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List of works by William Rainey

11-Ketotestosterone Is the Dominant Circulating Bioactive Androgen During Normal and Premature Adrenarche

scientific article published on 01 December 2018

11-Oxygenated C19 Steroids Do Not Decline With Age in Women

scientific article published on 01 July 2019

11-Oxygenated androgens in health and disease

scientific article published on 16 March 2020

18-oxocortisol measurement in adrenal vein sampling as a biomarker for subclassifying primary aldosteronism

scientific article

3βHSD and CYB5A double positive adrenocortical cells during adrenal development/aging

scientific article

A microdeletion in the ligand binding domain of human steroidogenic factor 1 causes XY sex reversal without adrenal insufficiency

scientific article

A role for the NGFI-B family in adrenal zonation and adrenocortical disease

scientific article

ACTH is a potent regulator of gene expression in human adrenal cells

scientific article published on 11 May 2010

ATR-101, a Selective and Potent Inhibitor of Acyl-CoA Acyltransferase 1, Induces Apoptosis in H295R Adrenocortical Cells and in the Adrenal Cortex of Dogs

scientific article published on 17 March 2016

Aberrant gonadotropin-releasing hormone receptor (GnRHR) expression and its regulation of CYP11B2 expression and aldosterone production in adrenal aldosterone-producing adenoma (APA).

scientific article published on 25 January 2014

Acute and chronic regulation of aldosterone production ⬇️

scientific article published on August 4, 2011

Adrenal CYP11B1/2 expression in primary aldosteronism: immunohistochemical analysis using novel monoclonal antibodies

scientific article

Adrenal Vein Sampling Lateralization Despite Mineralocorticoid Receptor Antagonists Exposure in Primary Aldosteronism

scientific article published on 01 February 2019

Adrenal androgens in human physiology

scientific article published in November 2004

Adrenal cell aldosterone production is stimulated by very-low-density lipoprotein (VLDL).

scientific article published on 20 December 2011

Adrenal changes associated with adrenarche

scientific article published on March 2009

Adrenal disorders in pregnancy

scientific article published on 11 September 2012

Adrenal-derived 11-oxygenated 19-carbon steroids are the dominant androgens in classic 21-hydroxylase deficiency

scientific article published on 10 February 2016

Adrenarche - physiology, biochemistry and human disease

scientific article

Adrenocortical cell lines

scientific article

Adrenocorticotropin Acutely Regulates Pregnenolone Sulfate Production by the Human Adrenal In Vivo and In Vitro

scientific article published on 6 November 2017

Age-Related Autonomous Aldosteronism

scientific article published on 31 May 2017

Age-dependent Increases in Adrenal Cytochrome b5 and Serum 5-Androstenediol-3-sulfate

scientific article published on 13 September 2016

Aging and Adrenal Aldosterone Production

scientific article published on 11 December 2017

Aldosterone production in human adrenocortical cells is stimulated by high-density lipoprotein 2 (HDL2) through increased expression of aldosterone synthase (CYP11B2)

scientific article

Aldosterone-Producing Cell Clusters Frequently Harbor Somatic Mutations and Accumulate With Age in Normal Adrenals

scientific article published on 12 May 2017

Aldosterone-Producing Cell Clusters in Normal and Pathological States

scientific article published on 4 December 2017

Aldosterone-stimulating somatic gene mutations are common in normal adrenal glands

scientific article

Angiotensin II receptor blockers differentially affect CYP11B2 expression in human adrenal H295R cells.

scientific article published on 12 December 2013

Angiotensin II regulation of adrenocortical gene transcription

scientific article published on 03 September 2008

Angiotensin-II acute regulation of rapid response genes in human, bovine, and rat adrenocortical cells

scientific article published on December 2007

Biochemical, Histopathological and Genetic Characterization of Posture Responsive and Unresponsive APAs

scientific article published on 09 June 2020

Bone Morphogenetic Protein-4 (BMP4): A Paracrine Regulator of Human Adrenal C19 Steroid Synthesis

scientific article published on 13 April 2015

COUP-TF and transcriptional co-regulators in adrenal steroidogenesis

scientific article

Calmodulin-dependent kinase I regulates adrenal cell expression of aldosterone synthase

scientific article (publication date: September 2002)

