List of works by Jiří Bártek

53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

scientific article

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

scientific article

53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

scientific article published on 13 February 2011

A CHEK2 genetic variant contributing to a substantial fraction of familial breast cancer

scientific article published on 28 July 2002

A Deep Learning Framework for Predicting Response to Therapy in Cancer

scientific article published on 01 December 2019

A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS -Mutant Cancer

A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer

scientific article

A clonal expression biomarker associates with lung cancer mortality

scientific article published on 07 October 2019

A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression

scientific article

A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence

scientific article published on 10 January 2018

A quantitative 14-3-3 interaction screen connects the nuclear exosome targeting complex to the DNA damage response

scientific article published on 4 September 2014

A requirement for cyclin D3-cyclin-dependent kinase (cdk)-4 assembly in the cyclic adenosine monophosphate-dependent proliferation of thyrocytes

scientific article

A short acidic motif in ARF guards against mitochondrial dysfunction and melanoma susceptibility.

scientific article published on 5 November 2014

AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity

scientific article published on 14 April 2021

ATM activation in normal human tissues and testicular cancer

scientific article published on 13 June 2005

ATM targets hnRNPK to control p53.

scientific article

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

scientific article (publication date: 2006)

ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration

scientific article published on 24 September 2020

ATR mediates a checkpoint at the nuclear envelope in response to mechanical stress

scientific article

ATR prohibits replication catastrophe by preventing global exhaustion of RPA.

scientific article

ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage

scientific article

ATR-Chk1-APC/CCdh1-dependent stabilization of Cdc7-ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress

scientific article published on November 2013

Aberrantly elevated suprabasin in the bone marrow as a candidate biomarker of advanced disease state in myelodysplastic syndromes

scientific article published on 21 July 2020

Aberrations of the Chk2 tumour suppressor in advanced urinary bladder cancer

scientific article published on 01 November 2004

Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene

scientific article (publication date: December 2008)

Abnormal patterns of D-type cyclin expression and G1 regulation in human head and neck cancer

scientific article

Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex

scientific article

Acetylation dynamics of human nuclear proteins during the ionizing radiation-induced DNA damage response

scientific article published on May 2013

Adaptation to the ionizing radiation-induced G2 checkpoint occurs in human cells and depends on checkpoint kinase 1 and Polo-like kinase 1 kinases

scientific article published on November 2006

Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4.

scientific article

Alternative splicing and mutation status of CHEK2 in stage III breast cancer

scientific article

An oncogene-induced DNA damage model for cancer development

scientific article

Analysis of EMT by flow cytometry and immunohistochemistry

scientific article published on January 2013

Analysis of epithelial and mesenchymal markers in ovarian cancer reveals phenotypic heterogeneity and plasticity

scientific article

Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation

scientific article published on 14 February 2003

Author Correction: BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity

scientific article published in Nature Communications

Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth

scientific article published on 5 March 2012

Autocrine regulation of glioblastoma cell cycle progression, viability and radioresistance through the VEGF-VEGFR2 (KDR) interplay

scientific article

Autophagy role(s) in response to oncogenes and DNA replication stress

scientific article published on 14 August 2019

BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity

scientific article

Bacterial intoxication evokes cellular senescence with persistent DNA damage and cytokine signalling

scientific article

Biological safety and tissue distribution of (16-mercaptohexadecyl)trimethylammonium bromide-modified cationic gold nanorods.

scientific article

CB-05THE ROLE OF Emb-5 IN GLIOBLASTOMA MAINTENANCE AND THERAPEUTIC RESISTANCE

CBIO-35THE ROLE OF Spt6 IN GLIOBLASTOMA MAINTENANCE AND THERAPEUTIC RESISTANCE.

scientific article

CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination

scientific article

CHEK2 variant I157T may be associated with increased breast cancer risk

scientific article published in September 2004

CSIG-05. THE HISTONE CHAPERONE Spt6 IS REQUIRED FOR GENOMIC STABILITY OF GLIOBLASTOMA CANCER STEM-LIKE CELLS

Cancer Cells Employ Nuclear Caspase-8 to Overcome the p53-Dependent G2/M Checkpoint through Cleavage of USP28

scientific article published on 22 January 2020

Cancer cell stemness, responses to experimental genotoxic treatments, cytomegalovirus protein expression and DNA replication stress in pediatric medulloblastomas

scientific article published on 13 February 2020

Cancer-associated mutations in the ribosomal protein L5 gene dysregulate the HDM2/p53-mediated ribosome biogenesis checkpoint

scientific article published on 27 February 2020

Cannabidiol-induced activation of the metallothionein pathway impedes anticancer effects of disulfiram and its metabolite CuET

scientific article published on 26 October 2021

Cdc7 kinase stimulates Aurora B kinase in M-phase

scientific article published on 09 December 2019

Cell biology. Balancing life-or-death decisions.

