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List of works by Marie Stiborová

3-aminobenzanthrone, a human metabolite of the carcinogenic environmental pollutant 3-nitrobenzanthrone, induces biotransformation enzymes in rat kidney and lung.

scientific article published on 3 May 2009

3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone, forms DNA adducts after metabolic activation by human and rat liver microsomes: evidence for activation by cytochrome P450 1A1 and P450 1A2.

scientific article published on August 2004

32P-Postlabelling Analysis of DNA Adducts with 1-(Phenylazo)-2-naphthol (Sudan I, Solvent Yellow 14) Formed in vivo in Fisher 344 Rats

article by Marie Stiborová et al published 1999 in Collection of Czechoslovak Chemical Communications

32P-post-labelling analysis of DNA adducts formed by aristolochic acid in tissues from patients with Chinese herbs nephropathy

article

32P-postlabeling analysis of adducts formed from 1-phenylazo-2-hydroxynaphthalene (Sudan I, Solvent Yellow 14) with DNA and homopolydeoxyribonucleotides.

scientific article

A Mechanism of O-Demethylation of Aristolochic Acid I by Cytochromes P450 and Their Contributions to This Reaction in Human and Rat Livers: Experimental and Theoretical Approaches

scientific article

A new way to carcinogenicity of azo dyes: The benzenediazonium ion formed from a non-aminoazo dye, 1-phenylazo-2-hydroxynaphthalene(Sudan I) by microsomal enzymes binds to deoxyguanosine residues of DNA

scientific article published on 01 June 1988

A novel insight into the cardiotoxicity of antineoplastic drug doxorubicin.

scientific article published on 31 October 2013

A one-electron oxidation of carcinogenic nonaminoazo dye Sudan I by horseradish peroxidase

scientific article

A reconstituted cytochrome P450 system from tulip bulbs (Tulipa fosteriana L.) oxidizes xenobiotics

scientific article published in 1995

A study on 17alpha-ethinylestradiol metabolism in rat and Pleurotus ostreatus

scientific article

Activation and detoxification metabolism of urban air pollutants 2-nitrobenzanthrone and carcinogenic 3-nitrobenzanthrone by rat and mouse hepatic microsomes.

scientific article published on January 2012

Activation of carcinogens by peroxidase. Horseradish peroxidase-mediated formation of benzenediazonium ion from a non-aminoazo dye, 1-phenylazo-2-hydroxynaphthalene (Sudan I) and its binding to DNA.

scientific article

Active Site Mutations as a Suitable Tool Contributing to Explain a Mechanism of Aristolochic Acid I Nitroreduction by Cytochromes P450 1A1, 1A2 and 1B1.

scientific article published on 5 February 2016

Aerobic biodegradation of dinitrophenols and their mixture in continuous operations by an immobilized mixed microbial community

scholarly article by Pavlina Karlova et al published 11 May 2014 in Clean Technologies and Environmental Policy

Aerobic degradation of 2,4-dinitrotoluene by individual bacterial strains and defined mixed population in submerged cultures

article

Alcoholic liver cirrhosis increases the risk of left ventricular diastolic dysfunction

scientific article published in January 2013

An efficient modification of ellipticine synthesis and preparation of 13-hydroxyellipticine

An insight into the complex roles of metallothioneins in malignant diseases with emphasis on (sub)isoforms/isoforms and epigenetics phenomena

scientific article

Analysis of benzo[a]pyrene metabolites formed by rat hepatic microsomes using high pressure liquid chromatography: optimization of the method ⬇️

scientific article published on December 28, 2009

Analysis of covalent ellipticine- and doxorubicin-derived adducts in DNA of neuroblastoma cells by the ³²P-postlabeling technique.

scientific article

Anthracyclines and ellipticines as DNA-damaging anticancer drugs: recent advances

scientific article published on 03 August 2011

Anticancer agent ellipticine combined with histone deacetylase inhibitors, valproic acid and trichostatin A, is an effective DNA damage strategy in human neuroblastoma

scientific article published on January 1, 2011

Antitumor drug ellipticine inhibits the activities of rat hepatic cytochromes P450

scientific article published on 01 December 2005

Apoferritin as an ubiquitous nanocarrier with excellent shelf life.

scientific article

Apoferritin modified magnetic particles as doxorubicin carriers for anticancer drug delivery

scientific article

Application of hepatic cytochrome b/P450 reductase null (HBRN) mice to study the role of cytochrome b in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine

scientific article published on 25 January 2019

Aristolochic acid as a probable human cancer hazard in herbal remedies: a review.

scientific article published in July 2002

Aristolochic acid mutagenesis: molecular clues to the aetiology of Balkan endemic nephropathy-associated urothelial cancer.

scientific article published on 13 April 2007

Aryl hydrocarbon receptor ligands benzo[a]pyrene, ellipticine and Sudan I are potent inducers of cytochrome b5 in rats

scientific article published in September 2014

Assays for determination of matrix metalloproteinases and their activity

Automated assay of the potency of natural antioxidants using pipetting robot and spectrophotometry

Balkan Endemic Nephropathy and the Causative Role of Aristolochic Acid

scientific article published on 01 May 2019

Balkan endemic nephropathy: an update on its aetiology

scientific article

Benzenediazonium ion derived from Sudan I forms an 8-(phenylazo)guanine adduct in DNA.

scientific article published in June 1995

Bioactivation of 3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone: evidence for DNA adduct formation mediated by cytochrome P450 enzymes and peroxidases

scientific article published in March 2006

Bioactivation versus detoxication of the urothelial carcinogen aristolochic acid I by human cytochrome P450 1A1 and 1A2.

scientific article published on 15 November 2011

Biodegradation of a mixture of mononitrophenols in a packed-bed aerobic reactor

scientific article published in January 2013

Biodegradation of nitroglycerin and ethylene glycol dinitrate by free and immobilized mixed cultures.

