List of works - Franck Amblard

2'-Chloro,2'-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture.

scientific article published on 8 June 2017

Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides

scientific article published on 13 July 2009

Approaches to hepatitis C treatment and cure using NS5A inhibitors

scientific article published on 05 March 2014

Asymmetric binding to NS5A by daclatasvir (BMS-790052) and analogs suggests two novel modes of HCV inhibition

scientific article

Azetidines and spiro azetidines as novel P2 units in hepatitis C virus NS3 protease inhibitors

scientific article published on 30 September 2013

Biochemical Characterization of the Active Anti-Hepatitis C Virus Metabolites of 2,6-Diaminopurine Ribonucleoside Prodrug Compared to Sofosbuvir and BMS-986094.

scientific article

Characterization of β-d-N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus

scientific article

Chutes and ladders in hepatitis C nucleoside drug development

scientific article

Correction for Mavigner et al., "Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques"

Cu(I)-catalyzed Huisgen azide-alkyne 1,3-dipolar cycloaddition reaction in nucleoside, nucleotide, and oligonucleotide chemistry

scientific article published on September 2009

Design, synthesis and evaluation of novel anti-HCV molecules that deliver intracellularly three highly potent NS5A inhibitors

scientific article

Discovery of a Series of 2'-α-Fluoro,2'-β-bromo-ribonucleosides and Their Phosphoramidate Prodrugs as Potent Pan-Genotypic Inhibitors of Hepatitis C Virus

scientific article published on 07 February 2019

Efficient synthesis of nucleoside aryloxy phosphoramidate prodrugs utilizing benzyloxycarbonyl protection

scientific article published on July 2011

Efficient synthesis of various acycloalkenyl derivatives of pyrimidine using cross-metathesis and Pd(0) methodologies

article published in 2005

Expression, purification, and characterization of a GII.4 norovirus protease.

scientific article

Facile purification of honokiol and its antiviral and cytotoxic properties

scientific article

Increased activity of unlinked Zika virus NS2B/NS3 protease compared to linked Zika virus protease

scientific article (publication date: March 2017)

Metabolism of Nucleosides and Nucleotides Prodrugs

scientific article published on 11 October 2017

Metabolism, Biochemical Actions, and Chemical Synthesis of Anticancer Nucleosides, Nucleotides, and Base Analogs

scientific article

Nucleotide Substrate Specificity of Anti-Hepatitis C Virus Nucleoside Analogs for Human Mitochondrial RNA Polymerase

scientific article published on 30 May 2017

Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques

scholarly article by Maud Mavigner et al published 15 September 2018 in Journal of Virology

Structural and Antiviral Studies of the Human Norovirus GII.4 Protease

scientific article published on 16 January 2019

Synthesis and Evaluation of 2,6-Modified Purine 2'-C-Methyl Ribonucleosides as Inhibitors of HCV Replication

scientific article published on 23 November 2015

Synthesis and anti-HCV activity of a series of β-d-2'-deoxy-2'-dibromo nucleosides and their corresponding phosphoramidate prodrugs

scientific article

Synthesis and antiviral activity of novel acyclic nucleosides in the 5-alkynyl- and 6-alkylfuro[2,3-d]pyrimidine series.

scientific article published on February 2005

Synthesis and antiviral evaluation of 2-amino-6-carbamoylpurine dioxolane nucleoside derivatives and their phosphoramidates prodrugs

scientific article published on 13 October 2014

Synthesis and antiviral evaluation of 2′,2′,3′,3′-tetrafluoro nucleoside analogs

scientific article

Synthesis and antiviral evaluation of fluorinated acyclo-nucleosides and their phosphoramidates

scientific article published on 19 October 2016

Synthesis and antiviral evaluation of novel heteroarylpyrimidines analogs as HBV capsid effectors

scientific article published on 6 January 2017

Synthesis and biological evaluation of new potent and selective HCV NS5A inhibitors ⬇️

scientific article published on March 29, 2012

Synthesis and evaluation of 3'-azido-2',3'-dideoxypurine nucleosides as inhibitors of human immunodeficiency virus

scientific article

Synthesis and evaluation of Janus type nucleosides as potential HCV NS5B polymerase inhibitors

scientific article published on 29 March 2013

Synthesis and evaluation of non-dimeric HCV NS5A inhibitors

scientific article published on 13 February 2013

Synthesis and evaluation of novel potent HCV NS5A inhibitors ⬇️

scientific article published on May 24, 2012

Synthesis of (2S)-2-Chloro-2-fluororibolactone via Stereoselective Electrophilic Fluorination

scientific article

Synthesis of 5′-Methylene-Phosphonate Furanonucleoside Prodrugs: Application to D-2′-Deoxy-2′-α-fluoro-2′-β-C-methyl Nucleosides ⬇️

scientific article published on August 23, 2012

Synthesis of cyclopentanyl carbocyclic 5-fluorocytosine ((-)-5-fluorocarbodine) using a facially selective hydrogenation approach

scientific article published on 26 December 2012

Synthesis of nucleoside phosphate and phosphonate prodrugs

scientific article

Synthesis of sulfamoylbenzamide derivatives as HBV capsid assembly effector

scientific article published on 29 June 2017

Synthesis, antiviral activity, and stability of nucleoside analogs containing tricyclic bases

scientific article published on 8 April 2009

Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol

scientific article published on 10 June 2007

β-D-2'-C-Methyl-2,6-diaminopurine Ribonucleoside Phosphoramidates are Potent and Selective Inhibitors of Hepatitis C Virus (HCV) and Are Bioconverted Intracellularly to Bioactive 2,6-Diaminopurine and Guanosine 5'-Triphosphate Forms

scientific article

List of works by Franck Amblard

2'-Chloro,2'-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture.

Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides

Approaches to hepatitis C treatment and cure using NS5A inhibitors

Asymmetric binding to NS5A by daclatasvir (BMS-790052) and analogs suggests two novel modes of HCV inhibition

Azetidines and spiro azetidines as novel P2 units in hepatitis C virus NS3 protease inhibitors

Biochemical Characterization of the Active Anti-Hepatitis C Virus Metabolites of 2,6-Diaminopurine Ribonucleoside Prodrug Compared to Sofosbuvir and BMS-986094.

Characterization of β-d-N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus

Chutes and ladders in hepatitis C nucleoside drug development

Correction for Mavigner et al., "Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques"

Cu(I)-catalyzed Huisgen azide-alkyne 1,3-dipolar cycloaddition reaction in nucleoside, nucleotide, and oligonucleotide chemistry

Design, synthesis and evaluation of novel anti-HCV molecules that deliver intracellularly three highly potent NS5A inhibitors

Discovery of a Series of 2'-α-Fluoro,2'-β-bromo-ribonucleosides and Their Phosphoramidate Prodrugs as Potent Pan-Genotypic Inhibitors of Hepatitis C Virus

Efficient synthesis of nucleoside aryloxy phosphoramidate prodrugs utilizing benzyloxycarbonyl protection

Efficient synthesis of various acycloalkenyl derivatives of pyrimidine using cross-metathesis and Pd(0) methodologies

Expression, purification, and characterization of a GII.4 norovirus protease.

Facile purification of honokiol and its antiviral and cytotoxic properties

Increased activity of unlinked Zika virus NS2B/NS3 protease compared to linked Zika virus protease

Metabolism of Nucleosides and Nucleotides Prodrugs

Metabolism, Biochemical Actions, and Chemical Synthesis of Anticancer Nucleosides, Nucleotides, and Base Analogs

Nucleotide Substrate Specificity of Anti-Hepatitis C Virus Nucleoside Analogs for Human Mitochondrial RNA Polymerase

Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques

Structural and Antiviral Studies of the Human Norovirus GII.4 Protease

Synthesis and Evaluation of 2,6-Modified Purine 2'-C-Methyl Ribonucleosides as Inhibitors of HCV Replication

Synthesis and anti-HCV activity of a series of β-d-2'-deoxy-2'-dibromo nucleosides and their corresponding phosphoramidate prodrugs

Synthesis and antiviral activity of novel acyclic nucleosides in the 5-alkynyl- and 6-alkylfuro[2,3-d]pyrimidine series.

Synthesis and antiviral evaluation of 2-amino-6-carbamoylpurine dioxolane nucleoside derivatives and their phosphoramidates prodrugs

Synthesis and antiviral evaluation of 2′,2′,3′,3′-tetrafluoro nucleoside analogs

Synthesis and antiviral evaluation of fluorinated acyclo-nucleosides and their phosphoramidates

Synthesis and antiviral evaluation of novel heteroarylpyrimidines analogs as HBV capsid effectors

Synthesis and biological evaluation of new potent and selective HCV NS5A inhibitors ⬇️

Synthesis and evaluation of 3'-azido-2',3'-dideoxypurine nucleosides as inhibitors of human immunodeficiency virus

Synthesis and evaluation of Janus type nucleosides as potential HCV NS5B polymerase inhibitors

Synthesis and evaluation of non-dimeric HCV NS5A inhibitors

Synthesis and evaluation of novel potent HCV NS5A inhibitors ⬇️

Synthesis of (2S)-2-Chloro-2-fluororibolactone via Stereoselective Electrophilic Fluorination

Synthesis of 5′-Methylene-Phosphonate Furanonucleoside Prodrugs: Application to D-2′-Deoxy-2′-α-fluoro-2′-β-C-methyl Nucleosides ⬇️

Synthesis of cyclopentanyl carbocyclic 5-fluorocytosine ((-)-5-fluorocarbodine) using a facially selective hydrogenation approach

Synthesis of nucleoside phosphate and phosphonate prodrugs

Synthesis of sulfamoylbenzamide derivatives as HBV capsid assembly effector

Synthesis, antiviral activity, and stability of nucleoside analogs containing tricyclic bases

Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol

β-D-2'-C-Methyl-2,6-diaminopurine Ribonucleoside Phosphoramidates are Potent and Selective Inhibitors of Hepatitis C Virus (HCV) and Are Bioconverted Intracellularly to Bioactive 2,6-Diaminopurine and Guanosine 5'-Triphosphate Forms