List of works - Howard Jacobs

A cytoplasmic suppressor of a nuclear mutation affecting mitochondrial functions in Drosophila

scientific article

A mitochondrial ribosomal and RNA decay pathway blocks cell proliferation.

scientific article published on 28 February 2013

A novel mitochondrial point mutation in a maternal pedigree with sensorineural deafness.

scientific article published in January 1994

A prevalent POLG CAG microsatellite length allele in humans and African great apes.

scientific article

A rolling circle replication mechanism produces multimeric lariats of mitochondrial DNA in Caenorhabditis elegans

scientific article (publication date: February 2015)

A tRNA suppressor mutation in human mitochondria

scientific article published on 01 April 1998

Acquisition of the wobble modification in mitochondrial tRNALeu(CUN) bearing the G12300A mutation suppresses the MELAS molecular defect.

scientific article published on 30 January 2006

Alternative oxidase confers nutritional limitation on Drosophila development

scientific article published on 20 June 2019

Alternative oxidase expression in the mouse enables bypassing cytochrome c oxidase blockade and limits mitochondrial ROS overproduction

scientific article

Alternative oxidase rescues mitochondria-mediated dopaminergic cell loss in Drosophila.

scientific article published on 7 March 2012

Alternative oxidase‐mediated respiration prevents lethal mitochondrial cardiomyopathy

scientific article published on 01 January 2019

Alternative respiratory chain enzymes: Therapeutic potential and possible pitfalls

scientific article published on 17 October 2018

Analysis of replication intermediates indicates that Drosophila melanogaster mitochondrial DNA replicates by a strand-coupled theta mechanism.

scientific article

Apparent functional independence of the mitochondrial and nuclear transcription systems in cultured human cells.

scientific article published on December 1994

Behaviour of a population of partially duplicated mitochondrial DNA molecules in cell culture: segregation, maintenance and recombination dependent upon nuclear background

scientific article published on 01 August 1997

Biased incorporation of ribonucleotides on the mitochondrial L-strand accounts for apparent strand-asymmetric DNA replication.

scientific article published in November 2002

Black scientists matter

scientific article published on 15 November 2020

Broad AOX expression in a genetically tractable mouse model does not disturb normal physiology

scientific article published on 14 December 2016

Characterisation of Saccharomyces cerevisiae genes encoding ribosomal protein YL6.

scientific article published on April 1995

Characterization of a high-affinity binding site for a DNA-binding protein from sea urchin embryo mitochondria.

scientific article

Ciona intestinalis NADH dehydrogenase NDX confers stress-resistance and extended lifespan on Drosophila

scientific article published on 12 August 2014

Comparative Genetics of Functional Trinucleotide Tandem Repeats in Humans and Apes

article

Complete nucleotide sequences of the nuclear pseudogenes for cytochrome oxidase subunit I and the large mitochondrial ribosomal RNA in the sea urchin Strongylocentrotus purpuratus.

scientific article published in February 1986

Conserved tRNA gene cluster in starfish mitochondrial DNA

scientific article published on 01 March 1989

Correction: Mitochondrial Dysfunction Plus High-Sugar Diet Provokes a Metabolic Crisis That Inhibits Growth.

scientific article published on 8 March 2016

DNA conformation-dependent activities of human mitochondrial RNA polymerase

scientific article published on 14 July 2009

Developmental and pathological changes in the human cardiac muscle mitochondrial DNA organization, replication and copy number

scientific article

Developmental arrest in Drosophila melanogaster caused by mitochondrial DNA replication defects cannot be rescued by the alternative oxidase

scientific article published in Scientific Reports

Different cellular backgrounds confer a marked advantage to either mutant or wild-type mitochondrial genomes.

scientific article

Diiron centre mutations in Ciona intestinalis alternative oxidase abolish enzymatic activity and prevent rescue of cytochrome oxidase deficiency in flies

scientific article

Do ribosomes regulate mitochondrial RNA synthesis?

scientific article published on July 1989

Effects on mitochondrial transcription of manipulating mTERF protein levels in cultured human HEK293 cells.

scientific article published on 16 September 2010

Engineering the alternative oxidase gene to better understand and counteract mitochondrial defects: state of the art and perspectives.

