List of works by Dieter Steinhilber

1-Oleoyl-2-acetylglycerol stimulates 5-lipoxygenase activity via a putative (phospho)lipid binding site within the N-terminal C2-like domain

scientific article published on 27 May 2005

222 Isothiocyanate Sulforaphane Inhibits Protooncogenic Ornithine Decarboxylase Activity in Colorectal Cancer Cells via Induction of the TGFβ/SMAD Signalling Pathway

scientific article published in May 2010

5-Lipoxygenase activation by MAPKAPK-2 and ERKs.

scientific article published in January 2003

5-Lipoxygenase contributes to PPARγ activation in macrophages in response to apoptotic cells

scientific article published on 13 September 2013

5-Lipoxygenase inhibitors: a review of recent patents (2010-2012).

scientific article published on 21 April 2013

5-Lipoxygenase is a direct p53 target gene in humans

scientific article published on 9 June 2015

5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease

scientific article (publication date: April 2015)

5-Lipoxygenase: regulation of expression and enzyme activity

scientific article published on 18 June 2007

5-lipoxygenase is a direct target of miR-19a-3p and miR-125b-5p

scientific article

5-lipoxygenase mRNA and protein isoforms

scientific article

5-lipoxygenase: underappreciated role of a pro-inflammatory enzyme in tumorigenesis

scientific article published on 24 December 2010

A class of 5-benzylidene-2-phenylthiazolinones with high potency as direct 5-lipoxygenase inhibitors

scientific article published on 22 February 2011

A mutation interfering with 5-lipoxygenase domain interaction leads to increased enzyme activity.

scientific article published on 28 January 2014

A simple cell line based in vitro test system for N-methyl-D-aspartate (NMDA) receptor ligands

scientific article

AF4 and AF4-MLL mediate transcriptional elongation of 5-lipoxygenase mRNA by 1, 25-dihydroxyvitamin D3

scientific article published on 27 July 2015

Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes

scientific article published in February 2002

Analysis of 5-lipoxygenase phosphorylation on molecular level by MALDI-MS

scientific article

Analysis of the 5-lipoxygenase promoter and characterization of a vitamin D receptor binding site

scientific article

Antidiabetic sulfonylureas modulate farnesoid X receptor activation and target gene transcription

scientific article

Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2).

scientific article published on 13 February 2002

Aspirin prevents colorectal cancer metastasis in mice by splitting the crosstalk between platelets and tumor cells

scientific article published on 8 April 2016

CD69 is a TGF-β/1α,25-dihydroxyvitamin D3 target gene in monocytes

scientific article

Calcitriol upregulates open chromatin and elongation markers at functional vitamin D response elements in the distal part of the 5-lipoxygenase gene

scientific article published on 24 October 2009

Camptothecin and its analog SN-38, the active metabolite of irinotecan, inhibit binding of the transcriptional regulator and oncoprotein FUBP1 to its DNA target sequence FUSE.

scientific article published on 12 October 2017

Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes

scientific article published in May 2008

Caspase-mediated degradation of human 5-lipoxygenase in B lymphocytic cells

scientific article

Celecoxib inhibits 5-lipoxygenase

scientific article

Cell type-dependent activation of 5-lipoxygenase by arachidonic acid

scientific article published in January 2003

Cellular membranes function as a storage compartment for celecoxib

scientific article

Challenges in the Development of a Thiol-Based Broad-Spectrum Inhibitor for Metallo-β-Lactamases

scientific article published on 26 November 2017

Characterization of the molecular mechanism of 5-lipoxygenase inhibition by 2-aminothiazoles

scientific article published on 23 September 2016

Characterizing ligands for farnesoid X receptor--available in vitro test systems for farnesoid X receptor modulator development

scientific article

ChemInform Abstract: Characterization of Taxlllaids A-G; Natural Products from Xenorhabdus indica

Chiral chromatography-tandem mass spectrometry applied to the determination of pro-resolving lipid mediators

scientific article published on 29 July 2014

Cholesterol and its anionic derivatives inhibit 5-lipoxygenase activation in polymorphonuclear leukocytes and MonoMac6 cells

scientific article published on February 2006

Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102.

scientific article published on 14 December 2009

Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production

scientific article

Combined treatment of Caco-2 cells with butyrate and mesalazine inhibits cell proliferation and reduces Survivin protein level

scientific article

Correction: CD69 Is a TGF-β/1α,25-dihydroxyvitamin D3 Target Gene in Monocytes.