scientific article

Biosynthesis of Rabbit Serum Albumin in a Heterologous Fractionated Subcellular System

scientific article published on 01 March 1983

Biotransformation enzymes in development of renal injury and urothelial cancer caused by aristolochic acid

scientific article published in June 2008

Biotransformation of xenobiotics in the human colon and rectum and its association with colorectal cancer

scientific article

Carcinogenic Non-Aminoazo Dye 1-Phenylazo-2-hydroxynaphthalene (Sudan I) Is Oxidized by Rat Liver Microsomal Cytochrome P-450 to Metabolites Binding to Macromolecules (Nucleic Acids and Proteins)

scholarly article by Marie Stiborová & Pavel Anzenbacher published 1992 in Collection of Czechoslovak Chemical Communications

Carcinogenic aristolochic acids upon activation by DT-diaphorase form adducts found in DNA of patients with Chinese herbs nephropathy.

scientific article

Carcinogenic azo dyes modify the acceptance of transfer ribonucleic acid for some amino acids

scientific article published on 01 September 1980

Carcinogenic pollutants o-nitroanisole and o-anisidine are substrates and inducers of cytochromes P450.

scientific article

Characterization of DNA adducts formed by aristolochic acids in the target organ (forestomach) of rats by 32P-postlabelling analysis using different chromatographic procedures

scientific article published on 01 June 1994

Chemopreventive compounds--view from the other side.

scientific article published on 22 January 2009

Chicken Egg Yolk as an Excellent Source of Highly Specific Antibodies Against Cytochromes P450

scientific article published in 2004

Chicken immunoglobulins for prophylaxis: Effect of inhaled antibodies on inflammatory parameters in rat airways

Cisplatin-resistant prostate cancer model: Differences in antioxidant system, apoptosis and cell cycle.

scientific article published on 20 December 2013

Comparative gene expression profiling of human metallothionein-3 up-regulation in neuroblastoma cells and its impact on susceptibility to cisplatin

scientific article published on 16 December 2017

Comparison of DNA adduct formation by aristolochic acids in various in vitro activation systems by 32P-post-labelling: evidence for reductive activation by peroxidases

article

Comparison of activation of aristolochic acid I and II with NADPH:quinone oxidoreductase, sulphotransferases and N-acetyltranferases

scientific article published on 01 January 2011

Comparison of human cytochrome P450 1A1-catalysed oxidation of benzo[a]pyrene in prokaryotic and eukaryotic expression systems

scientific article published on 10 July 2017

Comparison of the oxidation of carcinogenic aristolochic acid I and II by microsomal cytochromes P450 in vitro: experimental and theoretical approaches

scientific article

Continuous aerobic phenol degradation by defined mixed immobilized culture in packed bed reactors.

scientific article published in January 2005

Contribution of biotransformation enzymes to the development of renal injury and urothelial cancer caused by aristolochic acid: urgent questions, difficult answers ⬇️

scientific article published on June 1, 2008

Correction to NADH:Cytochrome b5 Reductase and Cytochrome b5 Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene

scientific article published on 30 August 2016

Covalent binding of the anticancer drug ellipticine to DNA in V79 cells transfected with human cytochrome P450 enzymes

scientific article published on July 2002

Cytochrome P-450 and Peroxidase Oxidize Detoxication Products of Carcinogenic Aristolochic Acids (Aristolactams) to Reactive Metabolites Binding to DNA in vitro

Cytochrome P-450 from Tulip Bulbs (Tulipa fosteriana L.) Oxidizes an Azo Dye Sudan I (1-Phenylazo-2-hydroxynaphthalene, Solvent Yellow 14) in vitro

article by Marie Stiborová & Hana Hansíková published 1996 in Collection of Czechoslovak Chemical Communications

Cytochrome P450 3A activities and their modulation by α-naphthoflavone in vitro are dictated by the efficiencies of model experimental systems

Cytochrome P450 and flavin-containing monooxygenase enzymes are responsible for differential oxidation of the anti-thyroid-cancer drug vandetanib by human and rat hepatic microsomal systems

scientific article published on 03 December 2019

Cytochrome P450- and peroxidase-mediated oxidation of anticancer alkaloid ellipticine dictates its anti-tumor efficiency.

scientific article published on 08 June 2010

Cytochrome P450-mediated metabolism of N-(2-methoxyphenyl)-hydroxylamine, a human metabolite of the environmental pollutants and carcinogens o-anisidine and o-nitroanisole

scientific article

Cytochrome b 5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b 5 /P450 reductase null (HBRN) mice

scientific article published on 24 January 2018

Cytochrome b5 and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions.

scientific article published on 14 February 2014

Cytochrome b5 increases cytochrome P450 3A4-mediated activation of anticancer drug ellipticine to 13-hydroxyellipticine whose covalent binding to DNA is elevated by sulfotransferases and N,O-acetyltransferases.

scientific article published on 15 March 2012

Cytochrome b5 plays a dual role in the reaction cycle of cytochrome P450 3A4 during oxidation of the anticancer drug ellipticine.

scientific article published on 4 July 2017

Cytochrome b5 shifts oxidation of the anticancer drug ellipticine by cytochromes P450 1A1 and 1A2 from its detoxication to activation, thereby modulating its pharmacological efficacy

scientific article published on 13 June 2011

Cytochromes P450 reconstituted with NADPH: P450 reductase mimic the activating and detoxicating metabolism of the anticancer drug ellipticine in microsomes

scientific article published on 01 December 2006

Cytotoxicity of and DNA adduct formation by ellipticine and its micellar form in human leukemia cells in vitro

scientific article published on 12 October 2015

Cytotoxicity of and DNA adduct formation by ellipticine in human U87MG glioblastoma cancer cells

scientific article

DNA Adduct Formation by the Anticancer Drug Ellipticine and Its Hydroxy Derivatives in Human Breast Adenocarcinoma MCF-7 Cells

