List of works - Julien Verrax

AICAR induces Nrf2 activation by an AMPK-independent mechanism in hepatocarcinoma cells

scientific article

Aminopyrimidoisoquinolinequinone (APIQ) redox cycling is potentiated by ascorbate and induces oxidative stress leading to necrotic-like cancer cell death.

scientific article published on 5 April 2011

Arsenic trioxide treatment decreases the oxygen consumption rate of tumor cells and radiosensitizes solid tumors

scientific article published on 2 December 2011

Ascorbate potentiates the cytotoxicity of menadione leading to an oxidative stress that kills cancer cells by a non-apoptotic caspase-3 independent form of cell death

scientific article published on March 2004

Ascorbate/menadione-induced oxidative stress kills cancer cells that express normal or mutated forms of the oncogenic protein Bcr-Abl. An in vitro and in vivo mechanistic study

scientific article

Binding of dihydroxynaphthyl aryl ketones to tubulin colchicine site inhibits microtubule assembly

scientific article published on 11 September 2015

Biological Evaluation of 3-Acyl-2-Arylamino-1,4-Naphthoquinones as Inhibitors of Hsp90 Chaperoning Function

scientific article published on January 1, 2012

Biological evaluation of donor-acceptor aminonaphthoquinones as antitumor agents

scientific article published on October 14, 2010

Botulinum toxin potentiates cancer radiotherapy and chemotherapy

scientific article published on 01 February 2006

Catalase expression in MCF-7 breast cancer cells is mainly controlled by PI3K/Akt/mTor signaling pathway

scientific article published on 11 March 2014

Catalase overexpression in mammary cancer cells leads to a less aggressive phenotype and an altered response to chemotherapy.

scientific article published on 13 June 2011

Chromatin remodeling regulates catalase expression during cancer cells adaptation to chronic oxidative stress

scientific article published on 31 August 2016

Comparison of methods for measuring oxygen consumption in tumor cells in vitro.

scientific article published on 18 September 2009

Delivery of soluble VEGF receptor 1 (sFlt1) by gene electrotransfer as a new antiangiogenic cancer therapy.

scientific article published on 13 May 2011

Endoplasmic reticulum calcium release potentiates the ER stress and cell death caused by an oxidative stress in MCF-7 cells.

scientific article

Enhancement of quinone redox cycling by ascorbate induces a caspase-3 independent cell death in human leukaemia cells. An in vitro comparative study

scientific article published on June 2005

Hsp90 cleavage by an oxidative stress leads to its client proteins degradation and cancer cell death.

scientific article

Hsp90 is cleaved by reactive oxygen species at a highly conserved N-terminal amino acid motif

scientific article

Intracellular ATP levels determine cell death fate of cancer cells exposed to both standard and redox chemotherapeutic agents ⬇️

scientific article published on August 9, 2011

Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells

scientific article published in 2012

Menadione reduction by pharmacological doses of ascorbate induces an oxidative stress that kills breast cancer cells

scientific article

Overexpression of GRP94 in breast cancer cells resistant to oxidative stress promotes high levels of cancer cell proliferation and migration: implications for tumor recurrence.

scientific article published on 2 January 2012

Overexpression of NAD(P)H:quinone oxidoreductase 1 (NQO1) and genomic gain of the NQO1 locus modulates breast cancer cell sensitivity to quinones

scientific article published on 10 December 2015

Oxidative stress by ascorbate/menadione association kills K562 human chronic myelogenous leukaemia cells and inhibits its tumour growth in nude mice.

scientific article published on 7 July 2006

Pharmacologic concentrations of ascorbate are achieved by parenteral administration and exhibit antitumoral effects

scientific article

Regulation of catalase expression in healthy and cancerous cells

scientific article published on 24 June 2015

Restoring specific lactobacilli levels decreases inflammation and muscle atrophy markers in an acute leukemia mouse model

scientific article

Role of AMPK activation in oxidative cell damage: Implications for alcohol-induced liver disease ⬇️

scientific article published on May 17, 2013

Role of glycolysis inhibition and poly(ADP-ribose) polymerase activation in necrotic-like cell death caused by ascorbate/menadione-induced oxidative stress in K562 human chronic myelogenous leukemic cells

scientific article published on 01 March 2007

Sodium orthovanadate associated with pharmacological doses of ascorbate causes an increased generation of ROS in tumor cells that inhibits proliferation and triggers apoptosis.

scientific article

Synthesis and antitumor evaluation of 8-phenylaminopyrimido[4,5-c]isoquinolinequinones.

scientific article

Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis.

scientific article

The association of vitamins C and K3 kills cancer cells mainly by autoschizis, a novel form of cell death. Basis for their potential use as coadjuvants in anticancer therapy

scientific article

Tumor reoxygenation following administration of Mitogen-Activated Protein Kinase inhibitors: a rationale for combination with radiation therapy.