scientific article

Cell biology. The stress of finding NEMO.

scientific article

Cell cycle arrest by the PTEN tumor suppressor is target cell specific and may require protein phosphatase activity

scientific article

Cell cycle. Order from destruction

scientific article

Cell-cycle checkpoints and cancer

scientific article

Cell-cycle regulatory proteins in human wound healing

scientific article

Cells and Stripes: A novel quantitative photo-manipulation technique

scientific article published on 18 January 2016

Cellular microenvironment controls the nuclear architecture of breast epithelia through β1-integrin

scientific article published on 28 January 2016

Centrosome clustering and chromosomal (in)stability: a matter of life and death

scientific article published on 19 May 2011

Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase

scientific article

Cep63 recruits Cdk1 to the centrosome: implications for regulation of mitotic entry, centrosome amplification, and genome maintenance

scientific article published on March 2011

Cep63 recruits cdk1 to the centrosome-letter.

scientific article published on 2 February 2015

Checking on DNA damage in S phase

scientific article published in October 2004

Checking out the centrosome

scientific article published on 22 November 2004

Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

scientific article published on March 2003

Chk1-dependent regulation of Cdc25B functions to coordinate mitotic events

scientific article published on 25 September 2006

Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway

scientific article published on 23 July 2006

Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing

scientific article published on 20 June 2016

Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation

scientific article

Complementary genetic screens identify the E3 ubiquitin ligase CBLC, as a modifier of PARP inhibitor sensitivity

scientific article

Correction to Oplustilova L, et al. Cell Cycle Volume 11, Issue 20; pp. 3837–50.

scientific article published on 19 June 2013

Correction: Analysis of Epithelial and Mesenchymal Markers in Ovarian Cancer Reveals Phenotypic Heterogeneity and Plasticity.

scientific article published on 11 February 2011

Correction: Identification of neoepitopes recognized by tumor-infiltrating lymphocytes (TILs) from patients with glioma

Correlation of CHEK2 protein expression and c.1100delC mutation status with tumor characteristics among unselected breast cancer patients

scientific article published in February 2005

Cyclin D1 multitasks

scientific article published in Nature

Cyclin D2 induces proliferation of cardiac myocytes and represses hypertrophy.

scientific article

Cyclin D3-dependent kinases in lymphoma: redundancy and implications for therapy.

scientific article

Cytokine-induced 'bystander' senescence in DDR and immuno-surveillance

scientific article published on October 2013

Cytokines shape chemotherapy-induced and 'bystander' senescence

scientific article published on July 2010

DNA damage checkpoints: from initiation to recovery or adaptation

scientific article published on 15 February 2007

DNA damage response and inflammatory signaling limit the MLL-ENL-induced leukemogenesis in vivo.

scientific article published in April 2012

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

scientific article (publication date: 14 April 2005)

DNA damage response as an anti-cancer barrier: damage threshold and the concept of 'conditional haploinsufficiency'.

scientific article published on 18 July 2007

DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours

scientific article

DNA damage signaling recruits the RNA polymerase II binding protein Che-1 to the p53 promoter

scientific article published on December 2006

DNA damage signalling barrier, oxidative stress and treatment-relevant DNA repair factor alterations during progression of human prostate cancer

scientific article

DNA damage-induced accumulation of centrosomal Chk1 contributes to its checkpoint function

scientific article published on 30 July 2007

DNA damage-induced dynamic changes in abundance and cytosol-nuclear translocation of proteins involved in translational processes, metabolism, and autophagy

scholarly article by Martin V Bennetzen published in September 2018

DNA damage-induced regulatory interplay between DAXX, p53, ATM kinase and Wip1 phosphatase

scientific article

DNA damage: a histone-code mediator leaves the stage

scientific article published on 01 May 2008

DNA repair: Damage alert

scientific article published in Nature

DNA repair: New tales of an old tail

scientific article

DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer

scientific article

Daughters sense their mother's stress.