DNA Adducts Formed by Aristolochic Acid Are Unique Biomarkers of Exposure and Explain the Initiation Phase of Upper Urothelial Cancer

scientific article published on 14 October 2017

DNA adduct formation by the anticancer drug ellipticine in human leukemia HL-60 and CCRF-CEM cells

scientific article published on 16 February 2007

DNA adduct formation by the anticancer drug ellipticine in rats determined by 32P postlabeling

scientific article published in December 2003

DNA adduct formation from quaternary benzo[c]phenanthridine alkaloids sanguinarine and chelerythrine as revealed by the 32P-postlabeling technique

scientific article published in August 2002

DNA and histone deacetylases as targets for neuroblastoma treatment

scientific article

DNA interaction with platinum-based cytostatics revealed by DNA sequencing.

scientific article

Determination of isoflavones in soy bits by fast column high-performance liquid chromatography coupled with UV-visible diode-array detection

scientific article

Detoxication products of the carcinogenic azodye Sudan I (solvent yellow 14) bind to nucleic acids after activation by peroxidase

scientific article

Dicoumarol inhibits rat NAD(P)H:quinone oxidoreductase in vitro and induces its expression in vivo

scientific article published in January 2014

Differentiation-associated urothelial cytochrome P450 oxidoreductase predicates the xenobiotic-metabolizing activity of "luminal" muscle-invasive bladder cancers.

scientific article

Direct evidence for the formation of deoxyribonucleotide adducts from carcinogenic N-nitroso-N-methylaniline revealed by the 32P-postlabeling technique

article

Disposition of sanguinarine in the rat

Doxorubicin Encapsulation Investigated by Capillary Electrophoresis with Laser-Induced Fluorescence Detection

article published in 2014

Doxorubicin interactions with bovine serum albumin revealed by microdialysis with on-line laser-induced fluorescence detection at subpicogram level.

scientific article published on 25 March 2015

Effect of chicken antibodies on inflammation in human lung epithelial cell lines

scientific article

Effect of dihydromyricetin on benzo[a]pyrene activation in rats

scientific article published on January 2014

Effect of heavy metal ions on growth and biochemical characteristics of photosynthesis of barley and maize seedlings

scientific article published in 1987

Effect of hepatic cytochrome P450 (P450) oxidoreductase deficiency on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA adduct formation in P450 reductase conditional null mice.

scientific article published on 22 September 2011

Effectiveness of human cytochrome P450 3A4 present in liposomal and microsomal nanoparticles in formation of covalent DNA adducts by ellipticine

scientific article published on 18 December 2016

Effects of cytochrome P450 inhibitors on peroxidase activity

scientific article published on 01 January 2012

Electroanalytical techniques for determination of flavonoids

scholarly article by Miroslava Beklova et al published October 2008 in Toxicology Letters

Electrochemical biosensor for investigation of anticancer drugs interactions (doxorubicin and ellipticine) with DNA

Electrochemical sensing of etoposide using carbon quantum dot modified glassy carbon electrode

scientific article published on 17 February 2016

Electrochemical study of ellipticine interaction with single and double stranded oligonucleotides.

scientific article

Ellipticine and benzo(a)pyrene increase their own metabolic activation via modulation of expression and enzymatic activity of cytochromes P450 1A1 and 1A2 ⬇️

scientific article published on September 1, 2008

Ellipticine cytotoxicity to cancer cell lines - a comparative study

scientific article

Ellipticine oxidation and DNA adduct formation in human hepatocytes is catalyzed by human cytochromes P450 and enhanced by cytochrome b5.

scientific article

Ellipticine-loaded apoferritin nanocarrier retains DNA adduct-based cytochrome P450-facilitated toxicity in neuroblastoma cells

scientific article published on 23 March 2019

Ellipticines as DNA-targeted chemotherapeutics

scientific article

Environmental pollutant and potent mutagen 3-nitrobenzanthrone forms DNA adducts after reduction by NAD(P)H:quinone oxidoreductase and conjugation by acetyltransferases and sulfotransferases in human hepatic cytosols

scientific article (publication date: April 2005)

Enzymes involved in the metabolism of the carcinogen 2-nitroanisole: evidence for its oxidative detoxication by human cytochromes P450.

scientific article published on May 2004

Enzymes metabolizing aristolochic acid and their contribution to the development of aristolochic acid nephropathy and urothelial cancer.

scientific article published on July 2013

Enzymes oxidizing the azo dye 1-phenylazo-2-naphthol (Sudan I) and their contribution to its genotoxicity and carcinogenicity

scientific article published on January 2014

Erratum to: Induced expression of microsomal cytochrome b 5 determined at mRNA and protein levels in rats exposed to ellipticine, benzo[a]pyrene, and 1-phenylazo-2-naphthol (Sudan I)

scholarly article published in Monatshefte für Chemie

Evaluation of anti-PAIIL lectin hen yolk antibody as an agent inhibiting Pseudomonas aeruginosa adherence to epithelial cells

Evaluation of isoflavone aglycon and glycoside distribution in soy plants and soybeans by fast column high-performance liquid chromatography coupled with a diode-array detector

scientific article published in July 2005

Evidence for reductive activation of carcinogenic aristolochic acids by prostaglandin H synthase -- (32)P-postlabeling analysis of DNA adduct formation

scientific article published in June 2001

Exceptionally long-term persistence of DNA adducts formed by carcinogenic aristolochic acid I in renal tissue from patients with aristolochic acid nephropathy

article

Experimental approaches to evaluate activities of cytochromes P450 3A

scientific article

Exposure of rats to exogenous endocrine disruptors 17alpha-ethinylestradiol and benzo(a)pyrene and an estrogenic hormone estradiol induces expression of cytochromes P450 involved in their metabolism

scientific article published on 18 December 2016

Exposure to benzo[a]pyrene of Hepatic Cytochrome P450 Reductase Null (HRN) and P450 Reductase Conditional Null (RCN) mice: Detection of benzo[a]pyrene diol epoxide-DNA adducts by immunohistochemistry and 32P-postlabelling.

