List of works by Mara Dierssen Sotos

A behavioral assessment of Ts65Dn mice: a putative Down syndrome model.

scientific article published in October 1995

A cluster of protein kinases and phosphatases modulated in fetal Down syndrome (trisomy 21) brain

scientific article published on 5 March 2015

A commentary on: Overexpression of Dyrk1A inhibits choline acetyltransferase induction by oleic acid in cellular models of Down syndrome

scientific article

A gel-based proteomic method reveals several protein pathway abnormalities in fetal Down syndrome brain.

scientific article

A murine model for Down syndrome shows reduced responsiveness to pain.

scientific article published in April 1999

A new cognitive evaluation battery for Down syndrome and its relevance for clinical trials

scientific article published on 4 June 2015

A new mouse model for the trisomy of the Abcg1-U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome

scientific article published on 26 September 2009

A specific prelimbic-nucleus accumbens pathway controls resilience versus vulnerability to food addiction

scientific article published on 07 February 2020

AGC1-malate aspartate shuttle activity is critical for dopamine handling in the nigrostriatal pathway

scientific article published in February 2013

Aberrant brain microRNA target and miRISC gene expression in the anx/anx anorexia mouse model

scientific article published on 30 January 2012

Action on noradrenergic transmission of an anticholinesterase: 9-amino-1,2,3,4-tetrahydroacridine

article

Acute effects of tetrahydroaminoacridine on beta-adrenoceptor-linked cyclic AMP accumulation in brain of young and middle-aged rats

scientific article published in October 1991

Age-associated motor and visuo-spatial learning phenotype in Dyrk1A heterozygous mutant mice.

scientific article published on 4 August 2009

Alterations in the phenotype of neocortical pyramidal cells in the Dyrk1A+/- mouse

scientific article published in October 2005

Alterations of central noradrenergic transmission in Ts65Dn mouse, a model for Down syndrome

scientific article published on February 1997

An animal model of compulsive food-taking behaviour

scientific article

Aneuploidy: from a physiological mechanism of variance to Down syndrome

scientific article published on July 2009

Anomalous White Matter Structure and the Effect of Age in Down Syndrome Patients.

scientific article

Anomalous brain functional connectivity contributing to poor adaptive behavior in Down syndrome.

scientific article published on 28 October 2014

Application of Alu-splice PCR on chromosome 21: DSCR1 and Intersectin.

scientific article

Association of NTRK3 and its interaction with NGF suggest an altered cross-regulation of the neurotrophin signaling pathway in eating disorders

scientific article

Behavioral characterization of a mouse model overexpressing DSCR1/ RCAN1.

scientific article

Beta-amyloid controls altered Reelin expression and processing in Alzheimer's disease

scientific article

Beta-amyloid precursor protein, ETS-2 and collagen alpha 1 (VI) chain precursor, encoded on chromosome 21, are not overexpressed in fetal Down syndrome: further evidence against gene dosage effect.

scientific article

Brain G protein-dependent signaling pathways in Down syndrome and Alzheimer's disease

scientific article published on 4 April 2006

Brain-derived neurotrophic factor modulates the severity of cognitive alterations induced by mutant huntingtin: involvement of phospholipaseCgamma activity and glutamate receptor expression

scientific article

Ca2+ channel modulation by dihydropyridines modifies sufentanil-induced respiratory depression in cats

scientific article

Calcium channel modulation by dihydropyridines modifies sufentanil-induced antinociception in acute and tolerant conditions.

scientific article published in November 1990

Candidate genes for panic disorder: insight from human and mouse genetic studies.

scientific article published on June 2007

Cannabinoid type-1 receptor blockade restores neurological phenotypes in two models for Down syndrome

scientific article published on 25 January 2019

Carnitine palmitoyltransferase 1C deficiency causes motor impairment and hypoactivity.

scientific article published on 21 August 2013

Ceramide levels regulated by carnitine palmitoyltransferase 1C control dendritic spine maturation and cognition

scientific article

Changing Paradigms in Down Syndrome: The First International Conference of the Trisomy 21 Research Society.

scientific article published on 16 September 2016

Chapter 5.9 Modelling Down syndrome in mice

Characterization of a mouse model overexpressing beta-site APP-cleaving enzyme 2 reveals a new role for BACE2.

scientific article published on 22 September 2009

Cholinergic, serotonergic and catecholaminergic neurons are not affected in Ts65Dn mice.

