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List of works by Rudi Balling

"4D Biology for health and disease" workshop report

scientific article published on 15 October 2010

1alpha,25-Dihydroxyvitamin D3 is a potent suppressor of interferon gamma-mediated macrophage activation

scientific article published on 23 August 2005

A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes

scientific article published on 14 February 2020

A gene for autosomal dominant sacral agenesis maps to the holoprosencephaly region at 7q36.

scientific article

A locus for radiation-induced gastroschisis on mouse Chromosome 7

scientific article published on 01 December 1998

A mouse model for valproate teratogenicity: parental effects, homeotic transformations, and altered HOX expression.

scientific article published in January 2000

A new Pax gene, Pax-9, maps to mouse chromosome 12.

scientific article

A non-functioning vitamin D receptor predisposes to leukaemoid reactions in mice

scientific article published in December 2010

A novel Fanconi anaemia subtype associated with a dominant-negative mutation in RAD51

scientific journal article

A rare loss-of-function variant of ADAM17 is associated with late-onset familial Alzheimer disease

scientific article published on 09 July 2018

A roadmap towards personalized immunology.

scientific article published on 6 February 2018

A systems medicine clinical platform for understanding and managing non- communicable diseases.

scientific article published on January 2014

Accelerating the Development and Validation of New Value-Based Diagnostics by Leveraging Biobanks

scientific article published on June 2016

Addressing the Increased Expectations of Nutrition

scientific article published on 01 August 2019

Aey2, a new mutation in the betaB2-crystallin-encoding gene of the mouse

scientific journal article

An action plan for pan-European defence against new SARS-CoV-2 variants

Analysis of the Pax-3 gene in the mouse mutant splotch

scientific article published on 01 August 1993

Antagonistic Interactions between FGF and BMP Signaling Pathways: A Mechanism for Positioning the Sites of Tooth Formation ⬇️

scientific article published on July 25, 1997

Asparagine and Glutamine Metabolism in Chicks ⬇️

scientific article published on April 1, 1984

Assignment of the paired box gene Pax1 to rat chromosome 3

scientific article published on 01 September 1995

AsthmaMap: an interactive knowledge repository for mechanisms of asthma

scientific article published on 09 December 2020

Author Correction: COVID-19 Disease Map, building a computational repository of SARS-CoV-2 virus-host interaction mechanisms

scientific article published on 17 July 2020

Beethoven, a mouse model for dominant, progressive hearing loss DFNA36.

scientific article

COVID-19 Disease Map, building a computational repository of SARS-CoV-2 virus-host interaction mechanisms

scientific article published on 05 May 2020

CRABP and the teratogenic effects of retinoids ⬇️

scientific article published on 01 February 1991

Cadherin-11 is highly expressed in rhabdomyosarcomas and during differentiation of myoblasts in vitro

scientific article published on 01 January 1999

Challenges associated with projecting urbanization-induced heat-related mortality.

scientific article

Characterization and developmental expression of Pax9, a paired-box-containing gene related to Pax1

scientific article

Characterization of Differentiated SH-SY5Y as Neuronal Screening Model Reveals Increased Oxidative Vulnerability

scientific article

Characterization of a new, dominant V124E mutation in the mouse alphaA-crystallin-encoding gene

scientific journal article

Chromosomal localization of the murine cadherin-11

scientific article published on 01 April 1995

Cloning and expression analysis of a novel mesodermally expressed cadherin.

scientific article

Commentaries on "Informatics and medicine: from molecules to populations"

scientific article (publication date: 2008)

Common diseases alter the physiological age-related blood microRNA profile

scientific article published on 24 November 2020

Community-driven roadmap for integrated disease maps

scientific article published on 23 April 2018

Comparative analysis of the genomic organization of Pax9 and its conserved physical association with Nkx2-9 in the human, mouse, and pufferfish genomes.

scientific article published in March 2001

Comprehensive blood metabolomics profiling of Parkinson’s disease reveals coordinated alterations in xanthine metabolism

scientific article published on 19 March 2024

Conditional inactivation of Sox9: a mouse model for campomelic dysplasia

scientific article published in February 2002

Connecting environmental exposure and neurodegeneration using cheminformatics and high resolution mass spectrometry: potential and challenges

scientific article published on 01 September 2019

Critical transitions in chronic disease: transferring concepts from ecology to systems medicine

scientific article

Degree of methylation of transgenes is dependent on gamete of origin

scientific article published in Nature

Deletion of deoxyribonucleic acid binding domain of the vitamin D receptor abrogates genomic and nongenomic functions of vitamin D.