Cell-based assays for screening androgen receptor ligands

scientific article

Cellular and Genetic Causes of Idiopathic Hyperaldosteronism

scientific article published on 01 October 2018

Chemogenetic activation of adrenocortical Gq signaling causes hyperaldosteronism and disrupts functional zonation

scientific article published on 01 January 2020

Circadian rhythms of 11-oxygenated C19 steroids and ∆5-steroid sulfates in healthy men

scientific article published in 2021

Circulating 11-oxygenated androgens across species

scientific article published on 05 April 2019

Clinical, Biochemical, and Molecular Characterization of Macronodular Adrenocortical Hyperplasia of the Zona Reticularis: A New Syndrome ⬇️

scientific article published on November 17, 2010

Coactivation of SF-1-mediated transcription of steroidogenic enzymes by Ubc9 and PIAS1

scientific article

Comprehensive Analysis of Steroid Biomarkers for Guiding Primary Aldosteronism Subtyping

scientific article published on 02 December 2019

Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma

scientific article

Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma

article

Corticotroph tumor progression after bilateral adrenalectomy (Nelson’s syndrome): systematic review and expert consensus recommendations ⬇️

journal article from 'European Journal of Endocrinology' published in 2021

Corticotropin-releasing hormone (CRH) and urocortin act through type 1 CRH receptors to stimulate dehydroepiandrosterone sulfate production in human fetal adrenal cells

scientific article published on 12 July 2005

Corticotropin-releasing hormone directly stimulates cortisol and the cortisol biosynthetic pathway in human fetal adrenal cells

scientific article published on 19 October 2004

Development of a novel cell based androgen screening model

scientific article published on 12 November 2015

Development of adrenal cortex zonation

scientific article published on June 2015

Development of monoclonal antibodies against human CYP11B1 and CYP11B2.

scientific article published on 08 December 2013

Development of monoclonal antibodies against the human 3β-hydroxysteroid dehydrogenase/isomerase isozymes

scientific article published on 29 August 2017

Development of the human adrenal zona reticularis: morphometric and immunohistochemical studies from birth to adolescence

scientific article

Differential effects of high and low steroidogenic factor-1 expression on CYP11B2 expression and aldosterone production in adrenocortical cells

scientific article published on 30 October 2008

Differential gene expression in the adrenals of normal and anencephalic fetuses and studies focused on the Fras-1-related extracellular matrix protein (FREM2) gene

scientific article

Discordance between Imaging and Immunohistochemistry in Unilateral Primary Aldosteronism.

scientific article published on 08 August 2017

Dissecting human adrenal androgen production

scientific article

Double adrenocortical adenomas harboring independent KCNJ5 and PRKACA somatic mutations

scientific article published on 10 May 2016

Editorial: polymorphisms in CYP11B genes and 11-hydroxylase activity

scientific article published on 01 February 2005

Effect of KCNJ5 mutations on gene expression in aldosterone-producing adenomas and adrenocortical cells.

scientific article

Effect of adrenocorticotropic hormone stimulation during adrenal vein sampling in primary aldosteronism

scientific article published on 13 February 2012

Eighteenth Conference on the Adrenal Cortex Munich, Germany June 25-27, 2018

scientific article published on 01 August 2019

Elevated expression of luteinizing hormone receptor in aldosterone-producing adenomas

scientific article

Estrogen-related receptor α in normal adrenal cortex and adrenocortical tumors: Involvement in development and oncogenesis ⬇️

scientific article published on October 30, 2012

Exploiting the Unusual to Find the Rare: Novel Steroid Metabolites Pinpoint Adrenal Cancer Patients

scientific article published on 12 June 2015

Expression profiles for steroidogenic enzymes in adrenocortical disease

scientific article published on 28 June 2005

G protein-coupled receptor expression in the adult and fetal adrenal glands

scientific article

G-protein-coupled receptors in aldosterone-producing adenomas: a potential cause of hyperaldosteronism

scientific article

GATA-6 is expressed in the human adrenal and regulates transcription of genes required for adrenal androgen biosynthesis

scientific article (publication date: October 2003)

