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List of works by William H Chappell

Advances in targeting signal transduction pathways

scientific article

Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy

scientific article published on 21 February 2008

Cooperative effects of Akt-1 and Raf-1 on the induction of cellular senescence in doxorubicin or tamoxifen treated breast cancer cells

scientific article published on August 2011

Dominant roles of the Raf/MEK/ERK pathway in cell cycle progression, prevention of apoptosis and sensitivity to chemotherapeutic drugs

scientific article published on 15 April 2010

Effects of Ectopic Expression of NGAL on Doxorubicin Sensitivity ⬇️

scientific article published on October 1, 2012

Emerging MEK inhibitors.

scientific article published on June 2010

Emerging Raf inhibitors.

scientific article published on December 2009

Enhancing therapeutic efficacy by targeting non-oncogene addicted cells with combinations of signal transduction inhibitors and chemotherapy

scientific article published on 15 May 2010

Inhibition of GSK-3β activity can result in drug and hormonal resistance and alter sensitivity to targeted therapy in MCF-7 breast cancer cells

scientific article published on 09 January 2014

Involvement of Akt and mTOR in chemotherapeutic- and hormonal-based drug resistance and response to radiation in breast cancer cells

scientific article published on September 2011

Involvement of Akt-1 and mTOR in sensitivity of breast cancer to targeted therapy

scientific article published on July 2011

Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response

scientific article published on September 2012

Novel approaches to target cancer initiating cells-eliminating the root of the cancer

scientific article published on January 2012

Novel roles of androgen receptor, epidermal growth factor receptor, TP53, regulatory RNAs, NF-kappa-B, chromosomal translocations, neutrophil associated gelatinase, and matrix metalloproteinase-9 in prostate cancer and prostate cancer stem cells

scientific article

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance

scientific article

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health

scientific article published on March 2011

Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

scientific article

Targeting prostate cancer based on signal transduction and cell cycle pathways.

scientific article published on 16 June 2008

Targeting signal transduction pathways to eliminate chemotherapeutic drug resistance and cancer stem cells.

scientific article

Targeting the cancer initiating cell: the ultimate target for cancer therapy.

scientific article published on January 2012

The Raf/MEK/ERK pathway can govern drug resistance, apoptosis and sensitivity to targeted therapy

scientific article published on 10 May 2010

Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways.

scientific article

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