scientific article

Use of a cocktail of spin traps for fingerprinting large range of free radicals in biological systems

scientific article

[Cancer: when recycling becomes a weakness].

scientific article published in April 2009

p38(MAPK)-regulated induction of p62 and NBR1 after photodynamic therapy promotes autophagic clearance of ubiquitin aggregates and reduces reactive oxygen species levels by supporting Nrf2-antioxidant signaling

scientific article published on 22 November 2013

List of works by Julien Verrax

AICAR induces Nrf2 activation by an AMPK-independent mechanism in hepatocarcinoma cells

Aminopyrimidoisoquinolinequinone (APIQ) redox cycling is potentiated by ascorbate and induces oxidative stress leading to necrotic-like cancer cell death.

Arsenic trioxide treatment decreases the oxygen consumption rate of tumor cells and radiosensitizes solid tumors

Ascorbate potentiates the cytotoxicity of menadione leading to an oxidative stress that kills cancer cells by a non-apoptotic caspase-3 independent form of cell death

Ascorbate/menadione-induced oxidative stress kills cancer cells that express normal or mutated forms of the oncogenic protein Bcr-Abl. An in vitro and in vivo mechanistic study

Binding of dihydroxynaphthyl aryl ketones to tubulin colchicine site inhibits microtubule assembly

Biological Evaluation of 3-Acyl-2-Arylamino-1,4-Naphthoquinones as Inhibitors of Hsp90 Chaperoning Function

Biological evaluation of donor-acceptor aminonaphthoquinones as antitumor agents

Botulinum toxin potentiates cancer radiotherapy and chemotherapy

Catalase expression in MCF-7 breast cancer cells is mainly controlled by PI3K/Akt/mTor signaling pathway

Catalase overexpression in mammary cancer cells leads to a less aggressive phenotype and an altered response to chemotherapy.

Chromatin remodeling regulates catalase expression during cancer cells adaptation to chronic oxidative stress

Comparison of methods for measuring oxygen consumption in tumor cells in vitro.

Delivery of soluble VEGF receptor 1 (sFlt1) by gene electrotransfer as a new antiangiogenic cancer therapy.

Endoplasmic reticulum calcium release potentiates the ER stress and cell death caused by an oxidative stress in MCF-7 cells.

Enhancement of quinone redox cycling by ascorbate induces a caspase-3 independent cell death in human leukaemia cells. An in vitro comparative study

Hsp90 cleavage by an oxidative stress leads to its client proteins degradation and cancer cell death.

Hsp90 is cleaved by reactive oxygen species at a highly conserved N-terminal amino acid motif

Intracellular ATP levels determine cell death fate of cancer cells exposed to both standard and redox chemotherapeutic agents ⬇️

Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells

Menadione reduction by pharmacological doses of ascorbate induces an oxidative stress that kills breast cancer cells

Overexpression of GRP94 in breast cancer cells resistant to oxidative stress promotes high levels of cancer cell proliferation and migration: implications for tumor recurrence.

Overexpression of NAD(P)H:quinone oxidoreductase 1 (NQO1) and genomic gain of the NQO1 locus modulates breast cancer cell sensitivity to quinones

Oxidative stress by ascorbate/menadione association kills K562 human chronic myelogenous leukaemia cells and inhibits its tumour growth in nude mice.

Pharmacologic concentrations of ascorbate are achieved by parenteral administration and exhibit antitumoral effects

Regulation of catalase expression in healthy and cancerous cells

Restoring specific lactobacilli levels decreases inflammation and muscle atrophy markers in an acute leukemia mouse model

Role of AMPK activation in oxidative cell damage: Implications for alcohol-induced liver disease ⬇️

Role of glycolysis inhibition and poly(ADP-ribose) polymerase activation in necrotic-like cell death caused by ascorbate/menadione-induced oxidative stress in K562 human chronic myelogenous leukemic cells

Sodium orthovanadate associated with pharmacological doses of ascorbate causes an increased generation of ROS in tumor cells that inhibits proliferation and triggers apoptosis.

Synthesis and antitumor evaluation of 8-phenylaminopyrimido[4,5-c]isoquinolinequinones.

Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis.

The association of vitamins C and K3 kills cancer cells mainly by autoschizis, a novel form of cell death. Basis for their potential use as coadjuvants in anticancer therapy

Tumor reoxygenation following administration of Mitogen-Activated Protein Kinase inhibitors: a rationale for combination with radiation therapy.

Use of a cocktail of spin traps for fingerprinting large range of free radicals in biological systems

[Cancer: when recycling becomes a weakness].

p38(MAPK)-regulated induction of p62 and NBR1 after photodynamic therapy promotes autophagic clearance of ubiquitin aggregates and reduces reactive oxygen species levels by supporting Nrf2-antioxidant signaling