scientific article published in July 2002

Development(s) in mouse genetics

scientific article published on 01 February 1990

Direct effects of nicotine on rabbit preimplantation embryos

scientific article published on 01 March 1985

Diseases as network perturbations

scientific article published on 13 August 2010

Dynamic cumulative activity of transcription factors as a mechanism of quantitative gene regulation.

scientific article

ENU Mutagenesis: Analyzing Gene Function in Mice ⬇️

scientific article published on January 1, 2001

Effect of dietary asparagine and protein-equivalents in crystalline amino acid diets on asparagine metabolism in chicks

scientific article published on 01 October 1981

Embryonic development of selectively vulnerable neurons in Parkinson's disease.

scientific article

Emergence of the silicon human and network targeting drugs

article

Erratum to: Making sense of big data in health research: towards an EU action plan

scientific article

Ethylnitrosourea-induced mutation in mice leads to the expression of a novel protein in the eye and to dominant cataracts.

scientific article

Evaluating the Use of Circulating MicroRNA Profiles for Lung Cancer Detection in Symptomatic Patients

scientific article published on 05 March 2020

Exome-wide analysis of mutational burden in patients with typical and atypical Rolandic epilepsy

scientific article

Expression and function of Pax 1 during development of the pectoral girdle ⬇️

scientific article published on October 1, 1994

Expression of avian Pax1 and Pax9 is intrinsically regulated in the pharyngeal endoderm, but depends on environmental influences in the paraxial mesoderm.

scientific article published in September 1996

Finding and sharing: new approaches to registries of databases and services for the biomedical sciences

scientific article

Fine genetic mapping of the proximal part of mouse chromosome 2 excludes Pax-8 as a candidate gene for Danforth's short tail (Sd)

scientific article published on 01 January 1993

From developmental biology to developmental toxicology.

scientific article published on January 2000

From hype to reality: data science enabling personalized medicine

scientific article published on 27 August 2018

From mouse genetics to systems biology

scientific article published on July 2007

From parathyroid to thymus, via glial cells

scientific article published on 01 August 2000

From systems biology to systems biomedicine

scientific article

Functional analysis of genes involved in skeletal development

scientific article published on 01 January 2000

Gene Regulatory Network Inference of Immunoresponsive Gene 1 (IRG1) Identifies Interferon Regulatory Factor 1 (IRF1) as Its Transcriptional Regulator in Mammalian Macrophages

scientific article published on 12 February 2016

Genes associated with Parkinson's disease respond to increasing polychlorinated biphenyl levels in the blood of healthy females

article

Genetic and molecular control of folate-homocysteine metabolism in mutant mice

scientific article

Genome-wide, large-scale production of mutant mice by ENU mutagenesis.

scientific article

Global implementation of genomic medicine: We are not alone

scientific article

Great times for mouse genetics: getting ready for large-scale ENU-mutagenesis

article

Humanized mice for modeling human infectious disease: challenges, progress, and outlook.

scientific article published on July 2009

Hydrogen peroxide-mediated killing of Caenorhabditis elegans by Streptococcus pyogenes

scientific article

Identification of immunological relevant phenotypes in ENU mutagenized mice

scholarly article by Heinrich Flaswinkel et al published July 2000 in Mammalian Genome

Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

scientific article

Impaired insulin secretory capacity in mice lacking a functional vitamin D receptor

scientific article

In situ gene expression analysis during BMP2-induced ectopic bone formation in mice shows simultaneous endochondral and intramembranous ossification

scientific article published on 01 December 2002

Influenza H3N2 infection of the collaborative cross founder strains reveals highly divergent host responses and identifies a unique phenotype in CAST/EiJ mice

scientific article

Initial steps of myogenesis in somites are independent of influence from axial structures.

scientific article published in November 1994

Insertion of a bacterial gene into the mouse germ line using an infectious retrovirus vector.

scientific article published on December 1985

Integrating pathways of Parkinson's disease in a molecular interaction map.

scientific article published on 07 July 2013

Integration and Visualization of Translational Medicine Data for Better Understanding of Human Diseases

scientific article

Interaction between undulated and Patch leads to an extreme form of spina bifida in double-mutant mice.

