List of works - David Eisenberg

3D domain swapping: as domains continue to swap

scientific article

A Double S Shape Provides the Structural Basis for the Extraordinary Binding Specificity of Dscam Isoforms

scientific article

A pair of peptides inhibits seeding of the hormone transporter transthyretin into amyloid fibrils

scientific article published on 07 February 2019

Ab initio structure determination from prion nanocrystals at atomic resolution by MicroED.

scientific article published on 19 September 2016

Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity

scientific article

An amyloid-forming peptide from the yeast prion Sup35 reveals a dehydrated beta-sheet structure for amyloid

scientific article (publication date: 27 February 2001)

Atomic Structures Suggest Determinants of Transmission Barriers in Mammalian Prion Disease

scientific article

Atomic View of a Toxic Amyloid Small Oligomer

scientific article

Atomic insights into the genesis of cellular filaments by globular proteins

scholarly article by Laura McPartland published in August 2018

Atomic structure of the cross-β spine of islet amyloid polypeptide (amylin)

scientific article

Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process

scientific article

Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation

scientific article published on 21 May 2018

Atomic structures of amyloid cross-beta spines reveal varied steric zippers

scientific article

Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity

scientific article published on 03 January 2017

Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks.

scientific article published in February 2018

Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2

scientific article published on 12 March 2018

Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED.

scientific article published on 13 February 2017

Author Correction: Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation

scientific article published on 01 October 2019

Author Correction: Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design

scientific article published on 01 December 2018

Characteristics of Amyloid-Related Oligomers Revealed by Crystal Structures of Macrocyclic β-Sheet Mimics

scientific article

Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel

scientific article published in Nature Communications

Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils

scientific article published on 15 June 2020

Cryo-EM structure of a human prion fibril with a hydrophobic, protease-resistant core

scientific article published on 13 April 2020

Cryo-EM structures of four polymorphic TDP-43 amyloid cores

scientific article published on 24 June 2019

CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid

scientific article published on 14 August 2020

Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease

scientific article published on 03 June 2020

Crystal structure of a major secreted protein of Mycobacterium tuberculosis-MPT63 at 1.5-Å resolution

scientific article

Crystal structures of a pantothenate synthetase fromM. tuberculosisand its complexes with substrates and a reaction intermediate

scientific article (publication date: May 2003)

Crystal structures of truncated alphaA and alphaB crystallins reveal structural mechanisms of polydispersity important for eye lens function

scientific article

Crystallographic Studies of Prion Protein (PrP) Segments Suggest How Structural Changes Encoded by Polymorphism at Residue 129 Modulate Susceptibility to Human Prion Disease

scientific article

DIP, the Database of Interacting Proteins: a research tool for studying cellular networks of protein interactions

scientific article

Gram-positive DsbE proteins function differently from Gram-negative DsbE homologs. A structure to function analysis of DsbE from Mycobacterium tuberculosis

scientific article

Granulysin crystal structure and a structure-derived lytic mechanism

scientific article

Heterologous expression of mycobacterial Esx complexes in Escherichia coli for structural studies is facilitated by the use of maltose binding protein fusions

scientific article

How Hard It Is Seeing What Is in Front of Your Eyes

Identification of two principal amyloid-driving segments in variable domains of Ig light chains in systemic light chain amyloidosis

scientific article published in Journal of Biological Chemistry

Inference of protein function and protein linkages in Mycobacterium tuberculosis based on prokaryotic genome organization: a combined computational approach

scientific article

Inferring protein domain interactions from databases of interacting proteins

scientific article

Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design

article by Qin Cao et al published 8 October 2018 in Nature Chemistry

Inhibition of synucleinopathic seeding by rationally designed inhibitors

scientific article published on 02 January 2020

Intrinsic electronic conductivity of individual atomically resolved amyloid crystals reveals micrometer-long hole hopping via tyrosines

scientific article published on 01 January 2021

Mechanically rigid supramolecular assemblies formed from an Fmoc-guanine conjugated peptide nucleic acid

scientific article published on 20 November 2019

Molecular basis for amyloid- polymorphism

scientific article

Molecular basis for insulin fibril assembly

scientific article

Molecular mechanisms for protein-encoded inheritance

scientific article

Multicopy crystallographic refinement of a relaxed glutamine synthetase from Mycobacterium tuberculosis highlights flexible loops in the enzymatic mechanism and its regulation

scientific article

Out-of-register -sheets suggest a pathway to toxic amyloid aggregates

scientific article

Paul D. Boyer (1918–2018)

scientific article published in Science

Prolinks: a database of protein functional linkages derived from coevolution

scientific article

Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy

scientific article published in 2024

Structure and assembly of an augmented Sm-like archaeal protein 14-mer

scientific article (publication date: 15 April 2003)