GPER-independent inhibition of adrenocortical cancer growth by G-1 involves ROS/Egr-1/BAX pathway

scientific article published on 14 December 2017

Gene expression profiles in aldosterone-producing adenomas and adjacent adrenal glands ⬇️

scientific article published on January 19, 2011

Genetic Characteristics of Aldosterone-Producing Adenomas in Blacks

scientific article published on 01 April 2019

Genetic and Histopathologic Intertumor Heterogeneity in Primary Aldosteronism

scientific article published on 24 March 2017

Genetic and gene expression analyses of the polycystic ovary syndrome candidate gene fibrillin-3 and other fibrillin family members in human ovaries

scientific article published on 19 August 2009

Genetic, Cellular, and Molecular Heterogeneity in Adrenals With Aldosterone-Producing Adenoma

scientific article published on 02 March 2020

Genetics of aldosterone-producing adenomas with pathogenic KCNJ5 variants

scientific article published on 01 February 2019

H295R expression of melanocortin 2 receptor accessory protein results in ACTH responsiveness

scientific article published on 17 November 2015

High glucose stimulates expression of aldosterone synthase (CYP11B2) and secretion of aldosterone in human adrenal cells

scientific article published on 29 August 2017

High resolution tissue mass spectrometry imaging reveals a refined functional anatomy of the human adult adrenal gland

scientific article published on 29 January 2018

Histological Characterization of Aldosterone-producing Adrenocortical Adenomas with Different Somatic Mutations

scientific article published on 01 March 2020

Histopathological Classification of Cross-Sectional Image-Negative Hyperaldosteronism

scientific article published in April 2017

Human Urinary mRNA as a Biomarker of Cardiovascular Disease

article

Human adrenal cells that express both 3β-hydroxysteroid dehydrogenase type 2 (HSD3B2) and cytochrome b5 (CYB5A) contribute to adrenal androstenedione production ⬇️

scientific article published on December 23, 2010

Human adrenocortical carcinoma cell lines ⬇️

scientific article published on September 5, 2011

Human myometrial gene expression before and during parturition

scientific article published on 27 October 2004

Identification of Somatic Mutations in CLCN2 in Aldosterone-Producing Adenomas

scientific article published on 01 October 2020

International histopathology consensus for unilateral primary aldosteronism

scientific article published on 27 July 2020

Lessons from the gene expression pattern of the rat zona glomerulosa ⬇️

scientific article published on December 31, 2012

Liquid Chromatography–Tandem Mass Spectrometry Analysis of Human Adrenal Vein 19-Carbon Steroids Before and After ACTH Stimulation ⬇️

scientific article published on February 5, 2013

Liquid chromatography–tandem mass spectrometry analysis of human adrenal vein corticosteroids before and after adrenocorticotropic hormone stimulation ⬇️

scientific article published on June 1, 2012

Liver receptor homolog-1 regulates the expression of steroidogenic acute regulatory protein in human granulosa cells

scientific article published on June 2004

Measurement of peripheral plasma 18-oxocortisol can discriminate unilateral adenoma from bilateral diseases in patients with primary aldosteronism.

scientific article

Metallothionein-3 (MT-3) in the human adrenal cortex and its disorders

scientific article

Metastin stimulates aldosterone synthesis in human adrenal cells

scientific article published on December 2007

Molecular Heterogeneity in Aldosterone-Producing Adenomas

scientific article published on 14 January 2016

Molecular and Electrophysiological Analyses of ATP2B4 Gene Variants in Bilateral Adrenal Hyperaldosteronism

scientific article published on 30 January 2020

Mutated KCNJ5 activates the acute and chronic regulatory steps in aldosterone production

scientific article published on 20 April 2016

Nur-related factor 1 and nerve growth factor-induced clone B in human adrenal cortex and its disorders.