scientific article

Exposure to endocrine disruptors 17alpha-ethinylestradiol and estradiol influences cytochrome P450 1A1-mediated genotoxicity of benzo[a]pyrene and expression of this enzyme in rats

scientific article published in May 2018

Expression Patterns of Xenobiotic-Metabolizing Enzymes in Tumor and Adjacent Normal Mucosa Tissues among Patients with Colorectal Cancer: The ColoCare Study

scientific article published on 18 November 2019

Expression of cytochrome P450 1A1 and its contribution to oxidation of a potential human carcinogen 1-phenylazo-2-naphthol (Sudan I) in human livers

scientific article

Factors influencing the aerobic biodegradation of 2,4-dinitrotoluene in continuous packed bed reactors

scientific article published on 01 January 2011

Ferrous and ferric state of cytochromes P450 in intact Escherichia coli cells: a possible role of cytochrome P450-flavodoxin interactions

scientific article published on 12 October 2015

Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450.

scientific article

Flexible Docking-Based Molecular Dynamics/Steered Molecular Dynamics Calculations of Protein–Protein Contacts in a Complex of Cytochrome P450 1A2 with Cytochrome b5

article

Fluorescence Characterization of Gold Modified Liposomes with Antisense N-myc DNA Bound to the Magnetisable Particles with Encapsulated Anticancer Drugs (Doxorubicin, Ellipticine and Etoposide).

scientific article published on 25 February 2016

Fluorescent cellular assay for screening agents inhibiting Pseudomonas aeruginosa adherence

scientific article published on 16 January 2015

Folic acid-mediated re-shuttling of ferritin receptor specificity towards a selective delivery of highly cytotoxic nickel(II) coordination compounds

scientific article published on 31 December 2018

Formation and 32P-postlabeling of DNA and tRNA adducts derived from peroxidative activation of carcinogenic azo dye N,N-dimethyl-4-aminoazobenzene

scientific article published in September 1992

Formation and persistence of DNA adducts formed by the carcinogenic air pollutant 3-nitrobenzanthrone in target and non-target organs after intratracheal instillation in rats

scientific article published on 17 November 2006

Formation and persistence of DNA adducts of anticancer drug ellipticine in rats

scientific article

Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling.

scientific article published on 20 March 2018

Formation of DNA adducts by ellipticine and its micellar form in rats - a comparative study

scientific article

Formation, Persistence, and Identification of DNA Adducts Formed by the Carcinogenic Environmental Pollutant o-Anisidine in Rats

scientific article published on 08 March 2012

Fully automated two-step assay for detection of metallothionein through magnetic isolation using functionalized γ-Fe2O3 particles.

scientific article

Genotoxic mechanisms for the carcinogenicity of the environmental pollutants and carcinogens o-anisidine and 2-nitroanisole follow from adducts generated by their metabolite N-(2-methoxyphenyl)-hydroxylamine with deoxyguanosine in DNA.

scientific article

Glycosylation protects proteins against free radicals generated from toxic xenobiotics

scientific article

Heme Peroxidases: Structure, Function, Mechanism and Involvement in Activation of Carcinogens. A Review

article

Heterologous expression of human cytochrome P450 2S1 in Escherichia coli and investigation of its role in metabolism of benzo[a]pyrene and ellipticine.

scientific article published on 30 March 2016

Histone Deacetylase Inhibitors as Anticancer Drugs

scientific article

Histone deacetylase inhibitors in cancer therapy. A review.

scientific article

Histone deacetylase inhibitors valproate and trichostatin A are toxic to neuroblastoma cells and modulate cytochrome P450 1A1, 1B1 and 3A4 expression in these cells.

scientific article

Human cytochrome-P450 enzymes metabolize N-(2-methoxyphenyl)hydroxylamine, a metabolite of the carcinogens o-anisidine and o-nitroanisole, thereby dictating its genotoxicity

scientific article published on 18 September 2011

Human cytochromes P450 1A1 and 1A2 participate in detoxication of carcinogenic aristolochic acid.

scientific article

Human cytosolic enzymes involved in the metabolic activation of carcinogenic aristolochic acid: evidence for reductive activation by human NAD(P)H:quinone oxidoreductase.

scientific article published on 17 July 2003

Human enzymes involved in the metabolic activation of the environmental contaminant 3-nitrobenzanthrone: evidence for reductive activation by human NADPH:cytochrome p450 reductase.

scientific article

Human hepatic and renal microsomes, cytochromes P450 1A1/2, NADPH:cytochrome P450 reductase and prostaglandin H synthase mediate the formation of aristolochic acid-DNA adducts found in patients with urothelial cancer.

scientific article published in January 2005

Hypoxia-mediated histone acetylation and expression of N-myc transcription factor dictate aggressiveness of neuroblastoma cells

scientific article published on 27 January 2014

Identification of 1-(3,4-Dihydroxyphenylazo)-2-hydroxynaphthalene as the Product of Oxidation of 1-Phenylazo-2-hydroxynaphthalene (Sudan I, Solvent Yellow 14) by Rat Liver Microsomes

article by Marie Stiborová et al published 1994 in Collection of Czechoslovak Chemical Communications

Identification of Human Enzymes Oxidizing the Anti-Thyroid-Cancer Drug Vandetanib and Explanation of the High Efficiency of Cytochrome P450 3A4 in its Oxidation

scientific article published on 10 July 2019

Identification of a genotoxic mechanism for 2-nitroanisole carcinogenicity and of its carcinogenic potential for humans.

scientific article

Identification of a genotoxic mechanism for the carcinogenicity of the environmental pollutant and suspected human carcinogen o-anisidine

scientific article published in September 2005

Identification of benzo[c]phenanthridine metabolites in human hepatocytes by liquid chromatography with electrospray ion-trap and quadrupole time-of-flight mass spectrometry

scientific article published on 17 March 2011

Identification of human enzymes oxidizing a human metabolite of carcinogenic 2-nitroanisole, 2-nitrophenol. Evidence for its oxidative detoxification by human cytochromes P450

article

Identification of rat cytochromes P450 metabolizing N-(2-methoxyphenyl)hydroxylamine, a human metabolite of the environmental pollutants and carcinogens o-anisidine and o-nitroanisole

scientific journal article

Impact of beta-naphthoflavone on genotoxicity of food-derived carcinogens

scientific article published on 01 January 2011

Impact of genetic modulation of SULT1A enzymes on DNA adduct formation by aristolochic acids and 3-nitrobenzanthrone.