Structure and function of an archaeal homolog of survival protein E (SurEalpha): an acid phosphatase with purine nucleotide specificity

scientific article (publication date: 7 March 2003)

Structure and proposed activity of a member of the VapBC family of toxin-antitoxin systems. VapBC-5 from Mycobacterium tuberculosis

scientific article

Structure of a Nudix protein from Pyrobaculum aerophilum reveals a dimer with two intersubunit beta-sheets

scientific article

Structure of amyloid-β (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface

scientific article published on 26 July 2019

Structure of superoxide dismutase from Pyrobaculum aerophilum presents a challenging case in molecular replacement with multiple molecules, pseudo-symmetry and twinning

scientific article

Structure of the cross-beta spine of amyloid-like fibrils

scientific article

Structure of the toxic core of α-synuclein from invisible crystals

scientific article published on 9 September 2015

Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation

scientific article

Structure-based inhibitors halt prion-like seeding by Alzheimer's disease-and tauopathy-derived brain tissue samples

scientific article published on 19 September 2019

Structure-based inhibitors of amyloid beta core suggest a common interface with tau

scientific article published on 15 October 2019

Structure-based inhibitors of tau aggregation

scientific article

Structures of fibrils formed by α-synuclein hereditary disease mutant H50Q reveal new polymorphs

scientific article published on 06 November 2019

Structures of segments of α-synuclein fused to maltose-binding protein suggest intermediate states during amyloid formation

scientific article

Structures of the two 3D domain-swapped RNase A trimers

scientific article

Sub-ångström cryo-EM structure of a prion protofibril reveals a polar clasp.

scientific article published on 15 January 2018

Taking the measure of MicroED.

scientific article

Tertiary structure of plant RuBisCO: domains and their contacts

scientific article

The 3D profile method for identifying fibril-forming segments of proteins

scientific article

The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families

scientific article published in March 2007

The crystal structure of a heptameric archaeal Sm protein: Implications for the eukaryotic snRNP core

scientific article

The crystal structure of the Rv0301-Rv0300 VapBC-3 toxin-antitoxin complex fromM. tuberculosisreveals a Mg2+ion in the active site and a putative RNA-binding site

scientific article

The discovery of the alpha-helix and beta-sheet, the principal structural features of proteins

scientific article

The formation, function and regulation of amyloids: insights from structural biology

scientific article published on 30 May 2016

The oligomerization and ligand-binding properties of Sm-like archaeal proteins (SmAPs)

scientific article

The structure of a fibril-forming sequence, NNQQNY, in the context of a globular fold

scientific article

The structured core domain of B-crystallin can prevent amyloid fibrillation and associated toxicity

scientific article

Thiol-disulfide exchange in an immunoglobulin-like fold: structure of the N-terminal domain of DsbD

scientific article

Toward the structural genomics of complexes: Crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis

scientific article (publication date: 23 May 2006)

Towards a Pharmacophore for Amyloid

scientific article

X-ray Crystallographic Structure of an Artificial β-Sheet Dimer

scientific article

β2-microglobulin forms three-dimensional domain-swapped amyloid fibrils with disulfide linkages

scientific article

List of works by David Eisenberg

3D domain swapping: as domains continue to swap

A Double S Shape Provides the Structural Basis for the Extraordinary Binding Specificity of Dscam Isoforms

A pair of peptides inhibits seeding of the hormone transporter transthyretin into amyloid fibrils

Ab initio structure determination from prion nanocrystals at atomic resolution by MicroED.

Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity

An amyloid-forming peptide from the yeast prion Sup35 reveals a dehydrated beta-sheet structure for amyloid

Atomic Structures Suggest Determinants of Transmission Barriers in Mammalian Prion Disease

Atomic View of a Toxic Amyloid Small Oligomer

Atomic insights into the genesis of cellular filaments by globular proteins

Atomic structure of the cross-β spine of islet amyloid polypeptide (amylin)

Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process

Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation

Atomic structures of amyloid cross-beta spines reveal varied steric zippers

Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity

Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks.

Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2

Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED.

