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Authors whose works are in public domain in at least one jurisdiction

List of works by Christine M Fandozzi

2019 White Paper on Recent Issues in Bioanalysis: Chromatographic Assays (Part 1 - Innovation in Small Molecules and Oligonucleotides & Mass Spectrometric Method Development Strategies for Large Molecule Bioanalysis)

scientific article published on 01 November 2019

Assessment of Drug Interaction Potential Between the Hepatitis C Virus Direct-Acting Antiviral Agents Elbasvir/Grazoprevir and the Nucleotide Analog Reverse-Transcriptase Inhibitor Tenofovir Disoproxil Fumarate

scientific article published on 07 June 2019

Assessment of drug interaction potential between the HCV direct-acting antiviral agents elbasvir/grazoprevir and the HIV integrase inhibitors raltegravir and dolutegravir

scientific article published on 01 March 2019

Development of macrocyclic inhibitors of HCV NS3/4A protease with cyclic constrained P2–P4 linkers ⬇️

scientific article published on October 2, 2012

Development of potent macrocyclic inhibitors of genotype 3a HCV NS3/4A protease

scientific article published on 7 September 2012

Discovery of 3-substituted aminocyclopentanes as potent and orally bioavailable NR2B subtype-selective NMDA antagonists

scientific article

Discovery of MK-1220: A Macrocyclic Inhibitor of Hepatitis C Virus NS3/4A Protease with Improved Preclinical Plasma Exposure

scientific article published on 12 January 2011

Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor

scientific article

Discovery of MK‐8742: An HCV NS5A Inhibitor with Broad Genotype Activity ⬇️

scientific article published on October 14, 2013

Discovery of tetrahydropyridopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia ⬇️

scientific article published on July 27, 2012

Discovery of vaniprevir (MK-7009), a macrocyclic hepatitis C virus NS3/4a protease inhibitor

scientific article

Fine-Needle Aspiration for the Evaluation of Hepatic Pharmacokinetics of Vaniprevir: A Randomized Trial in Patients With Hepatitis C Virus Infection

scientific article published on 23 December 2019

MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants

scientific article

MK-5172, a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants

scientific article

MK-7009, a Potent and Selective Inhibitor of Hepatitis C Virus NS3/4A Protease

scientific article

MK-8825: A potent and selective CGRP receptor antagonist with good oral activity in rats ⬇️

scientific article published on April 30, 2012

Molecular modeling based approach to potent P2-P4 macrocyclic inhibitors of hepatitis C NS3/4A protease

scientific article published on 14 March 2008

Novel oxazolidinone calcitonin gene-related peptide (CGRP) receptor antagonists for the acute treatment of migraine

scientific article published on 14 July 2015

P2-quinazolinones and bis-macrocycles as new templates for next-generation hepatitis C virus NS3/4a protease inhibitors: discovery of MK-2748 and MK-6325.

scientific article

Pharmacokinetic Interactions Between Elbasvir/Grazoprevir and Immunosuppressant Drugs in Healthy Volunteers

scientific article published on 12 January 2018

Pharmacokinetic Interactions Between the Fixed-Dose Combinations of Elvitegravir/Cobicistat/Tenofovir Disoproxil Fumarate/Emtricitabine and Elbasvir/Grazoprevir in Healthy Adult Participants

scientific article published on 07 June 2019

Pharmacokinetic Interactions between the Hepatitis C Virus Inhibitors Elbasvir and Grazoprevir and HIV Protease Inhibitors Ritonavir, Atazanavir, Lopinavir, and Darunavir in Healthy Volunteers

scientific article published on 27 March 2019

Pharmacokinetics of elbasvir and grazoprevir in subjects with end-stage renal disease or severe renal impairment

scientific article published on 25 January 2019

Pharmacokinetics, Safety, and Tolerability of Single-Dose Elbasvir in Participants with Hepatic Impairment

scientific article published on 15 December 2017

Preclinical pharmacology and pharmacokinetics of CERC-301, a GluN2B-selective N-methyl-D-aspartate receptor antagonist

scientific article

Synthesis and evaluation of a new series of Neuropeptide S receptor antagonists

scientific article published on 5 May 2010

The Effect of Hepatic Impairment on the Pharmacokinetics of Grazoprevir, a Hepatitis C Virus Protease Inhibitor

scientific article published on 25 September 2017

The combination of MK-5172, peginterferon, and ribavirin is effective in treatment-naive patients with hepatitis C virus genotype 1 infection without cirrhosis

scientific article published on 12 April 2014

Use of density functional calculations to predict the regioselectivity of drugs and molecules metabolized by aldehyde oxidase

scientific article published on 25 August 2007

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