List of works - Masanori Onda

A flow cytometry method to quantitate internalized immunotoxins shows that taxol synergistically increases cellular immunotoxins uptake

scientific article

A recombinant immunotoxin against the tumor-associated antigen mesothelin reengineered for high activity, low off-target toxicity, and reduced antigenicity

scientific article published on 6 November 2012

A recombinant immunotoxin engineered for increased stability by adding a disulfide bond has decreased immunogenicity.

scientific article published on 17 November 2011

A recombinant immunotoxin targeting CD22 with low immunogenicity, low nonspecific toxicity, and high antitumor activity in mice.

scientific article

An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes

scholarly article

An improved recombinant Fab-immunotoxin targeting CD22 expressing malignancies

scientific article

Bortezomib reduces pre-existing antibodies to recombinant immunotoxins in mice

scientific article

Cell membrane-specific epitopes on CD30: Potentially superior targets for immunotherapy

scientific article

Characterization of a re-engineered, mesothelin-targeted Pseudomonas exotoxin fusion protein for lung cancer therapy

scientific article published on 14 July 2016

Comprehensive immunohistochemical study of mesothelin (MSLN) using different monoclonal antibodies 5B2 and MN-1 in 1562 tumors with evaluation of its prognostic value in malignant pleural mesothelioma

scientific article

Detection and quantitation of serum mesothelin, a tumor marker for patients with mesothelioma and ovarian cancer

scientific article

Dual B- and T-cell de-immunization of recombinant immunotoxin targeting mesothelin with high cytotoxic activity

scientific article published on 04 May 2016

Effectiveness of anti-folate receptor beta antibody conjugated with truncated Pseudomonas exotoxin in the targeting of rheumatoid arthritis synovial macrophages

scientific article

Expression of POTE protein in human testis detected by novel monoclonal antibodies

scientific article

HA22 (R490A) is a recombinant immunotoxin with increased antitumor activity without an increase in animal toxicity.

scientific article published on February 2005

High expression of a cytokeratin-associated protein in many cancers

scientific article

High-density Functional Display of Proteins on Bacteriophage Lambda ⬇️

scientific article published on November 21, 2003

Identification of a set of seven genes for the monitoring of minimal residual disease in pediatric acute myeloid leukemia

scientific article published on April 2006

Immunogenicity of therapeutic recombinant immunotoxins

scientific article published on March 2016

In vitro and in vivo cytotoxic activities of recombinant immunotoxin 8H9(Fv)-PE38 against breast cancer, osteosarcoma, and neuroblastoma

scientific article published on February 2004

In vitro and in vivo efficacy of a recombinant immunotoxin against folate receptor beta on the activation and proliferation of rheumatoid arthritis synovial cells

scientific article published on October 2006

In vitro antibody evolution targeting germline hot spots to increase activity of an anti-CD22 immunotoxin

scientific article

Mesothelin expression in human lung cancer

scientific article published on March 2007

Mesothelin, a possible target for immunotherapy, is expressed in primary AML cells

scientific article

Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors

scientific article

Mutants of immunotoxin anti-Tac(dsFv)-PE38 with variable number of lysine residues as candidates for site-specific chemical modification. 1. Properties of mutant molecules

scientific article published in March 2003

New monoclonal antibodies to mesothelin useful for immunohistochemistry, fluorescence-activated cell sorting, Western blotting, and ELISA.

scientific article published on August 2005

Novel anti-CD30 recombinant immunotoxins containing disulfide-stabilized Fv fragments

scientific article published on July 2002

Pentostatin Plus Cyclophosphamide Safely and Effectively Prevents Immunotoxin Immunogenicity in Murine Hosts ⬇️

scientific article published on April 26, 2011

Protection of the Furin Cleavage Site in Low-Toxicity Immunotoxins Based on Pseudomonas Exotoxin A.

scientific article published on 25 July 2016

Recombinant Immunotoxins with Low Endotoxins for Clinical and Animal Studies ⬇️

scientific article published on January 1, 2012

Recombinant immunotoxin against B-cell malignancies with no immunogenicity in mice by removal of B-cell epitopes.

scientific article

Recombinant immunotoxin engineered for low immunogenicity and antigenicity by identifying and silencing human B-cell epitopes

scientific article

Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes

scientific article

Reducing the immunogenicity of protein therapeutics

scientific article published on February 2009

Serum mesothelin and megakaryocyte potentiating factor in pancreatic and biliary cancers ⬇️

scientific article published on April 1, 2012

Soluble CD22 as a tumor marker for hairy cell leukemia

scientific article published on 2 July 2008

TP-3 immunotoxins improve antitumor activity in mice with osteosarcoma.