scientific article published in November 1997

Cognition and hippocampal plasticity in the mouse is altered by monosomy of a genomic region implicated in Down syndrome

scientific article

Cognitive deficits and associated neurological complications in individuals with Down's syndrome

scientific article published on June 2010

Combined Treatment With Environmental Enrichment and (-)-Epigallocatechin-3-Gallate Ameliorates Learning Deficits and Hippocampal Alterations in a Mouse Model of Down Syndrome

scientific article published on September 2016

Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models

scientific article published in November 2005

DNA methylation map of mouse and human brain identifies target genes in Alzheimer's disease.

scientific article published on 11 September 2013

DREAM controls the on/off switch of specific activity-dependent transcription pathways

scientific article

DYRK1A (dual-specificity tyrosine-phosphorylated and -regulated kinase 1A): a gene with dosage effect during development and neurogenesis.

scientific article published on 17 June 2006

DYRK1A Overexpression Alters Cognition and Neural-Related Proteomic Pathways in the Hippocampus That Are Rescued by Green Tea Extract and/or Environmental Enrichment

scientific article published on 15 November 2019

Deficits of neuronal density in CA1 and synaptic density in the dentate gyrus, CA3 and CA1, in a mouse model of Down syndrome.

scientific article published in October 2004

Dendritic pathology in mental retardation: from molecular genetics to neurobiology.

scientific article

Developmental molecular and functional cerebellar alterations induced by PCP4/PEP19 overexpression: implications for Down syndrome.

scientific article published on 28 November 2013

Differential effects of environmental enrichment on behavior and learning of male and female Ts65Dn mice, a model for Down syndrome

scientific article published in August 2002

Differential effects of physostigmine and 1,2,3,4-tetrahydro-9-aminoacridine on the beta-adrenoceptor transduction system

scientific article published in March 1993

Differential responses to anxiogenic drugs in a mouse model of panic disorder as revealed by Fos immunocytochemistry in specific areas of the fear circuitry.

scientific article published on 20 November 2006

Dissociation between CA3-CA1 synaptic plasticity and associative learning in TgNTRK3 transgenic mice.

scientific article

Dopaminergic deficiency in mice with reduced levels of the dual-specificity tyrosine-phosphorylated and regulated kinase 1A, Dyrk1A(+/-).

scientific article published on 28 November 2006

Down syndrome and the genes of human chromosome 21: current knowledge and future potentials

article

Down syndrome patients start early prenatal life with normal cholinergic, monoaminergic and serotoninergic innervation.

scientific article published in January 2001

Down syndrome: from understanding the neurobiology to therapy

scientific article

Down syndrome: the brain in trisomic mode

scientific article published in December 2012

Dyrk1A expression pattern supports specific roles of this kinase in the adult central nervous system

scientific article (publication date: 28 February 2003)

Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice

scientific article

Dyrk1A influences neuronal morphogenesis through regulation of cytoskeletal dynamics in mammalian cortical neurons.

scientific article

Dyrk1A is dynamically expressed on subsets of motor neurons and in the neuromuscular junction: possible role in Down syndrome

scientific article

Early Environmental Stimulation Produces Long-Lasting Changes on β-Adrenoceptor Transduction System ⬇️

scientific article published on July 1, 1995

Effect of epigallocatechin gallate on the body composition and lipid profile of down syndrome individuals: Implications for clinical management

scientific article published on 08 June 2019

Effects of age on α1-adrenoceptor subtypes in the heart ventricular muscle of the rat

scientific article published on 01 October 1993

El cerebro artístico. La creatividad desde la neurociencia

written work by Mara Dierssen Sotos

El cerebro artístico. La creatividad desde la neurociencia

2018 edition of written work by Mara Dierssen Sotos

El cerebro artístico. La creatividad desde la neurociencia

2019 edition of written work by Mara Dierssen Sotos

El cerebro del artista. La creatividad vista desde la neurociencia

2019 edition of written work by Mara Dierssen Sotos

Engineering DYRK1A overdosage yields Down syndrome-characteristic cortical splicing aberrations.

scientific article

Environmental Enrichment Induces Epigenomic and Genome Organization Changes Relevant for Cognition

scientific article published on 05 May 2021

Environmental enrichment rescues DYRK1A activity and hippocampal adult neurogenesis in TgDyrk1A.