scientific article

Impact of histone deacetylase inhibitor valproic acid on the anticancer effect of etoposide on neuroblastoma cells.

scientific article published on January 2012

In vivo metabolism of aristolochic acid I and II in rats is influenced by their co-exposure

scientific article published on 07 September 2020

Induced expression of cytochrome P450 1A and NAD(P)H:quinone oxidoreductase determined at mRNA, protein, and enzyme activity levels in rats exposed to the carcinogenic azo dye 1-phenylazo-2-naphthol (Sudan I).

scientific article

Induced expression of microsomal cytochrome b 5 determined at mRNA and protein levels in rats exposed to ellipticine, benzo[a]pyrene, and 1-phenylazo-2-naphthol (Sudan I).

scientific article published on 12 January 2016

Induction of biotransformation enzymes by the carcinogenic air-pollutant 3-nitrobenzanthrone in liver, kidney and lung, after intra-tracheal instillation in rats

scientific article published on 15 December 2010

Induction of cytochromes P450 1A1 and 1A2 suppresses formation of DNA adducts by carcinogenic aristolochic acid I in rats in vivo

scientific article published on February 2016

Induction of cytochromes P450 in small intestine by chemopreventive compounds

scientific article published in October 2008

Interaction of nad with rape alcohol dehydrogenase

article published in 1978

Introduction of water into the heme distal side by Leu65 mutations of an oxygen sensor, YddV, generates verdoheme and carbon monoxide, exerting the heme oxygenase reaction

scientific article published on 24 June 2014

Investigation of the properties of alcohol dehydrogenase from bean, rape, wheat and broad bean

scientific article published in 1975

Is aristolochic acid a risk factor for Balkan endemic nephropathy-associated urothelial cancer?

scientific article published in October 2002

Isolation and partial characterization of catechol 1,2-dioxygenase of phenol degrading yeast Candida tropicalis.

scientific article published in January 2009

Isolation and partial characterization of extracellular NADPH-dependent phenol hydroxylase oxidizing phenol to catechol in Comamonas testosteroni

scientific article published on January 1, 2011

Isolation and partial characterization of the adduct formed by 13-hydroxyellipticine with deoxyguanosine in DNA.

scientific article

Isolation of DT-Diaphorase [NAD(P)H Dehydrogenase (Quinone)] from Rat Liver Cytosol: Identification of New Enzyme Substrates, Carcinogenic Aristolochic Acids

Isolation of cytoplasmic NADPH-dependent phenol hydroxylase and catechol-1,2-dioxygenase from Candida tropicalis yeast ⬇️

scientific article published on December 1, 2008

Kinetics of phenol oxidation by Candida tropicalis: effects of oxygen supply rate and nutrients on phenol inhibition

scientific article published in January 2002

Kinetics of the reaction catalysed by rape alcohol dehydrogenase

Knockout and humanized mice as suitable tools to identify enzymes metabolizing the human carcinogen aristolochic acid.

scientific article published on 23 October 2013

Macleaya cordata extract and Sangrovit genotoxicity. Assessment in vivo.

scientific article

Mammalian metallothioneins: properties and functions

scientific article

Mammalian peroxidases activate anticancer drug ellipticine to intermediates forming deoxyguanosine adducts in DNA identical to those foundin vivo and generated from 12-hydroxyellipticine and 13-hydroxyellipticine

scientific article published in 2006

Mapping of cytochrome P450 2B4 substrate binding sites by photolabile probe 3-azidiamantane: identification of putative substrate access regions.

scientific article published on 29 September 2007

Mapping of interaction between cytochrome P450 2B4 and cytochrome b5: the first evidence of two mutual orientations

scientific article published on 01 January 2012

Mechanism of formation and 32P-postlabeling of DNA adducts derived from peroxidative activation of carcinogenic non-aminoazo dye 1-phenylazo-2-hydroxynaphthalene (Sudan I).

scientific article published in October 1990

Mechanism of formation of (deoxy)guanosine adducts derived from peroxidase-catalyzed oxidation of the carcinogenic nonaminoazo dye 1-phenylazo-2-hydroxynaphthalene (Sudan I).

scientific article published in November 2009

Mechanism of peroxidase-mediated oxidation of carcinogenic o-anisidine and its binding to DNA.

scientific article published in March 2002

Mechanisms of ellipticine-mediated resistance in UKF-NB-4 neuroblastoma cells

scientific article

Mechanisms of enzyme-catalyzed reduction of two carcinogenic nitro-aromatics, 3-nitrobenzanthrone and aristolochic acid I: Experimental and theoretical approaches

scientific article

Mechanisms of the different DNA adduct forming potentials of the urban air pollutants 2-nitrobenzanthrone and carcinogenic 3-nitrobenzanthrone

scientific article published on July 2010

Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice.

scientific article

Metabolic activation of carcinogenic aristolochic acid, a risk factor for Balkan endemic nephropathy.

scientific article published on 06 August 2007

Metabolism of Carcinogenic 2-Nitroanisole in Rat, Rabbit, Porcine and Human Hepatic Cytosol

Metabolism of Carcinogenic Azo Dye Sudan I by Rat, Rabbit, Minipig and Human Hepatic Microsomes

Metabolism of carcinogenic N-nitroso-N-methylaniline by purified cytochromes P450 2B1 and P450 2B2.

scientific article published in December 1996

Metal Containing Cytostatics and Their Interaction with Cellular Thiol Compounds Causing Chemoresistance.

scientific article

Metallothionein as a Scavenger of Free Radicals - New Cardioprotective Therapeutic Agent or Initiator of Tumor Chemoresistance?

scientific article published on October 2015

Metallothioneins and zinc in cancer diagnosis and therapy

scientific article

Modern imaging techniques for anthracycline cytostatics -  review of the literature

scientific article

Modern micro and nanoparticle-based imaging techniques

scientific article

Modulation of CYP1A1-mediated oxidation of carcinogenic azo dye Sudan I and its binding to DNA by cytochrome b5.

