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List of works by Yoshihiro Nakata

5-HT-induced, 5-HT3 receptor-mediated, and ruthenium red- and capsaicin-sensitive positive chronotropic effects in the isolated guinea pig atrium

scientific article published in July 2002

A critical role of conventional protein kinase C in morphological changes of rodent mast cells

scientific article

A β1/2 adrenergic receptor-sensitive intracellular signaling pathway modulates CCL2 production in cultured spinal astrocytes.

scientific article

Activation of the neurokinin-1 receptor by substance P triggers the release of substance P from cultured adult rat dorsal root ganglion neurons

scientific article

Activation of the neurokinin-1 receptor in rat spinal astrocytes induces Ca2+ release from IP3-sensitive Ca2+ stores and extracellular Ca2+ influx through TRPC3

scientific article published on October 7, 2010

Activation of transient receptor potential ankyrin 1 evokes nociception through substance P release from primary sensory neurons.

scientific article published on 6 February 2012

Amitriptyline induces brain-derived neurotrophic factor (BDNF) mRNA expression through ERK-dependent modulation of multiple BDNF mRNA variants in primary cultured rat cortical astrocytes and microglia

scientific article

Anti-allergic substances contained in the pollen of Cryptomeria japonica possess diverse effects on the degranulation of RBL-2H3 cells

scientific article published in July 2003

Antidepressant Acts on Astrocytes Leading to an Increase in the Expression of Neurotrophic/Growth Factors: Differential Regulation of FGF-2 by Noradrenaline

scientific article published on December 5, 2012

Antidepressants increase glial cell line-derived neurotrophic factor production through monoamine-independent activation of protein tyrosine kinase and extracellular signal-regulated kinase in glial cells

scientific article published on 8 January 2007

CB(1) cannabinoid receptor stimulation modulates transient receptor potential vanilloid receptor 1 activities in calcium influx and substance P Release in cultured rat dorsal root ganglion cells.

scientific article

Clock gene Per1 regulates the production of CCL2 and interleukin-6 through p38, JNK1 and NF-κB activation in spinal astrocytes

scientific journal article

Continuous infusion of substance P inhibits acute, but not subacute, inflammatory pain induced by complete Freund's adjuvant

scientific article published on 29 September 2020

Continuous infusion of substance P into rat striatum alleviates nociceptive behavior via phosphorylation of extracellular signal-regulated kinase 1/2.

scientific article

Continuous infusion of substance P into rat striatum relieves mechanical hypersensitivity caused by a partial sciatic nerve ligation via activation of striatal muscarinic receptors

scientific article published on 24 May 2020

Corticosterone Induces HMGB1 Release in Primary Cultured Rat Cortical Astrocytes: Involvement of Pannexin-1 and P2X7 Receptor-Dependent Mechanisms

scientific article published on 25 April 2020

Decoralin, a novel linear cationic alpha-helical peptide from the venom of the solitary eumenine wasp Oreumenes decoratus

scientific article published on 29 September 2007

Development of tactile allodynia and thermal hyperalgesia by intrathecally administered platelet-activating factor in mice

scientific article published in October 2004

Downregulation of connexin36 in mouse spinal dorsal horn neurons leads to mechanical allodynia

scientific article published on 14 November 2014

Downregulation of spinal astrocytic connexin43 leads to upregulation of interleukin-6 and cyclooxygenase-2 and mechanical hypersensitivity in mice.

scientific article

Downregulation of the spinal dorsal horn clock gene Per1 expression leads to mechanical hypersensitivity via c-jun N-terminal kinase and CCL2 production in mice.

scientific article published on 22 January 2016

Electrophysiological characterization of the tetrodotoxin-resistant Na+ channel, Na(v)1.9, in mouse dorsal root ganglion neurons

scientific article

Eumenitin, a novel antimicrobial peptide from the venom of the solitary eumenine wasp Eumenes rubronotatus

scientific article published on 9 June 2006

Extracellular ATP differentially modulates Toll-like receptor 4-mediated cell survival and death of microglia.

scientific article published on 28 January 2011

Fibroblast growth factor 2 mRNA expression evoked by amitriptyline involves extracellular signal-regulated kinase-dependent early growth response 1 production in rat primary cultured astrocytes

scientific article published on 16 July 2015

High-mobility group box 1-mediated microglial activation induces anxiodepressive-like behaviors in mice with neuropathic pain

scientific article published on 11 February 2019

History of the G protein-coupled receptor (GPCR) assays from traditional to a state-of-the-art biosensor assay

scientific article

Interleukin-1beta-induced substance P release from rat cultured primary afferent neurons driven by two phospholipase A2 enzymes: secretory type IIA and cytosolic type IV.

scientific article published in March 2002

Involvement of alpha7- and alpha4beta2-type postsynaptic nicotinic acetylcholine receptors in nicotine-induced excitation of dopaminergic neurons in the substantia nigra: a patch clamp and single-cell PCR study using acutely dissociated nigral neuro

scientific article published in October 2004

Involvement of voltage-gated sodium channel Na(v)1.8 in the regulation of the release and synthesis of substance P in adult mouse dorsal root ganglion neurons

scientific article

Isolation and identification of C-19 fatty acids with anti-tumor activity from the spores of Ganoderma lucidum (reishi mushroom)

scientific article published on 30 December 2011

Lycopene ameliorates neuropathic pain by upregulating spinal astrocytic connexin 43 expression.

