List of works - Natascha Hermann-Kleiter

A genome-wide analysis of DNA methylation identifies a novel association signal for Lp(a) concentrations in the LPA promoter

scientific article published on 28 April 2020

Beyond CTLA-4 and PD-1: Orphan nuclear receptor NR2F6 as T cell signaling switch and emerging target in cancer immunotherapy.

scientific article

Cbl-b mediates TGFβ sensitivity by downregulating inhibitory SMAD7 in primary T cells.

scientific article published on 24 May 2013

Coronin 1A is an essential regulator of the TGFβ receptor/SMAD3 signaling pathway in Th17 CD4(+) T cells.

scientific article

Defective IgG2a/2b class switching in PKC alpha-/- mice

scientific article published on 01 May 2006

Fcμ receptor as a Costimulatory Molecule for T Cells

scientific article published on 01 March 2019

Iron Supplementation Interferes With Immune Therapy of Murine Mammary Carcinoma by Inhibiting Anti-Tumor T Cell Function

scientific article published on 04 December 2020

LAMTOR2-mediated modulation of NGF/MAPK activation kinetics during differentiation of PC12 cells

scientific article

Lasp1 misexpression influences chondrocyte differentiation in the vertebral column.

scientific article published in January 2009

NFAT pulls the strings during CD4+ T helper cell effector functions

scientific article

Notch-mediated generation of monocyte-derived Langerhans cells: Phenotype and function

scientific article published on 06 June 2020

Nuclear Receptors Regulate Intestinal Inflammation in the Context of IBD

scientific article published on 14 May 2019

Nuclear orphan receptor NR2F6 directly antagonizes NFAT and RORγt binding to the Il17a promoter.

scientific article

Nuclear receptor NR2F6 inhibition potentiates responses to PD-L1/PD-1 cancer immune checkpoint blockade.

scientific article published on 18 April 2018

Orphan Nuclear Receptor NR2F6 Suppresses T Follicular Helper Cell Accumulation through Regulation of IL-21

scientific article published on 01 September 2019

Orphan nuclear receptor NR2F6 acts as an essential gatekeeper of Th17 CD4+ T cell effector functions

scientific article

PKC theta cooperates with PKC alpha in alloimmune responses of T cells in vivo

scientific article published on 7 April 2009

PKC-theta modulates the strength of T cell responses by targeting Cbl-b for ubiquitination and degradation

scientific article published on 23 June 2009

PKC-theta selectively controls the adhesion-stimulating molecule Rap1.

scientific article published on 16 September 2008

PKCtheta and Itk functionally interact during primary mouse CD3+ T cell activation

scientific article published on 12 August 2009

PKCtheta and PKA are antagonistic partners in the NF-AT transactivation pathway of primary mouse CD3+ T lymphocytes

scientific article published on 02 March 2006

PKCθ/β and CYLD are antagonistic partners in the NFκB and NFAT transactivation pathways in primary mouse CD3+ T lymphocytes

scientific article (publication date: 2013)

Proof of Principle for a T Lymphocyte Intrinsic Function of Coronin 1A.

scientific article published on 26 August 2016

Protein kinase C theta is dispensable for suppression mediated by CD25+CD4+ regulatory T cells.

scientific article published on 22 May 2017

Protein kinase C θ regulates the phenotype of murine CD4+ Th17 cells

scientific article (publication date: 2014)

Protein kinase Cepsilon is dispensable for TCR/CD3-signaling

scientific article published on 01 February 2005

Regulation of Lymphatic GM-CSF Expression by the E3 Ubiquitin Ligase Cbl-b

scientific article published on 08 October 2018

Regulation of the Germinal Center Response by Nuclear Receptors and Implications for Autoimmune Diseases

scientific article published on 04 April 2020

Role of PKCtheta in macrophage-mediated immune response to Salmonella typhimurium infection in mice

scientific article published on 28 July 2016

Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution.