scientific article published on 31 January 2014

Coupling of boswellic acid-induced Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes

scientific article published on 22 December 2003

Cysteinyl leukotriene-receptor-1 antagonists interfere with PGE2 synthesis by inhibiting mPGES-1 activity

scientific article published on 14 May 2013

DNA methylation regulates 5-lipoxygenase promoter activity

scientific article published on January 2003

Design and synthesis of novel 2-amino-5-hydroxyindole derivatives that inhibit human 5-lipoxygenase.

scientific article

Design of dual ligands using excessive pharmacophore query alignment.

scientific article

Design, Synthesis and Cellular Characterization of a Dual Inhibitor of 5-Lipoxygenase and Soluble Epoxide Hydrolase.

scientific article published on 29 December 2016

Development of 5-lipoxygenase inhibitors--lessons from cellular enzyme regulation

scientific article

Development of a method for expression and purification of the regulatory C2-like domain of human 5-lipoxygenase

scientific article

Development of novel aminothiazole-comprising 5-LO inhibitors

scientific article

Dimerization of human 5-lipoxygenase

scientific article

Drug-mediated intracellular donation of nitric oxide potently inhibits 5-lipoxygenase: a possible key to future anti-leukotriene therapy

scientific article

Dual-target virtual screening by pharmacophore elucidation and molecular shape filtering

scientific article

Editorial

scholarly article by Gökce Topal et al published September 2015 in Prostaglandins and Other Lipid Mediators

Editorial-Special issue of the 6th European Workshop on Lipid Mediators

scientific article

Effects of celecoxib on prostanoid biosynthesis and circulating angiogenesis proteins in familial adenomatous polyposis

scientific article published on 19 January 2012

Electrophilic fatty acid species inhibit 5-lipoxygenase and attenuate sepsis-induced pulmonary inflammation

scientific article

Exploring the chemical space of multitarget ligands using aligned self-organizing maps

scientific article

Extending the structure-activity relationship of anthranilic acid derivatives as farnesoid X receptor modulators: development of a highly potent partial farnesoid X receptor agonist

article

Extracellular signal-regulated kinases phosphorylate 5-lipoxygenase and stimulate 5-lipoxygenase product formation in leukocytes

scientific article published on July 2002

Extraction and visualization of potential pharmacophore points using support vector machines: application to ligand-based virtual screening for COX-2 inhibitors

scientific article published on November 2005

Fragment-based identification of multi-target ligands by self-organizing map alignment.

scientific article

From a multipotent stilbene to soluble epoxide hydrolase inhibitors with antiproliferative properties

scientific article

Functional characterization of vitamin D responding regions in the human 5-Lipoxygenase gene

scientific article published on 19 April 2007

GC-rich sequences in the 5-lipoxygenase gene promoter are required for expression in Mono Mac 6 cells, characterization of a novel Sp1 binding site

scientific article published on 27 December 2005

How do aspirin and company work? Cyclooxygenases--point of attack of nonsteroidal antirheumatics

scientific article (publication date: 2002)

How to effectively treat acute leukemia patients bearing MLL-rearrangements ?

scientific article

Hyperforin induces Ca(2+)-independent arachidonic acid release in human platelets by facilitating cytosolic phospholipase A(2) activation through select phospholipid interactions

scientific article published on 28 December 2009

Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase

scientific article (publication date: 15 December 2002)

Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo.

scientific article

Hypertonicity suppresses ionophore-induced product formation and translocation of 5-lipoxygenase in human leukocytes

scientific article published on March 2002

Identification and Characterization of a New Protein Isoform of Human 5-Lipoxygenase

scientific article

Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening

scientific article

Induction of 5-lipoxygenase activation in polymorphonuclear leukocytes by 1-oleoyl-2-acetylglycerol

scientific article

Inhibition of 5-lipoxygenase by U73122 is due to covalent binding to cysteine 416.

scientific article

Inhibition of the functional expression of N-methyl-D-aspartate receptors in a stably transformed cell line by cyclosporin A.

