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List of works by Alan W Thomas

A class of potent antimalarials and their specific accumulation in infected erythrocytes

scientific article published on February 2002

A diversity-covering approach to immunization with Plasmodium falciparum apical membrane antigen 1 induces broader allelic recognition and growth inhibition responses in rabbits

scientific article published on 31 March 2008

A large focus of naturally acquired Plasmodium knowlesi infections in human beings

scientific article

A malaria vaccine based on the polymorphic block 2 region of MSP-1 that elicits a broad serotype-spanning immune response

scientific article

A novel method to clean protein G agarose for affinity column matrix with renewed binding capacity and high IgG selectivity

scientific article published on 03 November 2009

A role for apical membrane antigen 1 during invasion of hepatocytes by Plasmodium falciparum sporozoites

scientific article (publication date: 5 March 2004)

Allelic diversity and naturally acquired allele-specific antibody responses to Plasmodium falciparum apical membrane antigen 1 in Kenya

scientific article

Antibodies to malaria peptide mimics inhibit Plasmodium falciparum invasion of erythrocytes ⬇️

scientific article

Antibody response of naturally infected individuals to recombinant Plasmodium vivax apical membrane antigen-1.

scientific article published on 19 December 2004

Antibody responses to a novel Plasmodium falciparum merozoite surface protein vaccine correlate with protection against experimental malaria infection in Aotus monkeys

scientific article published on 08 January 2014

Apical membrane antigen 1: a malaria vaccine candidate in review

scientific article published on 15 January 2008

Breadth and magnitude of antibody responses to multiple Plasmodium falciparum merozoite antigens are associated with protection from clinical malaria

scientific article published on 3 March 2008

Comparative characterization of hexose transporters of Plasmodium knowlesi, Plasmodium yoelii and Toxoplasma gondii highlights functional differences within the apicomplexan family

scientific article (publication date: 15 December 2002)

Comparative testing of six antigen-based malaria vaccine candidates directed toward merozoite-stage Plasmodium falciparum

scientific article published on 11 June 2008

Correction: MVA.85A Boosting of BCG and an Attenuated, Deficient Vaccine Both Show Protective Efficacy Against Tuberculosis in Rhesus Macaques

Cross-reactivity studies of an anti-Plasmodium vivax apical membrane antigen 1 monoclonal antibody: binding and structural characterisation

scientific article

Crystal structure of Plasmodium knowlesi apical membrane antigen 1 and its complex with an invasion-inhibitory monoclonal antibody ⬇️

scientific article published on 17 April 2015

Crystal structure of the malaria vaccine candidate apical membrane antigen 1.

scientific article published on 24 February 2005

Deep coverage mouse red blood cell proteome: a first comparison with the human red blood cell

scientific article

Deep-coverage rhesus red blood cell proteome: a first comparison with the human and mouse red blood cell

scientific article

Detection of new Babesia microti-like parasites in a rhesus monkey (Macaca mulatta) with a suppressed Plasmodium cynomolgi infection.

scientific article published in April 2008

Differential evidence of natural selection on two leading sporozoite stage malaria vaccine candidate antigens

scientific article published on 25 September 2006

Diversity covering AMA1-MSP119 fusion proteins as malaria vaccines

scientific article published on 19 February 2013

Effect of adjuvant on reactogenicity and long-term immunogenicity of the malaria Vaccine ICC-1132 in macaques

scientific article published in September 2005

Erratum: CORRIGENDUM: Genome variation and evolution of the malaria parasite Plasmodium falciparum

scientific article published in March 2007

Erratum: Corrigendum: Genome variation and evolution of the malaria parasite Plasmodium falciparum

scientific article published in April 2007

Evidence for diversifying selection on erythrocyte-binding antigens of Plasmodium falciparum and P. vivax

scientific article

Experimental infection of the olive baboon (Paplio anubis) with Plasmodium knowlesi: severe disease accompanied by cerebral involvement

scientific article published in August 2003

Expression, crystallization and preliminary structural analysis of the ectoplasmic region of apical membrane antigen 1 from Plasmodium vivax, a malaria-vaccine candidate

scientific article published on 20 October 2004

Fine mapping of an epitope recognized by an invasion-inhibitory monoclonal antibody on the malaria vaccine candidate apical membrane antigen 1.