Author Correction: Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation

Author Correction: Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design

Characteristics of Amyloid-Related Oligomers Revealed by Crystal Structures of Macrocyclic β-Sheet Mimics

Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel

Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils

Cryo-EM structure of a human prion fibril with a hydrophobic, protease-resistant core

Cryo-EM structures of four polymorphic TDP-43 amyloid cores

CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid

Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease

Crystal structure of a major secreted protein of Mycobacterium tuberculosis-MPT63 at 1.5-Å resolution

Crystal structures of a pantothenate synthetase fromM. tuberculosisand its complexes with substrates and a reaction intermediate

Crystal structures of truncated alphaA and alphaB crystallins reveal structural mechanisms of polydispersity important for eye lens function

Crystallographic Studies of Prion Protein (PrP) Segments Suggest How Structural Changes Encoded by Polymorphism at Residue 129 Modulate Susceptibility to Human Prion Disease

DIP, the Database of Interacting Proteins: a research tool for studying cellular networks of protein interactions

Gram-positive DsbE proteins function differently from Gram-negative DsbE homologs. A structure to function analysis of DsbE from Mycobacterium tuberculosis

Granulysin crystal structure and a structure-derived lytic mechanism

Heterologous expression of mycobacterial Esx complexes in Escherichia coli for structural studies is facilitated by the use of maltose binding protein fusions

How Hard It Is Seeing What Is in Front of Your Eyes

Identification of two principal amyloid-driving segments in variable domains of Ig light chains in systemic light chain amyloidosis

Inference of protein function and protein linkages in Mycobacterium tuberculosis based on prokaryotic genome organization: a combined computational approach

Inferring protein domain interactions from databases of interacting proteins

Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design

Inhibition of synucleinopathic seeding by rationally designed inhibitors

Intrinsic electronic conductivity of individual atomically resolved amyloid crystals reveals micrometer-long hole hopping via tyrosines

Mechanically rigid supramolecular assemblies formed from an Fmoc-guanine conjugated peptide nucleic acid

Molecular basis for amyloid- polymorphism

Molecular basis for insulin fibril assembly

Molecular mechanisms for protein-encoded inheritance

Multicopy crystallographic refinement of a relaxed glutamine synthetase from Mycobacterium tuberculosis highlights flexible loops in the enzymatic mechanism and its regulation

Out-of-register -sheets suggest a pathway to toxic amyloid aggregates

Paul D. Boyer (1918–2018)

Prolinks: a database of protein functional linkages derived from coevolution

Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy

Structure and assembly of an augmented Sm-like archaeal protein 14-mer

Structure and function of an archaeal homolog of survival protein E (SurEalpha): an acid phosphatase with purine nucleotide specificity

Structure and proposed activity of a member of the VapBC family of toxin-antitoxin systems. VapBC-5 from Mycobacterium tuberculosis

Structure of a Nudix protein from Pyrobaculum aerophilum reveals a dimer with two intersubunit beta-sheets

Structure of amyloid-β (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface

Structure of superoxide dismutase from Pyrobaculum aerophilum presents a challenging case in molecular replacement with multiple molecules, pseudo-symmetry and twinning

Structure of the cross-beta spine of amyloid-like fibrils

Structure of the toxic core of α-synuclein from invisible crystals

Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation

Structure-based inhibitors halt prion-like seeding by Alzheimer's disease-and tauopathy-derived brain tissue samples

Structure-based inhibitors of amyloid beta core suggest a common interface with tau

Structure-based inhibitors of tau aggregation

Structures of fibrils formed by α-synuclein hereditary disease mutant H50Q reveal new polymorphs

Structures of segments of α-synuclein fused to maltose-binding protein suggest intermediate states during amyloid formation

Structures of the two 3D domain-swapped RNase A trimers

Sub-ångström cryo-EM structure of a prion protofibril reveals a polar clasp.

Taking the measure of MicroED.

Tertiary structure of plant RuBisCO: domains and their contacts

The 3D profile method for identifying fibril-forming segments of proteins

The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families

The crystal structure of a heptameric archaeal Sm protein: Implications for the eukaryotic snRNP core

The crystal structure of the Rv0301-Rv0300 VapBC-3 toxin-antitoxin complex fromM. tuberculosisreveals a Mg2+ion in the active site and a putative RNA-binding site

The discovery of the alpha-helix and beta-sheet, the principal structural features of proteins

The formation, function and regulation of amyloids: insights from structural biology

The oligomerization and ligand-binding properties of Sm-like archaeal proteins (SmAPs)

The structure of a fibril-forming sequence, NNQQNY, in the context of a globular fold

The structured core domain of B-crystallin can prevent amyloid fibrillation and associated toxicity

Thiol-disulfide exchange in an immunoglobulin-like fold: structure of the N-terminal domain of DsbD

Toward the structural genomics of complexes: Crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis