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List of works by Per Ottar Seglen

2-Acetylaminofluorene promotion of liver carcinogenesis by a non-cytotoxic mechanism

scientific article

3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes

scientific article (publication date: March 1982)

6-substituted purines: a novel class of inhibitors of endogenous protein degradation in isolated rat hepatocytes

scientific article published on 01 August 1982

A Simple Cargo Sequestration Assay for Quantitative Measurement of Nonselective Autophagy in Cultured Cells.

scientific article published on 12 November 2016

A novel method for the study of autophagy: destruction of hepatocytic lysosomes, but not autophagosomes, by the photosensitizing porphyrin tetra(4-sulphonatophenyl)porphine

scientific article published on January 1997

A simple perfusion technique applied to glucocorticoid regulation of tryptophan oxygenase turnover and bile production in the isolated rat liver

scientific article published on 01 March 1969

Accumulation of autophagosomes after inhibition of hepatocytic protein degradation by vinblastine, leupeptin or a lysosomotropic amine

scientific article published on 01 January 1982

Adsorption, simple binding and complex binding of rat hepatocytes to various in vitro substrata ⬇️

scientific article published on 01 September 1980

Amino acid and energy requirements for rat hepatocytes in primary culture

scientific article published on 01 January 1982

Amino acid control of autophagic sequestration and protein degradation in isolated rat hepatocytes

scientific article published on August 1984

Amino acid control of protein synthesis and degradation in isolated rat hepatocytes

scientific article published on 01 January 1980

Amino acid inhibition of the autophagic/lysosomal pathway of protein degradation in isolated rat hepatocytes

scientific article published on 01 June 1980

Ammonia inhibition of protein degradation in isolated rat hepatocytes. Quantitative ultrastructural alterations in the lysosomal system

scientific article published on 01 July 1976

Ammonia inhibits protein secretion in isolated rat hepatocytes

scientific article published on January 24, 1977

An effect of ethanol administration on tryptophan oxygenase in the perfused rat liver. Decreased enzyme synthesis dependent on low perfusate pH

scientific article published on 01 July 1972

An effect of glucocorticoid hormone on the nuclear ribonucleoprotein of rat liver

scientific article published on 01 July 1970

Analytical methods for the study of liver cell proliferation

scientific article published on January 1, 1992

Autophagic activity measured in whole rat hepatocytes as the accumulation of a novel BHMT fragment (p10), generated in amphisomes by the asparaginyl proteinase, legumain ⬇️

scientific article published on September 1, 2011

Autophagic bulk sequestration of cytosolic cargo is independent of LC3, but requires GABARAPs

scientific article (publication date: April 2015)

Autophagic sequestration of [14C]sucrose introduced into isolated rat hepatocytes by electrical and non-electrical methods

Autophagic sequestration of [14C]sucrose, introduced into rat hepatocytes by reversible electro-permeabilization

scientific article published on 01 November 1982

Autophagic-lysosomal and mitochondrial sequestration of [14C]sucrose. Density gradient distribution of sequestered radioactivity

scientific article published in December 1985

Autophagosome-associated variant isoforms of cytosolic enzymes

scientific article published on December 2000

Autophagy and protein degradation in isolated rat hepatocytes

scientific article published in December 1985

Autophagy of cytoplasmic bulk cargo does not require LC3.

scientific article published on 3 August 2015

Autophagy proteins control goblet cell function by potentiating reactive oxygen species production

scientific journal article

Binucleation and polyploidization patterns in developmental and regenerative rat liver growth

scientific article published in November 1993

Cell cycle traverse and protein metabolism in human NHIK 3025 cells: the role of anchorage

scientific article published in December 1985

Changes in cellular ploidy and autophagic responsiveness during rat liver carcinogenesis

scientific article published in January 1986

Changes in ploidy distributions in human liver carcinogenesis

scientific article published in November 1988

Characterization of hepatocytes from carcinogen-treated rats by two-parametric flow cytometry

scientific article published in January 1986

Comigration of two autophagosome-associated dehydrogenases on two-dimensional polyacrylamide gels

scientific article

Control of glycogen metabolism in isolated rat liver cells by glucose, insulin and glucagon ⬇️

scientific article published on January 1, 1974

Conversion of dense lysosomes into light lysosomes during hepatocytic autophagy

scientific article published on 01 April 1985

Dependence of hepatocytic autophagy on intracellularly sequestered calcium

scientific article published on 01 December 1993

Differences between fluid-phase endocytosis (pinocytosis) and receptor-mediated endocytosis in isolated rat hepatocytes

scientific article published on 01 May 1997

Differential effects of proteinase inhibitors and amines on the lysosomal and non-lysosomal pathways of protein degradation in isolated rat hepatocytes

scientific article published on 01 September 1980

Diploid growth pattern of hepatocellular tumours induced by various carcinogenic treatments ⬇️

scientific article published on February 1, 1991

Diploid nature of hepatocellular tumours developing from transplanted preneoplastic liver cells

scientific article published on February 1989

Disruption of the cytokeratin cytoskeleton and inhibition of hepatocytic autophagy by okadaic acid.

