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List of works by Gordon J. Lithgow

A Caenorhabditis elegans Model Elucidates a Conserved Role for TRPA1-Nrf Signaling in Reactive α-Dicarbonyl Detoxification

scientific article

A DNA synthesis inhibitor is protective against proteotoxic stressors via modulation of fertility pathways in Caenorhabditis elegans

scientific article published on October 2013

A Simple Method for High Throughput Chemical Screening in Caenorhabditis Elegans

scientific article published on 20 March 2018

A long journey to reproducible results ⬇️

scientific article published on August 2017

A new look at old compounds ⬇️

scientific article published on April 1, 2011

A simplified design for the C. elegans lifespan machine

scientific article published on 26 October 2020

Acarbose improves health and lifespan in aging HET3 mice

scientific article published on 27 January 2019

Age-related micro-RNA abundance in individual C. elegans ⬇️

scientific article published on June 1, 2013

Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice

scientific article published on 01 September 2020

Aluminium exposure disrupts elemental homeostasis in Caenorhabditis elegans

scientific article published on 26 April 2012

Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan ⬇️

scientific article published on March 30, 2011

An automated high-throughput assay for survival of the nematode Caenorhabditis elegans.

scientific article

Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson's Disease

scientific article

Anti-inflammatory role of the isoflavone diadzein in lipopolysaccharide-stimulated microglia: implications for Parkinson's disease.

scientific article published on 10 May 2012

Automated lifespan determination across Caenorhabditis strains and species reveals assay-specific effects of chemical interventions

scientific article published on 10 December 2019

Caenorhabditis Intervention Testing Program: the creatine analog β-guanidinopropionic acid does not extend lifespan in nematodes

scientific article published on 02 January 2020

Caenorhabditis Intervention Testing Program: the farnesoid X receptor agonist obeticholic acid does not robustly extend lifespan in nematodes

scientific article published on 27 May 2020

Caenorhabditis Intervention Testing Program: the tyrosine kinase inhibitor imatinib mesylate does not extend lifespan in nematodes

scientific article published on 03 July 2019

Checkpoint proteins control survival of the postmitotic cells in Caenorhabditis elegans

scientific article published on June 2006

Chemical activation of a food deprivation signal extends lifespan

scientific article

Compounds that confer thermal stress resistance and extended lifespan

scientific article published on 20 September 2008

Cost-free longevity in mice?

scientific article published in Nature

Curcumin and neurodegenerative diseases ⬇️

scientific article published on January 10, 2013

DAF-12-dependent rescue of dauer formation in Caenorhabditis elegans by (25S)-cholestenoic acid

scientific article published on August 2006

Dimethyl sulfoxide and dimethyl formamide increase lifespan of C. elegans in liquid ⬇️

scientific article published on January 11, 2013

Does anti-aging equal anti-microbial?

scientific article

Dysregulated iron metabolism in C. elegans catp-6/ATP13A2 mutant impairs mitochondrial function

scientific article published on 05 February 2020

Fitness cost of extended lifespan in Caenorhabditis elegans

scientific article published on 01 December 2004

From discoveries in ageing research to therapeutics for healthy ageing

scientific article published on 10 July 2019

Geroscience: linking aging to chronic disease

scientific article

Identification of a novel cis-regulatory element involved in the heat shock response in Caenorhabditis elegans using microarray gene expression and computational methods

scientific article

Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects

scientific article

Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans

scientific article

Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans

scientific article

Iron promotes protein insolubility and aging in C. elegans

scientific article published on November 2014

Kavain suppresses human Aβ-induced paralysis in C. elegans

scientific article published on 21 May 2020

Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans

scientific article

Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin-like signals

scientific article published on 01 April 2003

Lifespan extension of Caenorhabditis elegans following repeated mild hormetic heat treatments

scientific article published on 07 July 2006

Lipophilic regulator of a developmental switch in Caenorhabditis elegans

scientific article published in December 2004

Long live FOXO: unraveling the role of FOXO proteins in aging and longevity

scientific article

Longitudinal Functional Study of Murine Aging: A Resource for Future Study Designs

scientific article published on 16 February 2021

Loss of NDG-4 extends lifespan and stress resistance in Caenorhabditis elegans

scientific article

M142.2 (cut-6), a novel Caenorhabditis elegans matrix gene important for dauer body shape

scientific article published in August 2003

Manganese disturbs metal and protein homeostasis in Caenorhabditis elegans

scientific article published on 24 July 2014

Manganous ion supplementation accelerates wild type development, enhances stress resistance, and rescues the life span of a short-lived Caenorhabditis elegans mutant

scientific article

MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8

scientific article

Mitochondrial Quality Control via the PGC1α-TFEB Signaling Pathway Is Compromised by Parkin Q311X Mutation But Independently Restored by Rapamycin

scientific article

N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans

scientific article

Natural Genetic Variation in Yeast Reveals That NEDD4 Is a Conserved Modifier of Mutant Polyglutamine Aggregation

scientific article published on 06 November 2018

Oxidative stress in Caenorhabditis elegans: protective effects of superoxide dismutase/catalase mimetics.

scientific article

Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans

scientific article published on 24 October 2007

Pharmacological intervention in invertebrate aging.

scientific article

Pharmacological lifespan extension of invertebrates

scientific article published on 6 July 2012

Pharmacological maintenance of protein homeostasis could postpone age‐related disease ⬇️

scientific article published on February 1, 2012

Polyunsaturated fatty acids and p38-MAPK link metabolic reprogramming to cytoprotective gene expression during dietary restriction

scientific article published on 25 September 2020

Proteomic analysis of age‐dependent changes in protein solubility identifies genes that modulate lifespan ⬇️

scientific article published on December 11, 2011

Quantification of Insoluble Protein Aggregation in Caenorhabditis elegans during Aging with a Novel Data-Independent Acquisition Workflow

scientific article published on 07 August 2020

S.W.A.T.--SOD weapons and tactics

scientific article

Science fact and the SENS agenda. What can we reasonably expect from ageing research?

scientific article

Stress biology and aging mechanisms: toward understanding the deep connection between adaptation to stress and longevity

scientific article

Stress resistance as a determinate of C. elegans lifespan

scientific article

Taurine deficiency as a driver of aging

scientific article published on 08 June 2023

The C. elegans ortholog of mammalian Ku70, interacts with insulin-like signaling to modulate stress resistance and life span.

scientific article published on 12 August 2005

The Caenorhabditis elegans K10C2.4 gene encodes a member of the fumarylacetoacetate hydrolase family: a Caenorhabditis elegans model of type I tyrosinemia

scientific article published on 28 January 2008

The nuclear hormone receptor DAF-12 has opposing effects on Caenorhabditis elegans lifespan and regulates genes repressed in multiple long-lived worms

scientific article published in April 2006

Tor1 regulates protein solubility in Saccharomyces cerevisiae ⬇️

scientific article published on October 24, 2012

Translating longevity research into healthspan

scientific article published on 3 September 2012

Trimethylamine modulates dauer formation, neurodegeneration, and lifespan through tyra-3/daf-11 signaling in Caenorhabditis elegans

scientific article published on 05 April 2021

Using Caenorhabditis elegans as a model for aging and age-related diseases

scientific article

Vitamin D Promotes Protein Homeostasis and Longevity via the Stress Response Pathway Genes skn-1, ire-1, and xbp-1.

scientific article

Why aging isn't regulated: a lamentation on the use of language in aging literature

scientific article published on 7 September 2006

Zinc Levels Modulate Lifespan through Multiple Longevity Pathways in Caenorhabditis elegans

scientific article (publication date: 2016)

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