scientific article published on August 2004

Inhibitors of actin polymerisation stimulate arachidonic acid release and 5-lipoxygenase activation by upregulation of Ca2+ mobilisation in polymorphonuclear leukocytes involving Src family kinases

scientific article published in September 2005

Inhibitors of the arachidonic acid cascade: interfering with multiple pathways

scientific article published on 11 October 2013

Intracellular localization of RORalpha is isoform and cell line-dependent

scientific article published on 17 May 2006

Investigation of imatinib and other approved drugs as starting points for antidiabetic drug discovery with FXR modulating activity

scientific article

Involvement of different nuclear hormone receptors in butyrate-mediated inhibition of inducible NF kappa B signalling

scientific article

Isothiocyanate sulforaphane inhibits protooncogenic ornithine decarboxylase activity in colorectal cancer cells via induction of the TGF-β/Smad signaling pathway

scientific article published on October 2010

Lipophilic prodrugs of amino acids and vitamin E as osmolytes for the compensation of hyperosmotic stress in human keratinocytes

scientific article

Lipoxin and resolvin biosynthesis is dependent on 5-lipoxygenase activating protein

scientific article published on 19 August 2015

Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse

scientific article

M1753 Characterization of a Plant-Derived Selective Glucocorticoid Receptor Agonist (SEGRA) for the Treatment of Inflammatory Bowel Disease

scientific article published in May 2010

Mass spectrometry-based proteomics identifies UPF1 as a critical gene expression regulator in MonoMac 6 cells

scientific article published on 24 May 2013

Medicinal Chemistry of Incretin Mimetics and DPP-4 Inhibitors

scientific article published on February 2010

Medicinal chemistry of farnesoid X receptor ligands: from agonists and antagonists to modulators

scientific article published on May 2012

MicroRNA Involved in Inflammation: Control of Eicosanoid Pathway

scientific article published on 21 July 2011

MicroRNAs-novel therapeutic targets of eicosanoid signalling

scientific article published on 18 September 2013

Mo1771 Adiponectin Antagonises Leptin-Induced Hepcidin Expression in Human Liver Cells: New Insights Into Obesity-Associated Iron Deficiency

scientific article published in May 2014

Mo1789 Sulforaphane Inhibits Expression of the Central Iron Regulator Hepcidin STAT3-Independently in an Inflammatory Cell Model

scientific article published in May 2014

Molecular pharmacological profile of the nonredox-type 5-lipoxygenase inhibitor CJ-13,610.

scientific article published on 14 June 2004

Monocyte-derived soluble protein confers 5-lipoxygenase activity Ca2+-dependent

scientific article published on July 2002

N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase/Peroxisome Proliferator-Activated Receptor γ Modulators

scientific article published on 23 November 2015

NSAIDs Ibuprofen, Indometacin, and Diclofenac do not interact with Farnesoid X Receptor

scientific article

Neutrophil Cellular Responses to Various Salmonella typhimurium LPS Chemotypes

article

Nitric oxide mediates distinct effects of various LPS chemotypes on phagocytosis and leukotriene synthesis in human neutrophils

scientific article published in February 2010

Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid

scientific article published on 19 August 2008

Novel insights into the regulation of cyclooxygenase-2 expression by platelet-cancer cell cross-talk

scientific article

Overexpression, refolding, and purification of polyhistidine-tagged human retinoic acid related orphan receptor RORalpha4.

scientific article published on 03 April 2006

PPARgamma is involved in mesalazine-mediated induction of apoptosis and inhibition of cell growth in colon cancer cells

scientific article published on 9 June 2008

Peroxisome proliferator-activated receptor alpha (PPAR alpha) down-regulation in cystic fibrosis lymphocytes

scientific article

PhAST: pharmacophore alignment search tool

scientific article

Pharmacological inhibition of platelet-tumor cell cross-talk prevents platelet-induced overexpression of cyclooxygenase-2 in HT29 human colon carcinoma cells

scientific article published on 11 April 2013

Phosphorylation- and stimulus-dependent inhibition of cellular 5-lipoxygenase activity by nonredox-type inhibitors

scientific article published on 28 March 2003

Phytochemicals resveratrol and sulforaphane as potential agents for enhancing the anti-tumor activities of conventional cancer therapies

scientific article published on January 2012

Pirinixic acids: flexible fatty acid mimetics with various biological activities

scientific article published on 27 August 2015

Post-transcriptional regulation of 5-lipoxygenase mRNA expression via alternative splicing and nonsense-mediated mRNA decay

scientific article

Potent inhibitors of 5-lipoxygenase identified using pseudoreceptors

scientific article published on 19 April 2011

Protein kinase A activates and phosphorylates RORα4 in vitro and takes part in RORα activation by CaMK-IV.

scientific article

R-Flurbiprofen Traps Prostaglandins within Cells by Inhibition of Multidrug Resistance-Associated Protein-4.

scientific article published on 30 December 2016

Recent advances in the search for novel 5-lipoxygenase inhibitors

scientific article

Regulation of steroidogenic acute regulatory protein transcription in largemouth bass by orphan nuclear receptor signaling pathways

scientific article

Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors: A basis for novel drugs targeting cancer cells?