scientific article published in June 1995

Does bafilomycin A1 block the fusion of autophagosomes with lysosomes?

scientific article published on 22 October 2008

Effect of serum step-down on protein metabolism and proliferation kinetics of NHIK 3025 cells

scientific article published on 01 April 1981

Effects of adrenergic agonists and antagonists on autophagic activity in isolated rat liver cells

scientific article published on 01 January 1991

Effects of amino acid analogues on protein degradation in isolated rat hepatocytes

scientific article published on 01 August 1981

Effects of amino acids and amino acid analogues on lysosomal protein degradation in isolated rat hepatocytes

scientific article published on January 1981

Effects of aminooxyacetate, alanine and other amino acids on protein synthesis in isolated rat hepatocytes

scientific article published on October 24, 1978

Effects of anaerobiosis, glucose, insulin and glucagon on glycogen metabolism in isolated parenchymal rat liver cells

scientific article

Effects of antibiotics on protein synthesis and degradation in primary cultures of rat hepatocytes

scientific article published on 01 January 1981

Effects of inhibitors of the vacuolar proton pump on hepatic heterophagy and autophagy

scientific article

Effects of insulin and anchorage on hepatocytic protein metabolism and amino acid transport

scientific article

Emergence of a population of small, diploid hepatocytes during hepatocarcinogenesis

scientific article published in October 1984

Endocytosis of asialo-glycoproteins and attachment to asialo-glycoproteins of hepatocytes from carcinogen-treated rats

scientific article published in January 1987

Energy dependence of autophagic protein degradation in isolated rat hepatocytes

scientific article published on April 1987

Energy dependence of different steps in the autophagic-lysosomal pathway

scientific article published in April 1989

Enrichment of glucagon sensitive adenyl cyclase upon preparation of parenchymal cells from rat liver

scientific article published on 01 June 1972

Evidence for acidity of prelysosomal autophagic/endocytic vacuoles (amphisomes).

scientific article published on April 1993

Experimental characterization of the autophagic-lysosomal pathway in isolated rat hepatocytes

scientific article published on 01 January 1989

Flow cytometric investigation of a possible precursor--product relationship between oval cells and parenchymal cells in the rat liver

scientific article published in January 1994

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

scientific article

Hepatocytic autophagy

scientific article published on January 1, 1991

How shall I eat thee?

scientific article published on 15 May 2007

Increase in cis-dichlorodiammineplatinum (II) cytotoxicity upon reversible electropermeabilization of the plasma membrane in cultured human NHIK 3025 cells

scientific article published on 01 December 1986

Induction of tryptophan oxygenase in primary rat liver cell suspensions by glucocorticoid hormone ⬇️

scientific article published on 01 June 1972

Inhibition of asialoglycoprotein endocytosis and degradation in rat hepatocytes by protein phosphatase inhibitors

scientific article published on October 1995

Inhibition of autophagic sequestration and endogenous protein degradation in isolated rat hepatocytes by methylated adenosine derivatives ⬇️

scientific article published on November 16, 1981

Inhibition of autophagic vacuole formation and protein degradation by amino acids in isolated hepatocytes ⬇️

scientific article published on 01 June 1981

Inhibition of autophagic-lysosomal delivery and autophagic lactolysis by asparagine

scientific article published on June 1991

Inhibition of autophagy and multiple steps in asialoglycoprotein endocytosis by inhibitors of tyrosine protein kinases (tyrphostins).

scientific article published on May 1995

Inhibition of cell spreading by lysosomotropic amines ⬇️

scientific article published on September 15, 1979

Inhibition of hepatocytic autophagy by adenosine, adenosine analogs and AMP

scientific article published on 01 November 1998

Inhibition of hepatocytic autophagy by adenosine, aminoimidazole-4-carboxamide riboside, and N6-mercaptopurine riboside. Evidence for involvement of amp-activated protein kinase

scientific article published on 01 September 1998

Inhibition of hepatocytic autophagy by okadaic acid and other protein phosphatase inhibitors

scientific article published in July 1993

Inhibition of hepatocytic protein degradation by inducers of autophagosome accumulation.

scientific article published on January 1982

Inhibition of hepatocytic protein degradation by methylaminopurines and inhibitors of protein synthesis.