scientific article published in December 2006

Modulation of cytochrome P450 enzyme system by selected flavonoids

scientific article published in January 2009

Modulation of human cytochrome P450 1A1-mediated oxidation of benzo[a]pyrene by NADPH:cytochrome P450 oxidoreductase and cytochrome b5.

scientific article published in January 2014

Modulation of induced cytotoxicity of doxorubicin by using apoferritin and liposomal cages

scientific article published on 11 December 2014

Modulation of the acceptance of transfer ribonucleic acids for amino acids by alkyl-aryltriazenes and imidazoles

scientific article published on 01 October 1981

Molecular mechanism of genotoxicity of the environmental pollutant 3-nitrobenzanthrone

scientific article

Molecular mechanisms of antineoplastic action of an anticancer drug ellipticine.

scientific article published on July 2006

Monitoring of DNA Adducts in Humans and 32P-Postlabelling Methods. A Review

article

Mutagenic potential of nitrenium ions of nitrobenzanthrones: correlation between theory and experiment

scientific article published in October 2008

Mutagenicity and DNA adduct formation of PAH, nitro-PAH, and oxy-PAH fractions of atmospheric particulate matter from São Paulo, Brazil

scientific article

NAD(P)H:quinone oxidoreductase expression in Cyp1a-knockout and CYP1A-humanized mouse lines and its effect on bioactivation of the carcinogen aristolochic acid I.

scientific article

NADH:Cytochrome b5 Reductase and Cytochrome b5 Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene.

scientific article published on 12 July 2016

NADPH- and NADH-dependent metabolism of and DNA adduct formation by benzo[a]pyrene catalyzed with rat hepatic microsomes and cytochrome P450 1A1.

scientific article published on 9 March 2016

Neuroblastoma stem cells - mechanisms of chemoresistance and histone deacetylase inhibitors.

scientific article published on January 2012

New Selective Inhibitors of Cytochrome P450 2B4 and an Activator of Cytochrome P450 3A6 in Rabbit Liver Microsomes

New selective inhibitors of cytochromes P450 2B and their application to antimutagenesis of tamoxifen.

scientific article

Optimalization of preparation of apocytochrome b5 utilizing apo-myoglobin ⬇️

scientific article published on September 1, 2008

Oxidation of 3-aminobenzanthrone, a human metabolite of carcinogenic environmental pollutant 3-nitrobenzanthrone, by cytochromes P450 - similarity between human and rat enzymes.

scientific article published in January 2009

Oxidation of Azo Dyes by Peroxidase: Additional Evidence of a One-Electron Mechanism of Oxidation of Dimethylaminoazobenzene and Sudan I (Solvent Yellow 14)

article

Oxidation of an antitumor drug ellipticine by peroxidases

scientific article published on 01 December 2005

Oxidation of carcinogenic 2-nitroanisole by rat cytochromes P450 - similarity between human and rat enzymes.

scientific article published on September 2008

Oxidation of carcinogenic benzo[a]pyrene by human and rat cytochrome P450 1A1 and its influencing by cytochrome b5 - a comparative study

scientific article published in January 2013

Oxidation of the carcinogenic non-aminoazo dye 1-phenylazo-2-hydroxy-naphthalene (Sudan I) by cytochromes P450 and peroxidases: a comparative study.

scientific article published on 28 September 2009

Oxidation of xenobiotics by plant microsomes, a reconstituted cytochrome P450 system and peroxidase: a comparative study

article

Oxidative detoxication of carcinogenic 2-nitroanisole by human, rat and rabbit cytochrome P450.

scientific article published in December 2006

Peroxidase oxidizes N-nitrosomethylaniline to ultimate carcinogens(s) binding to DNA and transfer RNA in vitro.

scientific article

Peroxidase-mediated reaction of the carcinogenic non-aminoazo dye 1-phenylazo-2-hydroxynaphthalene with transfer ribonucleic acid

scientific article published on 01 October 1990

Peroxidases from Tulip Bulbs (Tulipa fosteriana, L.) Oxidize Xenobiotics NNitrosodimethylamine and N-Nitroso-N-methylaniline in vitro

Photo-initiated crosslinking extends mapping of the protein-protein interface to membrane-embedded portions of cytochromes P450 2B4 and b₅.

scientific article published on 30 July 2015

Physiological changes of Candida tropicalis population degrading phenol in fed batch reactor

Pollutant interactions during the biodegradation of phenolic mixtures with either 2- or 3-mononitrophenol in a continuously operated packed bed reactor

scientific article published in January 2013

Preparation and application of anti-peptide antibodies for detection of orphan cytochromes P450.

scientific article published on 12 October 2015

Preparation of a biologically active apo-cytochrome b5 via heterologous expression in Escherichia coli

scientific article

Preparation of apo-cytochrome b5 utilizing heme transfer to apo-myoglobin

scientific article published on 01 January 2009

Pressure effects reveal that changes in the redox states of the heme iron complexes in the sensor domains of two heme-based oxygen sensor proteins, EcDOS and YddV, have profound effects on their flexibility.

scientific article published on 13 October 2014

Prostaglandin H synthase-medicated oxidation and binding to DNA of a detoxication metabolite of carcinogenic Sudan I, 1-(phenylazo)-2,6-dihydroxynaphthalene

scientific article

Prostate cancer-specific hallmarks of amino acids metabolism: Towards a paradigm of precision medicine

scientific article published on 29 January 2019

Prostate tumor attenuation in the nu/nu murine model due to anti-sarcosine antibodies in folate-targeted liposomes

scientific article published on 20 September 2016

Prostate-Specific Membrane Antigen-Targeted Site-Directed Antibody-Conjugated Apoferritin Nanovehicle Favorably Influences In Vivo Side Effects of Doxorubicin.

