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List of works by John Okombo

4-Aminoquinoline Antimalarials Containing a Benzylmethylpyridylmethylamine Group Are Active against Drug Resistant Plasmodium falciparum and Exhibit Oral Activity in Mice

scientific article published on 29 November 2017

A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug Piperaquine

scientific article

A genome wide association study of Plasmodium falciparum susceptibility to 22 antimalarial drugs in Kenya

scientific article (publication date: 2014)

Anticancer agents against malaria: time to revisit?

scientific article published on 6 January 2010

Antimalarial Pyrido[1,2- a]benzimidazole Derivatives with Mannich Base Side Chains: Synthesis, Pharmacological Evaluation, and Reactive Metabolite Trapping Studies

scientific article published on 17 January 2019

Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model.

scientific article published on 17 January 2017

Antimalarial activity of isoquine against Kenyan Plasmodium falciparum clinical isolates and association with polymorphisms in pfcrt and pfmdr1 genes

scientific article published on 20 November 2012

Antiplasmodial drug targets: a patent review (2000 - 2013).

scientific article

Antischistosomal Activity of Pyrido[1,2-a]benzimidazole Derivatives and Correlation with Inhibition of β-Hematin Formation

scientific article published on 25 April 2017

Baseline In Vitro Activities of the Antimalarials Pyronaridine and Methylene Blue against Plasmodium falciparum Isolates from Kenya ⬇️

scientific article published on November 28, 2011

Chloroquine-containing compounds: a patent review (2010 - 2014).

scientific article published on 26 May 2015

Comparison of allele frequencies of Plasmodium falciparum merozoite antigens in malaria infections sampled in different years in a Kenyan population

scientific article published on 6 May 2016

Correction: Recent updates in the discovery and development of novel antimalarial drug candidates

article

Designed Hybrid Compounds for Tropical Parasitic Diseases

Genetic screens reveal a central role for heme metabolism in artemisinin susceptibility

scientific article published on 23 September 2020

Genome-wide screen identifies new candidate genes associated with artemisinin susceptibility in Plasmodium falciparum in Kenya

scientific article

Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model

scientific article published on 25 October 2020

Impact of folate supplementation on the efficacy of sulfadoxine/pyrimethamine in preventing malaria in pregnancy: the potential of 5-methyl-tetrahydrofolate

scientific article published on 14 October 2013

In vitro activities of quinine and other antimalarials and pfnhe polymorphisms in Plasmodium isolates from Kenya

scientific article published on June 2010

In vitro activity of antifolate and polymorphism in dihydrofolate reductase of Plasmodium falciparum isolates from the Kenyan coast: emergence of parasites with Ile-164-Leu mutation

scientific article published on 15 June 2009

Insights into Integrated Lead Generation and Target Identification in Malaria and Tuberculosis Drug Discovery

scientific article

Malaria in the Era of Food Fortification With Folic Acid

scientific article published on 4 March 2016

Mono- and multimeric ferrocene congeners of quinoline-based polyamines as potential antiparasitics

scientific article published on 3 August 2016

Mono- and polynuclear ferrocenylthiosemicarbazones: Synthesis, characterisation and antimicrobial evaluation

Multistage Antiplasmodium Activity of Astemizole Analogues and Inhibition of Hemozoin Formation as a Contributor to Their Mode of Action

scientific article published on 07 January 2019

Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in <i>Plasmodium falciparum</i>

scientific article published on 23 February 2021

Pharmacokinetics and Organ Distribution of C-3 Alkyl Esters as Potential Antimycobacterial Prodrugs of Fusidic Acid

scientific article published on 03 February 2020

Plasmepsin Inhibitors in Antimalarial Drug Discovery: Medicinal Chemistry and Target Validation (2000 to Present)

scientific article published on 23 January 2020

Pyronaridine-Artesunate Shows Promise as an Effective and Well-Tolerated Treatment for Artemisinin-Resistant Plasmodium falciparum Malaria

scientific article published on 28 June 2019

Recent updates in the discovery and development of novel antimalarial drug candidates

article

Repeat polymorphisms in the low-complexity regions of Plasmodium falciparum ABC transporters and associations with in vitro antimalarial responses.

scientific article published on 30 September 2013

Semisynthetic Antimycobacterial C-3 Silicate and C-3/C-21 Ester Derivatives of Fusidic Acid: Pharmacological Evaluation and Stability Studies in Liver Microsomes, Rat Plasma, and Mycobacterium tuberculosis culture

scientific article published on 29 July 2019

Structure and drug resistance of the Plasmodium falciparum transporter PfCRT

scientific article published on 27 November 2019

Structure-Activity Relationship Studies and Plasmodium Life Cycle Profiling Identifies Pan-Active N-Aryl-3-trifluoromethyl Pyrido[1,2- a]benzimidazoles Which Are Efficacious in an in Vivo Mouse Model of Malaria

scientific article published on 24 December 2018

Structure-activity relationship analyses of fusidic acid derivatives highlight crucial role of the C-21 carboxylic acid moiety to its anti-mycobacterial activity

scientific article published on 25 April 2020

Synthesis and biological characterisation of ester and amide derivatives of fusidic acid as antiplasmodial agents

scientific article published on 25 November 2016

Temporal trends in prevalence of Plasmodium falciparum drug resistance alleles over two decades of changing antimalarial policy in coastal Kenya

scientific article (publication date: December 2014)

The MSPDBL2 codon 591 polymorphism is associated with lumefantrine in vitro drug responses in Plasmodium falciparum isolates from Kilifi, Kenya

scientific article

The polymorphic linker domain of pfmdr1 is associated with resistance-conferring mutations in Plasmodium falciparum populations from East and West Africa

scientific article

Update on genetic markers of quinine resistance in Plasmodium falciparum

scientific article published on February 2011

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