scientific article published in December 2017

Deep Learning and Association Rule Mining for Predicting Drug Response in Cancer. A Personalised Medicine Approach

scholarly article published 19 August 2016

Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation

scientific article (publication date: April 2002)

Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior

scientific article

Deregulation of the G1/S-phase control in human testicular germ cell tumours

scientific article

Deregulation of the RB pathway in human testicular germ cell tumours ⬇️

scientific article published on June 1, 2003

Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress

scientific article

Differences in DNA double strand breaks repair in male germ cell types: lessons learned from a differential expression of Mdc1 and 53BP1.

scientific article published on 21 March 2007

Differential Activity of ATR and WEE1 Inhibitors in a Highly Sensitive Subpopulation of DLBCL Linked to Replication Stress

scientific article published on 23 May 2019

Differential impact of diverse anticancer chemotherapeutics on the Cdc25A-degradation checkpoint pathway

scientific article

Differentiation-induced radioresistance in muscle cells

scientific article published on July 2004

Dissecting functions of the retinoblastoma tumor suppressor and the related pocket proteins by integrating genetic, cell biology, and electrophoretic techniques

scientific article published on 01 February 1999

Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation

scientific article published in April 2004

Distinct modes of deregulation of the proto-oncogenic Cdc25A phosphatase in human breast cancer cell lines

scientific article published on 01 November 2003

Distinct phosphorylation events regulate p130- and p107-mediated repression of E2F-4.

scientific article

Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage

scientific article

Distinct versus redundant properties among members of the INK4 family of cyclin-dependent kinase inhibitors

scientific article (publication date: 24 March 2000)

Disulfiram's anti-cancer activity reflects targeting NPL4, not inhibition of aldehyde dehydrogenase

scientific article published on 07 August 2019

Dopamine signaling: target in glioblastoma

scientific article

Double-strand breaks in ribosomal RNA genes activate a distinct signaling and chromatin response to facilitate nucleolar restructuring and repair

scientific article published on 01 September 2019

Downregulation of Wip1 phosphatase modulates the cellular threshold of DNA damage signaling in mitosis

scientific article published on 15 January 2012

Dynamic PML protein nucleolar associations with persistent DNA damage lesions in response to nucleolar stress and senescence-inducing stimuli

scientific article published on 07 September 2019

Dynamic alterations of bone marrow cytokine landscape of myelodysplastic syndromes patients treated with 5-azacytidine.

scientific article published on 13 May 2016

Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1

scientific article

Dynamics and organization of cortical microtubules as revealed by superresolution structured illumination microscopy

scientific article published on 31 March 2014

Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the (V600E)BRAF oncogene.

scientific article published on April 2013

Dysregulated Ribosome Biogenesis Reveals Therapeutic Liabilities in Cancer

scientific article published on 15 September 2020

E2F activity is essential for survival of Myc-overexpressing human cancer cells

scientific article

Enhanced chromatin dynamics by FACT promotes transcriptional restart after UV-induced DNA damage

scientific article

Epithelial junction opener JO-1 improves monoclonal antibody therapy of cancer

scientific article published on 11 October 2011

Erratum: Corrigendum: Replication stress links structural and numerical cancer chromosomal instability

scientific article published in Nature

Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment

scientific article

Evaluation ofRAD50 in familial breast cancer predisposition

FANCM c.5101C>T mutation associates with breast cancer survival and treatment outcome

scientific article published on 20 August 2016

FBH1 Catalyzes Regression of Stalled Replication Forks.

scientific article published on 10 March 2015

Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer

scientific article published on 14 July 2013

Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint

scientific article published on 6 May 2013

Glucocorticoids promote a glioma stem cell-like phenotype and resistance to chemotherapy in human glioblastoma primary cells: Biological and prognostic significance

scientific article published on 25 October 2017

Golgi feels DNA's pain.

scientific article

HCLK2 is required for activity of the DNA damage response kinase ATR.

