List of works - Birte Kalveram

A single-cycle replicable Rift Valley fever phlebovirus vaccine carrying a mutated NSs confers full protection from lethal challenge in mice

scientific article published in Scientific Reports

Characterization of Rift Valley fever virus MP-12 strain encoding NSs of Punta Toro virus or sandfly fever Sicilian virus

scientific article

Degradation of FAT10 by the 26S proteasome is independent of ubiquitylation but relies on NUB1L.

scientific article published on 21 January 2009

Discovery of Adamantane Carboxamides as Ebola Virus Cell Entry and Glycoprotein Inhibitors

scientific article published on 01 May 2020

FAT10, a ubiquitin-independent signal for proteasomal degradation

scientific article

Favipiravir (T-705) protects against Nipah virus infection in the hamster model.

scientific article

Filovirus Virulence in Interferon α/β and γ Double Knockout Mice, and Treatment with Favipiravir

scientific article published in 2019

Functional analysis of Rift Valley fever virus NSs encoding a partial truncation

scientific article

Furin Cleavage Site Is Key to SARS-CoV-2 Pathogenesis

scientific article published on 26 August 2020

Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis

scientific article published on 25 January 2021

NSs protein of rift valley fever virus promotes posttranslational downregulation of the TFIIH subunit p62.

scientific article published on 4 May 2011

Natural History and Pathogenesis of Wild-Type Marburg Virus Infection in STAT2 Knockout Hamsters

scholarly article by Colm Atkins et al published 22 November 2018 in Journal of Infectious Diseases

Peptidoglycan associated cyclic lipopeptide disrupts viral infectivity

scientific article published on 14 May 2019

Peptidoglycan-Associated Cyclic Lipopeptide Disrupts Viral Infectivity

scientific article published on 29 October 2019

Rift Valley fever virus MP-12 vaccine encoding Toscana virus NSs retains neuroinvasiveness in mice

scientific article published on 20 March 2013

Rift Valley fever virus NSs inhibits host transcription independently of the degradation of dsRNA-dependent protein kinase PKR.

scientific article published on 12 October 2012

SAR studies of 4-acyl-1,6-dialkylpiperazin-2-one arenavirus cell entry inhibitors

scientific article published on 24 August 2019

Spike mutation D614G alters SARS-CoV-2 fitness

scientific article published on 26 October 2020

Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility

scientific article published on 02 September 2020

Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility

scientific article published on 10 September 2020

The Dominant-Negative Inhibition of Double-Stranded RNA-Dependent Protein Kinase PKR Increases the Efficacy of Rift Valley Fever Virus MP-12 Vaccine.

scientific article published in November 2013

The UBA domains of NUB1L are required for binding but not for accelerated degradation of the ubiquitin-like modifier FAT10

scientific article

The dominant-negative inhibition of double-stranded RNA-dependent protein kinase PKR increases the efficacy of Rift Valley fever virus MP-12 vaccine

scientific article

The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation

scientific article published on 13 July 2012

The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition

scientific article

Toscana Virus NSs Protein Promotes Degradation of Double-Stranded RNA-Dependent Protein Kinase ⬇️

scientific article published on January 16, 2013

USE1 is a bispecific conjugating enzyme for ubiquitin and FAT10, which FAT10ylates itself in cis ⬇️

scientific article published on May 4, 2010

Using click chemistry to measure the effect of viral infection on host-cell RNA synthesis

scientific article published on 9 August 2013

Using reverse genetics to manipulate the NSs gene of the Rift Valley fever virus MP-12 strain to improve vaccine safety and efficacy

scientific article published in November 2011

Viral RNA-dependent RNA polymerase mutants display an altered mutation spectrum resulting in attenuation in both mosquito and vertebrate hosts

scientific article published on 04 April 2019

List of works by Birte Kalveram

A single-cycle replicable Rift Valley fever phlebovirus vaccine carrying a mutated NSs confers full protection from lethal challenge in mice

Characterization of Rift Valley fever virus MP-12 strain encoding NSs of Punta Toro virus or sandfly fever Sicilian virus

Degradation of FAT10 by the 26S proteasome is independent of ubiquitylation but relies on NUB1L.

Discovery of Adamantane Carboxamides as Ebola Virus Cell Entry and Glycoprotein Inhibitors

FAT10, a ubiquitin-independent signal for proteasomal degradation

Favipiravir (T-705) protects against Nipah virus infection in the hamster model.

Filovirus Virulence in Interferon α/β and γ Double Knockout Mice, and Treatment with Favipiravir

Functional analysis of Rift Valley fever virus NSs encoding a partial truncation

Furin Cleavage Site Is Key to SARS-CoV-2 Pathogenesis

Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis

NSs protein of rift valley fever virus promotes posttranslational downregulation of the TFIIH subunit p62.

Natural History and Pathogenesis of Wild-Type Marburg Virus Infection in STAT2 Knockout Hamsters

Peptidoglycan associated cyclic lipopeptide disrupts viral infectivity

Peptidoglycan-Associated Cyclic Lipopeptide Disrupts Viral Infectivity

Rift Valley fever virus MP-12 vaccine encoding Toscana virus NSs retains neuroinvasiveness in mice

Rift Valley fever virus NSs inhibits host transcription independently of the degradation of dsRNA-dependent protein kinase PKR.

SAR studies of 4-acyl-1,6-dialkylpiperazin-2-one arenavirus cell entry inhibitors

Spike mutation D614G alters SARS-CoV-2 fitness

Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility

Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility

The Dominant-Negative Inhibition of Double-Stranded RNA-Dependent Protein Kinase PKR Increases the Efficacy of Rift Valley Fever Virus MP-12 Vaccine.

The UBA domains of NUB1L are required for binding but not for accelerated degradation of the ubiquitin-like modifier FAT10

The dominant-negative inhibition of double-stranded RNA-dependent protein kinase PKR increases the efficacy of Rift Valley fever virus MP-12 vaccine

The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation

The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition

Toscana Virus NSs Protein Promotes Degradation of Double-Stranded RNA-Dependent Protein Kinase ⬇️

USE1 is a bispecific conjugating enzyme for ubiquitin and FAT10, which FAT10ylates itself in cis ⬇️

Using click chemistry to measure the effect of viral infection on host-cell RNA synthesis

Using reverse genetics to manipulate the NSs gene of the Rift Valley fever virus MP-12 strain to improve vaccine safety and efficacy

Viral RNA-dependent RNA polymerase mutants display an altered mutation spectrum resulting in attenuation in both mosquito and vertebrate hosts