scientific article published in September 1995

Introduction

scientific article published in August 2018

Isolation of the Pax9 cDNA from adult human esophagus

scientific article

Large-Scale N -Ethyl-N -Nitrosourea Mutagenesis of Mice - from Phenotypes to Genes

article

Large-scale validation of miRNAs by disease association, evolutionary conservation and pathway activity

scientific article published on 26 December 2018

Loss of SYNJ1 dual phosphatase activity leads to early onset refractory seizures and progressive neurological decline.

scientific article published on 19 July 2016

MIC-MAC: An automated pipeline for high-throughput characterization and classification of three-dimensional microglia morphologies in mouse and human postmortem brain samples

scientific article published on 14 April 2019

MINERVA-a platform for visualization and curation of molecular interaction networks

scientific article published on 22 September 2016

Maintaining your immune system--one method for enhanced longevity

scientific article published on 7 January 2004

Making sense of big data in health research: Towards an EU action plan

scientific article

Mapping of the Mod-1 locus on mouse chromosome 9

scientific article published on 01 January 1993

Mice, microbes and models of infection

scientific article

Mitochondria interaction networks show altered topological patterns in Parkinson's disease

scientific article published on 10 November 2020

Moratorium call

scientific article published in Nature

Mutation in the betaA3/A1-crystallin encoding gene Cryba1 causes a dominant cataract in the mouse

scientific article (publication date: 15 November 1999)

Mutations in STX1B, encoding a presynaptic protein, cause fever-associated epilepsy syndromes

scientific article published on 2 November 2014

Neurodegeneration by activation of the microglial complement-phagosome pathway.

scientific article

Neurological Diseases from a Systems Medicine Point of View

scientific article published on January 2016

Nutrition and the 2020 Pandemic

scientific article published on 01 September 2020

Oct-4: a germline-specific transcription factor mapping to the mouse t-complex

scientific journal article

PLAU inferred from a correlation network is critical for suppressor function of regulatory T cells

scientific article published on January 2012

Parkinson's disease mouse models in translational research

scientific article published on 11 May 2011

Pax genes and organogenesis.

scientific article

Pax genes and organogenesis: Pax9 meets tooth development.

scientific article published on January 1998

Pax-1, a regulator of sclerotome development is induced by notochord and floor plate signals in avian embryos.

scientific article published in April 1995

Pax1 and Pax9 activate Bapx1 to induce chondrogenic differentiation in the sclerotome

scientific journal article

Pax1 and Pax9 synergistically regulate vertebral column development.

scientific article published in December 1999

Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities.

scientific article

Pituitary Tumor Transforming Gene 1 Orchestrates Gene Regulatory Variation in Mouse Ventral Midbrain During Aging

scientific article published on 23 September 2020

Platelet mitochondrial membrane potential in Parkinson's disease

scientific article

Position-specific activity of the Hox1.1 promoter in transgenic mice

scientific article published on 01 March 1990

Presenting and sharing clinical data using the eTRIKS Standards Master Tree for tranSMART

Progressive loss of PAX9 expression correlates with increasing malignancy of dysplastic and cancerous epithelium of the human oesophagus

scientific article (publication date: July 2002)

ROS networks: designs, aging, Parkinson's disease and precision therapies

scientific article published on 26 October 2020

Rare ABCA7 variants in 2 German families with Alzheimer disease

scientific article published on 21 March 2018

Rare GABRA3 variants are associated with epileptic seizures, encephalopathy and dysmorphic features

scientific article

Rare coding variants in genes encoding GABAA receptors in genetic generalised epilepsies: an exome-based case-control study

article

Reborn for a new era

scientific article published in Nature

Recessive loss-of-function mutations in AP4S1 cause mild fever-sensitive seizures, developmental delay and spastic paraplegia through loss of AP-4 complex assembly.

scientific article

Recessive mutations in SLC13A5 result in a loss of citrate transport and cause neonatal epilepsy, developmental delay and teeth hypoplasia

scientific article

Recessive mutations in SLC35A3 cause early onset epileptic encephalopathy with skeletal defects

scientific article published in April 2017

Reduced intragraft mRNA expression of matrix metalloproteinases Mmp3, Mmp12, Mmp13 and Adam8, and diminished transplant arteriosclerosis in Ccr5-deficient mice

scientific article published on 01 September 2004

Reliable recovery of inbred mouse lines using cryopreserved spermatozoa.

scientific article published on August 1999

Respiratory mechanics in mice: strain and sex specific differences.

scientific article

Reverse engineering and verification of gene networks: principles, assumptions, and limitations of present methods and future perspectives.

