List of works - Emmanuel Le Poul

A Potent and Selective Metabotropic Glutamate Receptor 4 Positive Allosteric Modulator Improves Movement in Rodent Models of Parkinson's Disease ⬇️

scientific article published on July 11, 2012

A novel series of metabotropic glutamate receptor 5 negative allosteric modulators based on a 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine core

scientific article published on 25 June 2013

ADX71743, a potent and selective negative allosteric modulator of metabotropic glutamate receptor 7: in vitro and in vivo characterization

scientific article

Activation of CCR5 by chemokines involves an aromatic cluster between transmembrane helices 2 and 3.

scientific article published on 30 October 2002

Adaptation of aequorin functional assay to high throughput screening

scientific article published in February 2002

Aequorin-Based Functional Assays for G-Protein-Coupled Receptors, Ion Channels, and Tyrosine Kinase Receptors ⬇️

scientific article published on January 1, 2002

Characterization of an mGluR2/3 Negative Allosteric Modulator in Rodent Models of Depression ⬇️

scientific article published on December 1, 2011

Characterization of the novel positive allosteric modulator of the metabotropic glutamate receptor 4 ADX88178 in rodent models of neuropsychiatric disorders

scientific article

Discovery of 1,5-disubstituted pyridones: a new class of positive allosteric modulators of the metabotropic glutamate 2 receptor

scientific article published on 23 August 2010

Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation

scientific article (publication date: 11 July 2003)

Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8

scientific article

Lentiviral delivery of a vesicular glutamate transporter 1 (VGLUT1)-targeting short hairpin RNA vector into the mouse hippocampus impairs cognition

scientific article

Multiple active states and oligomerization of CCR5 revealed by functional properties of monoclonal antibodies

scientific article

Mutation of the DRY motif reveals different structural requirements for the CC chemokine receptor 5-mediated signaling and receptor endocytosis.

scientific article published on 10 March 2005

New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones

scientific article published on 21 December 2010

Pharmacological and pharmacokinetic properties of JNJ-40411813, a positive allosteric modulator of the mGlu2 receptor

scientific article

Pharmacological characterization of the human P2Y13 receptor

scientific article

Serotonin 5-HT(2B) receptor loss of function mutation in a patient with fenfluramine-associated primary pulmonary hypertension.

scientific article

Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids

scientific article

Supersensitivity of human metabotropic glutamate 1a receptor signaling in L929sA cells

scientific article published in May 2002

mGluR5 negative allosteric modulators overview: a medicinal chemistry approach towards a series of novel therapeutic agents

scientific article published on January 2011

List of works by Emmanuel Le Poul

A Potent and Selective Metabotropic Glutamate Receptor 4 Positive Allosteric Modulator Improves Movement in Rodent Models of Parkinson's Disease ⬇️

A novel series of metabotropic glutamate receptor 5 negative allosteric modulators based on a 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine core

ADX71743, a potent and selective negative allosteric modulator of metabotropic glutamate receptor 7: in vitro and in vivo characterization

Activation of CCR5 by chemokines involves an aromatic cluster between transmembrane helices 2 and 3.

Adaptation of aequorin functional assay to high throughput screening

Aequorin-Based Functional Assays for G-Protein-Coupled Receptors, Ion Channels, and Tyrosine Kinase Receptors ⬇️

Characterization of an mGluR2/3 Negative Allosteric Modulator in Rodent Models of Depression ⬇️

Characterization of the novel positive allosteric modulator of the metabotropic glutamate receptor 4 ADX88178 in rodent models of neuropsychiatric disorders

Discovery of 1,5-disubstituted pyridones: a new class of positive allosteric modulators of the metabotropic glutamate 2 receptor

Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation

Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8

Lentiviral delivery of a vesicular glutamate transporter 1 (VGLUT1)-targeting short hairpin RNA vector into the mouse hippocampus impairs cognition

Multiple active states and oligomerization of CCR5 revealed by functional properties of monoclonal antibodies

Mutation of the DRY motif reveals different structural requirements for the CC chemokine receptor 5-mediated signaling and receptor endocytosis.

New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones

Pharmacological and pharmacokinetic properties of JNJ-40411813, a positive allosteric modulator of the mGlu2 receptor

Pharmacological characterization of the human P2Y13 receptor

Serotonin 5-HT(2B) receptor loss of function mutation in a patient with fenfluramine-associated primary pulmonary hypertension.

Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids

Supersensitivity of human metabotropic glutamate 1a receptor signaling in L929sA cells

mGluR5 negative allosteric modulators overview: a medicinal chemistry approach towards a series of novel therapeutic agents