scientific article published on 19 December 2008

HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

scientific article

HERCulean giant orchestrates ubiquitin-mediated signaling on damaged chromosomes

scientific article published on 01 April 2010

Heterochromatin marks HP1γ, HP1α and H3K9me3, and DNA damage response activation in human testis development and germ cell tumours

scientific article published on August 2010

High speed of fork progression induces DNA replication stress and genomic instability

scientific article published in Nature

Histone displacement during nucleotide excision repair

scientific article

Homozygous deficiency of ubiquitin-ligase ring-finger protein RNF168 mimics the radiosensitivity syndrome of ataxia-telangiectasia

scientific article

Human Asf1 regulates the flow of S phase histones during replicational stress

scientific article

Human CtIP promotes DNA end resection

scientific article

Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities

scientific article

Human RTEL1 associates with Poldip3 to facilitate responses to replication stress and R-loop resolution

scientific article published on 19 June 2020

Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint

scientific article

Human Xip1 (C2orf13) is a novel regulator of cellular responses to DNA strand breaks

scientific article published on 16 May 2007

Human cytomegalovirus and Herpes Simplex type I virus can engage RNA polymerase I for transcription of immediate early genes

scientific article published on 29 October 2017

IL1- and TGFβ-Nox4 signaling, oxidative stress and DNA damage response are shared features of replicative, oncogene-induced, and drug-induced paracrine 'bystander senescence'.

scientific article published on December 2012

Identification of neoepitopes recognized by tumor-infiltrating lymphocytes (TILs) from patients with glioma.

scientific article

Imaging of protein movement induced by chromosomal breakage: tiny 'local' lesions pose great 'global' challenges

scientific article

Increased cytomegalovirus replication by 5-Azacytidine and viral-induced cytoplasmic expression of DNMT‑1 in medulloblastoma and endothelial cells.

scientific article

Induction, regulation and roles of neural adhesion molecule L1CAM in cellular senescence.

scientific article published in March 2018

Inhibition of Chk1 by CEP-3891 accelerates mitotic nuclear fragmentation in response to ionizing Radiation.

scientific article

Integrating proteomic and functional genomic technologies in discovery-driven translational breast cancer research

scientific article

Interferon gamma/NADPH oxidase defense system in immunity and cancer

scientific article published on September 2015

Interferon-regulated suprabasin is essential for stress-induced stem-like cell conversion and therapy resistance of human malignancies

scientific article published on 10 June 2019

Interleukin 6 signaling regulates promyelocytic leukemia protein gene expression in human normal and cancer cells

scientific article

Involvement of Myc activity in a G(1)/S-promoting mechanism parallel to the pRb/E2F pathway

scientific article

Involvement of cyclin D activity in left ventricle hypertrophy in vivo and in vitro

scientific article published in October 2002

JMJD1C demethylates MDC1 to regulate the RNF8 and BRCA1-mediated chromatin response to DNA breaks

scientific article published on 17 November 2013

Key concepts in glioblastoma therapy

scientific article published on 06 March 2012

LEDGF (p75) promotes DNA-end resection and homologous recombination

scientific article

Long-distance inflammatory and genotoxic impact of cancer in vivo ⬇️

scientific article published on October 6, 2010

Loss of Geminin induces rereplication in the presence of functional p53

scientific article

Low-dose DNA damage and replication stress responses quantified by optimized automated single-cell image analysis

scientific article

MDC1 is required for the intra-S-phase DNA damage checkpoint

scientific article (publication date: 27 February 2003)

MKK7 and ARF: new players in the DNA damage response scenery.

scientific article published on 26 March 2014

Machine learning and data mining frameworks for predicting drug response in cancer: An overview and a novel in silico screening process based on association rule mining

scientific article published on 30 July 2019

Macrophages, nitric oxide and microRNAs are associated with DNA damage response pathway and senescence in inflammatory bowel disease

scientific article

Mammalian G1- and S-phase checkpoints in response to DNA damage

scientific article (publication date: December 2001)

Mammalian cell cycle checkpoints: signalling pathways and their organization in space and time

scientific article published in August 2004

Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

scientific article

Mesothelin as a novel biomarker and immunotherapeutic target in human glioblastoma

scientific article published on 16 August 2017

MiR-34a expression has an effect for lower risk of metastasis and associates with expression patterns predicting clinical outcome in breast cancer

scientific article

Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection

scientific article

Modulation of the E2F1-driven cancer cell fate by the DNA damage response machinery and potential novel E2F1 targets in osteosarcomas

scientific article published on 18 June 2009

More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance

scientific article published on 03 October 2011

Mutant p53 can delay growth arrest and loss of CDK2 activity in senescing human fibroblasts without reducing p21WAF1 expression ⬇️

scientific article published on May 1, 2003

Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability.

