List of works - Steven Opal

2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference.

scientific article

A historical overview of bacteriophage therapy as an alternative to antibiotics for the treatment of bacterial pathogens

scientific article published on 13 August 2013

A monoclonal antibody against RAGE alters gene expression and is protective in experimental models of sepsis and pneumococcal pneumonia

scientific article published on 01 May 2011

A new paradigm for the treatment of sepsis: is it time to consider combination therapy?

scientific article

A novel approach for emerging and antibiotic resistant infections: Innate defense regulators as an agnostic therapy

scientific article

A simple method for amplifying RNA targets (SMART).

scientific article

Active immunization with a detoxified endotoxin vaccine protects against lethal polymicrobial sepsis: its use with CpG adjuvant and potential mechanisms

scientific article

Antithrombin, heparin, and heparan sulfate

scientific article

Bench-to-bedside review: Toll-like receptors and their role in septic shock

scientific article

Bench-to-bedside review: functional relationships between coagulation and the innate immune response and their respective roles in the pathogenesis of sepsis

scientific article

CD28 homodimer interface mimetic peptide acts as a preventive and therapeutic agent in models of severe bacterial sepsis and gram-negative bacterial peritonitis

scientific article published on 9 October 2014

Chloroquine enhances survival in Bacillus anthracis intoxication

scientific article published on 28 September 2004

Clinical Trial Design and Outcomes in Patients with Severe Sepsis ⬇️

scientific article published on October 1, 2003

Clinical review: the role of biomarkers in the diagnosis and management of community-acquired pneumonia

scientific article

Coagulation abnormalities in critically ill patients

scientific article (publication date: 2006)

Coming soon to an ICU near you: severe pandemic influenza in ICU patients in Spain.

scientific article

Communal living by bacteria and the pathogenesis of urinary tract infections

scientific article (publication date: December 2007)

Concept for a study design in patients with severe community-acquired pneumonia: A randomised controlled trial with a novel IGM-enriched immunoglobulin preparation - The CIGMA study

scientific article

Correlation between mortality and the levels of inter-alpha inhibitors in the plasma of patients with severe sepsis.

scientific article published on 26 August 2003

Detoxified endotoxin vaccine (J5dLPS/OMP) protects mice against lethal respiratory challenge with Francisella tularensis SchuS4.

scientific article

Development of an anti-core lipopolysaccharide vaccine for the prevention and treatment of sepsis

scientific article published on February 2004

Early in vitro transcription termination in human H5 influenza viral RNA synthesis.

scientific article published on 5 January 2011

Effect of anti-CD14 monoclonal antibody on clearance of Escherichia coli bacteremia and endotoxemia

scientific article published in March 2003

Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial

scientific article

Endotoxin as a drug target

scientific article

Endotoxins and other sepsis triggers

scientific article

Estrogen receptor beta agonism increases survival in experimentally induced sepsis and ameliorates the genomic sepsis signature: a pharmacogenomic study

scientific article published in April 2010

Evaluation of imipenem for prophylaxis and therapy of Yersinia pestis delivered by aerosol in a mouse model of pneumonic plague

scientific article

Immunomodulatory oligonucleotide IMT504: Effects on mesenchymal stem cells as a first-in-class immunoprotective/immunoregenerative therapy

scientific article (publication date: 26 March 2017)

Inhibition of the RAGE products increases survival in experimental models of severe sepsis and systemic infection

scientific article published in January 2007

Inter-alpha-inhibitor proteins are endogenous furin inhibitors and provide protection against experimental anthrax intoxication

scientific article

Inter-α inhibitor proteins: a novel therapeutic strategy for experimental anthrax infection

scientific article

Interactions between Coagulation and Inflammation ⬇️

scientific article published on January 1, 2003

Ligation with nucleic acid sequence-based amplification

scientific article

Longitudinal studies of inter-alpha inhibitor proteins in severely septic patients: a potential clinical marker and mediator of severe sepsis

scientific article published on 01 February 2007

Microdroplet sandwich real-time rt-PCR for detection of pandemic and seasonal influenza subtypes.

scientific article

Middle East respiratory syndrome (MERS): a new zoonotic viral pneumonia

scientific article

Orally administered recombinant human interleukin-11 is protective in experimental neutropenic sepsis

scientific article published on 13 December 2002

PHARMACOLOGICAL SIRT1 ACTIVATION IMPROVES MORTALITY AND MARKEDLY ALTERS TRANSCRIPTIONAL PROFILES THAT ACCOMPANY EXPERIMENTAL SEPSIS.