scientific article published on 20 August 2013

Epigallocatechin-3-Gallate Improves Facial Dysmorphology Associated with Down Syndrome

Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans

scientific article published on 14 September 2013

Erbb4 deletion from fast-spiking interneurons causes schizophrenia-like phenotypes.

scientific article

Excitation/inhibition balance and learning are modified by Dyrk1a gene dosage

scientific article published on 4 May 2014

Extinction and reinstatement of an operant responding maintained by food in different models of obesity

scientific article published on 28 December 2017

Fetal Down syndrome brains exhibit aberrant levels of neurotransmitters critical for normal brain development

scientific article published on 12 November 2007

Fibrinogen drives dystrophic muscle fibrosis via a TGFbeta/alternative macrophage activation pathway

scientific article published in July 2008

From neural to genetic substrates of panic disorder: Insights from human and mouse studies

scientific article published on 24 March 2015

Functional implications of hippocampal adult neurogenesis in intellectual disabilities

scientific article published on 20 April 2013

G-protein-associated signal transduction processes are restored after postweaning environmental enrichment in Ts65Dn, a Down syndrome mouse model

scientific article

Genome-wide miR-155 and miR-802 target gene identification in the hippocampus of Ts65Dn Down syndrome mouse model by miRNA sponges

scientific article

Haploinsufficiency of Dyrk1A in mice leads to specific alterations in the development and regulation of motor activity.

scientific article published in August 2004

Heterozygous deletion of the Williams-Beuren syndrome critical interval in mice recapitulates most features of the human disorder

scientific article published on 15 July 2014

Hippocampal changes produced by overexpression of the human CHRNA5/A3/B4 gene cluster may underlie cognitive deficits rescued by nicotine in transgenic mice

scientific article

Hippocampal hyperexcitability underlies enhanced fear memories in TgNTRK3, a panic disorder mouse model.

scientific article

Hippocampal volume and neuronal number in Ts65Dn mice: a murine model of Down syndrome.

scientific article published in September 1998

Human DNA methylomes of neurodegenerative diseases show common epigenomic patterns.

scientific article published on 19 January 2016

Hypothalamus transcriptome profile suggests an anorexia-cachexia syndrome in the anx/anx mouse model

scientific article published on 23 September 2008

Identificación de genes clave implicados en el síndrome de Down mediante terapia génica

article

Impaired cyclic AMP production in the hippocampus of a Down syndrome murine model

scientific article published in August 1996

Impaired short- and long-term memory in Ts65Dn mice, a model for Down syndrome

scientific article published in May 1998

Impaired spatial learning strategies and novel object recognition in mice haploinsufficient for the dual specificity tyrosine-regulated kinase-1A (Dyrk1A).

scientific article

In vivo effects of APP are not exacerbated by BACE2 co-overexpression: behavioural characterization of a double transgenic mouse model.

scientific article published on 2 July 2010

Increased NR2A expression and prolonged decay of NMDA-induced calcium transient in cerebellum of TgDyrk1A mice, a mouse model of Down syndrome.

scientific article

Increased levels of inflammatory plasma markers and obesity risk in a mouse model of Down syndrome.

scientific article published on 25 September 2017

Increased opioid dependence in a mouse model of panic disorder

scientific article

Influence of Bay K 8644 on the respiratory centers and its interaction with opiate activity

Infralimbic Neurotrophin-3 Infusion Rescues Fear Extinction Impairment in a Mouse Model of Pathological Fear

scientific article

Insights from mouse models to understand neurodegeneration in Down syndrome

scientific article published on August 2010

Long-chain polyunsaturated fatty acids in rat maternal milk, offspring brain and peripheral tissues in essential fatty acid deficiency

scientific article

Loss of SIRT2 leads to axonal degeneration and locomotor disability associated with redox and energy imbalance

scientific article published on 5 October 2017

Mechanism of the respiratory action of pentobarbital at the medullary and pontine levels

scientific article published in June 1986

Meta-analysis of transcriptomic data reveals clusters of consistently deregulated gene and disease ontologies in Down syndrome

scientific article published on 27 September 2021

Metabolomics predicts the pharmacological profile of new psychoactive substances

scientific article published on 19 November 2018

Molecular Rescue of Dyrk1A Overexpression Alterations in Mice with Fontup® Dietary Supplement: Role of Green Tea Catechins

