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List of works by Theo Wallimann

A molecular approach to the concerted action of kinases involved in energy homoeostasis

scientific article

A quantitative approach to membrane binding of human ubiquitous mitochondrial creatine kinase using surface plasmon resonance

scientific article (publication date: February 2000)

A short review on creatine-creatine kinase system in relation to cancer and some experimental results on creatine as adjuvant in cancer therapy

scientific article published on 19 July 2011

A versatile multidimensional protein purification system with full internet remote control based on a standard HPLC system

scientific article

AMPK-Mediated AS160 Phosphorylation in Skeletal Muscle Is Dependent on AMPK Catalytic and Regulatory Subunits

scientific article published on 01 July 2006

Acute and moderate-term creatine monohydrate supplementation does not affect creatine transporter mRNA or protein content in either young or elderly humans.

scientific article published in February 2003

Acute toxicity of doxorubicin on isolated perfused heart: response of kinases regulating energy supply

scientific article

Adult rat cardiomyocytes cultured in creatine-deficient medium display large mitochondria with paracrystalline inclusions, enriched for creatine kinase ⬇️

scientific article published on April 1, 1991

Alterations in myocardial energy metabolism induced by the anti-cancer drug doxorubicin

scientific article published on 21 June 2006

Ammonium alters creatine transport and synthesis in a 3D culture of developing brain cells, resulting in secondary cerebral creatine deficiency.

scientific article published in April 2008

An automated home-built low-cost fermenter suitable for large-scale bacterial expression of proteins in Escherichia coli

scientific article published on 01 August 2008

An increase in the myocardial PCr/ATP ratio in GLUT4 null mice

scientific article published in April 2002

Autophosphorylation of creatine kinase: characterization and identification of a specifically phosphorylated peptide ⬇️

scientific article published on September 6, 1995

Bioenergetics: Dissecting the role of creatine kinase

scientific article published on 01 January 1994

Brain ATP metabolism in hypoxia resistant mice fed guanidinopropionic acid.

scientific article published in January 1998

Brain-type creatine kinase BB-CK interacts with the Golgi Matrix Protein GM130 in early prophase

scientific article published on 12 October 2006

C-terminal lysines determine phospholipid interaction of sarcomeric mitochondrial creatine kinase

scientific article (publication date: 4 June 2004)

Calcium and energy transfer

scientific article published on 01 June 2005

Cardiac system bioenergetics: metabolic basis of the Frank-Starling law.

scientific article

Cardiolipin Clusters and Membrane Domain Formation Induced by Mitochondrial Proteins

scientific article published on 13 October 2006

Co-expression of LKB1, MO25alpha and STRADalpha in bacteria yield the functional and active heterotrimeric complex.

scientific article published in July 2007

Comment on “toxic hepatitis in a group of 20 male body-builders taking dietary supplements” by Timcheh-Hariri et al. (2012) ⬇️

scientific article published on October 26, 2012

Coupling of creatine kinase to glycolytic enzymes at the sarcomeric I-band of skeletal muscle: a biochemical study in situ

scientific article published on 01 January 2000

Creatine and creatine kinase in health and disease--a bright future ahead?

scientific article published on January 2007

Creatine and neurotrophin-4/5 promote survival of nitric oxide synthase-expressing interneurons in striatal cultures.

scientific article published on 28 November 2005

Creatine kinase and creatine transporter in normal, wounded, and diseased skin

scientific article (publication date: March 2002)

Creatine kinases: a cornerstone for structural research in the phosphagen kinase family.

scientific article published in January 2010

Creatine promotes the GABAergic phenotype in human fetal spinal cord cultures.

scientific article

Creatine supplementation improves dopaminergic cell survival and protects against MPP+ toxicity in an organotypic tissue culture system

scientific article published in January 2005

Creatine supplementation improves intracellular Ca2+ handling and survival in mdx skeletal muscle cells

scientific article published on 01 November 1998

Creatine supplementation in health and disease. Effects of chronic creatine ingestion in vivo: down-regulation of the expression of creatine transporter isoforms in skeletal muscle.

scientific article published in July 1998

Creatine supplementation reduces skeletal muscle degeneration and enhances mitochondrial function in mdx mice

scientific article published in February 2002

Creatine synthesis and transport during rat embryogenesis: spatiotemporal expression of AGAT, GAMT and CT1.

scientific article

Creatine transporter activity and content in the rat heart supplemented by and depleted of creatine

scientific article published in February 2003

Creatine transporters: a reappraisal.

scientific article published on January 2004

Creatine treatment promotes differentiation of GABA-ergic neuronal precursors in cultured fetal rat spinal cord.

scientific article published in July 2007

Creatine: a miserable life without it.

scientific article

Crystallization of Mitochondrial Creatine Kinase on Negatively Charged Lipid Layers

scientific article published on 01 March 1994

Crystallization of the Human, Mitochondrial Voltage-Dependent Anion-Selective Channel in the Presence of Phospholipids

scientific article published on 01 August 1999

Development and performance of an enzyme immunoassay to detect creatine kinase isoenzyme MB activity using anti-mitochondrial creatine kinase monoclonal antibodies

scientific article published in January 2009

Developmental changes in the expression of creatine synthesizing enzymes and creatine transporter in a precocial rodent, the spiny mouse

scientific article published in July 2009

Dietary phytoestrogens activate AMP-activated protein kinase with improvement in lipid and glucose metabolism

scientific article published on 16 April 2008

Differential effects of peroxynitrite on human mitochondrial creatine kinase isoenzymes. Inactivation, octamer destabilization, and identification of involved residues

scientific article (publication date: 10 January 2003)

Differentiation in cultures derived from embryonic chicken muscle. II. Phosphorylase histochemistry and fluorescent antibody staining for creatin kinase and aldolase

scientific article published on 01 February 1976

Dimer-dimer interactions in octameric mitochondrial creatine kinase

scientific article published on 01 May 1995

Direct Evidence for the Control of Mitochondrial Respiration by Mitochondrial Creatine Kinase in Oxidative Muscle Cellsin Situ

scientific article published in Journal of Biological Chemistry

Dissecting the role of 5'-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase

scientific article published on 30 August 2006

Divergent Enzyme Kinetics and Structural Properties of the Two Human Mitochondrial Creatine Kinase Isoenzymes

scientific article published on 01 November 2000

Dual mechanisms regulating AMPK kinase action in the ischemic heart.

scientific article published on 13 January 2005

Effects of N-linked glycosylation on the creatine transporter.

scientific article published on January 2006

Effects of creatine supplementation in cystic fibrosis: results of a pilot study.

scientific article published in December 2003

Effects of creatine treatment on the survival of dopaminergic neurons in cultured fetal ventral mesencephalic tissue.

scientific article published in January 2005

Enzymes of creatine biosynthesis, arginine and methionine metabolism in normal and malignant cells

scientific article

European research needs a dash of anarchy

scientific article published in Nature

Expressing creatine kinase in transgenic tobacco--a first step towards introducing an energy buffering system in plants

scientific article published in February 2002

Expression of creatine kinase isoenzyme genes during postnatal development of rat brain cerebellum: evidence for transcriptional regulation

scientific journal article

Functional aspects of creatine kinase in brain.

scientific article

Functional aspects of creatine kinase isoenzymes in endothelial cells.

scientific article published in July 2001

Functional aspects of the X-ray structure of mitochondrial creatine kinase: a molecular physiology approach

scientific article published on 01 July 1998

Functional expression of arginine kinase improves recovery from pH stress of Escherichia coli.

scientific article published in July 2003

Functional expression of phosphagen kinase systems confers resistance to transient stresses in Saccharomyces cerevisiae by buffering the ATP pool.

scientific article published on 29 May 2002

Functions and effects of creatine in the central nervous system.

scientific article published on 24 March 2008

Hair bundles are specialized for ATP delivery via creatine kinase.

scientific article

Higher respiratory rates and improved creatine stimulation in brain mitochondria isolated with anti-oxidants.

scientific article published in June 2004

Hodgkin disease-derived cell lines expressing ubiquitous mitochondrial creatine kinase show growth inhibition by cyclocreatine treatment independent of apoptosis.

scientific article

Homo-oligomerization and activation of AMP-activated protein kinase are mediated by the kinase domain alphaG-helix.

scientific article published on 03 August 2009

Human, rat and chicken small intestinal Na+ - Cl- -creatine transporter: functional, molecular characterization and localization.

scientific article published in November 2002

Identification of phosphorylation sites in AMP-activated protein kinase (AMPK) for upstream AMPK kinases and study of their roles by site-directed mutagenesis

scientific article published on 21 May 2003

Improved Reperfusion and Neuroprotection by Creatine in a Mouse Model of Stroke

Improved reperfusion and neuroprotection by creatine in a mouse model of stroke

scientific article published on 14 June 2006

In vivo brain phosphocreatine and ATP regulation in mice fed a creatine analog.

scientific article published in May 1997

Inhibition of cytosolic and mitochondrial creatine kinase by siRNA in HaCaT- and HeLaS3-cells affects cell viability and mitochondrial morphology

scientific article published on 28 July 2007

Inhibition of the mitochondrial permeability transition by creatine kinase substrates. Requirement for microcompartmentation.