scientific article

Role of DNA methylation and methyl-DNA binding proteins in the repression of 5-lipoxygenase promoter activity

scientific article published on 23 September 2009

Roles of coactosin-like protein (CLP) and 5-lipoxygenase-activating protein (FLAP) in cellular leukotriene biosynthesis

scientific article

Selective glucocorticoid receptor agonists for the treatment of inflammatory bowel disease: studies in mice with acute trinitrobenzene sulfonic acid colitis

scientific article published on 10 January 2012

Selective non-steroidal glucocorticoid receptor agonists attenuate inflammation but do not impair intestinal epithelial cell restitution in vitro

scientific article

Small molecules with anti-inflammatory properties in clinical development

scientific article

Stabilisation and characterisation of the isolated regulatory domain of human 5-lipoxygenase

scholarly article by Mirjam Schröder published in October 2014

Structural modification of resveratrol leads to increased anti-tumor activity, but causes profound changes in the mode of action

scientific article published on 2 June 2015

Structure-activity relationship and in vitro pharmacological evaluation of imidazo[1,2-a]pyridine-based inhibitors of 5-LO.

scientific article published on May 2013

Sulindac sulfide suppresses 5-lipoxygenase at clinically relevant concentrations

scientific article

Synthesis and structure-activity relationship studies of novel dual inhibitors of soluble epoxide hydrolase and 5-lipoxygenase

scientific article

Synthesis of thieno[2,3-b]pyridinones acting as cytoprotectants and as inhibitors of [3H]glycine binding to the N-methyl-D-aspartate (NMDA) receptor

scientific article

Synthesis, cytotoxicity, cellular uptake and influence on eicosanoid metabolism of cobalt-alkyne modified fructoses in comparison to auranofin and the cytotoxic COX inhibitor Co-ASS

scientific article (publication date: 21 June 2005)

TGFβ/SMAD signalling modulates MLL and MLL-AF4 mediated 5-lipoxygenase promoter activation

scientific article published on 10 August 2017

TLR2 ligands augment cPLA2alpha activity and lead to enhanced leukotriene release in human monocytes

scientific article

The 5-lipoxygenase promoter is regulated by DNA methylation

scientific article

The C2-like beta-barrel domain mediates the Ca2+-dependent resistance of 5-lipoxygenase activity against inhibition by glutathione peroxidase-1.

scientific article

The TGFbeta/Smad 3-signaling pathway is involved in butyrate-mediated vitamin D receptor (VDR)-expression

scientific article

The aminosteroid phospholipase C antagonist U-73122 (1-[6-[[17-beta-3-methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione) potently inhibits human 5-lipoxygenase in vivo and in vitro

scientific article

The dietary histone deacetylase inhibitor sulforaphane induces human beta-defensin-2 in intestinal epithelial cells

scientific article published on 27 March 2008

The histone deacetylase inhibitor trichostatin A mediates upregulation of 5-lipoxygenase promoter activity by recruitment of Sp1 to distinct GC-boxes

scientific article published on 17 August 2007

The pharmacology of immunosuppressives

scientific article published in January 2005

The role of diacylglyceride generation by phospholipase D and phosphatidic acid phosphatase in the activation of 5-lipoxygenase in polymorphonuclear leukocytes

scientific article published on 24 January 2008

The treatment of dyslipidemia--what's left in the pipeline?

scientific article published on February 2008

Therapeutic options for 5-lipoxygenase inhibitors

scientific article published on 11 July 2006

Thermodynamic properties of leukotriene A4 hydrolase inhibitors

scientific article

Toponomics analysis of drug-induced changes in arachidonic acid-dependent signaling pathways during spinal nociceptive processing

scientific article published in October 2009

Transient transfection of the human myeloid cell line Mono Mac 6 using electroporation

scientific article published on January 2003

Trichostatin A and structurally related histone deacetylase inhibitors induce 5-lipoxygenase promoter activity

scientific article published on May 2003

Trichostatin A induces 5-lipoxygenase promoter activity and mRNA expression via inhibition of histone deacetylase 2 and 3

scientific article published on July 2012

UPF1 regulates myeloid cell functions and S100A9 expression by the hnRNP E2/miRNA-328 balance

scientific article

Vitamin D in inflammatory diseases

scientific article

ZK 156718, a low calcemic, antiproliferative, and prodifferentiating vitamin D analog

scientific article published in January 2002

Zafirlukast Is a Dual Modulator of Human Soluble Epoxide Hydrolase and Peroxisome Proliferator-Activated Receptor γ

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