scientific article published on 19 February 2020

Monoamine deficits in the brain of methyl-CpG binding protein 2 null mice suggest the involvement of the cerebral cortex in early stages of Rett syndrome

scientific article published on 13 July 2010

Motor phenotypic alterations in TgDyrk1a transgenic mice implicate DYRK1A in Down syndrome motor dysfunction

scientific article published in February 2004

Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in Age-Related Hearing Loss

scientific article

NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the Down syndrome-related proteins DYRK1A and RCAN1 attenuate this effect

scientific article

Network analysis of Down syndrome and SARS-CoV-2 identifies risk and protective factors for COVID-19

scientific article published on 21 January 2021

Neurobehavioral development of two mouse lines commonly used in transgenic studies

scientific article published in August 2002

Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome.

scientific article

New Perspectives for the Rescue of Cognitive Disability in Down Syndrome

scientific article published on October 2015

New murine Niemann-Pick type C models bearing a pseudoexon-generating mutation recapitulate the main neurobehavioural and molecular features of the disease.

scientific article published on 07 February 2017

Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome

scientific article published on 5 December 2012

On dendrites in Down syndrome and DS murine models: a spiny way to learn.

scientific article

Opiate analgesia and calcium channels modulation by dihydropyridines under acute and tolerant conditions.

scientific article published in January 1990

Opposite phenotypes of muscle strength and locomotor function in mouse models of partial trisomy and monosomy 21 for the proximal Hspa13-App region.

scientific article

Overexpression of Dyrk1A, a Down Syndrome Candidate, Decreases Excitability and Impairs Gamma Oscillations in the Prefrontal Cortex.

scientific article published on March 2016

Overexpression of Reelin prevents the manifestation of behavioral phenotypes related to schizophrenia and bipolar disorder.

scientific article

Overexpression of the CHRNA5/A3/B4 genomic cluster in mice increases the sensitivity to nicotine and modifies its reinforcing effects.

scientific article published on 19 November 2011

Overexpression of α3/α5/β4 nicotinic receptor subunits modifies impulsive-like behavior

scientific article published on 22 October 2011

Overweighed mice show coordinated homeostatic and hedonic transcriptional response across brain

scientific article published on 08 January 2018

Paving the Way for Therapy: The Second International Conference of the Trisomy 21 Research Society

scientific article published on 30 October 2018

Pergola-web: a web server for the visualization and analysis of longitudinal behavioral data using repurposed genomics tools and standards

scientific article published on 01 July 2019

Pergola: Boosting Visualization and Analysis of Longitudinal Data by Unlocking Genomic Analysis Tools

scholarly article published 26 October 2018

Pitfalls and hopes in Down syndrome therapeutic approaches: in the search for evidence-based treatments.

scientific article

Plasticity as a therapeutic target for improving cognition and behavior in Down syndrome

scientific article published on 06 December 2019

Post-train administration of 9-amino-1,2,3,4-tetrahydroacridine enhances passive avoidance retention and decreases beta-adrenoceptor-linked cyclic AMP formation in middle-aged rats

scientific article published in July 1992

Postnatal handling induces long-term modifications in central beta-noradrenergic signalling in rats

scientific article published in June 2002

Potential Role of (-)-Epigallocatechin-3-Gallate (EGCG) in the Secondary Prevention of Alzheimer Disease.

scientific article published on 25 August 2015

Potential role of olive oil phenolic compounds in the prevention of neurodegenerative diseases

scientific article published on 13 March 2015

Potentiation of acute opioid-induced respiratory depression and reversal of tolerance by the calcium antagonist nimodipine in awake rats.

scientific article

Preface

Principal Component Analysis of the Effects of Environmental Enrichment and (-)-epigallocatechin-3-gallate on Age-Associated Learning Deficits in a Mouse Model of Down Syndrome

scientific article

Protein expression of BACE1, BACE2 and APP in Down syndrome brains

scientific article published on 29 December 2007

Proteomic analysis of the fetal brain

scientific article published in November 2002

Re-establishment of the epigenetic state and rescue of kinome deregulation in Ts65Dn mice upon treatment with green tea extract and environmental enrichment

scientific article published on 29 September 2020

Reduced Mid1 Expression and Delayed Neuromotor Development in daDREAM Transgenic Mice

scientific article published on 3 May 2012

Reduced cortical neurotransmitter receptor complex levels in fetal Down syndrome brain

scientific article published on 13 August 2015

Reduced phospholipase C-beta activity and isoform expression in the cerebellum of TS65Dn mouse: a model of Down syndrome.