scientific article

OR29-3 Targeted Assessment of G0S2 Methylation Identifies a Rapidly Recurrent, Routinely Fatal Molecular Subtype of Adrenocortical Carcinoma.

scientific article published on 30 April 2019

Ovarian granulosa cell lines

scientific article

PCP4: a regulator of aldosterone synthesis in human adrenocortical tissues

scientific article

Peroxisome proliferator-activated receptor-{gamma} suppresses CYP11B2 expression and aldosterone production

scientific article published on 19 January 2011

Phospholipase D activity underlies very-low-density lipoprotein (VLDL)-induced aldosterone production in adrenal glomerulosa cells

scientific article

Potassium channels related to primary aldosteronism: Expression similarities and differences between human and rat adrenals

scientific article published on 12 September 2015

Prevalence of somatic mutations in aldosterone-producing adenomas in Japanese

scientific article published on 26 August 2020

Primary aldosteronism diagnostics: KCNJ5 mutations and hybrid steroid synthesis in aldosterone-producing adenomas

scientific article published on 01 February 2020

Profiles of 21-Carbon Steroids in 21-hydroxylase Deficiency

scientific article published on 7 April 2015

Profiling the steroidogenic pathway in human fetal and adult adrenals

scientific article published in September 2003

Profiling transcript levels for steroidogenic enzymes in fetal tissues.

scientific article published in November 2003

Regulation of the adrenal androgen biosynthesis

scientific article

Role of Ca(2+)/calmodulin-dependent protein kinase kinase in adrenal aldosterone production

scientific article

Role of KCNJ5 in familial and sporadic primary aldosteronism ⬇️

scientific article published on December 11, 2012

Role of angiotensin II-induced rapid response genes in the regulation of enzymes needed for aldosterone synthesis

scientific article

SAT-010 Adrenal Androgen Synthesis in Aging Men.

scientific article published on 30 April 2019

SAT-061 Determinants of Cosyntropin Effect on Adrenal Vein Sampling Lateralization in Primary Aldosteronism

SAT-345 11-oxygenated Adrenal Androgens Are Produced In Several Mammalian Species.

scientific article published on 30 April 2019

SAT-352 Comprehensive Genetic Analysis of Cortisol-Producing Adenomas

scientific article published on 30 April 2019

SUN-364 In Search of Predictors of Concordance between Imaging and Adrenal Vein Sampling in Unilateral Primary Aldosteronism. ⬇️

scientific article published on 30 April 2019

SUN-387 ACTH-Independent Cushing Syndrome from Pregnancy-Induced Micronodular Hyperplasia

scientific article published on 30 April 2019

Sex Differences in 11-Oxygenated Androgen Patterns across Adulthood

scientific article published on 04 June 2020

Sodium deficiency regulates rat adrenal zona glomerulosa gene expression

scientific article published on 14 January 2014

Somatic CACNA1H Mutation As a Cause of Aldosterone-Producing Adenoma

scientific article published on 27 January 2020

Somatic mutations in adrenocortical carcinoma with primary aldosteronism or hyperreninemic hyperaldosteronism

scientific article published on 01 February 2019

Steroid biomarkers in human adrenal disease

scientific article published on 29 January 2019

Steroid sulfotransferase 2A1 gene transcription is regulated by steroidogenic factor 1 and GATA-6 in the human adrenal

scientific article

Suppressive effects of RXR agonist PA024 on adrenal CYP11B2 expression, aldosterone secretion and blood pressure

scientific article published on 11 August 2017

Synthetic High-Density Lipoprotein (sHDL) Inhibits Steroid Production in HAC15 Adrenal Cells

scientific article published on 2 June 2016

Targeted Assessment of G0S2 Methylation Identifies a Rapidly Recurrent, Routinely Fatal Molecular Subtype of Adrenocortical Carcinoma

scientific article published on 15 February 2019

Targeted Molecular Characterization of Aldosterone-Producing Adenomas in White Americans

scientific article published on 01 October 2018

Targeted RNAseq of Formalin-Fixed Paraffin-Embedded Tissue to Differentiate Among Benign and Malignant Adrenal Cortical Tumors

scientific article published on 13 August 2020

Telomerase immortalization of human myometrial cells

scientific article published on August 2002

The AP-1 family member FOS blocks transcriptional activity of the nuclear receptor steroidogenic factor 1.