scientific article published on 27 December 2006

Generation of humoral immune responses to multi-allele PfAMA1 vaccines; effect of adjuvant and number of component alleles on the breadth of response

scientific article (publication date: 3 November 2010)

Genome sequencing of chimpanzee malaria parasites reveals possible pathways of adaptation to human hosts.

scientific article

Genome variation and evolution of the malaria parasite Plasmodium falciparum

scientific article published on 10 December 2006

Heterologous promoter activity in stable and transient Plasmodium knowlesi transgenes

scientific article published on 01 August 2003

High-Level Expression of the Malaria Blood-Stage Vaccine Candidate Plasmodium falciparum Apical Membrane Antigen 1 and Induction of Antibodies That Inhibit Erythrocyte Invasion.

scientific article published in October 2002

High-level expression of the malaria blood-stage vaccine candidate Plasmodium falciparum apical membrane antigen 1 and induction of antibodies that inhibit erythrocyte invasion ⬇️

scientific article

Human antibodies to recombinant protein constructs of Plasmodium falciparum Apical Membrane Antigen 1 (AMA1) and their associations with protection from malaria

scientific article

Humoral immune response to mixed PfAMA1 alleles; multivalent PfAMA1 vaccines induce broad specificity

scientific article

Humoral immune responses to a single allele PfAMA1 vaccine in healthy malaria-naïve adults

scientific article (publication date: 2012)

Immunization with different PfAMA1 alleles in sequence induces clonal imprint humoral responses that are similar to responses induced by the same alleles as a vaccine cocktail in rabbits

scientific article (publication date: 14 February 2011)

In-depth analysis of the membrane and cytosolic proteome of red blood cells

scientific article published on August 2006

Interplay between AMA1 immunisation and parasite challenge leads to protection against malaria infection in rhesus macaques

scientific article published on 20 October 2010

KAI407, a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro

scientific article published on 23 December 2013

MVA.85A boosting of BCG and an attenuated, phoP deficient M. tuberculosis vaccine both show protective efficacy against tuberculosis in rhesus macaques

scientific article

Malaria infection by sporozoite challenge induces high functional antibody titres against blood stage antigens after a DNA prime, poxvirus boost vaccination strategy in Rhesus macaques

scientific article

Malaria vaccine-related benefits of a single protein comprising Plasmodium falciparum apical membrane antigen 1 domains I and II fused to a modified form of the 19-kilodalton C-terminal fragment of merozoite surface protein 1

scientific article

Malaria: towards a new treatment!

scientific article published in April 2005

Mode of action of invasion-inhibitory antibodies directed against apical membrane antigen 1 of Plasmodium falciparum ⬇️

scientific article published on April 2005

Multi-plasmid DNA vaccination avoids antigenic competition and enhances immunogenicity of a poorly immunogenic plasmid

article

Natural human antibody responses to Plasmodium vivax apical membrane antigen 1 under low transmission and unstable malaria conditions in Sri Lanka.

scientific article

New selectable markers and single crossover integration for the highly versatile Plasmodium knowlesi transfection system

scientific article published in March 2004

Orthologous gene sequences of merozoite surface protein 1 (MSP1) from Plasmodium reichenowi and P. gallinaceum confirm an ancient divergence of P. falciparum alleles

scientific article

Phage-displayed peptides bind to the malarial protein apical membrane antigen-1 and inhibit the merozoite invasion of host erythrocytes.