scientific article

Reduction of nucleoside diphosphate kinase B, Rab GDP-dissociation inhibitor beta and histidine triad nucleotide-binding protein in fetal Down syndrome brain

scientific article (publication date: 2001)

Respiratory actions induced by cholecystokinin at the brainstem level

scientific article published on 01 July 1988

RhoE deficiency alters postnatal subventricular zone development and the number of calbindin-expressing neurons in the olfactory bulb of mouse

scientific article published on 10 July 2014

RhoE deficiency produces postnatal lethality, profound motor deficits and neurodevelopmental delay in mice

scientific article

Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial.

scientific article

Semantic Verbal Fluency Pattern, Dementia Rating Scores and Adaptive Behavior Correlate With Plasma Aβ42 Concentrations in Down Syndrome Young Adults

scientific article

Short-term effects of postnatal manipulation on central beta-adrenoceptor transmission

scientific article published in December 1999

Special interest section--Down's syndrome: postgenomic approaches to neurobiological problems

scientific article published in June 2003

Susceptibility to stress in transgenic mice overexpressing TrkC, a model of panic disorder

scientific article published on 20 August 2009

Synaptic deficit in the temporal cortex of partial trisomy 16 (Ts65Dn) mice.

scientific article published in March 2000

Synthesis and evaluation of tacrine-related compounds for the treatment of Alzheimer's disease

scholarly article by F Aguado et al published January 1994 in European Journal of Medicinal Chemistry

Synthetic zinc finger repressors reduce mutant huntingtin expression in the brain of R6/2 mice

scientific article

Targeting Dyrk1A with AAVshRNA attenuates motor alterations in TgDyrk1A, a mouse model of Down syndrome.

scientific article

Targeting the endocannabinoid system in the treatment of fragile X syndrome.

scientific article published on 31 March 2013

The Ca2+ channel agonist Bay K 8644 induces central respiratory depression in cats, an effect blocked by naloxone

scientific article published on 01 August 1993

The cerebral cortex in fetal Down syndrome

scientific article

The mouse brain transcriptome by SAGE: differences in gene expression between P30 brains of the partial trisomy 16 mouse model of Down syndrome (Ts65Dn) and normals

scientific article

The role of nicotinic receptors in shaping and functioning of the glutamatergic system: a window into cognitive pathology

scientific article published on 29 May 2014

The α3β4* nicotinic ACh receptor subtype mediates physical dependence to morphine: mouse and human studies.

scientific article

Therapeutic approaches in the improvement of cognitive performance in Down syndrome: past, present, and future

scientific article published on January 2012

Time-course and dynamics of obesity-related behavioral changes induced by energy-dense foods in mice.

scientific article published on 10 January 2018

Transgenic mice overexpressing the full-length neurotrophin receptor TrkC exhibit increased catecholaminergic neuron density in specific brain areas and increased anxiety-like behavior and panic reaction

scientific article published on 11 September 2006

Transgenic over expression of nicotinic receptor alpha 5, alpha 3, and beta 4 subunit genes reduces ethanol intake in mice.

scientific article

Translational validity and implications of pharmacotherapies in preclinical models of Down syndrome

scientific article published on 01 November 2019

Unaltered expression of Fas (CD95/APO-1), caspase-3, Bcl-2 and annexins in brains of fetal Down syndrome: evidence against increased apoptosis.

scientific article

Understanding the human brain through mouse models

VNTR-DAT1 and COMTVal158Met Genotypes Modulate Mental Flexibility and Adaptive Behavior Skills in Down Syndrome

scientific article published on 17 October 2016

Where Environment Meets Cognition: A Focus on Two Developmental Intellectual Disability Disorders

scientific article

uPA deficiency exacerbates muscular dystrophy in MDX mice

scientific article

uPA deficiency exacerbates muscular dystrophy inMDXmice

scholarly article by Mònica Suelves et al published 8 October 2007 in Journal of Cell Biology

¿Cómo aprende (y recuerda) el cerebro?. Principios de la neurociencia para aplicar en la educación

written work by Mara Dierssen Sotos

¿Cómo aprende (y recuerda) el cerebro?. Principios de la neurociencia para aplicar en la educación

2018 edition of written work by Mara Dierssen Sotos

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