scientific article published on 16 March 2018

Myc and Ras oncogenes engage different energy metabolism programs and evoke distinct patterns of oxidative and DNA replication stress

scientific article

NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer

scientific article published on 30 May 2008

NQO1 expression correlates inversely with NFκB activation in human breast cancer

article published in 2011

NQO1*2 polymorphism predicts overall survival in MDS patients.

scientific article

NY-ESO-1- and survivin-specific T-cell responses in the peripheral blood from patients with glioma

scientific article

Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosis

scientific article

Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis.

scientific article published on 12 February 2018

Nucleoporin NUP153 guards genome integrity by promoting nuclear import of 53BP1

scientific article published on 11 November 2011

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

scientific article (publication date: 30 November 2006)

PARK2 orchestrates cyclins to avoid cancer.

scientific article

PML nuclear bodies are recruited to persistent DNA damage lesions in an RNF168-53BP1 dependent manner and contribute to DNA repair

scientific article published on 06 April 2019

Patterns of DNA damage response in intracranial germ cell tumors versus glioblastomas reflect cell of origin rather than brain environment: implications for the anti-tumor barrier concept and treatment

scientific article published on 9 July 2014

Perturbation of RNA Polymerase I transcription machinery by ablation of HEATR1 triggers the RPL5/RPL11-MDM2-p53 ribosome biogenesis stress checkpoint pathway in human cells

scientific article published on 16 November 2017

Perturbation of mitochondrial bioenergetics by polycations counteracts resistance to BRAFE600 inhibition in melanoma cells

scientific article published on 23 July 2019

Phosphatidylinositol 3-Kinase (PI3K) and phosphatidylinositol 3-kinase-related kinase (PIKK) inhibitors: importance of the morpholine ring.

scientific article published on 5 December 2014

Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin

scientific article published on 14 April 2008

Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization

scientific article

Polyethylenimine architecture-dependent metabolic imprints and perturbation of cellular redox homeostasis.

scientific article

Polyplex Evolution: Understanding Biology, Optimizing Performance

scientific article published on 5 March 2017

Protein phosphatase 2A associates with Rb2/p130 and mediates retinoic acid-induced growth suppression of ovarian carcinoma cells

scientific article published on 12 August 2003

Publisher Correction: A clonal expression biomarker associates with lung cancer mortality

scientific article published on 03 June 2020

Quantification of cellular protein and redox imbalance using SILAC-iodoTMT methodology.

scientific article published on 21 May 2019

REV7 counteracts DNA double-strand break resection and affects PARP inhibition

scientific article

RNA-interference screen for p53 regulators unveils a role of WDR75 in ribosome biogenesis

scientific article published in 2021

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

scientific article

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

scientific article

RPA mediates recombination repair during replication stress and is displaced from DNA by checkpoint signalling in human cells

scientific article

Reduced Expression of PROX1 Transitions Glioblastoma Cells into a Mesenchymal Gene Expression Subtype

article

Regulation and roles of Cdc7 kinase under replication stress

scientific article

Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability

scientific journal article

Regulation of mitotic function of Chk1 through phosphorylation at novel sites by cyclin-dependent kinase 1 (Cdk1).

scientific article published in May 2006

Regulation of replication fork progression through histone supply and demand

scientific article

Regulation of replication fork speed: Mechanisms and impact on genomic stability

scientific article published on 08 July 2019

Regulation of stem cell plasticity: mechanisms and relevance to tissue biology and cancer

scientific article

Regulation of the PML tumor suppressor in drug-induced senescence of human normal and cancer cells by JAK/STAT-mediated signaling.

scientific article published on 26 August 2010

Regulation of the Rab5 GTPase-activating protein RN-tre by the dual specificity phosphatase Cdc14A in human cells

scientific article

Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas

scientific article published on 28 June 2010

Replication stress links structural and numerical cancer chromosomal instability

scientific article published on February 2013

Replication stress, DNA damage signalling, and cytomegalovirus infection in human medulloblastomas

scientific article published on 6 April 2017

Repression of p15INK4b expression by Myc through association with Miz-1

scientific article (publication date: April 2001)

Response to Bakhoum et al.

scientific article published in February 2014

Retinoblastoma pathway defects show differential ability to activate the constitutive DNA damage response in human tumorigenesis

scientific article published on November 2006

Robust, universal biomarker assay to detect senescent cells in biological specimens

scientific article

Role of DNA Repair Factor Xeroderma Pigmentosum Protein Group C in Response to Replication Stress As Revealed by DNA Fragile Site Affinity Chromatography and Quantitative Proteomics

scientific article published on 30 October 2016

SPOP promotes transcriptional expression of DNA repair and replication factors to prevent replication stress and genomic instability

