List of works - Gary W Caldwell

A high-throughput monoamine oxidase inhibition assay using liquid chromatography with tandem mass spectrometry

scientific article published in January 2004

ADME optimization and toxicity assessment in early- and late-phase drug discovery

scientific article published on January 2009

Allometric scaling of pharmacokinetic parameters in drug discovery: can human CL, Vss and t1/2 be predicted from in-vivo rat data?

scientific article

An unusual intramolecular transfer of the fluorobenzyl cation between two remote amidic nitrogen atoms induced by collision in the gas phase

scientific article published on 01 January 2012

Application of Flow NMR to an Open-Access Pharmaceutical Environment ⬇️

scientific article published on April 15, 2003

Bioactivation of 4-methylphenol (p-cresol) via cytochrome P450-mediated aromatic oxidation in human liver microsomes

scientific article

Cone voltage induced in-source dissociation of glucuronides in electrospray and implications in biological analyses

scientific article published on 01 January 2003

Detection of a novel reactive metabolite of diclofenac: evidence for CYP2C9-mediated bioactivation via arene oxides

scientific article

Evaluation of the effect of oxygen exposure on human liver microsomal metabolism of mitomycin C in the presence of glutathione using liquid chromatography-quadrupole time of flight mass spectrometry

scientific article published in August 2005

High-content assays for evaluating cellular and hepatic diacylglycerol acyltransferase activity

scientific article

In silico tools used for compound selection during target-based drug discovery and development

scientific article published on 08 May 2015

In vitro identification of cytochrome P450 enzymes responsible for drug metabolism

scientific article published in January 2013

Isobaric metabolite interferences and the requirement for close examination of raw data in addition to stringent chromatographic separations in liquid chromatography/tandem mass spectrometric analysis of drugs in biological matrix

scientific article

Liquid chromatographic and tandem mass spectrometric assay for evaluation of in vivo inhibition of rat brain monoamine oxidases (MAO) A and B following a single dose of MAO inhibitors: application of biomarkers in drug discovery

scientific article published in October 2004

Metabolic tracing of monoacylglycerol acyltransferase-2 activity in vitro and in vivo

scientific article published on 22 September 2016

Rapid detection and characterization of minor reactive metabolites using stable-isotope trapping in combination with tandem mass spectrometry

scientific article published in January 2005

Screening for reactive intermediates and toxicity assessment in drug discovery

scientific article

Small Molecule Compound Logistics Outsourcing – Going Beyond the “Thought Experiment” ⬇️

scientific article published on January 1, 2012

Stable-isotope trapping and high-throughput screenings of reactive metabolites using the isotope MS signature

scientific article published in December 2004

The Current Status of Time Dependent CYP Inhibition Assay and In Silico Drug-drug Interaction Predictions ⬇️

scientific article published on January 1, 2012

The IC50 Concept Revisited ⬇️

scientific article published on January 1, 2012

The application of nuclear magnetic resonance-based metabonomics to the dominant-submissive rat behavioral model

scientific article

The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2 ⬇️

scientific article published on April 3, 2012

The use of the suicide CYP450 inhibitor ABT for distinguishing absorption and metabolism processes in in-vivo pharmacokinetic screens

scientific article published in January 2005

Unbiased high-throughput screening of reactive metabolites on the linear ion trap mass spectrometer using polarity switch and mass tag triggered data-dependent acquisition

scientific article

Use of stable isotope labeled probes to facilitate liquid chromatography/mass spectrometry based high-throughput screening of time-dependent CYP inhibitors

scientific article published in August 2010

List of works by Gary W Caldwell

A high-throughput monoamine oxidase inhibition assay using liquid chromatography with tandem mass spectrometry

ADME optimization and toxicity assessment in early- and late-phase drug discovery

Allometric scaling of pharmacokinetic parameters in drug discovery: can human CL, Vss and t1/2 be predicted from in-vivo rat data?

An unusual intramolecular transfer of the fluorobenzyl cation between two remote amidic nitrogen atoms induced by collision in the gas phase

Application of Flow NMR to an Open-Access Pharmaceutical Environment ⬇️

Bioactivation of 4-methylphenol (p-cresol) via cytochrome P450-mediated aromatic oxidation in human liver microsomes

Cone voltage induced in-source dissociation of glucuronides in electrospray and implications in biological analyses

Detection of a novel reactive metabolite of diclofenac: evidence for CYP2C9-mediated bioactivation via arene oxides

Evaluation of the effect of oxygen exposure on human liver microsomal metabolism of mitomycin C in the presence of glutathione using liquid chromatography-quadrupole time of flight mass spectrometry

High-content assays for evaluating cellular and hepatic diacylglycerol acyltransferase activity

In silico tools used for compound selection during target-based drug discovery and development

In vitro identification of cytochrome P450 enzymes responsible for drug metabolism

Isobaric metabolite interferences and the requirement for close examination of raw data in addition to stringent chromatographic separations in liquid chromatography/tandem mass spectrometric analysis of drugs in biological matrix

Liquid chromatographic and tandem mass spectrometric assay for evaluation of in vivo inhibition of rat brain monoamine oxidases (MAO) A and B following a single dose of MAO inhibitors: application of biomarkers in drug discovery

Metabolic tracing of monoacylglycerol acyltransferase-2 activity in vitro and in vivo

Rapid detection and characterization of minor reactive metabolites using stable-isotope trapping in combination with tandem mass spectrometry

Screening for reactive intermediates and toxicity assessment in drug discovery

Small Molecule Compound Logistics Outsourcing – Going Beyond the “Thought Experiment” ⬇️

Stable-isotope trapping and high-throughput screenings of reactive metabolites using the isotope MS signature

The Current Status of Time Dependent CYP Inhibition Assay and In Silico Drug-drug Interaction Predictions ⬇️

The IC50 Concept Revisited ⬇️

The application of nuclear magnetic resonance-based metabonomics to the dominant-submissive rat behavioral model

The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2 ⬇️

The use of the suicide CYP450 inhibitor ABT for distinguishing absorption and metabolism processes in in-vivo pharmacokinetic screens

Unbiased high-throughput screening of reactive metabolites on the linear ion trap mass spectrometer using polarity switch and mass tag triggered data-dependent acquisition

Use of stable isotope labeled probes to facilitate liquid chromatography/mass spectrometry based high-throughput screening of time-dependent CYP inhibitors