scientific article published on April 2016

Pathogenesis, treatment, and prevention of pneumococcal pneumonia

scientific article

Phase 2 trial of eritoran tetrasodium (E5564), a toll-like receptor 4 antagonist, in patients with severe sepsis

scientific article

Phase I study of detoxified Escherichia coli J5 lipopolysaccharide (J5dLPS)/group B meningococcal outer membrane protein (OMP) complex vaccine in human subjects ⬇️

scientific article published on November 7, 2003

Quality of life effects of antithrombin III in sepsis survivors: results from the KyberSept trial [ISRCTN22931023]

scientific article

Recombinant human platelet-activating factor acetylhydrolase for treatment of severe sepsis: results of a phase III, multicenter, randomized, double-blind, placebo-controlled, clinical trial

scientific article published in February 2004

Recombinant platelet-activating factor acetylhydrolase to prevent acute respiratory distress syndrome and mortality in severe sepsis: Phase IIb, multicenter, randomized, placebo-controlled, clinical trial

scientific article

Recombinant tissue factor pathway inhibitor in severe community-acquired pneumonia: a randomized trial

scientific article published on 4 February 2011

Sepsis definitions: time for change

scientific article

Severe Pneumonia Caused by Legionella pneumophila: Differential Diagnosis and Therapeutic Considerations

scientific article

Severe Sepsis and Septic Shock: Defining the Clinical Problem ⬇️

scientific article published on January 1, 2003

Sirt1 Activation Markedly Alters Transcription Profiles and Improves Outcome in Experimental Sepsis

scientific article

Subtyping Clinical Specimens of Influenza A Virus by Use of a Simple Method To Amplify RNA Targets ⬇️

scientific article published on July 31, 2013

Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012

scientific article

The PIRO concept: I is for infection

scientific article

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

scientific article

The Toll-like receptors and their role in septic shock ⬇️

scientific article published on October 1, 2003

The activity of pathway-selective estrogen receptor ligands in experimental septic shock

scientific article published on 01 December 2005

The clinical relevance of endotoxin in human sepsis: a critical analysis

scientific article

The controversy over H5N1 transmissibility research: an opportunity to define a practical response to a global threat

scientific article

The dysfunctional host response to influenza A H7N9: a potential treatment option?

scientific article

The next generation of sepsis clinical trial designs: what is next after the demise of recombinant human activated protein C?*.

scientific article

The novel immunotherapeutic oligodeoxynucleotide IMT504 protects neutropenic animals from fatal Pseudomonas aeruginosa bacteremia and sepsis

scientific article

The role of genetics and antibodies in sepsis

scientific article

WAY-202196, a selective estrogen receptor-beta agonist, protects against death in experimental septic shock

scientific article

List of works by Steven Opal

2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference.

A historical overview of bacteriophage therapy as an alternative to antibiotics for the treatment of bacterial pathogens

A monoclonal antibody against RAGE alters gene expression and is protective in experimental models of sepsis and pneumococcal pneumonia

A new paradigm for the treatment of sepsis: is it time to consider combination therapy?

A novel approach for emerging and antibiotic resistant infections: Innate defense regulators as an agnostic therapy

A simple method for amplifying RNA targets (SMART).

Active immunization with a detoxified endotoxin vaccine protects against lethal polymicrobial sepsis: its use with CpG adjuvant and potential mechanisms

Antithrombin, heparin, and heparan sulfate

Bench-to-bedside review: Toll-like receptors and their role in septic shock

Bench-to-bedside review: functional relationships between coagulation and the innate immune response and their respective roles in the pathogenesis of sepsis

CD28 homodimer interface mimetic peptide acts as a preventive and therapeutic agent in models of severe bacterial sepsis and gram-negative bacterial peritonitis

Chloroquine enhances survival in Bacillus anthracis intoxication

Clinical Trial Design and Outcomes in Patients with Severe Sepsis ⬇️

Clinical review: the role of biomarkers in the diagnosis and management of community-acquired pneumonia

Coagulation abnormalities in critically ill patients

Coming soon to an ICU near you: severe pandemic influenza in ICU patients in Spain.