SPOP promotes transcriptional expression of DNA repair and replication factors to prevent replication stress and genomic instability

scientific article published on 01 October 2018

SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells

scientific article published on 18 September 2020

SUMO boosts the DNA damage response barrier against cancer

scientific article published on January 2010

Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality.

scientific article published in June 2019

Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a).

scientific article published on February 2011

Senolytic Cocktail Dasatinib+Quercetin (D+Q) Does Not Enhance the Efficacy of Senescence-Inducing Chemotherapy in Liver Cancer

scientific article published on 30 October 2018

Sensitivity to growth suppression by 1alpha,25-dihydroxyvitamin D(3) among MCF-7 clones correlates with Vitamin D receptor protein induction

scientific article published on June 2002

Sensitizing ovarian cancer cells to chemotherapy by interfering with pathways that are involved in the formation of cancer stem cells

scientific article

Site-specific phosphorylation dynamics of the nuclear proteome during the DNA damage response

scientific article

Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

scientific article (publication date: 24 April 2006)

Structure meets function--centrosomes, genome maintenance and the DNA damage response

scientific article published on 20 June 2006

Superresolution live imaging of plant cells using structured illumination microscopy

scientific article published on 23 July 2015

TGF-β/NF1/Smad4-mediated suppression of ANT2 contributes to oxidative stress in cellular senescence

scientific article published on 16 September 2014

TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity

scientific article published on 25 January 2016

TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes

TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes

scientific article

Targeting genotoxic and proteotoxic stress-response pathways in human prostate cancer by clinically available PARP inhibitors, vorinostat and disulfiram

scientific article published on 29 November 2018

Targeting the NPL4 Adaptor of p97/VCP Segregase by Disulfiram as an Emerging Cancer Vulnerability Evokes Replication Stress and DNA Damage while Silencing the ATR Pathway

scientific article published on 18 February 2020

Tethered genes get checked during replication

scientific article published in July 2011

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

scientific article

The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways

scientific article published on 19 February 2002

The DNA-damage response in human biology and disease

scientific article

The causes and consequences of genetic heterogeneity in cancer evolution

scientific article (publication date: 19 September 2013)

The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

scientific article

The chromatin scaffold protein SAFB1 renders chromatin permissive for DNA damage signaling

scientific article published on 19 September 2013

The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage

scientific article

The combined status of ATM and p53 link tumor development with therapeutic response

scientific article

The emerging phenotype of the testicular carcinoma in situ germ cell

scientific article

The heart of the cycle

scientific article published in Nature

The roles of p27(Kip1) and DNA damage signalling in the chemotherapy-induced delayed cell cycle checkpoint

scientific article published on 16 August 2010

Thresholds of replication stress signaling in cancer development and treatment.

scientific article

Topoisomerase-1 and -2A gene copy numbers are elevated in mismatch repair-proficient colorectal cancers

scientific article published on 04 March 2015

Tumor growth accelerated by chemotherapy-induced senescent cells is suppressed by treatment with IL-12 producing cellular vaccines.

scientific article published on 19 July 2016

Tumor-infiltrating lymphocytes (TILs) from patients with glioma

scientific article

Two new CHEK2 germ-line variants detected in breast cancer/sarcoma families negative for BRCA1, BRCA2, and TP53 gene mutations

scientific article published on 12 May 2011

Two-Step Mechanism of Cellular Uptake of Cationic Gold Nanoparticles Modified by (16-Mercaptohexadecyl)trimethylammonium Bromide

scientific article

USP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of Claspin

scientific article

Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage

scientific article

Utilization of fluorescence in situ hybridization with cytokeratin discriminators in TOP2A assessment of chemotherapy-treated patients with breast cancer

article published in 2012

Valganciclovir as add-on to standard therapy in glioblastoma patients

scientific article published on 18 May 2020

Vascular endothelial growth factor in astroglioma stem cell biology and response to therapy

scientific article

Watching the DNA repair ensemble dance

scientific article published in September 2004

p16INK4A is a robust in vivo biomarker of cellular aging in human skin.

scientific article

p53 at the crossroad of DNA replication and ribosome biogenesis stress pathways

scientific article published in 2022

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