (HCV) and Are Bioconverted Intracellularly to Bioactive 2,6-Diaminopurine and Guanosine 5'-Triphosphate Forms