scientific article published in August 1981

Inhibition of the Lysosomal Pathway of Protein Degradation in Isolated Rat Hepatocytes by Ammonia, Methylamine, Chloroquine and Leupeptin ⬇️

scientific article published on April 2, 1979

Inhibitors and pathways of hepatocytic protein degradation.

scientific article

Insulin and amino-acid regulation of polysomes in perfused, diabetic rat liver

scientific article published on 01 February 1971

Insulin inhibition of tyrosine transaminase degradation in the isolated, perfused rat liver

scientific article published on 01 September 1968

Isolation and characterization of rat liver amphisomes. Evidence for fusion of autophagosomes with both early and late endosomes

scientific article

Isolation of carcinogen-induced diploid rat hepatocytes by centrifugal elutriation

scientific article published on 01 September 1986

Leucine inhibition of autophagic vacuole formation in isolated rat hepatocytes

scientific article

Liver tumor promoters stimulate growth of transplanted hepatocellular carcinomas

scientific article published on 01 August 1990

Macroautophagic cargo sequestration assays

scientific article published on 07 January 2015

Mass isolation and culture of rat kupffer cells ⬇️

scientific article published on January 1, 1975

Measurement of Bulk Autophagy by a Cargo Sequestration Assay

scientific article published on 01 January 2019

Methods for monitoring autophagy from yeast to human

scientific article published on 4 May 2007

Modulation of intracellular calcium homeostasis blocks autophagosome formation

scientific article published on 13 August 2013

Naringin-sensitive phosphorylation of plectin, a cytoskeletal cross-linking protein, in isolated rat hepatocytes

scientific journal article

Neuroendocrine dysdifferentiation and bombesin production in carcinogen-induced hepatocellular rat tumours

scientific article published on January 1989

Non-selective autophagy.

scientific article published on December 1990

Nonselective autophagy of cytosolic enzymes by isolated rat hepatocytes

scientific article

Novel steps in the autophagic-lysosomal pathway

scientific article published on 08 April 2015

Okadaic acid-induced, naringin-sensitive phosphorylation of glycine N-methyltransferase in isolated rat hepatocytes

scientific article

Paradoxical stimulation by amino acids of the degradation of [35S]methionine-labelled, short-lived protein in isolated rat hepatocytes

scientific article published on 01 December 1983

Pathways of intracellular sequestration and protein degradation in isolated rat hepatocytes

article published in 1985

Phosphorylated and non-phosphorylated forms of catechol O-methyltransferase in rat liver, brain and other tissues

scientific article

Ploidy-dependent growth and binucleation in cultured rat hepatocytes

scientific article published on October 1994

Prelysosomal and lysosomal connections between autophagy and endocytosis ⬇️

scientific article published on April 15, 1992

Prelysosomal convergence of autophagic and endocytic pathways

scientific article published on 01 February 1988

Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion

scientific article published on 01 December 1973

Preparation of rat liver cells. I. Effect of Ca 2+ on enzymatic dispersion of isolated, perfused liver

scientific article published on 01 October 1972

Preparation of rat liver cells. II. Effects of ions and chelators on tissue dispersion

scientific article published on 01 January 1973

Prevention of toxin-induced cytoskeletal disruption and apoptotic liver cell death by the grapefruit flavonoid, naringin

scientific article published in August 2000

Proceedings: Carbohydrate metabolism of isolated parenchymal rat liver cells

scientific article published on 01 October 1974

Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway

scientific article

Protection by naringin and some other flavonoids of hepatocytic autophagy and endocytosis against inhibition by okadaic acid

scientific article published on 01 March 1995

Protein degradation in isolated rat hepatocytes

scientific article published on January 1, 1977

Protein kinase-dependent effects of okadaic acid on hepatocytic autophagy and cytoskeletal integrity ⬇️

scientific article published on June 15, 1992

Protein metabolism and survival of rat hepatocytes in early culture ⬇️

scientific article published on 01 November 1980

Protein synthesis and protein degradation through the cell cycle of human NHIK 3025 cells in vitro

scientific article published on October 1, 1979

Proteomic Analysis of Membrane-Associated Proteins from Rat Liver Autophagosomes

scientific article published on 19 July 2007

Purification and characterization of autophagosomes from rat hepatocytes ⬇️

scientific article published on October 15, 1998

Radiolabelled sugars as probes of hepatocytic autophagy

scientific article published on January 1986

Reduced autophagic activity in primary rat hepatocellular carcinoma and ascites hepatoma cells

scientific article published in December 1993

Reduced autophagic activity, improved protein balance and enhanced in vitro survival of hepatocytes isolated from carcinogen-treated rats