scientific article published on April 2014

Expression of Ciona intestinalis AOX causes male reproductive defects in Drosophila melanogaster

scientific article

Expression of alternative oxidase in Drosophila ameliorates diverse phenotypes due to cytochrome oxidase deficiency

scientific article

Expression of the Alternative Oxidase Influences Jun N-Terminal Kinase Signaling and Cell Migration

scientific article published on 28 November 2018

Expression of the alternative oxidase mitigates beta-amyloid production and toxicity in model systems.

scientific article published on 14 April 2016

Expression of the gene for mitoribosomal protein S12 is controlled in human cells at the levels of transcription, RNA splicing, and translation.

scientific article

Expression of the nuclear gene encoding mitochondrial ATP synthase subunit alpha in early development of Drosophila and sea urchin.

scientific article

Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction.

scientific article published on 30 April 2010

Familial mitochondrial DNA depletion in liver: haplotype analysis of candidate genes

scientific article published on 01 March 1998

Gene dosage and selective expression modify phenotype in a Drosophila model of human mitochondrial disease.

scientific article published in October 2003

Gene expression in a Drosophila model of mitochondrial disease.

scientific article

Genome wide study of NF-Y type CCAAT boxes in unidirectional and bidirectional promoters in human and mouse

scientific article published on 05 May 2011

Germline knockdown of spargel (PGC-1) produces embryonic lethality in Drosophila

scientific article published on 29 August 2019

Glucose modulates respiratory complex I activity in response to acute mitochondrial dysfunction.

scientific article published on 24 September 2012

Heteroplasmic segregation associated with trisomy-9 in cultured human cells.

scientific article published in November 1999

Human heart mitochondrial DNA is organized in complex catenated networks containing abundant four-way junctions and replication forks

scientific article published on 12 June 2009

Human mitochondrial mTERF wraps around DNA through a left-handed superhelical tandem repeat

scientific article

Human mitochondrial transcription factor A induces a U-turn structure in the light strand promoter

scientific article

Hyperoxia but not AOX expression mitigates pathological cardiac remodeling in a mouse model of inflammatory cardiomyopathy

scientific article published on 04 September 2019

Intracellular vesicle trafficking plays an essential role in mitochondrial quality control

scientific article published on 17 January 2018

Isolation and purification of rat hepatoma nuclei active in the transport of messenger RNA in vitro

scientific article published on 01 January 1982

Ligand-Bound GeneSwitch Causes Developmental Aberrations in Drosophila that Are Alleviated by the Alternative Oxidase

scientific article published on 13 July 2016

Long-extension PCR to detect deleted mitochondrial DNA molecules is compromized by technical artefacts

scientific article published on 01 January 1999

Mammalian mitochondrial DNA replication intermediates are essentially duplex but contain extensive tracts of RNA/DNA hybrid

scientific article

Metazoan nuclear genes for mitoribosomal protein S12.

scientific article

Minimal effects of spargel (PGC-1) overexpression in a Drosophila mitochondrial disease model

scientific article published on 19 July 2019

Mitochondria are physiologically maintained at close to 50 °C.

scientific article published on 25 January 2018

Mitochondrial DNA sequences in the nuclear genome of Strongylocentrotus purpuratus.

scientific article published in April 1983

Mitochondrial Deafness

scientific article published on 01 December 1997

Mitochondrial ROS production correlates with, but does not directly regulate lifespan in Drosophila

scientific article

Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation

scientific article published on 28 April 2022

Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila.

scientific article published on 15 February 2017

Mitochondrial transcription termination factor 1 directs polar replication fork pausing

scientific article published on 25 April 2016

Mitochondrial transcription terminator family members mTTF and mTerf5 have opposing roles in coordination of mtDNA synthesis

scientific article

Modelling in Escherichia coli of mutations in mitoribosomal protein S12: novel mutant phenotypes of rpsL.

scientific article

Modulation of Mrps12/Sarsm promoter activity in response to mitochondrial stress.

scientific article published on 8 August 2008

Molecular Phenotype of the np 7472 Deafness-Associated Mitochondrial Mutation in Osteosarcoma Cell Cybrids

scientific article published on 01 November 1999

Molecular phenotype of a human lymphoblastoid cell-line homoplasmic for the np 7445 deafness-associated mitochondrial mutation.

scientific article published on March 1997

Mutations at the mitochondrial DNA polymerase (POLG) locus associated with male infertility

article

Mutually exclusive synthetic pathways for sea urchin mitochondrial rRNA and mRNA.

scientific article published on March 1989

No influence of Indy on lifespan in Drosophila after correction for genetic and cytoplasmic background effects

scientific article

Novel repetitive structures, deviant protein-encoding sequences and unidentified ORFs in the mitochondrial genome of the brachiopod Lingula anatina.

scientific article published on 14 June 2005

Oncogenes, mitochondria and immortality

scientific article published on 01 April 1991

Perturbed Redox Signaling Exacerbates a Mitochondrial Myopathy

scholarly article by Sukru Anil Dogan published in November 2018

Phenotypic effects of dietary stress in combination with a respiratory chain bypass in mice

scientific article published on 01 August 2019

Phenotypic rescue of a Drosophila model of mitochondrial ANT1 disease.

scientific article

Polyadenylation and degradation of structurally abnormal mitochondrial tRNAs in human cells.

scientific article published in June 2018

Post-transcriptional control of messenger abundance

scientific article published on 01 May 1981

Post-transcriptional regulation of messenger abundance in rat liver and hepatoma ⬇️

scientific article published on July 25, 1980

Premature ageing in mice expressing defective mitochondrial DNA polymerase

scientific article

Primer retention owing to the absence of RNase H1 is catastrophic for mitochondrial DNA replication

scientific article published on 10 July 2015

Prominent mitochondrial DNA recombination intermediates in human heart muscle.

scientific article

Regulation of growth in Drosophila melanogaster: the roles of mitochondrial metabolism

scientific article published on 01 March 2020

Replication of vertebrate mitochondrial DNA entails transient ribonucleotide incorporation throughout the lagging strand.

scientific article

Respiratory chain signalling is essential for adaptive remodelling following cardiac ischaemia

scientific article published on 10 February 2020

Response: The mitochondrial DNA replication bubble has not burst

scientific article published on 01 July 2003

Screen for mitochondrial DNA copy number maintenance genes reveals essential role for ATP synthase

scientific article

Stabilization of hypoxia-inducible factor-1alpha protein in hypoxia occurs independently of mitochondrial reactive oxygen species production.

scientific article

Structural rearrangements in the mitochondrial genome of Drosophila melanogaster induced by elevated levels of the replicative DNA helicase.

scientific article published on 8 February 2018

Structural similarities between a mitochondrially encoded polypeptide and a family of prokaryotic respiratory toxins involved in plasmid maintenance suggest a novel mechanism for the evolutionary maintenance of mitochondrial DNA ⬇️

scientific article published on April 1, 1991

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

scientific article published on 21 September 2016

Systematic segregation to mutant mitochondrial DNA and accompanying loss of mitochondrial DNA in human NT2 teratocarcinoma Cybrids.

scientific article published on 8 June 2005

The Euromit meetings: an international platform for the understanding and combat of mitochondrial disease

scientific article published on 01 December 2004

The alternative oxidase (AOX) increases sulphide tolerance in the highly invasive marine invertebrate Ciona intestinalis

scientific article published on 23 August 2021

The alternative oxidase AOX does not rescue the phenotype of tko25t mutant flies

scientific article

The alternative oxidase, a tool for compensating cytochrome c oxidase deficiency in human cells.

scientific article

The bidirectional promoter of two genes for the mitochondrial translational apparatus in mouse is regulated by an array of CCAAT boxes interacting with the transcription factor NF-Y

scientific article published on 19 December 2006

The dangers of extended PCR in the clinic

scientific article published on 01 September 1999

The dominant cold-sensitive Out-cold mutants of Drosophila melanogaster have novel missense mutations in the voltage-gated sodium channel gene paralytic

scientific article published on 24 August 2008

The mitochondrial theory of aging: dead or alive?

scientific article published in February 2003

The relationship between mRNA half-life and gene function in the yeast Saccharomyces cerevisiae.