scientific article

Phase 1 randomized controlled trial to evaluate the safety and immunogenicity of recombinant Pichia pastoris-expressed Plasmodium falciparum apical membrane antigen 1 (PfAMA1-FVO [25-545]) in healthy Malian adults in Bandiagara

scientific article published on 30 August 2016

Plasmodium CDP-DAG synthase: an atypical gene with an essential N-terminal extension

scientific article published on 10 April 2010

Plasmodium falciparum 19-kilodalton merozoite surface protein 1 (MSP1)-specific antibodies that interfere with parasite growth in vitro can inhibit MSP1 processing, merozoite invasion, and intracellular parasite development ⬇️

scientific article published on 27 December 2011

Plasmodium falciparum apical membrane antigen 1 (PfAMA-1) is translocated within micronemes along subpellicular microtubules during merozoite development

scientific article published on 05 August 2003

Plasmodium falciparum-activated chloride channels are defective in erythrocytes from cystic fibrosis patients.

scientific article published on 16 December 2003

Plasmodium knowlesi provides a rapid in vitro and in vivo transfection system that enables double-crossover gene knockout studies

scientific article

Plasmodium vivax: in vitro susceptibility of blood stages to synthetic trioxolane compounds and the diamidine DB75.

scientific article published on 3 February 2006

Preclinical evaluation of a chimeric malaria vaccine candidate in Montanide ISA 720: immunogenicity and safety in rhesus macaques

scientific article published in September 2006

Prodrugs of bisthiazolium salts are orally potent antimalarials

scholarly article

Production, Quality Control, Stability and Pharmacotoxicity of a Malaria Vaccine Comprising Three Highly Similar PfAMA1 Protein Molecules to Overcome Antigenic Variation

scientific article

Production, quality control, stability and pharmacotoxicity of cGMP-produced Plasmodium falciparum AMA1 FVO strain ectodomain expressed in Pichia pastoris

scientific article published on 17 September 2008

Prospective identification of malaria parasite genes under balancing selection

scientific article published on 15 May 2009

Proteomic and genetic analyses demonstrate that Plasmodium berghei blood stages export a large and diverse repertoire of proteins

scientific article published on 28 November 2012

Red blood cell (RBC) membrane proteomics--Part I: Proteomics and RBC physiology

scientific article published on 21 June 2009

Red blood cell (RBC) membrane proteomics--Part II: Comparative proteomics and RBC patho-physiology

scientific article published on 19 July 2009

Reduced CD36-dependent tissue sequestration of Plasmodium-infected erythrocytes is detrimental to malaria parasite growth in vivo

scientific article published on 19 December 2011

Safety and immunogenicity of a recombinant Plasmodium falciparum AMA1 malaria vaccine adjuvanted with Alhydrogel, Montanide ISA 720 or AS02.

scientific article

Safety and immunogenicity of multi-antigen AMA1-based vaccines formulated with CoVaccine HTTM and Montanide ISA 51 in rhesus macaques

scientific article (publication date: 4 July 2011)

Statistical model to evaluate in vivo activities of antimalarial drugs in a Plasmodium cynomolgi-macaque model for Plasmodium vivax malaria

scientific article

Structural comparison of apical membrane antigen 1 orthologues and paralogues in apicomplexan parasites

scientific article published in 2005

Suppression of Plasmodium cynomolgi in rhesus macaques by coinfection with Babesia microti

scientific article

Targeted deletion of Plasmodium knowlesi Duffy binding protein confirms its role in junction formation during invasion

scientific article published in March 2005

The RON2-AMA1 interaction is a critical step in moving junction-dependent invasion by apicomplexan parasites

scientific article (publication date: 10 February 2011)

Towards an in vitro model of Plasmodium hypnozoites suitable for drug discovery

scientific article

Transfected Plasmodium knowlesi produces bioactive host gamma interferon: a new perspective for modulating immune responses to malaria parasites

scientific article

Transgenic Plasmodium knowlesi: relieving a bottleneck in malaria research?

scientific article published on 25 July 2009

Transgenic fluorescent Plasmodium cynomolgi liver stages enable live imaging and purification of Malaria hypnozoite-forms

scientific article

Vaccination with Plasmodium knowlesi AMA1 formulated in the novel adjuvant co-vaccine HT™ protects against blood-stage challenge in rhesus macaques

scientific article (publication date: 2011)

Variable BCG efficacy in rhesus populations: Pulmonary BCG provides protection where standard intra-dermal vaccination fails.

scientific article

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