scientific article

Pulmonary Inflammation Impacts on CYP1A1-Mediated Respiratory Tract DNA Damage Induced by the Carcinogenic Air Pollutant Benzo[a]pyrene

scientific article

Quantification of interactions between cytochrome P450 2B4 and cytochrome b5 in a functional membrane complex.

scientific article published in January 2014

Rat cytochromes P450 oxidize 2-nitrophenol, a human metabolite of carcinogenic 2-nitroanisole.

scientific article published in January 2009

Rat cytochromes P450 oxidize 3-aminobenzanthrone, a human metabolite of the carcinogenic environmental pollutant 3-nitrobenzanthrone.

scientific article published on September 2008

Rat liver microsomal metabolism of o-aminophenol and N-(2-methoxyphenyl)hydroxylamine, two metabolites of the environmental pollutant and carcinogen o-anisidine in humans

Rat microsomes activating the anticancer drug ellipticine to species covalently binding to deoxyguanosine in DNA are a suitable model mimicking ellipticine bioactivation in humans.

scientific article published in January 2003

Redox cycling in the metabolism of the environmental pollutant and suspected human carcinogen o-anisidine by rat and rabbit hepatic microsomes

scientific article published on 15 July 2008

Relation of exposure to amino acids involved in sarcosine metabolic pathway on behavior of non-tumor and malignant prostatic cell lines

scientific article published on 5 February 2016

Respirometry kinetics of phenol oxidation by Comamonas testosteroni Pb50 under various conditions of nutritional stress

Retracted: Sarcosine Up-Regulates Expression of Genes Involved in Cell Cycle Progression of Metastatic Models of Prostate Cancer

retracted article

Role of P450 1A1 and P450 1A2 in bioactivation versus detoxication of the renal carcinogen aristolochic acid I: studies in Cyp1a1-/-, Cyp1a2-/-, and Cyp1a1/1a2-/- mice.

scientific article published on 29 September 2011

Role of cytochromes P450 1A1/2 in detoxication and activation of carcinogenic aristolochic acid I: studies with the hepatic NADPH:cytochrome P450 reductase null (HRN) mouse model.

scientific article

Role of cytochromes P450 and peroxidases in metabolism of the anticancer drug ellipticine: additional evidence of their contribution to ellipticine activation in rat liver, lung and kidney

scientific article published on January 1, 2010

Role of cytochromes P450 in metabolism of carcinogenic aristolochic acid I: evidence of their contribution to aristolochic acid I detoxication and activation in rat liver

scientific article published on January 1, 2011

Role of dihydromyricetin in cytochrome P450-mediated metabolism and carcinogen activation

scientific article published in January 2015

Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: studies with the hepatic NADPH:cytochrome P450 reductase null mouse.

scientific article published on 26 September 2007

Role of rat cytochromes P450 in the oxidation of 17α-ethinylestradiol

scientific article published on 18 October 2014

Sanguinarine and chelerythrine: assessment of safety on pigs in ninety days feeding experiment.

scientific article published in January 2004

Sarcosine as a potential prostate cancer biomarker--a review

scientific article published on 04 July 2013

Sarcosine influences apoptosis and growth of prostate cells via cell-type specific regulation of distinct sets of genes.

scientific article

Sarcosine is a prostate epigenetic modifier that elicits aberrant methylation patterns through the SAMe-Dnmts axis

scientific article published on 09 March 2019

Science in Central Europe

scientific article published in Nature

Serum metallothionein in newly diagnosed patients with childhood solid tumours

scientific article published on November 9, 2010

Simple models for the continuous aerobic biodegradation of phenol in a packed bed reactor

scholarly article by Andrew Mark Gerrard et al published July 2006 in Brazilian Archives of Biology and Technology

Site-Directed Conjugation of Antibodies to Apoferritin Nanocarrier for Targeted Drug Delivery to Prostate Cancer Cells

scientific article published on 02 June 2016

Square-Wave Voltammetry as a Tool for Investigation of Doxorubicin Interactions with DNA Isolated from Neuroblastoma Cells

Structural analysis of binding of a diamantoid substrate to cytochrome P450 2B4: possible role of Arg 133 in modulation of function and activity of this enzyme.

scientific article

Structural requirements for inhibitors of cytochromes P450 2B: assessment of the enzyme interaction with diamondoids

scientific article published in February 2005

Structure of phosphoenol pyruvate carboxylase from maize leaves

scientific article published in 1986

Study of DNA-ellipticine interaction by capillary electrophoresis with laser-induced fluorescence detection.

scientific article

Study on N-Demethylation of N,N-Dimethyl-4-aminoazobenzene and N-Nitrosamines by Prostaglandin H Synthase

Sudan I is a potential carcinogen for humans: evidence for its metabolic activation and detoxication by human recombinant cytochrome P450 1A1 and liver microsomes.

scientific article

THE ENVIRONMENTAL POLLUTANT AND CARCINOGEN 3-NITROBENZANTHRONE AND ITS HUMAN METABOLITE 3-AMINOBENZANTHRONE ARE POTENT INDUCERS OF RAT HEPATIC CYTOCHROMES P450 1A1 AND -1A2 AND NAD(P)H:QUINONE OXIDOREDUCTASE

scientific article published on 19 May 2006

The Anticancer Drug Ellipticine is an Inducer of Rat NAD(P)H:Quinone Oxidoreductase

scientific article published in 2007

The Effect of pH on Peroxidase-Mediated Oxidation of and DNA Adduct Formation by Ellipticine

scientific article published in 2006

The Hepatic Reductase Null (HRN™) and Reductase Conditional Null (RCN) mouse models as suitable tools to study metabolism, toxicity and carcinogenicity of environmental pollutants

article

The Histone Deacetylase Inhibitor Valproic Acid Exerts a Synergistic Cytotoxicity with the DNA-Damaging Drug Ellipticine in Neuroblastoma Cells

scientific article

The anticancer agent ellipticine on activation by cytochrome P450 forms covalent DNA adducts

scientific article published in December 2001

The anticancer drug ellipticine activated with cytochrome P450 mediates DNA damage determining its pharmacological efficiencies: studies with rats, Hepatic Cytochrome P450 Reductase Null (HRN™) mice and pure enzymes.