scientific article published on 5 March 2003

Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491.

scientific article

Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the 'phosphocreatine circuit' for cellular energy homeostasis

scientific article

Intradialytic creatine supplementation: A scientific rationale for improving the health and quality of life of dialysis patients

scientific article published on 7 December 2016

Introduction--creatine: cheap ergogenic supplement with great potential for health and disease.

scientific article published in January 2007

Isoenzyme-directed selection and characterization of anti-creatine kinase single chain Fv antibodies from a human phage display library.

scientific article

Isoenzyme-specific localization of M-line bound creatine kinase in myogenic cells ⬇️

scientific article published on 01 August 1983

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

scientific journal article

Light-chain movement and regulation in scallop myosin ⬇️

scientific article published on February 10, 1983

Localization of creatine kinase isoenzymes in myofibrils. I. Chicken skeletal muscle ⬇️

scientific article published on November 1, 1977

Localization of creatine kinase isoenzymes in myofibrils. II. Chicken heart muscle ⬇️

scientific article published on November 1, 1977

Localization of reactive cysteine residues by maleidoyl undecagold in the mitochondrial creatine kinase octamer

scientific article published on May 1995

Macroenzyme creatine kinase (CK) type 2 in HIV-infected patients is significantly associated with TDF and consists of ubiquitous mitochondrial CK

scientific article published on 01 January 2006

Mammalian AMP-activated protein kinase: functional, heterotrimeric complexes by co-expression of subunits in Escherichia coli

scientific article published in August 2003

Membrane-Binding and Lipid Vesicle Cross-Linking Kinetics of the Mitochondrial Creatine Kinase Octamer†

scientific article published on 01 December 1996

Metabolic compartmentation - a system level property of muscle cells: real problems of diffusion in living cells.

scientific article published on 09 May 2008

Metabolite Channeling: Creatine Kinase Microcompartments

article published in 2004

Metabolite channelling in aerobic energy metabolism

scientific article published on 01 September 1992

Mitochondrial creatine kinase and mitochondrial outer membrane porin show a direct interaction that is modulated by calcium

scientific article (publication date: 21 December 2001)

Mitochondrial creatine kinase in human health and disease

scientific article

Mitochondrial creatine kinase is a prime target of peroxynitrite-induced modification and inactivation.

scientific article published in July 1998

Mitochondrial creatine kinase: a key enzyme of aerobic energy metabolism

scientific article published on September 25, 1992

Mitochondrial intermembrane inclusion bodies: the common denominator between human mitochondrial myopathies and creatine depletion, due to impairment of cellular energetics

scientific article published on September 1997

Modular organization of cardiac energy metabolism: energy conversion, transfer and feedback regulation.

scientific article

Molecular system bioenergetics: regulation of substrate supply in response to heart energy demands

scientific article published on 28 September 2006

Molecular system bioenergics of the heart: experimental studies of metabolic compartmentation and energy fluxes versus computer modeling

scientific article

Monovalent antibodies against MM-creatine kinase remove the M line from myofibrils ⬇️

scientific article published on September 1, 1978

Multiple interference of anthracyclines with mitochondrial creatine kinases: preferential damage of the cardiac isoenzyme and its implications for drug cardiotoxicity

scientific article published in March 2002

Multiple-state equilibrium unfolding of guanidino kinases ⬇️

scientific article published on August 22, 1995

Muscle-type creatine kinase interacts with central domains of the M-band proteins myomesin and M-protein

scientific article (publication date: 26 September 2003)

Mutation of cis-proline 207 in mitochondrial creatine kinase to alanine leads to increased acid stability

scientific article published on 01 July 1998

Mutation of conserved active-site threonine residues in creatine kinase affects autophosphorylation and enzyme kinetics

scientific article published on May 2002

Neuroprotection of creatine supplementation in neonatal rats with transient cerebral hypoxia-ischemia.

scientific article published in January 2002

New candidate targets of AMP-activated protein kinase in murine brain revealed by a novel multidimensional substrate-screen for protein kinases.

scientific article

New creatine transporter assay and identification of distinct creatine transporter isoforms in muscle

scientific article

New insights into doxorubicin-induced cardiotoxicity: the critical role of cellular energetics.

scientific article published on August 2006

Novel lipid transfer property of two mitochondrial proteins that bridge the inner and outer membranes

scientific article

Novel mitochondrial creatine transport activity. Implications for intracellular creatine compartments and bioenergetics.