Communal living by bacteria and the pathogenesis of urinary tract infections

Concept for a study design in patients with severe community-acquired pneumonia: A randomised controlled trial with a novel IGM-enriched immunoglobulin preparation - The CIGMA study

Correlation between mortality and the levels of inter-alpha inhibitors in the plasma of patients with severe sepsis.

Detoxified endotoxin vaccine (J5dLPS/OMP) protects mice against lethal respiratory challenge with Francisella tularensis SchuS4.

Development of an anti-core lipopolysaccharide vaccine for the prevention and treatment of sepsis

Early in vitro transcription termination in human H5 influenza viral RNA synthesis.

Effect of anti-CD14 monoclonal antibody on clearance of Escherichia coli bacteremia and endotoxemia

Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial

Endotoxin as a drug target

Endotoxins and other sepsis triggers

Estrogen receptor beta agonism increases survival in experimentally induced sepsis and ameliorates the genomic sepsis signature: a pharmacogenomic study

Evaluation of imipenem for prophylaxis and therapy of Yersinia pestis delivered by aerosol in a mouse model of pneumonic plague

Immunomodulatory oligonucleotide IMT504: Effects on mesenchymal stem cells as a first-in-class immunoprotective/immunoregenerative therapy

Inhibition of the RAGE products increases survival in experimental models of severe sepsis and systemic infection

Inter-alpha-inhibitor proteins are endogenous furin inhibitors and provide protection against experimental anthrax intoxication

Inter-α inhibitor proteins: a novel therapeutic strategy for experimental anthrax infection

Interactions between Coagulation and Inflammation ⬇️

Ligation with nucleic acid sequence-based amplification

Longitudinal studies of inter-alpha inhibitor proteins in severely septic patients: a potential clinical marker and mediator of severe sepsis

Microdroplet sandwich real-time rt-PCR for detection of pandemic and seasonal influenza subtypes.

Middle East respiratory syndrome (MERS): a new zoonotic viral pneumonia

Orally administered recombinant human interleukin-11 is protective in experimental neutropenic sepsis

PHARMACOLOGICAL SIRT1 ACTIVATION IMPROVES MORTALITY AND MARKEDLY ALTERS TRANSCRIPTIONAL PROFILES THAT ACCOMPANY EXPERIMENTAL SEPSIS.

Pathogenesis, treatment, and prevention of pneumococcal pneumonia

Phase 2 trial of eritoran tetrasodium (E5564), a toll-like receptor 4 antagonist, in patients with severe sepsis

Phase I study of detoxified Escherichia coli J5 lipopolysaccharide (J5dLPS)/group B meningococcal outer membrane protein (OMP) complex vaccine in human subjects ⬇️

Quality of life effects of antithrombin III in sepsis survivors: results from the KyberSept trial [ISRCTN22931023]

Recombinant human platelet-activating factor acetylhydrolase for treatment of severe sepsis: results of a phase III, multicenter, randomized, double-blind, placebo-controlled, clinical trial

Recombinant platelet-activating factor acetylhydrolase to prevent acute respiratory distress syndrome and mortality in severe sepsis: Phase IIb, multicenter, randomized, placebo-controlled, clinical trial

Recombinant tissue factor pathway inhibitor in severe community-acquired pneumonia: a randomized trial

Sepsis definitions: time for change

Severe Pneumonia Caused by Legionella pneumophila: Differential Diagnosis and Therapeutic Considerations

Severe Sepsis and Septic Shock: Defining the Clinical Problem ⬇️

Sirt1 Activation Markedly Alters Transcription Profiles and Improves Outcome in Experimental Sepsis

Subtyping Clinical Specimens of Influenza A Virus by Use of a Simple Method To Amplify RNA Targets ⬇️

Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012

The PIRO concept: I is for infection

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

The Toll-like receptors and their role in septic shock ⬇️

The activity of pathway-selective estrogen receptor ligands in experimental septic shock

The clinical relevance of endotoxin in human sepsis: a critical analysis

The controversy over H5N1 transmissibility research: an opportunity to define a practical response to a global threat

The dysfunctional host response to influenza A H7N9: a potential treatment option?

The next generation of sepsis clinical trial designs: what is next after the demise of recombinant human activated protein C?*.

The novel immunotherapeutic oligodeoxynucleotide IMT504 protects neutropenic animals from fatal Pseudomonas aeruginosa bacteremia and sepsis

The role of genetics and antibodies in sepsis

WAY-202196, a selective estrogen receptor-beta agonist, protects against death in experimental septic shock