scientific article published on 2 January 2018

Targeting the orphan nuclear receptor NR2F6 in T cells primes tumors for immune checkpoint therapy

scientific article published on 14 January 2020

The Nuclear Orphan Receptor NR2F6 Is a Central Checkpoint for Cancer Immune Surveillance

scientific article

The kinase PKCα selectively upregulates interleukin-17A during Th17 cell immune responses

scientific article published on 3 January 2013

The nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17-dependent autoimmunity

scientific article published on August 2008

The potent protein kinase C-selective inhibitor AEB071 (sotrastaurin) represents a new class of immunosuppressive agents affecting early T-cell activation.

scientific article published on 2 June 2009

List of works by Natascha Hermann-Kleiter

A genome-wide analysis of DNA methylation identifies a novel association signal for Lp(a) concentrations in the LPA promoter

Beyond CTLA-4 and PD-1: Orphan nuclear receptor NR2F6 as T cell signaling switch and emerging target in cancer immunotherapy.

Cbl-b mediates TGFβ sensitivity by downregulating inhibitory SMAD7 in primary T cells.

Coronin 1A is an essential regulator of the TGFβ receptor/SMAD3 signaling pathway in Th17 CD4(+) T cells.

Defective IgG2a/2b class switching in PKC alpha-/- mice

Fcμ receptor as a Costimulatory Molecule for T Cells

Iron Supplementation Interferes With Immune Therapy of Murine Mammary Carcinoma by Inhibiting Anti-Tumor T Cell Function

LAMTOR2-mediated modulation of NGF/MAPK activation kinetics during differentiation of PC12 cells

Lasp1 misexpression influences chondrocyte differentiation in the vertebral column.

NFAT pulls the strings during CD4+ T helper cell effector functions

Notch-mediated generation of monocyte-derived Langerhans cells: Phenotype and function

Nuclear Receptors Regulate Intestinal Inflammation in the Context of IBD

Nuclear orphan receptor NR2F6 directly antagonizes NFAT and RORγt binding to the Il17a promoter.

Nuclear receptor NR2F6 inhibition potentiates responses to PD-L1/PD-1 cancer immune checkpoint blockade.

Orphan Nuclear Receptor NR2F6 Suppresses T Follicular Helper Cell Accumulation through Regulation of IL-21

Orphan nuclear receptor NR2F6 acts as an essential gatekeeper of Th17 CD4+ T cell effector functions

PKC theta cooperates with PKC alpha in alloimmune responses of T cells in vivo

PKC-theta modulates the strength of T cell responses by targeting Cbl-b for ubiquitination and degradation

PKC-theta selectively controls the adhesion-stimulating molecule Rap1.

PKCtheta and Itk functionally interact during primary mouse CD3+ T cell activation

PKCtheta and PKA are antagonistic partners in the NF-AT transactivation pathway of primary mouse CD3+ T lymphocytes

PKCθ/β and CYLD are antagonistic partners in the NFκB and NFAT transactivation pathways in primary mouse CD3+ T lymphocytes

Proof of Principle for a T Lymphocyte Intrinsic Function of Coronin 1A.

Protein kinase C theta is dispensable for suppression mediated by CD25+CD4+ regulatory T cells.

Protein kinase C θ regulates the phenotype of murine CD4+ Th17 cells

Protein kinase Cepsilon is dispensable for TCR/CD3-signaling

Regulation of Lymphatic GM-CSF Expression by the E3 Ubiquitin Ligase Cbl-b

Regulation of the Germinal Center Response by Nuclear Receptors and Implications for Autoimmune Diseases

Role of PKCtheta in macrophage-mediated immune response to Salmonella typhimurium infection in mice

Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution.

Targeting the orphan nuclear receptor NR2F6 in T cells primes tumors for immune checkpoint therapy

The Nuclear Orphan Receptor NR2F6 Is a Central Checkpoint for Cancer Immune Surveillance

The kinase PKCα selectively upregulates interleukin-17A during Th17 cell immune responses

The nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17-dependent autoimmunity

The potent protein kinase C-selective inhibitor AEB071 (sotrastaurin) represents a new class of immunosuppressive agents affecting early T-cell activation.