scientific article published on January 2005

Targeted therapy against human lung cancer in nude mice by high-affinity recombinant antimesothelin single-chain Fv immunotoxin

scientific article published in June 2002

The improvement of an anti-CD22 immunotoxin: conversion to single-chain and disulfide stabilized form and affinity maturation by alanine scan

scientific article published on September 2011

Tofacitinib suppresses antibody responses to protein therapeutics in murine hosts.

scientific article

Transient silencing of synaptic transmitter release from specific neuronal types by recombinant tetanus toxin light chain fused to antibody variable region.

scientific article

List of works by Masanori Onda

A flow cytometry method to quantitate internalized immunotoxins shows that taxol synergistically increases cellular immunotoxins uptake

A recombinant immunotoxin against the tumor-associated antigen mesothelin reengineered for high activity, low off-target toxicity, and reduced antigenicity

A recombinant immunotoxin engineered for increased stability by adding a disulfide bond has decreased immunogenicity.

A recombinant immunotoxin targeting CD22 with low immunogenicity, low nonspecific toxicity, and high antitumor activity in mice.

An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes

An improved recombinant Fab-immunotoxin targeting CD22 expressing malignancies

Bortezomib reduces pre-existing antibodies to recombinant immunotoxins in mice

Cell membrane-specific epitopes on CD30: Potentially superior targets for immunotherapy

Characterization of a re-engineered, mesothelin-targeted Pseudomonas exotoxin fusion protein for lung cancer therapy

Comprehensive immunohistochemical study of mesothelin (MSLN) using different monoclonal antibodies 5B2 and MN-1 in 1562 tumors with evaluation of its prognostic value in malignant pleural mesothelioma

Detection and quantitation of serum mesothelin, a tumor marker for patients with mesothelioma and ovarian cancer

Dual B- and T-cell de-immunization of recombinant immunotoxin targeting mesothelin with high cytotoxic activity

Effectiveness of anti-folate receptor beta antibody conjugated with truncated Pseudomonas exotoxin in the targeting of rheumatoid arthritis synovial macrophages

Expression of POTE protein in human testis detected by novel monoclonal antibodies

HA22 (R490A) is a recombinant immunotoxin with increased antitumor activity without an increase in animal toxicity.

High expression of a cytokeratin-associated protein in many cancers

High-density Functional Display of Proteins on Bacteriophage Lambda ⬇️

Identification of a set of seven genes for the monitoring of minimal residual disease in pediatric acute myeloid leukemia

Immunogenicity of therapeutic recombinant immunotoxins

In vitro and in vivo cytotoxic activities of recombinant immunotoxin 8H9(Fv)-PE38 against breast cancer, osteosarcoma, and neuroblastoma

In vitro and in vivo efficacy of a recombinant immunotoxin against folate receptor beta on the activation and proliferation of rheumatoid arthritis synovial cells

In vitro antibody evolution targeting germline hot spots to increase activity of an anti-CD22 immunotoxin

Mesothelin expression in human lung cancer

Mesothelin, a possible target for immunotherapy, is expressed in primary AML cells

Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors

Mutants of immunotoxin anti-Tac(dsFv)-PE38 with variable number of lysine residues as candidates for site-specific chemical modification. 1. Properties of mutant molecules

New monoclonal antibodies to mesothelin useful for immunohistochemistry, fluorescence-activated cell sorting, Western blotting, and ELISA.

Novel anti-CD30 recombinant immunotoxins containing disulfide-stabilized Fv fragments

Pentostatin Plus Cyclophosphamide Safely and Effectively Prevents Immunotoxin Immunogenicity in Murine Hosts ⬇️

Protection of the Furin Cleavage Site in Low-Toxicity Immunotoxins Based on Pseudomonas Exotoxin A.

Recombinant Immunotoxins with Low Endotoxins for Clinical and Animal Studies ⬇️

Recombinant immunotoxin against B-cell malignancies with no immunogenicity in mice by removal of B-cell epitopes.

Recombinant immunotoxin engineered for low immunogenicity and antigenicity by identifying and silencing human B-cell epitopes

Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes

Reducing the immunogenicity of protein therapeutics

Serum mesothelin and megakaryocyte potentiating factor in pancreatic and biliary cancers ⬇️

Soluble CD22 as a tumor marker for hairy cell leukemia

TP-3 immunotoxins improve antitumor activity in mice with osteosarcoma.

Targeted therapy against human lung cancer in nude mice by high-affinity recombinant antimesothelin single-chain Fv immunotoxin

The improvement of an anti-CD22 immunotoxin: conversion to single-chain and disulfide stabilized form and affinity maturation by alanine scan

Tofacitinib suppresses antibody responses to protein therapeutics in murine hosts.

Transient silencing of synaptic transmitter release from specific neuronal types by recombinant tetanus toxin light chain fused to antibody variable region.