scientific article published in March 1985

Regulation of tyrosine transaminase degradation in the isolated perfused rat liver by cycloheximide and insulin

scientific article published on 01 February 1971

Role of Microtubuli in the Lysosomal Degradation of Endogenous and Exogenous Protein in Isolated Rat Hepatocytes ⬇️

scientific article published on 01 May 1981

Role of cAMP in the regulation of hepatocytic autophagy

scientific article published on 01 February 1996

Role of cyclic nucleotides in the control of hepatic autophagy

scientific article published on 01 January 1991

Seeing is believing: the impact of electron microscopy on autophagy research

scientific article

Separation of lysosomes and autophagosomes by means of glycyl-phenylalanine-naphthylamide, a lysosome-disrupting cathepsin-C substrate

scientific article published in April 1994

Sequestration and hydrolysis of electroinjected [14C]lactose as a means of investigating autophagosome-lysosome fusion in isolated rat hepatocytes

scientific article

Sequestration assays for mammalian autophagy

scientific article published in January 2009

Stimulation of hepatocytic AMP-activated protein kinase by okadaic acid and other autophagy-suppressive toxins.

scientific article published on March 2005

Structural and physical changes in lysosomes from isolated rat hepatocytes treated with methylamine

scientific article published on 01 October 1983

Structural aspects of autophagy

scientific article published on January 1996

Studies on the mitoinhibitory effect of orotic acid on hepatocytes in primary culture

scientific article published in June 1990

Subcellular distribution of proteolytically generated valine in isolated rat hepatocytes

scientific article published on 01 June 1980

Sugar uptake by fluid-phase pinocytosis and diffusion in isolated rat hepatocytes

scientific article published on May 1987

Temperature dependence of protein degradation, autophagic sequestration and mitochondrial sugar uptake in rat hepatocytes

scientific article published on 01 July 1987

The Norse god of autophagy. Interviewed by Daniel J Klionsky

scientific article published in November 2010

The effect of perfusate pH on respiration and glycolysis in the isolated rat liver perfused with an erythrocyte- and protein-free medium

scientific article published in May 1972

The fraction of cells in G1 with bound retinoblastoma protein increases with the duration of the cell cycle

scientific article published on February 1994

The polyploidizing growth pattern of normal rat liver is replaced by divisional, diploid growth in hepatocellular nodules and carcinomas ⬇️

scientific article published on 01 June 1988

The relation between protein accumulation and cell cycle traverse of human NHIK 3025 cells in unbalanced growth

scientific article published on 01 July 1982

The role of protein accumulation in the cell cycle control of human NHIK 3025 cells ⬇️

scientific article published on 01 December 1981

The skewness of science ⬇️

journal article from Per O. Seglen published in 1992

The use of Metrizamide as a gradient medium for isopycnic separation of rat liver cells

scientific article published in August 1974

Transplantation of preneoplastic rat hepatocytes by intraportal injection

scientific article published in January 1987

Trapping of electro-injected [14C]sucrose by hepatocyte mitochondria: a mechanism for cellular autofiltration?

scientific article published on 01 March 1984

Tryptophan oxygenase activation and ascorbate oxidation in whole homogenates from rat liver ⬇️

scientific article published on 01 January 1969

Tyrosine transaminase degradation in perfused liver after inhibition of protein synthesis by cycloheximide.

scientific article

Ultrastructural and immunocytochemical characterization of autophagic vacuoles in isolated hepatocytes: effects of vinblastine and asparagine on vacuole distributions

scientific article

Ultrastructural characterization of the delimiting membranes of isolated autophagosomes and amphisomes by freeze-fracture electron microscopy

scientific article published on 01 December 2000

Use of [3H]raffinose as a specific probe of autophagic sequestration

scientific article published on 01 January 1986

Use of a hydrolysable probe, [14C]lactose, to distinguish between pre-lysosomal and lysosomal steps in the autophagic pathway

scientific article published on September 1986

Use of digitonin extraction to distinguish between autophagic-lysosomal sequestration and mitochondrial uptake of [14C]sucrose in hepatocytes

scientific article

Use of electrical methods in the study of hepatocytic autophagy

scientific article published on 01 January 1986

Valine Uptake and Incorporation into Protein in Isolated Rat Hepatocytes. Nature of the Precursor Pool for Protein Synthesis ⬇️

scientific article published on 01 April 1978

Vanadate inhibition of hepatocytic autophagy. Calcium-modulated and osmolality-modulated antagonism by asparagine

scientific article published on 01 May 1995

Vanadate inhibits protein degradation in isolated rat hepatocytes ⬇️

scientific article published on August 10, 1981

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