scientific article published on 22 July 2009

Revolutionizing medicine in the 21st century through systems approaches

scientific article published on 20 July 2012

Screening for dysmorphological abnormalities—a powerful tool to isolate new mouse mutants

article published in 2000

Segment-specific expression of the gap junction gene connexin31 during hindbrain development

scientific article published on 01 November 1997

Separate elements cause lineage restriction and specify boundaries of Hox-1.1 expression ⬇️

scientific article published on May 1, 1991

Sequence interpretation. Functional annotation of mouse genome sequences

scientific article

Similar α-Synuclein staining in the colon mucosa in patients with Parkinson's disease and controls

scientific article published on 21 June 2016

Single-cell transcriptomics reveals distinct inflammation-induced microglia signatures

scientific article published on 11 September 2018

Structure, expression and chromosomal location of the Oct-4 gene.

scientific article published in November 1991

Sudden and unexpected

scientific article published on 01 December 2007

Systems genomics evaluation of the SH-SY5Y neuroblastoma cell line as a model for Parkinson's disease

scientific article

Systems medicine and integrated care to combat chronic noncommunicable diseases

scientific article

Systems medicine approaches for the definition of complex phenotypes in chronic diseases and ageing. From concept to implementation and policies

scientific article published on January 2014

Systems medicine disease maps: community-driven comprehensive representation of disease mechanisms.

scientific article published on 2 June 2018

Tailchaser (Tlc): a new mouse mutation affecting hair bundle differentiation and hair cell survival.

scientific article published in October 1999

Targeted disruption of Pax1 defines its null phenotype and proves haploinsufficiency

scientific article

Targeted disruption of the peptide transporter Pept2 gene in mice defines its physiological role in the kidney

scientific article published in May 2003

Teeth. Where and how to make them.

scientific article

The European dimension for the mouse genome mutagenesis program

scientific article

The Luxembourg Parkinson's Study: A Comprehensive Approach for Stratification and Early Diagnosis

scholarly article by Geraldine Hipp et al published 2018 in Frontiers in Aging Neuroscience

The Notch ligand Jagged1 is required for inner ear sensory development.

scholarly article

The P4 Health Spectrum - A Predictive, Preventive, Personalized and Participatory Continuum for Promoting Healthspan

scientific article

The SOX10/Sox10 gene from human and mouse: sequence, expression, and transactivation by the encoded HMG domain transcription factor

scientific article

The biochemical metabolite screen in the Munich ENU Mouse Mutagenesis Project: determination of amino acids and acylcarnitines by tandem mass spectrometry

The clinical-chemical screen in the Munich ENU Mouse Mutagenesis Project: screening for clinically relevant phenotypes

article by Birgit Rathkolb et al published July 2000 in Mammalian Genome

The genetic map around the tail kinks (tk) locus on mouse chromosome 9

scientific article published on 01 January 1993

The genetics of skeletal development.

scientific article

The hallmarks of Parkinson's disease

scientific article published on 10 June 2013

The large-scale Munich ENU-mouse-mutagenesis screen

The molecular and genetic analysis of mouse development ⬇️

scientific article published on February 15, 1992

The mouse brain metabolome: region-specific signatures and response to excitotoxic neuronal injury.

scientific article published on 28 April 2015

The role of Pax-1 in axial skeleton development.

scientific article

The role of regulatory T cells in neurodegenerative diseases ⬇️

scientific article published on August 15, 2012

The ventralizing effect of the notochord on somite differentiation in chick embryos

scientific article published on 01 September 1993

Thymopoiesis requires Pax9 function in thymic epithelial cells

scientific journal article

Toward Omics-Based, Systems Biomedicine, and Path and Drug Discovery Methodologies for Depression-Inflammation Research

scientific article published on 02 May 2015

Understanding complexity in neurodegenerative diseases: in silico reconstruction of emergence

scientific article published on 23 July 2012

V76D mutation in a conserved gD-crystallin region leads to dominant cataracts in mice

scientific article published on 01 August 2002

Waardenburg's syndrome patients have mutations in the human homologue of the Pax-3 paired box gene

scientific article (publication date: 13 February 1992)

Whose law for sharing research tools?

journal article; published in Nature, 1998-12

Workshop Report: Systems Genetics of Neurodegenerative Disease, a Summer School in Systems Medicine, 25th August-1st September 2017

article

[Transgenic mice--biological fundamentals, practices and applications]

scientific article published on 01 March 1994

undulated, a mutation affecting the development of the mouse skeleton, has a point mutation in the paired box of Pax 1

scientific article published on 01 November 1988

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