scientific article

The Age-Dependent Changes of the Human Adrenal Cortical Zones Are Not Congruent

scientific article published in 2021

The Concordance between Imaging and Adrenal Venous Sampling Varies with Aldosterone-Driver Somatic Mutation

scientific article published on 27 July 2020

The NGFI-B family of transcription factors regulates expression of 3beta-hydroxysteroid dehydrogenase type 2 in the human ovary

scientific article published on 22 December 2004

The Potential Role of Aldosterone-Producing Cell Clusters in Adrenal Disease

scientific article published on 30 March 2020

The adrenal genetic puzzle: how do the fetal and adult pieces differ?

scientific article

The development of hypertension and hyperaldosteronism in a rodent model of life-long obesity

scientific article published on 21 February 2012

The effects of ACTH on steroid metabolomic profiles in human adrenal cells

scientific article published on 23 March 2011

The farnesoid X receptor regulates transcription of 3beta-hydroxysteroid dehydrogenase type 2 in human adrenal cells

scientific article

The human fetal adrenal gland, corticotropin-releasing hormone, and parturition

scientific article published on January 2007

The human fetal adrenal: making adrenal androgens for placental estrogens

scientific article

The mechanism for protein kinase C inhibition of androgen production and 17alpha-hydroxylase expression in a theca cell tumor model.

scientific article

The mediator complex subunit 1 enhances transcription of genes needed for adrenal androgen production

scientific article

The orphan nuclear receptor NGFIB regulates transcription of 3beta-hydroxysteroid dehydrogenase. implications for the control of adrenal functional zonation

scientific article

The orphan nuclear receptors NURR1 and NGFIB regulate adrenal aldosterone production

scientific article published on 26 November 2003

The post-menopausal ovary displays a unique pattern of steroidogenic enzyme expression

scientific article published on 27 October 2005

The regulation of adrenocorticotrophic hormone receptor by corticotropin-releasing hormone in human fetal adrenal definitive/transitional zone cells

scientific article published in September 2007

The regulation of aldosterone synthase expression

scientific article

The rise in adrenal androgen biosynthesis: adrenarche

scientific article

The role of TASK1 in aldosterone production and its expression in normal adrenal and aldosterone-producing adenomas

scientific article

The role of the orphan nuclear receptor, liver receptor homologue-1, in the regulation of human corpus luteum 3beta-hydroxysteroid dehydrogenase type II.

scientific article

The steroid metabolome of adrenarche ⬇️

scientific article published on June 19, 2012

Three Discrete Patterns of Primary Aldosteronism Lateralization in Response to Cosyntropin During Adrenal Vein Sampling

scientific article published on 01 December 2019

Transcriptional regulation of dehydroepiandrosterone sulfotransferase (SULT2A1) by estrogen-related receptor alpha

scientific article

Transcriptome Analysis Reveals Differentially Expressed Transcripts in Rat Adrenal Zona Glomerulosa and Zona Fasciculata ⬇️

scientific article published on February 28, 2012

Transcriptome profiling reveals differentially expressed transcripts between the human adrenal zona fasciculata and zona reticularis

scientific article published on January 2013

Type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) contributes to testosterone production in the adrenal reticularis

scientific article

Ubc9 and Protein Inhibitor of Activated STAT 1 Activate Chicken Ovalbumin Upstream Promoter-Transcription Factor I-mediated Human CYP11B2 Gene Transcription

scientific article

Understanding primary aldosteronism: impact of next generation sequencing and expression profiling.

scientific article

VLDL-activated cell signaling pathways that stimulate adrenal cell aldosterone production

scientific article

Very low-density lipoprotein (VLDL)-induced signals mediating aldosterone production

scientific article published on 2 December 2016

a Novel Y152C KCNJ5 mutation responsible for familial hyperaldosteronism type III.

scientific article published on 13 September 2013

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