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List of works by Guojiang Chen

A novel IL-23p19/Ebi3 (IL-39) cytokine mediates inflammation in Lupus-like mice.

scientific article published on 13 April 2016

Active tolerance induction and prevention of autoimmune diabetes by immunogene therapy using recombinant adenoassociated virus expressing glutamic acid decarboxylase 65 peptide GAD(500-585).

scientific article

An epithelial-to-mesenchymal transition-inducing potential of granulocyte macrophage colony-stimulating factor in colon cancer.

scientific article published on 15 August 2017

Anti‑IL‑39 (IL‑23p19/Ebi3) polyclonal antibodies ameliorate autoimmune symptoms in lupus‑like mice

scientific article published on 14 November 2017

B cell activating factor (BAFF) selects IL-10-B cells over IL-10+B cells during inflammatory responses

scientific article published on 12 February 2017

B cells regulate thymic CD8+T cell differentiation in lupus-prone mice.

scientific article published on 5 July 2017

BAFF maintains T-cell survival by inducing OPN expression in B cells

scientific article published on 28 September 2013

BAFF suppresses IL-15 expression in B cells

scientific article published on 26 March 2014

Blockade of B-cell activating factor with TACI-IgG effectively reduced Th1 and Th17 cells but not memory T cells in experimental allergic encephalomyelitis mice

scientific article

Blockade of complement activation product C5a activity using specific antibody attenuates intestinal damage in trinitrobenzene sulfonic acid induced model of colitis ⬇️

scientific article published on November 22, 2010

Both Notch1 and its ligands in B cells promote antibody production

scientific article published on 29 August 2017

C5a regulates IL-12+ DC migration to induce pathogenic Th1 and Th17 cells in sepsis

scientific article

CD19 regulates ADAM28-mediated Notch2 cleavage to control the differentiation of marginal zone precursors to MZ B cells.

scientific article published on 14 July 2017

CD8+ regulatory T cells are responsible for GAD-IgG gene-transferred tolerance induction in NOD mice

scientific article published on 20 June 2008

Combination of TACI-IgG and anti-IL-15 treats murine lupus by reducing mature and memory B cells

scientific article published on 12 April 2014

Complement C5a regulates IL-17 by affecting the crosstalk between DC and gammadelta T cells in CLP-induced sepsis

scientific article published in April 2010

Critical role for thymic CD19+CD5+CD1dhiIL-10+ regulatory B cells in immune homeostasis

scientific article

Diabetes is not prevented by Foxp3-transduced CD4(+)T cells under the IL-12Rbeta2 promoter control

Dysregulated Tim-3 expression and its correlation with imbalanced CD4 helper T cell function in ulcerative colitis.

scientific article

Foxd3 suppresses interleukin-10 expression in B cells

scientific article published on 20 December 2016

Functional identification of the stable transfection C5aR cell line Molt-4.

scientific article published on December 2007

GAD-IgG-inducing CD4+Foxp3+Treg cells suppressing diabetes are involved in the increasing ratio of CD80+:CD86+ CELLS in NOD mice.

scientific article published in April 2008

GM-CSF facilitates the development of inflammation-associated colorectal carcinoma

scientific article

Gene delivery GAD 500 autoantigen by AAV serotype 1 prevented diabetes in NOD mice: transduction efficiency do not play important roles

scientific article published on 9 November 2007

Glutamic acid decarboxylase-derived epitopes with specific domains expand CD4(+)CD25(+) regulatory T cells

scientific article

IL-15-secreting γδT cells induce memory T cells in experimental allergic encephalomyelitis (EAE) mice

scientific article published on 18 May 2015

IL-17A signaling in colonic epithelial cells inhibits pro-inflammatory cytokine production by enhancing the activity of ERK and PI3K.

scientific article

Identify the key amino acid of BAFF binding with TACI.

scientific article published on 14 June 2013

Increased mTOR cancels out the effect of reduced Xbp-1 on antibody secretion in IL-1α-deficient B cells.

scientific article published on 24 February 2018

Induction of active tolerance and involvement of CD1d-restricted natural killer T cells in anti-CD3 F(ab')2 treatment-reversed new-onset diabetes in nonobese diabetic mice

scientific article published on 18 March 2008

Interleukin-17-producing gammadelta+ T cells protect NOD mice from type 1 diabetes through a mechanism involving transforming growth factor-beta

scientific article published on 4 August 2009

Involvement of T cell Ig Mucin-3 (Tim-3) in the negative regulation of inflammatory bowel disease

scientific article published on 13 November 2009

Ligation of metabotropic glutamate receptor 3 (Grm3) ameliorates lupus-like disease by reducing B cells.

scientific article published on 9 June 2015

MAE4, an eLtaS monoclonal antibody, blocks Staphylococcus aureus virulence

scientific article

Metabotropic glutamate receptor 3 is involved in B-cell-related tumor apoptosis

scientific article published on 15 July 2016

Natural killer cells modulate overt autoimmunity to homeostasis in nonobese diabetic mice after anti-CD3 F(ab')2 antibody treatment through secreting transforming growth factor-beta

scientific article published on 30 July 2009

Negative regulation of Nod-like receptor protein 3 inflammasome activation by T cell Ig mucin-3 protects against peritonitis.

scientific article

Opposite role of tumor necrosis factor receptors in dextran sulfate sodium-induced colitis in mice

scientific article

Pre-existing CD19-independent GL7(-) Breg cells are expanded during inflammation and in mice with lupus-like disease.

scientific article published on 4 February 2016

Protective role of tumor necrosis factor (TNF) receptors in chronic intestinal inflammation: TNFR1 ablation boosts systemic inflammatory response

scientific article published on 29 July 2013

Regulation of IL-8 production by complement-activated product, C5a, in vitro and in vivo during sepsis

scientific article published on 29 June 2010

Spliceosome protein Eftud2 promotes colitis-associated tumorigenesis by modulating inflammatory response of macrophage

scientific article published on 05 July 2019

T cell Ig mucin-3 promotes homeostasis of sepsis by negatively regulating the TLR response.

scientific article published on 30 January 2013

The N- and C-terminal carbohydrate recognition domains of galectin-9 contribute differently to its multiple functions in innate immunity and adaptive immunity ⬇️

scientific article published on December 10, 2010

Tim-3 inhibits macrophage control of Listeria monocytogenes by inhibiting Nrf2.

scientific article published on 16 February 2017

Tim-3 promotes intestinal homeostasis in DSS colitis by inhibiting M1 polarization of macrophages

scientific article

Tim-3 promotes tumor-promoting M2 macrophage polarization by binding to STAT1 and suppressing the STAT1-miR-155 signaling axis.

scientific article

Tim-3: an activation marker and activation limiter of innate immune cells

scientific article published on 10 December 2013

Tumor-derived GM-CSF promotes inflammatory colon carcinogenesis via stimulating epithelial release of VEGF.

scientific article published on 23 December 2013

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