scientific article

The anticancer drug ellipticine forms covalent DNA adducts, mediated by human cytochromes P450, through metabolism to 13-hydroxyellipticine and ellipticine N2-oxide

scientific article published in November 2004

The anticancer drug ellipticine is a potent inducer of rat cytochromes P450 1A1 and 1A2, thereby modulating its own metabolism

scientific article published on 26 July 2007

The application of an emerging technique for protein-protein interaction interface mapping: the combination of photo-initiated cross-linking protein nanoprobes with mass spectrometry.

scientific article

The binding affinity of carcinogenic N-nitrosodimethylamine and N-nitrosomethylaniline to cytochromes P450 2B4, 2E1 and 3A6 does not dictate the rate of their enzymatic N-demethylation

scientific article published on June 2010

The binding of aristolochic acid I to the active site of human cytochromes P450 1A1 and 1A2 explains their potential to reductively activate this human carcinogen

scientific article published on 24 August 2005

The bonding of 8-anilino-1-naphthalene sulfonate to rape (Brassica napus ) alcohol dehydrogenase

scientific article published on 01 August 1979

The capacity and effectiveness of diosmectite and charcoal in trapping the compounds causing the most frequent intoxications in acute medicine: A comparative study.

scientific article published on 17 April 2017

The comparison of cytotoxicity of the anticancer drugs doxorubicin and ellipticine to human neuroblastoma cells

scientific article

The effect of aristolochic acid I on expression of NAD(P)H:quinone oxidoreductase in mice and rats--a comparative study.

scientific article

The effect of benzo[a]pyrene on metabolic activation of anticancer drug ellipticine in mice

The effects of heavy metal ions, phthalates and ochratoxin A on oxidation of carcinogenic aristolochic acid I causing Balkan endemic nephropathy

scientific article published on 12 October 2015

The effects of selected flavonoids on cytochromes P450 in rat liver and small intestine ⬇️

scientific article published on September 28, 2009

The environmental pollutant and carcinogen 3-nitrobenzanthrone induces cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase in rat lung and kidney, thereby enhancing its own genotoxicity

scientific article published on 6 February 2008

The epidemiology, diagnosis, and management of aristolochic acid nephropathy: a narrative review

scientific article

The first identification of the benzenediazonium ion formation from a non-aminoazo dye, 1-phenylazo-2-hydroxynaphthalene (Sudan I) by microsomes of rat livers

scientific article published in June 1988

The human carcinogen aristolochic acid i is activated to form DNA adducts by human NAD(P)H:quinone oxidoreductase without the contribution of acetyltransferases or sulfotransferases

scientific article published on 02 March 2011

The impact of chemotherapeutic drugs on the CYP1A1-catalysed metabolism of the environmental carcinogen benzo[a]pyrene: Effects in human colorectal HCT116 TP53(+/+), TP53(+/-) and TP53(-/-) cells

scientific article published on 19 February 2018

The impact of individual cytochrome P450 enzymes on oxidative metabolism of benzo[a]pyrene in human livers.

scientific article published on 26 February 2016

The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/-) and Trp53(-/-) mice

scientific article published on 21 May 2015

The impact of p53 on aristolochic acid I-induced nephrotoxicity and DNA damage in vivo and in vitro

scientific article published on 10 October 2019

The influence of dicoumarol on the bioactivation of the carcinogen aristolochic acid I in rats

scientific article published on 05 March 2014

The influence of ochratoxin A on DNA adduct formation by the carcinogen aristolochic acid in rats

scientific article published on 11 September 2014

The mechanism of cytotoxicity and DNA adduct formation by the anticancer drug ellipticine in human neuroblastoma cells.

scientific article

The relationship between DNA adduct formation by benzo[a]pyrene and expression of its activation enzyme cytochrome P450 1A1 in rat.

scientific article published on 17 September 2013

The role of biotransformation enzymes in the development of renal injury and urothelial cancer caused by aristolochic acid: urgent questions and difficult answers

scientific article published on March 2009

The role of metallothionein in oxidative stress

scientific article published on 15 March 2013

The synergistic effects of DNA-damaging drugs cisplatin and etoposide with a histone deacetylase inhibitor valproate in high-risk neuroblastoma cells

scientific article published on 11 May 2015

Theoretical investigation of differences in nitroreduction of aristolochic acid I by cytochromes P450 1A1, 1A2 and 1B1.

scientific article

To the Mechanism of 2-Nitroanisole Carcinogenicity: in vitro Metabolism of 2-Nitroanisole Mediated by Peroxidasesand Xanthine Oxidase

To the Mechanism of Horseradish Peroxidase-Mediated Degradation of a Recalcitrant Dye Remazol Brilliant Blue R

Toxicological aspects of flavonoid interaction with biomacromolecules

scientific article published on 01 December 2006

Tyrosine kinase inhibitors vandetanib, lenvatinib and cabozantinib modulate oxidation of an anticancer agent ellipticine catalyzed by cytochromes P450 in vitro

scientific article published on 01 February 2019

Utilizing of Square Wave Voltammetry to Detect Flavonoids in the Presence of Human Urine.

scientific article published on 19 October 2007

VPA does not enhance platinum binding to DNA in cisplatin-resistant neuroblastoma cancer cells

scientific article published in September 2017

Vacuolar-ATPase-mediated intracellular sequestration of ellipticine contributes to drug resistance in neuroblastoma cells.

scientific article

Vertebrate metallothioneins as target molecules for analytical techniques

Zinc and zinc-containing biomolecules in childhood brain tumors.

scientific article published on 16 September 2016

alpha-Naphthoflavone acts as activator and reversible or irreversible inhibitor of rabbit microsomal CYP3A6.

scientific article published in October 2001

alpha5beta1 integrin antagonists reduce chemotherapy-induced premature senescence and facilitate apoptosis in human glioblastoma cells

scientific article published in September 2010

³²P-postlabeling analysis of DNA adducts

scientific article published in January 2013

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