scientific article published on 26 July 2002

Novel staining pattern of skeletal muscle M-lines upon incubation with antibodies against MM-creatine kinase ⬇️

scientific article published on June 1, 1983

Nucleotide binding to creatine kinase: an isothermal titration microcalorimetry study

scientific article

Octamer-dimer Transitions of Mitochondrial Creatine Kinase in Heart Disease

scientific article published on 01 April 1999

Octameric mitochondrial creatine kinase induces and stabilizes contact sites between the inner and outer membrane

scientific article published on January 2005

Oligomeric state and membrane binding behaviour of creatine kinase isoenzymes: implications for cellular function and mitochondrial structure.

scientific article published in July 1998

Origin of Leg Musculature during Drosophila Metamorphosis ⬇️

scientific article published on October 1, 1972

PKA phosphorylates and inactivates AMPKalpha to promote efficient lipolysis

scientific article

Phosphocreatine interacts with phospholipids, affects membrane properties and exerts membrane-protective effects

scientific article

Phosphorylation of chicken brain-type creatine kinase affects a physiologically important kinetic parameter and gives rise to protein microheterogeneity in vivo

scientific article published in September 1990

Progressive decrease of phosphocreatine, creatine and creatine kinase in skeletal muscle upon transformation to sarcoma.

scientific article published on 13 May 2008

Protective Effect of the Energy Precursor Creatine Against Toxicity of Glutamate and β-Amyloid in Rat Hippocampal Neurons

article

Protective effects of oral creatine supplementation on spinal cord injury in rats.

scientific article published in September 2002

Rapid suppression of mitochondrial permeability transition by methylglyoxal. Role of reversible arginine modification.

scientific article

Reconstituted adenine nucleotide translocase forms a channel for small molecules comparable to the mitochondrial permeability transition pore ⬇️

scientific article published on April 10, 1998

Reduced creatine kinase activity in transgenic amyotrophic lateral sclerosis mice

scientific article published in May 2002

Reduced creatine-stimulated respiration in doxorubicin challenged mitochondria: particular sensitivity of the heart

scientific article published on 8 September 2007

Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells

scientific article

Science and security: a European view

scientific article

Signaling by AMP-activated Protein Kinase

article

Some new aspects of creatine kinase (CK): compartmentation, structure, function and regulation for cellular and mitochondrial bioenergetics and physiology.

scientific article

Stabilization of ubiquitous mitochondrial creatine kinase preprotein by APP family proteins.

scientific article published on 2 November 2005

Stimulation of mitochondrial gene expression and proliferation of mitochondria following impairment of cellular energy transfer by inhibition of the phosphocreatine circuit in rat hearts

scientific article published on 01 December 1999

Structural Properties of AMP-activated Protein Kinase

scientific article published in Journal of Biological Chemistry

Structural changes of creatine kinase upon substrate binding.

scientific article

Structure of the mitochondrial creatine kinase octamer: high-resolution shadowing and image averaging of single molecules and formation of linear filaments under specific staining conditions ⬇️

scientific article published on January 1, 1991

The Phosphocreatine Circuit: Molecular and Cellular Physiology of Creatine Kinases, Sensitivity to Free Radicals, and Enhancement by Creatine Supplementation

article

The creatine kinase phosphotransfer network: thermodynamic and kinetic considerations, the impact of the mitochondrial outer membrane and modelling approaches.

scientific article published on January 2007

The creatine kinase system and pleiotropic effects of creatine ⬇️

scientific article published on March 30, 2011

The creatine kinase system in human skin: protective effects of creatine against oxidative and UV damage in vitro and in vivo

scientific article

The creatine kinase/creatine connection to Alzheimer's disease: CK-inactivation, APP-CK complexes and focal creatine deposits

scientific article

The effects of creatine supplementation on striatal neural progenitor cells depend on developmental stage

scientific article published on 29 April 2016

The extended, dynamic mitochondrial reticulum in skeletal muscle and the creatine kinase (CK)/phosphocreatine (PCr) shuttle are working hand in hand for optimal energy provision

scientific article

The in vitro kinetics of mitochondrial and cytosolic creatine kinase determined by saturation transfer 31P-NMR.

scientific article published in May 1996

The interaction of skeletal myosin subfragment 1 with the polyanion, heparin ⬇️

scientific article published on 01 September 1984

The role of creatine kinase in inhibition of mitochondrial permeability transition ⬇️

scientific article published on September 8, 1997

Tracking and quantification of 32P-labeled phosphopeptides in liquid chromatography matrix-assisted laser desorption/ionization mass spectrometry

scientific article

Two different B-type creatine kinase subunits dimerize in a tissue-specific manner

scientific article published in March 1990

Unity in diversity

Where Have the Fluxes Gone? ⬇️

scientific article published on December 24, 2010

Why is creatine kinase a dimer? Evidence for cooperativity between the two subunits

article

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