scientific article published in December 1995

The study of cell-death proteins in the outer mitochondrial membrane by chemical cross-linking ⬇️

scientific article published on July 15, 1997

Therapies in inborn errors of oxidative metabolism.

scientific article

Transcripts of three mitochondrial genes in the RNA of sea urchin eggs and embryos

scientific article published on 01 June 1983

Two distinct, sequence-specific DNA-binding proteins interact independently with the major replication pause region of sea urchin mtDNA. ⬇️

scientific article

Unique features of DNA replication in mitochondria: a functional and evolutionary perspective

scientific article published on 12 September 2014

Very short repeats and coordinate induction of genes

scientific article published on 01 February 1983

Xenotopic expression of alternative electron transport enzymes in animal mitochondria and their impact in health and disease

scientific article published on 31 January 2018

dj-1β regulates oxidative stress, insulin-like signaling and development in Drosophila melanogaster.

scientific article

β carbonic anhydrase is required for female fertility in Drosophila melanogaster.

scientific article

List of works by Howard Jacobs

A cytoplasmic suppressor of a nuclear mutation affecting mitochondrial functions in Drosophila

A mitochondrial ribosomal and RNA decay pathway blocks cell proliferation.

A novel mitochondrial point mutation in a maternal pedigree with sensorineural deafness.

A prevalent POLG CAG microsatellite length allele in humans and African great apes.

A rolling circle replication mechanism produces multimeric lariats of mitochondrial DNA in Caenorhabditis elegans

A tRNA suppressor mutation in human mitochondria

Acquisition of the wobble modification in mitochondrial tRNALeu(CUN) bearing the G12300A mutation suppresses the MELAS molecular defect.

Alternative oxidase confers nutritional limitation on Drosophila development

Alternative oxidase expression in the mouse enables bypassing cytochrome c oxidase blockade and limits mitochondrial ROS overproduction

Alternative oxidase rescues mitochondria-mediated dopaminergic cell loss in Drosophila.

Alternative oxidase‐mediated respiration prevents lethal mitochondrial cardiomyopathy

Alternative respiratory chain enzymes: Therapeutic potential and possible pitfalls

Analysis of replication intermediates indicates that Drosophila melanogaster mitochondrial DNA replicates by a strand-coupled theta mechanism.

Apparent functional independence of the mitochondrial and nuclear transcription systems in cultured human cells.

Behaviour of a population of partially duplicated mitochondrial DNA molecules in cell culture: segregation, maintenance and recombination dependent upon nuclear background

Biased incorporation of ribonucleotides on the mitochondrial L-strand accounts for apparent strand-asymmetric DNA replication.

Black scientists matter

Broad AOX expression in a genetically tractable mouse model does not disturb normal physiology

Characterisation of Saccharomyces cerevisiae genes encoding ribosomal protein YL6.

Characterization of a high-affinity binding site for a DNA-binding protein from sea urchin embryo mitochondria.

Ciona intestinalis NADH dehydrogenase NDX confers stress-resistance and extended lifespan on Drosophila

Comparative Genetics of Functional Trinucleotide Tandem Repeats in Humans and Apes

Complete nucleotide sequences of the nuclear pseudogenes for cytochrome oxidase subunit I and the large mitochondrial ribosomal RNA in the sea urchin Strongylocentrotus purpuratus.

Conserved tRNA gene cluster in starfish mitochondrial DNA

Correction: Mitochondrial Dysfunction Plus High-Sugar Diet Provokes a Metabolic Crisis That Inhibits Growth.

DNA conformation-dependent activities of human mitochondrial RNA polymerase

Developmental and pathological changes in the human cardiac muscle mitochondrial DNA organization, replication and copy number

Developmental arrest in Drosophila melanogaster caused by mitochondrial DNA replication defects cannot be rescued by the alternative oxidase

Different cellular backgrounds confer a marked advantage to either mutant or wild-type mitochondrial genomes.

Diiron centre mutations in Ciona intestinalis alternative oxidase abolish enzymatic activity and prevent rescue of cytochrome oxidase deficiency in flies

Do ribosomes regulate mitochondrial RNA synthesis?

Effects on mitochondrial transcription of manipulating mTERF protein levels in cultured human HEK293 cells.