scientific article

Lysophosphatidic acid induces thrombospondin-1 production in primary cultured rat cortical astrocytes

scientific article published on 28 October 2020

Mechanisms of antidepressants and serotonin (5-HT)-induced glial cell line-derived neurotrophic factor (GDNF) releases in rat C6 gliobrastoma cells

scientific article published in February 2005

Microglial alpha7 nicotinic acetylcholine receptors drive a phospholipase C/IP3 pathway and modulate the cell activation toward a neuroprotective role

scientific article published in June 2006

Mirtazapine increases glial cell line-derived neurotrophic factor production through lysophosphatidic acid 1 receptor-mediated extracellular signal-regulated kinase signaling in astrocytes

scientific article published on 13 July 2019

Modulation of the substance P release from cultured rat primary afferent neurons by zinc ions

scientific article published on 01 July 2009

Neuropathic pain in rats with a partial sciatic nerve ligation is alleviated by intravenous injection of monoclonal antibody to high mobility group box-1

scientific article

New Mastoparan Peptides in the Venom of the Solitary Eumenine Wasp

scientific article published on 10 March 2019

New findings on the structure-phototoxicity relationship and photostability of fluoroquinolones with various substituents at position 1.

scientific article

Noradrenaline induces clock gene Per1 mRNA expression in C6 glioma cells through beta(2)-adrenergic receptor coupled with protein kinase A - cAMP response element binding protein (PKA-CREB) and Src-tyrosine kinase - glycogen synthase kinase-3beta (S

scientific article published on 29 June 2010

Noradrenaline reduces the ATP-stimulated phosphorylation of p38 MAP kinase via beta-adrenergic receptors-cAMP-protein kinase A-dependent mechanism in cultured rat spinal microglia.

scientific article

Novel PKCα-mediated phosphorylation site(s) on cofilin and their potential role in terminating histamine release

scientific article published on August 1, 2012

Olopatadine attenuates the enhancement of capsaicin-evoked substance P release by bradykinin from cultured dorsal root ganglion neurons.

scientific article published on 23 September 2006

P2X(7) receptor stimulation in primary cultures of rat spinal microglia induces downregulation of the activity for glutamate transport

scientific article published in April 2008

PS127. Antidepressant amitriptyline activates matrix metalloproteinase in astroglial cells: involvement in glial cell line-derived neurotrophic factor expression

scientific article published on 27 May 2016

Paclitaxel and vinorelbine, evoked the release of substance P from cultured rat dorsal root ganglion cells through different PKC isoform-sensitive ion channels.

scientific article published on 17 April 2009

Perineural expression of high-mobility group box-1 contributes to long-lasting mechanical hypersensitivity via matrix metalloproteinase-9 upregulation in mice with painful peripheral neuropathy.

scientific article published on 18 November 2015

Pharmacological Activation Gi/o Protein Increases Glial Cell Line-Derived Neurotrophic Factor Production through Fibroblast Growth Factor Receptor and Extracellular Signal-Regulated Kinase Pathway in Primary Cultured Rat Cortical Astrocytes

scientific article

Phosphorylation of TRPV1 by neurokinin-1 receptor agonist exaggerates the capsaicin-mediated substance P release from cultured rat dorsal root ganglion neurons.

scientific article published on 17 September 2008

Possible involvement of P2X7 receptor activation in microglial neuroprotection against focal cerebral ischemia in rats

scientific article published in June 2008

Possible involvement of long chain fatty acids in the spores of Ganoderma lucidum (Reishi Houshi) to its anti-tumor activity

scientific article published in October 2008

Production and release of neuroprotective tumor necrosis factor by P2X7 receptor-activated microglia.

scientific article

Proinflammatory cytokines downregulate connexin 43-gap junctions via the ubiquitin-proteasome system in rat spinal astrocytes.

scientific article

Protein kinase C-alpha mediates TNF release process in RBL-2H3 mast cells.

scientific article

Regulation by Nicotinic Acetylcholine Receptors of Microglial Glutamate Transporters: Role of Microglia in Neuroprotection

Role of Connexins in Chronic Pain and Their Potential as Therapeutic Targets for Next-Generation Analgesics

scientific article published on 01 January 2019

Selective blockade of N-methyl-D-aspartate channels in combination with dopamine receptor antagonism induces loss of the righting reflex in mice, but not immobility

scientific article published on 31 May 2014

Sensitization of vanilloid receptor 1 induced by bradykinin via the activation of second messenger signaling cascades in rat primary afferent neurons.

