Search filters

List of works by Zhengyin Yan

A high-throughput monoamine oxidase inhibition assay using liquid chromatography with tandem mass spectrometry

scientific article published in January 2004

ADME optimization and toxicity assessment in early- and late-phase drug discovery

scientific article published on January 2009

Allometric scaling of pharmacokinetic parameters in drug discovery: can human CL, Vss and t1/2 be predicted from in-vivo rat data?

scientific article

Alternative functional in vitro models of human intestinal epithelia.

scientific article published on 8 July 2013

An unusual intramolecular transfer of the fluorobenzyl cation between two remote amidic nitrogen atoms induced by collision in the gas phase

scientific article published on 01 January 2012

Bioactivation of 4-methylphenol (p-cresol) via cytochrome P450-mediated aromatic oxidation in human liver microsomes

scientific article

Biotin-ubiquitin tagging of mammalian proteins in Escherichia coli

scientific article

Comparative assessment for rat strain differences in metabolic profiles of 14 drugs in Wistar Han and Sprague Dawley hepatocytes

scientific article published on 27 July 2020

Cone voltage induced in-source dissociation of glucuronides in electrospray and implications in biological analyses

scientific article published on 01 January 2003

Detection of a novel reactive metabolite of diclofenac: evidence for CYP2C9-mediated bioactivation via arene oxides

scientific article

Development of a mass spectrometry-based tryptophan 2, 3-dioxygenase assay using liver cytosol from multiple species

scientific article published on 28 June 2018

Effects of individual ginsenosides, ginkgolides and flavonoids on CYP2C19 and CYP2D6 activity in human liver microsomes

scientific article published on 01 September 2006

Ester Prodrugs of IHVR-19029 with Enhanced Oral Exposure and Prevention of Gastrointestinal Glucosidase Interaction

scientific article

Highly predictive and interpretable models for PAMPA permeability

scientific article published on 31 December 2016

Human and non-human primate intestinal FcRn expression and immunoglobulin G transcytosis

scientific article published on 26 September 2013

Improving Confidence in the Determination of Free Fraction for Highly Bound Drugs Using Bi-directional Equilibrium Dialysis

scientific article published on 14 October 2018

In vitro identification of cytochrome P450 enzymes responsible for drug metabolism

scientific article published in January 2013

Industry Perspective on Contemporary Protein-Binding Methodologies: Considerations for Regulatory Drug-Drug Interaction and Related Guidelines on Highly Bound Drugs

scientific article published on 16 September 2017

Isobaric metabolite interferences and the requirement for close examination of raw data in addition to stringent chromatographic separations in liquid chromatography/tandem mass spectrometric analysis of drugs in biological matrix

scientific article

Metabolism and bioactivation of 3-methylindole by human liver microsomes.

scientific article published in January 2007

NADPH-Independent Inactivation of CYP2B6 and NADPH-dependent Inactivation of CYP3A4/5 by Pyrrolobenzodiazepine Dimer (PBD) and Potential Implication for Assessing Covalent Modulators for Time-dependent Inhibition

scientific article published on 01 June 2020

Rapid detection and characterization of minor reactive metabolites using stable-isotope trapping in combination with tandem mass spectrometry

scientific article published in January 2005

Screening for reactive intermediates and toxicity assessment in drug discovery

scientific article

Stable-isotope trapping and high-throughput screenings of reactive metabolites using the isotope MS signature

scientific article published in December 2004

Strategy for Determining the Free Fraction of Labile Covalent Modulators in Plasma Using Equilibrium Dialysis

scientific article published on 11 July 2020

The Current Status of Time Dependent CYP Inhibition Assay and In Silico Drug-drug Interaction Predictions ⬇️

scientific article published on January 1, 2012

The IC50 Concept Revisited ⬇️

scientific article published on January 1, 2012

The synthesis and evaluation of 10- and 12-membered ring benzofused enediyne amino acids

scientific article

Unbiased high-throughput screening of reactive metabolites on the linear ion trap mass spectrometer using polarity switch and mass tag triggered data-dependent acquisition

scientific article

Use of a trapping agent for simultaneous capturing and high-throughput screening of both "soft" and "hard" reactive metabolites.

scientific article

Use of stable isotope labeled probes to facilitate liquid chromatography/mass spectrometry based high-throughput screening of time-dependent CYP inhibitors

scientific article published in August 2010

Utility of Pooled Cryopreserved Human Enterocytes as An In Vitro Model for Assessing Intestinal Clearance and Drug-Drug Interactions

scientific article published on 12 December 2017

Paulina is supported by:

About Paulina

Help