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Authors whose works are in public domain in at least one jurisdiction

List of works by Xuelei Yan

Discovery and initial SAR of arylsulfonylpiperazine inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)

scientific article

Discovery and optimization of piperidyl benzamide derivatives as a novel class of 11beta-HSD1 inhibitors

scientific article

Discovery of AM-7209, a potent and selective 4-amidobenzoic acid inhibitor of the MDM2-p53 interaction

scientific article

Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development

scientific article

Discovery of Potent and Simplified Piperidinone-Based Inhibitors of the MDM2-p53 Interaction

scientific article

Discovery of novel, potent benzamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) exhibiting oral activity in an enzyme inhibition ex vivo model

scientific article

Distinctive molecular inhibition mechanisms for selective inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1

scientific article

Novel inhibitors of the MDM2-p53 interaction featuring hydrogen bond acceptors as carboxylic acid isosteres

scientific article

Optimization of novel di-substituted cyclohexylbenzamide derivatives as potent 11 beta-HSD1 inhibitors

scientific article

Rational design and binding mode duality of MDM2-p53 inhibitors

scientific article

Selective and potent morpholinone inhibitors of the MDM2-p53 protein-protein interaction

scientific article

Structure-Based Design of Novel Inhibitors of the MDM2–p53 Interaction ⬇️

scientific article published on May 9, 2012

Synthesis and optimization of novel 4,4-disubstituted cyclohexylbenzamide derivatives as potent 11β-HSD1 inhibitors ⬇️

scientific article published on October 31, 2010

The synthesis and SAR of novel diarylsulfone 11β-HSD1 inhibitors ⬇️

scientific article published on September 29, 2010

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