Engineering the alternative oxidase gene to better understand and counteract mitochondrial defects: state of the art and perspectives.

Expression of Ciona intestinalis AOX causes male reproductive defects in Drosophila melanogaster

Expression of alternative oxidase in Drosophila ameliorates diverse phenotypes due to cytochrome oxidase deficiency

Expression of the Alternative Oxidase Influences Jun N-Terminal Kinase Signaling and Cell Migration

Expression of the alternative oxidase mitigates beta-amyloid production and toxicity in model systems.

Expression of the gene for mitoribosomal protein S12 is controlled in human cells at the levels of transcription, RNA splicing, and translation.

Expression of the nuclear gene encoding mitochondrial ATP synthase subunit alpha in early development of Drosophila and sea urchin.

Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction.

Familial mitochondrial DNA depletion in liver: haplotype analysis of candidate genes

Gene dosage and selective expression modify phenotype in a Drosophila model of human mitochondrial disease.

Gene expression in a Drosophila model of mitochondrial disease.

Genome wide study of NF-Y type CCAAT boxes in unidirectional and bidirectional promoters in human and mouse

Germline knockdown of spargel (PGC-1) produces embryonic lethality in Drosophila

Glucose modulates respiratory complex I activity in response to acute mitochondrial dysfunction.

Heteroplasmic segregation associated with trisomy-9 in cultured human cells.

Human heart mitochondrial DNA is organized in complex catenated networks containing abundant four-way junctions and replication forks

Human mitochondrial mTERF wraps around DNA through a left-handed superhelical tandem repeat

Human mitochondrial transcription factor A induces a U-turn structure in the light strand promoter

Hyperoxia but not AOX expression mitigates pathological cardiac remodeling in a mouse model of inflammatory cardiomyopathy

Intracellular vesicle trafficking plays an essential role in mitochondrial quality control

Isolation and purification of rat hepatoma nuclei active in the transport of messenger RNA in vitro

Ligand-Bound GeneSwitch Causes Developmental Aberrations in Drosophila that Are Alleviated by the Alternative Oxidase

Long-extension PCR to detect deleted mitochondrial DNA molecules is compromized by technical artefacts

Mammalian mitochondrial DNA replication intermediates are essentially duplex but contain extensive tracts of RNA/DNA hybrid

Metazoan nuclear genes for mitoribosomal protein S12.

Minimal effects of spargel (PGC-1) overexpression in a Drosophila mitochondrial disease model

Mitochondria are physiologically maintained at close to 50 °C.

Mitochondrial DNA sequences in the nuclear genome of Strongylocentrotus purpuratus.

Mitochondrial Deafness

Mitochondrial ROS production correlates with, but does not directly regulate lifespan in Drosophila

Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation

Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila.

Mitochondrial transcription termination factor 1 directs polar replication fork pausing

Mitochondrial transcription terminator family members mTTF and mTerf5 have opposing roles in coordination of mtDNA synthesis

Modelling in Escherichia coli of mutations in mitoribosomal protein S12: novel mutant phenotypes of rpsL.

Modulation of Mrps12/Sarsm promoter activity in response to mitochondrial stress.

Molecular Phenotype of the np 7472 Deafness-Associated Mitochondrial Mutation in Osteosarcoma Cell Cybrids

Molecular phenotype of a human lymphoblastoid cell-line homoplasmic for the np 7445 deafness-associated mitochondrial mutation.

Mutations at the mitochondrial DNA polymerase (POLG) locus associated with male infertility

Mutually exclusive synthetic pathways for sea urchin mitochondrial rRNA and mRNA.

No influence of Indy on lifespan in Drosophila after correction for genetic and cytoplasmic background effects

Novel repetitive structures, deviant protein-encoding sequences and unidentified ORFs in the mitochondrial genome of the brachiopod Lingula anatina.

Oncogenes, mitochondria and immortality

Perturbed Redox Signaling Exacerbates a Mitochondrial Myopathy

Phenotypic effects of dietary stress in combination with a respiratory chain bypass in mice

Phenotypic rescue of a Drosophila model of mitochondrial ANT1 disease.

Polyadenylation and degradation of structurally abnormal mitochondrial tRNAs in human cells.