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List of works by De-Maw Chuang

A new avenue for lithium: intervention in traumatic brain injury

scientific article

Angiotensin II AT1 receptor blockade ameliorates brain inflammation

scientific article

Antidepressant mechanism of ketamine: perspective from preclinical studies

scientific article

Bax inhibitor 1, a modulator of calcium homeostasis, confers affective resilience

scientific article

Beneficial effects of mood stabilizers lithium, valproate and lamotrigine in experimental stroke models ⬇️

scientific article published on November 7, 2011

Chronic valproate treatment enhances postischemic angiogenesis and promotes functional recovery in a rat model of ischemic stroke

scientific article

Combined Treatment with the Mood Stabilizers Lithium and Valproate Produces Multiple Beneficial Effects in Transgenic Mouse Models of Huntington's Disease ⬇️

scientific article published on July 27, 2011

Differential roles of glycogen synthase kinase-3 isoforms in the regulation of transcriptional activation

scientific article published on 15 August 2006

Downregulated AEG-1 together with inhibited PI3K/Akt pathway is associated with reduced viability of motor neurons in an ALS model

scientific article published on 27 August 2015

Endogenous alpha-synuclein is induced by valproic acid through histone deacetylase inhibition and participates in neuroprotection against glutamate-induced excitotoxicity.

scientific article published in July 2006

Fluoxetine modulates G protein alpha s, alpha q, and alpha 12 subunit mRNA expression in rat brain

scientific article (publication date: October 1992)

Functional MRI of delayed chronic lithium treatment in rat focal cerebral ischemia

scientific article published on 10 January 2008

GSK-3 as a Target for Lithium-Induced Neuroprotection Against Excitotoxicity in Neuronal Cultures and Animal Models of Ischemic Stroke

scientific article

GSK-3 is a viable potential target for therapeutic intervention in bipolar disorder

scientific article

GSK3β negatively regulates TRAX, a scaffold protein implicated in mental disorders, for NHEJ-mediated DNA repair in neurons.

scientific article published on 3 January 2018

Genetic disruption of ankyrin-G in adult mouse forebrain causes cortical synapse alteration and behavior reminiscent of bipolar disorder

scientific article published on 11 September 2017

Glutamate-modulating drugs as a potential therapeutic strategy in obsessive-compulsive disorder.

scientific article published on 20 March 2017

Glyceraldehyde-3-phosphate dehydrogenase, apoptosis, and neurodegenerative diseases

scientific article

HDAC inhibitors mitigate ischemia-induced oligodendrocyte damage: potential roles of oligodendrogenesis, VEGF, and anti-inflammation

scientific article

Histone deacetylase inhibition alters histone methylation associated with heat shock protein 70 promoter modifications in astrocytes and neurons

scientific journal article

Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action.

scientific article published on 19 March 2007

Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons

scientific article published on 09 July 2008

In search of the Holy Grail for the treatment of neurodegenerative disorders: has a simple cation been overlooked?

scientific article

Lentivirally mediated GSK-3β silencing in the hippocampal dentate gyrus induces antidepressant-like effects in stressed mice

scientific article

Lithium Ameliorates Neurodegeneration, Suppresses Neuroinflammation, and Improves Behavioral Performance in a Mouse Model of Traumatic Brain Injury ⬇️

scientific article published on January 20, 2012

Lithium ameliorates phenotypic deficits in a mouse model of fragile X syndrome

scientific article

Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: an essential step for neuroprotection against glutamate excitotoxicity.

scientific article

Lithium inhibits Smad3/4 transactivation via increased CREB activity induced by enhanced PKA and AKT signaling

scientific article published on 9 November 2007

Lithium neuroprotection: molecular mechanisms and clinical implications

scientific article published on 18 October 2004

Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation.

scientific article

Lithium reduces BACE1 overexpression, β amyloid accumulation, and spatial learning deficits in mice with traumatic brain injury

scientific article

Lithium reduces ischemia-induced hippocampal CA1 damage and behavioral deficits in gerbils

scientific article published on 29 September 2007

Lithium upregulates vascular endothelial growth factor in brain endothelial cells and astrocytes

scientific article published on 30 October 2008

Lithium-induced inhibition of Src tyrosine kinase in rat cerebral cortical neurons: a role in neuroprotection against N-methyl-D-aspartate receptor-mediated excitotoxicity

scientific article

Mesenchymal stem cells primed with valproate and lithium robustly migrate to infarcted regions and facilitate recovery in a stroke model.

scientific article

Molecular actions and therapeutic potential of lithium in preclinical and clinical studies of CNS disorders

scientific article

Mood stabilizer-regulated miRNAs in neuropsychiatric and neurodegenerative diseases: identifying associations and functions

scientific article published on 24 May 2013

Multiple roles of HDAC inhibition in neurodegenerative conditions.

scientific article published on 21 September 2009

Neuroprotective action of lithium in disorders of the central nervous system ⬇️

scientific article published on June 1, 2011

Neuroprotective actions of lithium

scientific article published on January 1, 2003

Neuroprotective and neurotrophic actions of the mood stabilizer lithium: can it be used to treat neurodegenerative diseases?

scientific article

Neuroprotective effects of lithium in cultured cells and animal models of diseases.

scientific article

Neuroprotective effects of the mood stabilizer lamotrigine against glutamate excitotoxicity: roles of chromatin remodelling and Bcl-2 induction ⬇️

scientific article published on May 8, 2012

Nuclear factor-kappaB-dependent cyclin D1 induction and DNA replication associated with N-methyl-D-aspartate receptor-mediated apoptosis in rat striatum

scientific article published in May 2007

Overexpression and nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase in a transgenic mouse model of Huntington’s disease ⬇️

scientific article published on March 1, 2003

Overexpression of fibroblast growth factor-21 (FGF-21) protects mesenchymal stem cells against caspase-dependent apoptosis induced by oxidative stress and inflammation

scientific article published on 18 June 2020

PET imaging with [11C]PBR28 can localize and quantify upregulated peripheral benzodiazepine receptors associated with cerebral ischemia in rat.

scientific article published on 28 November 2006

Post-insult valproate treatment potentially improved functional recovery in patients with acute middle cerebral artery infarction

scientific article

Post-insult valproic acid-regulated microRNAs: potential targets for cerebral ischemia

scientific article

Postinsult treatment with lithium reduces brain damage and facilitates neurological recovery in a rat ischemia/reperfusion model ⬇️

scientific article published on May 5, 2003

Posttrauma cotreatment with lithium and valproate: reduction of lesion volume, attenuation of blood-brain barrier disruption, and improvement in motor coordination in mice with traumatic brain injury

scientific article published on 12 July 2013

Potent neuroprotective effects of novel structural derivatives of valproic acid: potential roles of HDAC inhibition and HSP70 induction.

scientific article

Potential roles of HDAC inhibitors in mitigating ischemia-induced brain damage and facilitating endogenous regeneration and recovery.

scientific article published on January 2013

Preclinical and clinical investigations of mood stabilizers for Huntington's disease: what have we learned?

scientific article

Preconditioning mesenchymal stem cells with the mood stabilizers lithium and valproic acid enhances therapeutic efficacy in a mouse model of Huntington's disease

scientific article published on 13 April 2016

Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis.

scientific article

Regulation and function of glycogen synthase kinase-3 isoforms in neuronal survival

scientific article published on 5 December 2006

Regulation of c-Jun N-terminal kinase, p38 kinase and AP-1 DNA binding in cultured brain neurons: roles in glutamate excitotoxicity and lithium neuroprotection

scientific article

Safety and efficacy of valproic acid treatment in SCA3/MJD patients

scientific article

Susceptibility of striatal neurons to excitotoxic injury correlates with basal levels of Bcl-2 and the induction of P53 and c-Myc immunoreactivity

scientific article published on November 2005

Synergistic neuroprotective effects of lithium and valproic acid or other histone deacetylase inhibitors in neurons: roles of glycogen synthase kinase-3 inhibition

scientific article

The HDAC inhibitor, sodium butyrate, stimulates neurogenesis in the ischemic brain

scientific article published on 15 June 2009

The antiapoptotic actions of mood stabilizers: molecular mechanisms and therapeutic potentials

scientific article

The mood stabilizer lithium potentiates the antidepressant-like effects and ameliorates oxidative stress induced by acute ketamine in a mouse model of stress

scientific article

The mood stabilizers valproic acid and lithium enhance mesenchymal stem cell migration via distinct mechanisms

scientific journal article

Therapeutic Potential of Mood Stabilizers Lithium and Valproic Acid: Beyond Bipolar Disorder ⬇️

scientific article published on January 8, 2013

Transplantation of Mesenchymal Stem Cells Overexpressing Fibroblast Growth Factor 21 Facilitates Cognitive Recovery and Enhances Neurogenesis in a Mouse Model of Traumatic Brain Injury

scientific article published on 20 August 2019

Tubastatin A, an HDAC6 inhibitor, alleviates stroke-induced brain infarction and functional deficits: potential roles of α-tubulin acetylation and FGF-21 up-regulation

scientific article published on 21 January 2016

Valproate pretreatment protects dopaminergic neurons from LPS-induced neurotoxicity in rat primary midbrain cultures: role of microglia.

scientific article published on 25 November 2004

Valproic Acid and Other HDAC Inhibitors Upregulate FGF21 Gene Expression and Promote Process Elongation in Glia by Inhibiting HDAC2 and 3

scientific article published on 06 May 2016

Valproic acid attenuates microgliosis in injured spinal cord and purinergic P2X4 receptor expression in activated microglia

scientific article published on 13 February 2013

Valproic acid induces functional heat-shock protein 70 via Class I histone deacetylase inhibition in cortical neurons: a potential role of Sp1 acetylation

scientific journal article

Valproic acid reduces brain damage induced by transient focal cerebral ischemia in rats: potential roles of histone deacetylase inhibition and heat shock protein induction

scientific article

Valproic acid, a mood stabilizer and anticonvulsant, protects rat cerebral cortical neurons from spontaneous cell death: a role of histone deacetylase inhibition ⬇️

scientific article published on May 8, 2003

[Research strategy for understanding neuronal plasticity and degeneration]

scientific article published on 01 January 2003

miR-25 alleviates polyQ-mediated cytotoxicity by silencing ATXN3.

scientific article published on 20 November 2014

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