scientific article published in September 2004

Serotonin (5-HT) induces glial cell line-derived neurotrophic factor (GDNF) mRNA expression via the transactivation of fibroblast growth factor receptor 2 (FGFR2) in rat C6 glioma cells

scientific article

Serotonin increases glial cell line-derived neurotrophic factor release in rat C6 glioblastoma cells

scientific article published on March 2004

Spinal astrocytes contribute to the circadian oscillation of glutamine synthase, cyclooxygenase-1 and clock genes in the lumbar spinal cord of mice

scientific article published on March 16, 2012

Spinal astrocytes stimulated by tumor necrosis factor-α and/or interferon-γ attenuate connexin 43-gap junction via c-jun terminal kinase activity

scientific article published on 29 March 2013

Spinal high-mobility group box-1 induces long-lasting mechanical hypersensitivity through the toll-like receptor 4 and upregulation of interleukin-1β in activated astrocytes

scientific article published on 28 July 2019

Stimulation of nuclear receptor REV-ERBs regulates tumor necrosis factor-induced expression of proinflammatory molecules in C6 astroglial cells

scientific article published on 23 November 2015

Stimulation of nuclear receptor REV-ERBs suppresses production of pronociceptive molecules in cultured spinal astrocytes and ameliorates mechanical hypersensitivity of inflammatory and neuropathic pain of mice

scientific article published on 22 January 2019

Stimulation of spinal dorsal horn β2-adrenergic receptor ameliorates neuropathic mechanical hypersensitivity through a reduction of phosphorylation of microglial p38 MAP kinase and astrocytic c-jun N-terminal kinase

scientific article published on 10 November 2016

Stimulation of toll-like receptor 4 downregulates the expression of α7 nicotinic acetylcholine receptors via histone deacetylase in rodent microglia

scientific article published on 12 May 2020

Stimulation of α7 nicotinic acetylcholine receptor regulates glutamate transporter GLAST via basic fibroblast growth factor production in cultured cortical microglia

scientific article published on 28 August 2015

Studies on the constituents of whole plants of Youngia japonica.

scientific article published in July 2009

Substance P release evoked by capsaicin or potassium from rat cultured dorsal root ganglion neurons is conversely modulated with bradykinin.

scientific article published in June 2006

The activation of P2Y6 receptor in cultured spinal microglia induces the production of CCL2 through the MAP kinases-NF-κB pathway

scientific article published on 2 August 2013

The activation of transient receptor potential vanilloid receptor subtype 1 by capsaicin without extracellular Ca2+ is involved in the mechanism of distinct substance P release in cultured rat dorsal root ganglion neurons.

scientific article published on 23 November 2007

The expression of glial cell line-derived neurotrophic factor mRNA by antidepressants involves matrix metalloproteinase-9 activation in rat astroglial cells

scientific article published on 24 September 2016

The indirect γ-aminobutyric acid (GABA) receptor agonist gabaculine-induced loss of the righting reflex may inhibit the descending analgesic pathway

scientific article published on 07 September 2020

The induction of Per1 expression by the combined treatment with glutamate, 5-hydroxytriptamine and dopamine initiates a ripple effect on Bmal1 and Cry1 mRNA expression via the ERK signaling pathway in cultured rat spinal astrocytes.

scientific article

The long-term exposure of rat cultured dorsal root ganglion cells to bradykinin induced the release of prostaglandin E2 by the activation of cyclooxygenase-2.

scientific article

The presence of BRAF point mutation in adult papillary thyroid carcinomas from atomic bomb survivors correlates with radiation dose

scientific article published on 01 March 2007

The regulation of exon-specific brain-derived neurotrophic factor mRNA expression by protein kinase C in rat cultured dorsal root ganglion neurons.

scientific article published on 23 March 2013

The regulation of glycine transporter GLYT1 is mainly mediated by protein kinase Calpha in C6 glioma cells

scientific article published on 19 August 2008

The release of substance P from cultured dorsal root ganglion neurons requires the non-neuronal cells around these neurons.

scientific article published on 6 November 2007

The role of transactivation as a signal transduction mechanism in the central nervous system

scientific article published in June 2009

Tricyclic Antidepressant Amitriptyline-induced Glial Cell Line-derived Neurotrophic Factor Production Involves Pertussis Toxin-sensitive Gαi/o Activation in Astroglial Cells

scientific article published on 13 April 2015

Tricyclic antidepressant amitriptyline activates fibroblast growth factor receptor signaling in glial cells: involvement in glial cell line-derived neurotrophic factor production

scientific article

Tumor necrosis factor-mediated downregulation of spinal astrocytic connexin43 leads to increased glutamatergic neurotransmission and neuropathic pain in mice

scientific article

Volume transmission of substance P in striatum induced by intraplantar formalin injection attenuates nociceptive responses via activation of the neurokinin 1 receptor.

scientific article published on 20 March 2013

Zaltoprofen inhibits bradykinin-induced responses by blocking the activation of second messenger signaling cascades in rat dorsal root ganglion cells.

scientific article published in June 2005

[Cannabis use disorder and treatment of dependence]

scientific article published on 01 August 2010

[Neurogenic inflammation facilitates neuropeptides release from primary afferent neurons]

scientific article published on 01 March 2006

[Role of platelet-activating factor on spinal pain transduction]

scientific article published on 01 January 2006

β-catenin accumulation in nuclei of hepatocellular carcinoma cells up-regulates glutathione-s-transferase M3 mRNA

scientific article published on April 7, 2011