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List of works by David J Grdina

A manganese superoxide dismutase (SOD2)-mediated adaptive response.

scientific article published on 13 December 2012

A survivin-associated adaptive response in radiation therapy

scientific article published on 07 May 2013

Activation of the nuclear transcription factor kappaB (NFkappaB) and differential gene expression in U87 glioma cells after exposure to the cytoprotector amifostine

scientific article

Altered expression of a metformin-mediated radiation response in SA-NH and FSa tumor cells treated under in vitro and in vivo growth conditions

scientific article published on 10 March 2017

Amifostine induces antioxidant enzymatic activities in normal tissues and a transplantable tumor that can affect radiation response

scientific article published on March 2009

Amifostine metabolite WR-1065 disrupts homologous recombination in mammalian cells

scientific article

Andrographis paniculata Diterpenoids Protect against Radiation-Induced Transformation in BALB/3T3 Cells

scientific article published on 11 May 2017

Antimetastatic effectiveness of amifostine therapy following surgical removal of Sa-NH tumors in mice

scientific article

CDK1 Enhances Mitochondrial Bioenergetics for Radiation-Induced DNA Repair

scientific article

CDK4-mediated MnSOD activation and mitochondrial homeostasis in radioadaptive protection

scientific article

Coactivation of ATM/ERK/NF-kappaB in the low-dose radiation-induced radioadaptive response in human skin keratinocytes.

scientific article published on 24 March 2009

Comparing radiation toxicities across species: an examination of radiation effects in Mus musculus and Peromyscus leucopus.

scientific article published on 4 March 2013

CyclinB1/Cdk1 phosphorylates mitochondrial antioxidant MnSOD in cell adaptive response to radiation stress

scientific article published on 12 December 2012

Delayed cytoprotection after enhancement of Sod2 (MnSOD) gene expression in SA-NH mouse sarcoma cells exposed to WR-1065, the active metabolite of amifostine

scientific article

Delayed radioprotection by NFkappaB-mediated induction of Sod2 (MnSOD) in SA-NH tumor cells after exposure to clinically used thiol-containing drugs.

scientific article

Delayed radioprotection by nuclear transcription factor kappaB -mediated induction of manganese superoxide dismutase in human microvascular endothelial cells after exposure to the free radical scavenger WR1065.

scientific article

Differential activation of nuclear transcription factor kappaB, gene expression, and proteins by amifostine's free thiol in human microvascular endothelial and glioma cells

scientific article published in January 2002

Dual blockade of CD47 and HER2 eliminates radioresistant breast cancer cells

scientific article published on 14 September 2020

Flow cytometric analysis of phosphorylated histone H2AX following exposure to ionizing radiation in human microvascular endothelial cells

scientific article

Incidence of tissue toxicities in gamma ray and fission neutron-exposed mice treated with Amifostine

scientific article published in August 2008

Induction of cellular antioxidant defense by amifostine improves ventilator-induced lung injury* ⬇️

scientific article published on December 1, 2011

Inhibition of spontaneous metastases formation by amifostine ⬇️

scientific article published on January 10, 2002

Interaction of amifostine and ionizing radiation on transcriptional patterns of apoptotic genes expressed in human microvascular endothelial cells (HMEC).

scientific article published in October 2004

Low doses of amifostine protect from chromosomal inversions in spleen in vivo when administered after an occupationally relevant X-radiation dose

Maintenance of manganese superoxide dismutase (SOD2)-mediated delayed radioprotection induced by repeated administration of the free thiol form of amifostine

scientific article published on May 2008

Manganese superoxide dismutase (SOD2)-mediated delayed radioprotection induced by the free thiol form of amifostine and tumor necrosis factor alpha

scientific article published on April 2007

Manganese superoxide dismutase interacts with a large scale of cellular and mitochondrial proteins in low-dose radiation-induced adaptive radioprotection

scientific article

Metformin exhibits radiation countermeasures efficacy when used alone or in combination with sulfhydryl containing drugs

scientific article

Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3-4, 2003

scientific article published on 01 December 2004

NFκB and Survivin-Mediated Radio-Adaptive Response

scientific article

Oral administration is as effective as intraperitoneal administration of amifostine in decreasing nitroxide EPR signal decay in vivo

scientific article published in March 2003

Protection from radiation-induced apoptosis by the radioprotector amifostine (WR-2721) is radiation dose dependent

scientific article published on 24 January 2014

ROS Modifiers and NOX4 Affect the Expression of the Survivin-Associated Radio-Adaptive Response

scientific article published on 13 April 2018

Radioprotectants: current status and new directions

scientific article

Relationship between phosphorylated histone H2AX formation and cell survival in human microvascular endothelial cells (HMEC) as a function of ionizing radiation exposure in the presence or absence of thiol-containing drugs

scientific article published on July 2007

Relationships between cytoprotection and mutation prevention by WR-1065.

scientific article published in February 2002

SOD2-mediated effects induced by WR1065 and low-dose ionizing radiation on micronucleus formation in RKO human colon carcinoma cells

scientific article

TP53 Mutational Status and ROS Effect the Expression of the Survivin-Associated Radio-Adaptive Response

scientific article

The Increase in Animal Mortality Risk following Exposure to Sparsely Ionizing Radiation Is Not Linear Quadratic with Dose

scientific article

The effects of radiation and dose-fractionation on cancer and non-tumor disease development

scientific article published on 18 December 2012

Very low doses of ionizing radiation and redox associated modifiers affect survivin-associated changes in radiation sensitivity.

scientific article published on 14 July 2016

WR-1065, the active metabolite of amifostine, mitigates radiation-induced delayed genomic instability.

scientific article published on 18 September 2008

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